Explanipedia

Accelerometer-measured moderate-to-vigorous physical activity is associated with reduced risk of bowel resection and mortality in inflammatory bowel disease: a prospective cohort study Open

Zixuan He, Yuhao Sun, Hanyi Huang, Judith Wellens, Yilong Liu , et al. · 2025

Background: There is limited consensus on physical activity recommendations for inflammatory bowel disease (IBD) patients due to insufficient high-quality evidence. Methods: We collected data from 1303 UK Biobank participants with IBD diag…

Author Correction: Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation Open

Shuai Yuan, Jie Chen, Xixian Ruan, Yuying Li, Sarah Abramowitz , et al. · 2025

Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation Open

Shuai Yuan, Jie Chen, Xixian Ruan, Yuying Li, Sarah Abramowitz , et al. · 2025

Mediterranean diet adherence and incident acute pancreatitis: a prospective cohort study Open

Chunhua Zhou, Jiawei Geng, Zhipeng Wu, Lintao Dan, Hanyi Huang , et al. · 2025

Background: The relationship between Mediterranean diet (MedDiet) adherence and acute pancreatitis (AP) risk is largely unknown. Objectives: To investigate the associations between MedDiet adherence and AP risk and joint associations of ge…

Genome-wide association study and Mendelian randomization analyses reveal insights into bladder cancer etiology Open

Susanna C. Larsson, Jie Chen, Xixian Ruan, Xue Li, Shuai Yuan · 2025

Background The causes of bladder cancer are not completely understood. Our objective was to identify blood proteins and modifiable causal risk factors for bladder cancer by combining genome-wide association study (GWAS) and Mendelian rando…

Adherence to Planetary Health Diet Promotes Dual Sustainability of Prognosis and Environment Among Patients with Inflammatory Bowel Disease: A Prospective Cohort Study Open

Lintao Dan, Hong Shu, Yuhao Sun, Judith Wellens, Yang Chen , et al. · 2025

Unveiling CTRB2, RSPO3, KLOTB, and ROR1 as obesity-pancreatic disease association proteins: a comprehensive Mendelian randomization study Open

Chunhua Zhou, Xixian Ruan, Tianyi Che, Yao Zhang, Shuai Yuan , et al. · 2025

Background Obesity is recognized as a prominent contributing factor for pancreatic diseases; however, the mechanisms remain elusive. We aimed to identify the mediating role of circulating proteins in these associations. Methods A two-step …

Network Mendelian randomisation analysis deciphers protein pathways linking type 2 diabetes and gastrointestinal disease Open

Jiawei Geng, Xixian Ruan, Xing Wu, Xuejie Chen, Tian Fu , et al. · 2024

Aims The molecular mechanisms underlying the association between type 2 diabetes (T2D) and gastrointestinal (GI) disease are unclear. To identify protein pathways, we conducted a two‐stage network Mendelian randomisation (MR) study. Materi…

Device-measured moderate-to-vigorous physical activity and prognosis of inflammatory bowel disease Open

Zixuan He, Yuhao Sun, Hanyi Huang, Yilong Liu, Lintao Dan , et al. · 2024

Importance Evidence on physical activity recommendations for inflammatory bowel disease (IBD) patients is limited, with concerns about high-intensity activity. Objective To investigate the associations of accelerometer-measured moderate-to…

Mendelian randomisation analysis for intestinal disease: achievement and future Open

Xixian Ruan, Tianyi Che, Xuejie Chen, Yuhao Sun, Tian Fu , et al. · 2024

Intestinal disease is a group of complex digestive system diseases imposing a significant burden globally. Identifying the risk factors and potential complications of intestinal disease is important for its prevention and treatment. Howeve…

Sedentary lifestyle, physical activity, and gastrointestinal diseases: evidence from mendelian randomization analysis Open

