Xing Zhou
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View article: Empirical Examination of Large Language Models in Regional Psychological Structures Simulation: Personality and Well-being
Empirical Examination of Large Language Models in Regional Psychological Structures Simulation: Personality and Well-being Open
The rapid advancement of large language models (LLMs) had opened new avenues for simulating psychological structures at the population level. This study compared the performance of Kimi-Chat v1.5 (a China-trained model) and GPT-4 (a global…
View article: Integrated transcriptomic and immunoinformatics analysis identifies tpx2, bub1b, and ube2c as diagnostic biomarkers and therapeutic targets in endometrial carcinoma
Integrated transcriptomic and immunoinformatics analysis identifies tpx2, bub1b, and ube2c as diagnostic biomarkers and therapeutic targets in endometrial carcinoma Open
View article: In vivo mechanisms of resveratrol liposomes in targeting the TLR4/NLRP3 pathway in lung cancer
In vivo mechanisms of resveratrol liposomes in targeting the TLR4/NLRP3 pathway in lung cancer Open
View article: Targeting circulating tumor cell‒neutrophil interactions: nanoengineered strategies for inhibiting cancer metastasis
Targeting circulating tumor cell‒neutrophil interactions: nanoengineered strategies for inhibiting cancer metastasis Open
Metastasis remains the leading cause of cancer-related mortality, with a persistently poor prognosis for metastatic cancer patients despite extensive therapeutic efforts. Circulating tumor cells (CTCs), which detach from primary tumors and…
View article: Expression Significance and Relationship of Serum miR-542-3p and lncRNA TUG1 in STBI Patients and Their Predictive Value for Prognosis
Expression Significance and Relationship of Serum miR-542-3p and lncRNA TUG1 in STBI Patients and Their Predictive Value for Prognosis Open
miR-542-3p is downregulated and lncRNA TUG1 upregulated in STBI. Both are significantly correlated with prognosis and offer strong predictive value, especially when combined.
View article: A Numerical Investigation of Enhanced Microfluidic Immunoassay by Multiple-Frequency Alternating-Current Electrothermal Convection
A Numerical Investigation of Enhanced Microfluidic Immunoassay by Multiple-Frequency Alternating-Current Electrothermal Convection Open
Compared with traditional immunoassay methods, microfluidic immunoassay restricts the immune response in confined microchannels, significantly reducing sample consumption and improving reaction efficiency, making it worthy of widespread ap…
View article: Immunoengineered mitochondria for efficient therapy of acute organ injuries via modulation of inflammation and cell repair
Immunoengineered mitochondria for efficient therapy of acute organ injuries via modulation of inflammation and cell repair Open
Acute organ injuries represent a major public health concern, driven by inflammation and mitochondrial dysfunction, leading to cell damage and organ failure. In this study, we engineered neutrophil membrane–fused mitochondria (nMITO), whic…
View article: Regulation of testosterone synthesis by circadian clock genes and its research progress in male diseases
Regulation of testosterone synthesis by circadian clock genes and its research progress in male diseases Open
The circadian clock is an important internal time regulatory system for a range of physiological and behavioral rhythms within living organisms. Testosterone, as one of the most critical sex hormones, is essential for the development of th…
View article: Machine Learning‐Driven Prediction, Preparation, and Evaluation of Functional Nanomedicines Via Drug–Drug Self‐Assembly
Machine Learning‐Driven Prediction, Preparation, and Evaluation of Functional Nanomedicines Via Drug–Drug Self‐Assembly Open
Small molecules as nanomedicine carriers offer advantages in drug loading and preparation. Selecting effective small molecules for stable nanomedicines is challenging. This study used artificial intelligence (AI) to screen drug combination…
View article: From Blood to Therapy: The Revolutionary Application of Platelets in Cancer-Targeted Drug Delivery
From Blood to Therapy: The Revolutionary Application of Platelets in Cancer-Targeted Drug Delivery Open
Biomimetic nanodrug delivery systems based on cell membranes have emerged as a promising approach for targeted cancer therapy due to their biocompatibility and low immunogenicity. Among them, platelet-mediated systems are particularly note…
