Xiuting Chen
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View article: Broad neutralizing antibody response of a monomeric spike–based SARS-CoV-2 bivalent vaccine against diverse variants
Broad neutralizing antibody response of a monomeric spike–based SARS-CoV-2 bivalent vaccine against diverse variants Open
severeacute respiratory syndrome coronavirus 2 (SARS-CoV-2) bivalent vaccines show potential against variants but lack a full understanding of the immunological mechanisms that drive broadly neutralizing antibodies (bnAbs). This study expl…
View article: Predicting recurrence risk in endometrial cancer: a multisequence MRI intratumoral and peritumoral radiomics nomogram approach
Predicting recurrence risk in endometrial cancer: a multisequence MRI intratumoral and peritumoral radiomics nomogram approach Open
Objective To assess the predictive value of a nomogram model incorporating clinical factors and multisequence MRI intratumoral and peritumoral radiomics features for estimating recurrence risk in endometrial cancer (EC) patients. Materials…
View article: A novel HBc-S230 protein chimeric VLPs induced robust immune responses against SARS-CoV-2
A novel HBc-S230 protein chimeric VLPs induced robust immune responses against SARS-CoV-2 Open
Here, we report that four functional fragments of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) spike protein including receptor binding motif (RBM), fusion peptide (FP), heptad repeat 1 (HR1) and heptad repeat 2 (HR2) w…
View article: A Thorium(IV) metallacyclopropyne complex
A Thorium(IV) metallacyclopropyne complex Open
Actinide metallacyclic chemistry has been of interest due to its involvement in various chemical processes. However, fundamental understanding on the key species, actinide metallacyclic complexes, is limited to metallacyclopropenes whereas…
View article: Cinnamaldehyde protects SH-SY5Y cells against advanced glycation end-products induced ectopic cell cycle re-entry
Cinnamaldehyde protects SH-SY5Y cells against advanced glycation end-products induced ectopic cell cycle re-entry Open
Accumulation of advanced glycation end-products (AGEs) in the brain contributes significantly to cognitive impairment in patients with diabetes by disrupting the post-mitotic state of neuronal cells, thereby triggering ectopic cell cycle r…
View article: A neutralizing antibody potently prevents RSV A and B infections by targeting a conserved region of the prefusion F
A neutralizing antibody potently prevents RSV A and B infections by targeting a conserved region of the prefusion F Open
Respiratory syncytial virus (RSV) poses a significant public health challenge, especially among children. Although palivizumab and nirsevimab, neutralizing antibodies (nAbs) targeting the RSV F protein, have been used for prophylaxis, thei…
View article: Structural basis for broad neutralization of human antibody against Omicron sublineages and evasion by XBB variant
Structural basis for broad neutralization of human antibody against Omicron sublineages and evasion by XBB variant Open
The continuous emergence of SARS-CoV-2 variants, particularly the newly circulating Omicron XBB subvariants, has led to a significant reduction in the neutralizing potency and breadth of antibodies. In this study, we report a SARS-CoV-2 hu…
View article: Case Report: Chronic hepatitis E virus Infection in an individual without evidence for immune deficiency
Case Report: Chronic hepatitis E virus Infection in an individual without evidence for immune deficiency Open
Chronic hepatitis E virus (HEV) infection occurs mainly in immunosuppressed populations. We describe an investigation of chronic HEV infection of genotype 3a in an individual without evidence for immune deficiency who presented hepatitis w…
View article: Cover Image
Cover Image Open
The cover image is based on the Research Article Gas-phase formation of Grignard-type organolanthanide (III) ions RLnCl3-: The influences of lanthanide center and hydrocarbyl group by Meixian Yang et al., https://doi.org/10.1002/rcm.9512.
View article: Gas-Phase Formation of Grignard-type Organolanthanide(III) Ions RLnCl3-: the Influences of Lanthanide Center and Hydrocarbyl Group
Gas-Phase Formation of Grignard-type Organolanthanide(III) Ions RLnCl3-: the Influences of Lanthanide Center and Hydrocarbyl Group Open
Rationale: The fundamental understanding of Grignard-type organolanthanides(III) is still in its infancy. Decarboxylation of metal carboxylate ions is a powerful method to obtain organometallic ions which are well suited for gas-phase inve…
View article: A sulfur monoxide complex of platinum fluoride with a positively charged ligand
A sulfur monoxide complex of platinum fluoride with a positively charged ligand Open
A sulfur monoxide complex of platinum difluoride was prepared via isomerization of Pt(SOF 2 ) under UV-vis irradiation in argon matrixes. Both experimental and theoretical results indicate the presence of a positively charged SO ligand.