Jie Chen, Xixian Ruan, Tian Fu, Shiyuan Lu, Dipender Gill , et al. · 2024

Risk of subsequent gastrointestinal disease assessed by skeletal muscle strength and mass in a prospective cohort study Open

Lintao Dan, Pei Qin, Siyuan Xie, Yuhao Sun, Tian Fu , et al. · 2024

Mendelian Randomization Unveiling Blood CTRB2, RSPO3, KLOTB, and ROR1 as Protein Mediators of Obesity-Pancreatic Disease Association Open

Chunhua Zhou, Xixian Ruan, Tianyi Che, Yao Zhang, Shuai Yuan , et al. · 2024

Multi-omic insight into the molecular networks of mitochondrial dysfunction in the pathogenesis of inflammatory bowel disease Open

Jie Chen, Xixian Ruan, Yuhao Sun, Shiyuan Lu, Shixian Hu , et al. · 2023

XL is supported by the Natural Science Fund for Distinguished Young Scholars of Zhejiang Province (LR22H260001) and Healthy Zhejiang One Million People Cohort (K-20230085).

Proteomic insights into modifiable risk of venous thromboembolism and cardiovascular comorbidities Open

Shuai Yuan, Fengzhe Xu, Han Zhang, Jie Chen, Xixian Ruan , et al. · 2023

Prioritization of therapeutic targets for amyotrophic lateral sclerosis using protein-wide Mendelian randomization analysis Open

Jiawei Geng, Luxi Chen, Chenyu Yang, Xixian Ruan, Shixian Hu , et al. · 2023

Background and Objectives Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease with an increasing global burden. Available treatments for ALS present marginal efficacy. To identify novel candidate therapeu…

Therapeutic role of interleukin-1 receptor antagonist in pancreatic diseases: mendelian randomization study Open

Shuai Yuan, Yuyang Miao, Xixian Ruan, Jie Chen, Xue Li , et al. · 2023

Background The interleukin-1 pathway has been linked to pancreatic diseases. We applied the Mendelian randomization approach to explore whether higher interleukin-1 receptor antagonist (IL-1RA) levels reduce the risk of acute and chronic p…

Birth weight, childhood obesity, adulthood obesity and body composition, and gastrointestinal diseases: a Mendelian randomization study Open

Shuai Yuan, Xixian Ruan, Yuhao Sun, Tian Fu, Jianhui Zhao , et al. · 2023

Objective This Mendelian randomization study aimed to investigate the associations of birth weight, childhood BMI, and adulthood BMI, waist‐hip ratio, and body composition with the risk of 24 gastrointestinal diseases. Methods Independent …

Depression and 24 gastrointestinal diseases: a Mendelian randomization study Open

Xixian Ruan, Jie Chen, Yuhao Sun, Yao Zhang, Jianhui Zhao , et al. · 2023

The causality of the association between depression and gastrointestinal diseases is undetermined. We conducted Mendelian randomization (MR) analyses to systematically explore the associations of depression with 24 gastrointestinal disease…

Letter: disentangling the role of redox‐active compounds in the development of inflammatory bowel diseases—moving towards causal associations. Authors' reply Open

Jie Chen, Xixian Ruan, Shuai Yuan, Evropi Τheodoratou, Jack Satsangi , et al. · 2023

LINKED CONTENT This article is linked to Chen et al papers. To view these articles, visit https://doi.org/10.1111/apt.17392 and https://doi.org/10.1111/apt.17455

Editorial: in search of environmental risk factors of Crohn's disease and ulcerative colitis with mendelian randomisation—authors' reply Open

Jie Chen, Xixian Ruan, Shuai Yuan, Evropi Τheodoratou, Jack Satsangi , et al. · 2023

We thank Drs. Meyer, Amiot and Carbonnel for taking the time to consider in detail our research article and for sharing thoughts on its implications.1, 2 We agree that previous studies have not arrived at a consensus on the causal relation…