View article: Computer-Aided Construction and Evaluation of Poly-L-Lysine/Hyodeoxycholic Acid Nanoparticles for Hemorrhage and Infection Therapy
Computer-Aided Construction and Evaluation of Poly-L-Lysine/Hyodeoxycholic Acid Nanoparticles for Hemorrhage and Infection Therapy Open
Background: Traumatic hemorrhage and infection are major causes of mortality in wounds caused by battlefield injuries, hospital procedures, and traffic accidents. Developing a multifunctional nano-drug capable of simultaneously controlling…
View article: CTC-neutrophil interaction: A key driver and therapeutic target of cancer metastasis
CTC-neutrophil interaction: A key driver and therapeutic target of cancer metastasis Open
Circulating tumor cells (CTCs) are cancer cells that detach from the primary tumor and enter the bloodstream, where they can seed new metastatic lesions in distant organs. CTCs are often associated with white blood cells (WBCs), especially…
View article: Development and Evaluation of a Water-Free In Situ Depot Gel Formulation for Long-Acting and Stable Delivery of Peptide Drug ACTY116
Development and Evaluation of a Water-Free In Situ Depot Gel Formulation for Long-Acting and Stable Delivery of Peptide Drug ACTY116 Open
In situ depot gel is a type of polymeric long-acting injectable (pLAI) drug delivery system; compared to microsphere technology, its preparation process is simpler and more conducive to industrialization. To ensure the chemical stability o…
View article: The Development of a Stable Peptide-Loaded Long-Acting Injection Formulation through a Comprehensive Understanding of Peptide Degradation Mechanisms: A QbD-Based Approach
The Development of a Stable Peptide-Loaded Long-Acting Injection Formulation through a Comprehensive Understanding of Peptide Degradation Mechanisms: A QbD-Based Approach Open
Quality by design (QbD) serves as a systematic approach to pharmaceutical development, beginning with predefined objectives and emphasizing an understanding of the product based on sound science and risk management. The purpose of this stu…
View article: Exosome-mimetic vesicles derived from fibroblasts carrying matrine for wound healing
Exosome-mimetic vesicles derived from fibroblasts carrying matrine for wound healing Open
Background Chronic skin wounds are a leading cause of hospital admissions and reduced life expectancy among older people and individuals with diabetes. Delayed wound healing is often attributed to a series of cellular abnormalities. Matrin…
View article: Future Self
Future Self Open
This project explored dignity as a design principle for a service supporting formerly incarcerated students by helping them achieve their higher education goals and career ambitions. We highlight autonomy as the foundation of dignity and e…
View article: Systematic analysis of the prognosis and immune infiltration of E2Fs in thyroid carcinoma
Systematic analysis of the prognosis and immune infiltration of E2Fs in thyroid carcinoma Open
Purpose: To evaluate the diagnostic and prognostic utility of E2F transcription factors (E2Fs) in thyroid carcinoma (THCA) and their association with immune infiltration. Methods: The transcription and protein levels of E2Fs in THCA tissue…
View article: Effect of Steam on Carbonation of CaO in Ca-Looping
Effect of Steam on Carbonation of CaO in Ca-Looping Open
Ca-looping is an effective way to capture CO2 from coal-fired power plants. However, there are still issues that require further study. One of these issues is the effect of steam on the Ca-looping process. In this paper, a self-madethermog…
View article: Immuno-Engineered Mitochondria for Efficient Therapy of Acute Organ Injuries via Modulation of Inflammation and Cell Repair
Immuno-Engineered Mitochondria for Efficient Therapy of Acute Organ Injuries via Modulation of Inflammation and Cell Repair Open
Acute organ injuries represent a major public health concern, and despite recent advances in organ support therapy, managing patients with organ failure stemming from such injuries remains a formidable challenge. The pathogenesis of acute …
View article: GABAergic signaling abnormalities in a novel CLU mutation Alzheimer's disease mouse model
GABAergic signaling abnormalities in a novel CLU mutation Alzheimer's disease mouse model Open
View article: New Process Combining Fe-Based Chemical Looping and Biomass Pyrolysis for Cogeneration of Hydrogen, Biochar, Bio-Oil and Electricity with In-Suit CO2 Separation
New Process Combining Fe-Based Chemical Looping and Biomass Pyrolysis for Cogeneration of Hydrogen, Biochar, Bio-Oil and Electricity with In-Suit CO2 Separation Open
