Xiyan Hou
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View article: Optimization of Fermentation Conditions for Antarctic Bacteria and Investigation of Its Antimicrobial Mechanism Against Klebsiella pneumoniae
Optimization of Fermentation Conditions for Antarctic Bacteria and Investigation of Its Antimicrobial Mechanism Against Klebsiella pneumoniae Open
Klebsiella pneumoniae is the second-most common opportunistic pathogen in clinical practice and has developed resistance to potent antibacterial drugs such as carbapenems. Therefore, developing safe and effective strategies for the prevent…
View article: Optimization of Fermentation Conditions for Endophytic Fungi from Schisandra chinensis and Investigation of Their Antibacterial Mechanisms Against Methicillin-Resistant Staphylococcus aureus
Optimization of Fermentation Conditions for Endophytic Fungi from Schisandra chinensis and Investigation of Their Antibacterial Mechanisms Against Methicillin-Resistant Staphylococcus aureus Open
Methicillin-resistant Staphylococcus aureus (MRSA) is a highly pathogenic bacterium for which safe and effective prevention as well as treatment methods are currently lacking. In this study, Rhizoctonia bicornis S10 was isolated from Schis…
View article: Structural Modification and Biological Evaluation of 2,8-Disubstituted Adenine and Its Nucleosides as A<sub>2A</sub> Adenosine Receptor Antagonists: Exploring the Roles of Ribose at Adenosine Receptors
Structural Modification and Biological Evaluation of 2,8-Disubstituted Adenine and Its Nucleosides as A<sub>2A</sub> Adenosine Receptor Antagonists: Exploring the Roles of Ribose at Adenosine Receptors Open
Building on the preceding structural analysis and a structure-activity relationship (SAR) of 8-aryl-2-hexynyl nucleoside hA2AAR antagonist 2a, we strategically inverted C2/C8 substituents and eliminated the ribose moiety. These modificatio…
View article: Correction to “Structure–Activity Relationship of Truncated 2,8-Disubstituted-Adenosine Derivatives as Dual A<sub>2A</sub>/A<sub>3</sub> Adenosine Receptor Antagonists and Their Cancer Immunotherapeutic Activity”
Correction to “Structure–Activity Relationship of Truncated 2,8-Disubstituted-Adenosine Derivatives as Dual A<sub>2A</sub>/A<sub>3</sub> Adenosine Receptor Antagonists and Their Cancer Immunotherapeutic Activity” Open
ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Structure–Activity Relationship of Truncated 2,8-Disubstituted-Adenosine Derivatives as Dual A2A/A3 Adenosine Receptor Antago…
View article: Structure–Activity Relationship of Truncated 2,8-Disubstituted-Adenosine Derivatives as Dual A<sub>2A</sub>/A<sub>3</sub> Adenosine Receptor Antagonists and Their Cancer Immunotherapeutic Activity
Structure–Activity Relationship of Truncated 2,8-Disubstituted-Adenosine Derivatives as Dual A<sub>2A</sub>/A<sub>3</sub> Adenosine Receptor Antagonists and Their Cancer Immunotherapeutic Activity Open
Based on hA2AAR structures, a hydrophobic C8-heteroaromatic ring in 5'-truncated adenosine analogues occupies the subpocket tightly, converting hA2AAR agonists into antagonists while maintaining affinity toward hA3AR. The final compounds o…
View article: GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A<sub>2A</sub> Adenosine Receptor
GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A<sub>2A</sub> Adenosine Receptor Open
Modulators of the G protein-coupled A2A adenosine receptor (A2AAR) have been considered promising agents to treat Parkinson's disease, inflammation, cancer, and central nervous system disorders. Herein, we demonstrate that a thiophene modi…
Subtle Chemical Changes Cross the Boundary between Agonist and Antagonist: New A<sub>3</sub> Adenosine Receptor Homology Models and Structural Network Analysis Can Predict This Boundary Open
Distinguishing compounds' agonistic or antagonistic behavior would be of great utility for the rational discovery of selective modulators. We synthesized truncated nucleoside derivatives and discovered 6c (Ki = 2.40 nM) as a potent human A…
View article: Dual Actions of A2A and A3 Adenosine Receptor Ligand Prevents Obstruction-Induced Kidney Fibrosis in Mice
Dual Actions of A2A and A3 Adenosine Receptor Ligand Prevents Obstruction-Induced Kidney Fibrosis in Mice Open
Kidney fibrosis is the final outcome of chronic kidney disease (CKD). Adenosine plays a significant role in protection against cellular damage by activating four subtypes of adenosine receptors (ARs), A1AR, A2AAR, A2BAR, and A3AR. A2AAR ag…
Widespread Existence of Quorum Sensing Inhibitors in Marine Bacteria: Potential Drugs to Combat Pathogens with Novel Strategies Open
Quorum sensing (QS) is a phenomenon of intercellular communication discovered mainly in bacteria. A QS system consisting of QS signal molecules and regulatory protein components could control physiological behaviors and virulence gene expr…
Synthesis, Characteristics and Bioactivities of Novel Isosteviol Derivatives Open
金宇婷 a 高雪琴 a 王 倩 a 孙 蕾 a 赵龙铉 * ,a,d 朴 花 * ,e ( a 辽宁师范大学化学化工学院 辽宁大连 116029) ( b 大连民族大学生命科学学院 辽宁大连 116600) ( c 延边大学药学院 吉林延吉 133002) ( d 辽宁师范大学 生物技术与分子药物研发辽宁省重点实验室 辽宁大连 116029) ( e 大连医科大学基础医学院 辽宁大连 116044)
Interface-Active Metal Organic Frameworks for Knoevenagel Condensations in Water Open
It is desirable but challenging to locate solid catalysts at the oil-water interface to stabilize “Pickering emulsions”, which is one of the promising ways to develop efficient green chemical processes. Herein, water-stable metal organic f…
Sonication enhances quality and antioxidant activity of blueberry juice Open
Effect of sonication on the blueberry juice was studied by evaluating the pH, viscosity, electric conductivity, color, total sugars, soluble solids, polyphenol, anthocyanidin, and radical scavenging activities. There were not any remarkabl…
Sonication enhances quality and antioxidant activity of blueberry juice Open
Effect of sonication on the blueberry juice was studied by evaluating the pH, viscosity, electric conductivity, color, total sugars, soluble solids, polyphenol, anthocyanidin, and radical scavenging activities. There were not any remarkabl…
Optimization of culture medium for production of melanin by Auricularia auricula Open
Melanin is a natural high molecular weight pigment with the huge application value and development potential in food industry. In the present study, medium composition for melanin production by fungus Auricularia auricula was investigated.…
Discovery and Synthesis of Amino Acids Modified Deoxycholic Acid Derivatives and <i>in Vitro</i> Antiproliferative Evaluation Open
A series of deoxycholic acid (DCA) derivatives bearing amino acid moiety has been synthesized and investigated for their potential antiproliferative activities. DCA derivative compounds were synthesized by a two or three step synthetic app…
Histamine production by Enterobacter aerogenes in chub mackerel (Scomber japonicus) at various storage temperatures Open
Growth of Enterobacter aerogenes and accumulation of histamine in chub mackerel (Scomber japonicus) were investigated through measuring bacterial count, histidine decarboxylase (HDC) activity and histamine content in fish samples stored at…
Potential Pharmacological Resources: Natural Bioactive Compounds from Marine-Derived Fungi Open
In recent years, a considerable number of structurally unique metabolites with biological and pharmacological activities have been isolated from the marine-derived fungi, such as polyketides, alkaloids, peptides, lactones, terpenoids and s…