Sedentary lifestyle, Physical Activity, and Gastrointestinal Diseases: Evidence from Mendelian Randomization Analysis Open

Jie Chen, Xixian Ruan, Tian Fu, Shiyuan Lu, Dipender Gill , et al. · 2023

Objectives The causal associations of physical activity and sedentary behavior with the risk of gastrointestinal disease is unclear. We performed a Mendelian randomization analysis to examine these associations. Methods Genetic instruments…

Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analyses Open

Jie Chen, Fengzhe Xu, Xixian Ruan, Jing Sun, Yao Zhang , et al. · 2023

Gastrointestinal Consequences of Type 2 Diabetes Mellitus and Impaired Glycemic Homeostasis: A Mendelian Randomization Study Open

Jie Chen, Shuai Yuan, Tian Fu, Xixian Ruan, Jie Qiao , et al. · 2023

OBJECTIVE We conducted a Mendelian randomization (MR) study to examine the associations of type 2 diabetes and glycemic traits with gastrointestinal diseases (GDs). RESEARCH DESIGN & METHODS Uncorrelate…

Gastrointestinal Consequences of Type 2 Diabetes Mellitus and Impaired Glycemic Homeostasis: A Mendelian Randomization Study Open

Jie Chen, Shuai Yuan, Tian Fu, Xixian Ruan, Jie Qiao , et al. · 2023

OBJECTIVE We conducted a Mendelian randomization (MR) study to examine the associations of type 2 diabetes and glycemic traits with gastrointestinal diseases (GDs). RESEARCH DESIGN & METHODS Uncorrelate…

Gastrointestinal Consequences of Type 2 Diabetes Mellitus and Impaired Glycemic Homeostasis: A Mendelian Randomization Study Open

Jie Chen, Shuai Yuan, Tian Fu, Xixian Ruan, Jie Qiao , et al. · 2023

OBJECTIVE We conducted a Mendelian randomization (MR) study to examine the associations of type 2 diabetes and glycemic traits with gastrointestinal diseases (GDs). RESEARCH DESIGN AND METHODS Uncorrelated genetic variants associated with …

Smoking, alcohol consumption, and 24 gastrointestinal diseases: Mendelian randomization analysis Open

Shuai Yuan, Jie Chen, Xixian Ruan, Yuhao Sun, Ke Zhang , et al. · 2023

Background: Whether the positive associations of smoking and alcohol consumption with gastrointestinal diseases are causal is uncertain. We conducted this Mendelian randomization (MR) to comprehensively examine associations of smoking and …

Antioxidants, minerals and vitamins in relation to Crohn's disease and ulcerative colitis: A Mendelian randomization study Open

Jie Chen, Xixian Ruan, Shuai Yuan, Minzi Deng, Han Zhang , et al. · 2023

Summary Background Evidence for antioxidants, minerals and vitamins in relation to the risk of Crohn's disease (CD) and ulcerative colitis (UC) is limited and inconsistent. This mendelian randomization (MR) study aimed to examine the causa…

Associations of sugar-sweetened beverages, artificially sweetened beverages, and natural juices with cardiovascular disease and all-cause mortality in individuals with inflammatory bowel disease in a prospective cohort study Open

Lintao Dan, Tian Fu, Yuhao Sun, Xixian Ruan, Shiyuan Lu , et al. · 2023

Background: Beverage consumption was found to be associated with cardiovascular disease and mortality in the general population. However, it is unclear whether this association still exists in individuals with inflammatory bowel disease (I…

Author response: Smoking, alcohol consumption, and 24 gastrointestinal diseases: Mendelian randomization analysis Open

Shuai Yuan, Jie Chen, Xixian Ruan, Yuhao Sun, Ke Zhang , et al. · 2022

Article Figures and data Abstract Editor's evaluation eLife digest Introduction Materials and methods Results Discussion Data availability References Decision letter Author response Article and author information Metrics Abstract Backgroun…

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