Fe-based chemical looping gasification is a clean biomass technology, which has the advantage of reducing CO2 emissions and the potential of self-sustaining operation without supplemental heating. A novel process combining Fe-based chemica…
View article: Experimental Study on Electrochemical Desulfurization of Coal Liquefaction Residue
Experimental Study on Electrochemical Desulfurization of Coal Liquefaction Residue Open
The occurrence of sulfur in coal direct liquefaction residue affects its further high quality and high value utilization. Electrochemical desulfurization is characterized by mild reaction conditions, simple operation, easy separation of su…
View article: Advances in Oral Drug Delivery Systems: Challenges and Opportunities
Advances in Oral Drug Delivery Systems: Challenges and Opportunities Open
The oral route is the most preferred route for systemic and local drug delivery. However, the oral drug delivery system faces the harsh physiological and physicochemical environment of the gastrointestinal tract, which limits the bioavaila…
View article: METTL3-mediated long non-coding RNA MIR99AHG methylation targets miR-4660 to promote bone marrow mesenchymal stem cell osteogenic differentiation
METTL3-mediated long non-coding RNA MIR99AHG methylation targets miR-4660 to promote bone marrow mesenchymal stem cell osteogenic differentiation Open
Whether long non-coding RNA Mir-99a-Let-7c Cluster Host Gene (LncRNA MIR99AHG) is involved in osteoporosis (OP) remains vague, so we hereby center on its implication. Old C57BL/6J mice were injected with the silencing lentivirus of MIR99AH…
View article: Hyperbaric oxygen protects HT22 cells and PC12 cells from damage caused by oxygen-glucose deprivation/reperfusion via the inhibition of Nrf2/System Xc-/GPX4 axis-mediated ferroptosis
Hyperbaric oxygen protects HT22 cells and PC12 cells from damage caused by oxygen-glucose deprivation/reperfusion via the inhibition of Nrf2/System Xc-/GPX4 axis-mediated ferroptosis Open
This study was to investigate the protective effect of hyperbaric oxygen (HBO) on HT22 and PC12 cell damage caused by oxygen-glucose deprivation/reperfusion-induced ferroptosis. A 2-h oxygen-glucose deprivation and 24-h reperfusion model o…
View article: PLK4 Is a Potential Biomarker for Abnormal Tumor Proliferation, Immune Infiltration, and Prognosis in ccRCC
PLK4 Is a Potential Biomarker for Abnormal Tumor Proliferation, Immune Infiltration, and Prognosis in ccRCC Open
Background. PLK4 is highly expressed and associated with poor prognosis in various malignancies. However, the role of PLK4 in clear cell renal cell carcinoma (ccRCC) is still unclear. This study is aimed at analyzing the expression, the po…
View article: Biomaterial-Based Therapeutic Strategies for Obesity and Its Comorbidities
Biomaterial-Based Therapeutic Strategies for Obesity and Its Comorbidities Open
Obesity is a global public health issue that results in many health complications or comorbidities, including type 2 diabetes mellitus, cardiovascular disease, and fatty liver. Pharmacotherapy alone or combined with either lifestyle altera…
View article: PD-L1 Inhibits T Cell-Induced Cytokines and Hyaluronan Expression via the CD40-CD40L Pathway in Orbital Fibroblasts From Patients With Thyroid Associated Ophthalmopathy
PD-L1 Inhibits T Cell-Induced Cytokines and Hyaluronan Expression via the CD40-CD40L Pathway in Orbital Fibroblasts From Patients With Thyroid Associated Ophthalmopathy Open
Thyroid associated ophthalmopathy (TAO), characterized by T cell infiltration and orbital fibroblast activation, is an organ-specific autoimmune disease which is still short of effective and safety therapeutic drugs. The PD-1/PD-L1 pathway…
View article: Recent Progress of Novel Nanotechnology Challenging the Multidrug Resistance of Cancer
Recent Progress of Novel Nanotechnology Challenging the Multidrug Resistance of Cancer Open
Multidrug resistance (MDR) of tumors is one of the clinical direct reasons for chemotherapy failure. MDR directly leads to tumor recurrence and metastasis, with extremely grievous mortality. Engineering a novel nano-delivery system for the…
View article: The RapidIO Routing Strategy Based on the Double-Antibody Group Multi-Objective Artificial Immunity Algorithm
The RapidIO Routing Strategy Based on the Double-Antibody Group Multi-Objective Artificial Immunity Algorithm Open
The RapidIO standard is a packet-switching interconnection technology similar to the Internet Protocol (IP) conceptually. It realizes the high-speed transmission of RapidIO packets at the transport layer, but this greatly increases the pro…