View article: Cinnamomum cassia Presl flavonoids prevent hyperglycemia-induced cognitive impairment via inhibiting of AGEs accumulation and oxidative stress
Cinnamomum cassia Presl flavonoids prevent hyperglycemia-induced cognitive impairment via inhibiting of AGEs accumulation and oxidative stress Open
Cinnamomum cassia Presl (CCP) has a beneficial impact on diabetes and dementia. In this research, the underlying mechanism of flavonoids of Cinnamomum cassia Presl (CFS) on diabetes-related cognitive impairment (DRCI) were inferred by a ne…
View article: Three SARS-CoV-2 antibodies provide broad and synergistic neutralization against variants of concern, including Omicron
Three SARS-CoV-2 antibodies provide broad and synergistic neutralization against variants of concern, including Omicron Open
The rapidly spreading Omicron variant is highly resistant to vaccines, convalescent sera, and neutralizing antibodies (nAbs), highlighting the urgent need for potent therapeutic nAbs. Here, a panel of human nAbs from severe acute respirato…
View article: Probiotics on Intestinal Flora Disturbance and Bacterial Translocation in Mice with Inflammatory Bowel Disease
Probiotics on Intestinal Flora Disturbance and Bacterial Translocation in Mice with Inflammatory Bowel Disease Open
Inflammatory bowel disease is becoming more and more common in western countries and less common in China. However, with the change of dietary structure, the incidence of inflammatory bowel disease is also increasing in China. It will caus…
View article: A Metabolic Insight Into the Neuroprotective Effect of Jin-Mai-Tong (JMT) Decoction on Diabetic Rats With Peripheral Neuropathy Using Untargeted Metabolomics Strategy
A Metabolic Insight Into the Neuroprotective Effect of Jin-Mai-Tong (JMT) Decoction on Diabetic Rats With Peripheral Neuropathy Using Untargeted Metabolomics Strategy Open
Jin-Mai-Tong (JMT) decoction is a traditional Chinese compound prescription for treating diabetic peripheral neuropathy (DPN). The aim of this study is to investigate the neuroprotective effect of JMT decoction on diabetic rats with periph…
View article: WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death
WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death Open
Mutations in the macroautophagy/autophagy gene WDR45 cause β-propeller protein-associated neurodegeneration (BPAN); however the molecular and cellular mechanism of the disease process is largely unknown. Here we generated constitutive wdr4…
View article: Isobaric tag for relative and absolute quantitation based quantitative proteomics reveals unique urinary protein profiles in patients with preeclampsia
Isobaric tag for relative and absolute quantitation based quantitative proteomics reveals unique urinary protein profiles in patients with preeclampsia Open
Preeclampsia (PE) is one of the most significant pregnancy‐related hypertensive disorders. Currently, there are no useful markers to predict the onset of the condition in pregnant women. To provide further insights into the pathogenesis of…
View article: WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death
WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death Open
Mutations in the macroautophagy/autophagy gene WDR45 cause β-propeller protein-associated neurodegeneration (BPAN); however the molecular and cellular mechanism of the disease process is largely unknown. Here we generated constitutive wdr4…
View article: Alterations in the gut microbiome and metabolism with coronary artery disease severity
Alterations in the gut microbiome and metabolism with coronary artery disease severity Open
Overall, the composition and functions of the gut microbial community differed from healthy controls to diverse coronary artery disease subtypes. Our study identified the relationships between the features of the gut microbiota and circula…
View article: Additional file 2: of Alterations in the gut microbiome and metabolism with coronary artery disease severity
Additional file 2: of Alterations in the gut microbiome and metabolism with coronary artery disease severity Open
Table S1. The extrinsic host factor profile included diet, lifestyle, and stool consistency in CAD and control individuals. Table S2. Description of metabolite clusters of serum metabolites under polar ionic mode and their associations wi…
View article: WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death
WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death Open
Mutations in the macroautophagy/autophagy gene WDR45 cause β-propeller protein-associated neurodegeneration (BPAN); however the molecular and cellular mechanism of the disease process is largely unknown. Here we generated constitutive wdr4…
View article: WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death
WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death Open
Mutations in the autophagy gene WDR45 cause β-propeller protein-associated neurodegeneration (BPAN); however the molecular and cellular mechanism of the disease process is largely unknown. Here we generated constitutive Wdr45 knockout (KO)…
View article: Micro<scp>RNA</scp> 26b promotes colorectal cancer metastasis by downregulating phosphatase and tensin homolog and wingless‐type <scp>MMTV</scp> integration site family member 5A
Micro<span>RNA</span> 26b promotes colorectal cancer metastasis by downregulating phosphatase and tensin homolog and wingless‐type <span>MMTV</span> integration site family member 5A Open
Invasion and metastasis are crucially important factors in the survival of malignant tumors. Epithelial‐mesenchymal transition ( EMT ) is an early step in metastatic progression and the presence of cancer stem cells is closely related to t…