Xiuyan Han
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View article: The role of VCAM1 in post-stroke cognitive impairment: Molecular mechanisms and therapeutic potential
The role of VCAM1 in post-stroke cognitive impairment: Molecular mechanisms and therapeutic potential Open
Ischemic stroke constitutes a critical medical condition that can lead to post-stroke cognitive impairment (PSCI), yet the underlying molecular mechanisms remain incompletely understood. This study investigated the role of vascular cell ad…
View article: Novel CT Image‐Based Intracerebral Bleeding Risk Score for Patients With Acute Ischemic Stroke Undergoing Thrombolysis
Novel CT Image‐Based Intracerebral Bleeding Risk Score for Patients With Acute Ischemic Stroke Undergoing Thrombolysis Open
Background Symptomatic intracerebral hemorrhage (sICH) after intravenous recombinant tissue plasminogen activator in patients with acute ischemic stroke (AIS) remains a feared yet unpredictable complication. We aimed to develop and validat…
View article: High-throughput fluorescent screening of β-lactamase inhibitors to improve antibiotic treatment strategies for tuberculosis
High-throughput fluorescent screening of β-lactamase inhibitors to improve antibiotic treatment strategies for tuberculosis Open
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb), which is a major threat to global public health. Currently, β-lactam antibiotics are rarely used in the treatment of TB, since Mtb naturally expresses β…
View article: GlmU inhibitor from the roots of <i>Euphorbia ebracteolata</i> as an anti-tuberculosis agent
GlmU inhibitor from the roots of <i>Euphorbia ebracteolata</i> as an anti-tuberculosis agent Open
Ebractenoid F was identified to be a GlmU inhibitor from Euphorbia ebracteolata , which could inhibit the cell wall biosynthesis of M. tb H37Ra, along with the biofilm formation.
View article: Study on Heavy Metal Pollution Characteristics and its Health Risk Assessment from Sludge of Sewage Treatment Plants in Industrial Parks
Study on Heavy Metal Pollution Characteristics and its Health Risk Assessment from Sludge of Sewage Treatment Plants in Industrial Parks Open
Background In order to study the characteristics of heavy metal pollution from sludge in industrial parks and the effective methods of health risk assessment, in this paper, the pollution characteristics of eight heavy metals including Zn,…
View article: Analysis of metagenome-assembled genomes from the mouse gut microbiota reveals distinctive strain-level characteristics
Analysis of metagenome-assembled genomes from the mouse gut microbiota reveals distinctive strain-level characteristics Open
The laboratorial mouse harbors a unique gut microbiota with potential value for human microbiota-associated studies. Mouse gut microbiota has been explored at the genus and species levels, but features rarely been showed at the strain leve…
View article: Study on the measurement method of environmental pollution loss based on shadow price model of waste gases emission from energy consumption in China's industrial parks
Study on the measurement method of environmental pollution loss based on shadow price model of waste gases emission from energy consumption in China's industrial parks Open
Background: China's industrial parks are areas where energy consumption is relatively concentrated and air pollution is relatively serious. Air pollution threatens the living environment, health and even life of the residents around the in…
View article: Characterization of the Pig Gut Microbiome and Antibiotic Resistome in Industrialized Feedlots in China
Characterization of the Pig Gut Microbiome and Antibiotic Resistome in Industrialized Feedlots in China Open
The gut microbiota is believed to be closely related to many important physical functions in the host. Comprehensive data on mammalian gut metagenomes has facilitated research on host-microbiome interaction mechanisms, but less is known ab…
View article: Structural changes in the gut microbiome of short-term and long-term medical workers compared to normal controls
Structural changes in the gut microbiome of short-term and long-term medical workers compared to normal controls Open
Objective Hospital environment has been implicated in enrichment and exchange of pathogens and antibiotic resistances, but its potential in shaping the symbiotic microbial community of the hospital staff is unclear. This study was designed…
View article: Action of Dicumarol on Glucosamine-1-Phosphate Acetyltransferase of GlmU and Mycobacterium tuberculosis
Action of Dicumarol on Glucosamine-1-Phosphate Acetyltransferase of GlmU and Mycobacterium tuberculosis Open
Mycobacterium tuberculosis is one of most pathogenic microorganisms in the world. Previously, the bifunctional enzyme GlmU with glucosamine-1-phosphate acetyltransferase activity and N-acetylglucosamine-1-phosphate uridyltransferase activi…
View article: The Inhibitory Effect of GlmU Acetyltransferase Inhibitor TPSA on Mycobacterium tuberculosis May Be Affected Due to Its Methylation by Methyltransferase Rv0560c
The Inhibitory Effect of GlmU Acetyltransferase Inhibitor TPSA on Mycobacterium tuberculosis May Be Affected Due to Its Methylation by Methyltransferase Rv0560c Open
Mycobacterium tuberculosis bifunctional enzyme GlmU is a novel target for anti-TB drugs and is involved in glycosyl donor UDP-N-acetylglucosamine biosynthesis. Here, we found that TPSA (2-[5-(2-{[4-(2-thienyl)-2-pyrimidinyl]sulfanyl}acetyl…
View article: Alterations of the Gut Microbiome in Hypertension
Alterations of the Gut Microbiome in Hypertension Open
Introduction: Human gut microbiota is believed to be directly or indirectly involved in cardiovascular diseases and hypertension. However, the identification and functional status of the hypertension-related gut microbe(s) have not yet bee…