Xiyun Yan
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View article: Probiotic-based oral vaccine mucosal delivery system enabling genetically encoded dual-antigen arrays
Probiotic-based oral vaccine mucosal delivery system enabling genetically encoded dual-antigen arrays Open
Oral vaccines provide a non-invasive approach for cancer immunotherapy but face challenges in gastrointestinal stability, antigen presentation, and mucosal delivery. Here, we present an engineered probiotic-based oral vaccine system, BacOR…
View article: Harnessing dental stem cell-derived synovial cells for IBD therapy: dual modulation of gut immunity and crypt repair
Harnessing dental stem cell-derived synovial cells for IBD therapy: dual modulation of gut immunity and crypt repair Open
Supported by Beijing Natural Science Foundation (7242034, 7242092, L232077), National Natural Science Foundation of China (81870393, 81970500, 82473154, 81970500, and 82203559), and Jiangsu Province Basic Research Special Fund (BK20240117).
View article: Thermally Gated Dual‐Cascade Nanozyme for Enhanced Mild‐Temperature Photothermal Therapy
Thermally Gated Dual‐Cascade Nanozyme for Enhanced Mild‐Temperature Photothermal Therapy Open
Mild‐temperature photothermal therapy (mPTT) is attractive for cancer treatment due to its safety and precision but is limited by heat shock protein 70 (HSP70)‐mediated thermotolerance, which allows tumor cells to survive sublethal heating…
View article: Nanozyme eye drops for retinal barrier penetration and vasculopathy repair
Nanozyme eye drops for retinal barrier penetration and vasculopathy repair Open
Retinal neovascularization diseases cause vision impairment due to abnormal blood vessel growth in the retina. Current treatments, including repeated intraocular anti–vascular endothelial growth factor injections, are invasive and often le…
View article: Nanozymes expanding the boundaries of biocatalysis
Nanozymes expanding the boundaries of biocatalysis Open
Biocatalysis is fundamental to biological processes and sustainable applications. Over time, the understanding of biocatalysis has evolved considerably. Initially, protein enzymes were recognized as the primary biocatalysts due to their hi…
View article: Lipid Droplet‐Organized MDM2‐Mediated P53 Degradation: A Metabolic Switch Governing Diet‐Driven Tumor Progression
Lipid Droplet‐Organized MDM2‐Mediated P53 Degradation: A Metabolic Switch Governing Diet‐Driven Tumor Progression Open
TP53 inactivation in human cancers often results from MDM2/MDMX overexpression, yet therapeutic targeting remains challenging owing to incomplete mechanistic understanding. Lipid droplet (LD) enrichment is identified as a key trigger for M…
View article: Nanozyme-driven multifunctional dressings: moving beyond enzyme-like catalysis in chronic wound treatment
Nanozyme-driven multifunctional dressings: moving beyond enzyme-like catalysis in chronic wound treatment Open
The treatment of chronic wounds presents significant challenges due to the necessity of accelerating healing within complex microenvironments characterized by persistent inflammation and biochemical imbalances. Factors such as bacterial in…
View article: Lactobacillus paracasei fermented goji juice improves constipation in mice through inhibiting inflammation and regulating intestinal microecology
Lactobacillus paracasei fermented goji juice improves constipation in mice through inhibiting inflammation and regulating intestinal microecology Open
This study investigated the effects of Lactobacillus paracasei (L. paracasei)-fermented Goji juice supernatant (FGS) on constipation. GC–MS data showed that the critical metabolites of FGS were nicotinamide, squalene, L-proline, melatonin,…
View article: Involvement of CD146 in the <i>Cryptococcus neoformans</i> adhesion and infection of brain endothelial cells
Involvement of CD146 in the <i>Cryptococcus neoformans</i> adhesion and infection of brain endothelial cells Open
Cryptococcal meningitis is a common and refractory central nervous system (CNS) infection with high mortality and disability. For Cryptococcus neoformans ( C. neoformans ) to penetrate the CNS, it first adheres to and breaches the blood‒br…
View article: Spatial Isolation of Single Copper(I) Sites for Cascade Enzyme‐Like Catalysis and Simultaneous Ferroptosis/Cuproptosis Boosted Immunotherapy
Spatial Isolation of Single Copper(I) Sites for Cascade Enzyme‐Like Catalysis and Simultaneous Ferroptosis/Cuproptosis Boosted Immunotherapy Open
Nanozyme‐based immunogenic cell death (ICD) inducers that effectively induce a strong immune response via enzyme‐like process have attracted great attention, but how to ensure controllable active sites and maximize site utilization remains…
View article: Bioengineered ferritin-based LYTAC platform for tumor-targeted therapy
Bioengineered ferritin-based LYTAC platform for tumor-targeted therapy Open
Lysosome-targeted chimeras (LYTACs) have emerged as promising therapeutic agents because of their ability to degrade pathogenesis-related proteins. However, the current LYTAC systems often require considerable effort for individual constru…
View article: Association of pyridoxal 5′-phosphate (PLP) with lipid profiles: a population-based cohort study
Association of pyridoxal 5′-phosphate (PLP) with lipid profiles: a population-based cohort study Open
Objectives This study aims to explore the correlation between Pyridoxal 5′-Phosphate (PLP) levels and lipid profiles in adult individuals, utilizing data from the National Health and Nutrition Examination Survey (NHANES) database. Methods …
View article: Bioengineered protein nanocarrier facilitating siRNA escape from lysosomes for targeted RNAi therapy in glioblastoma
Bioengineered protein nanocarrier facilitating siRNA escape from lysosomes for targeted RNAi therapy in glioblastoma Open
RNA interference (RNAi) represents a promising gene-specific therapy against tumors. However, its clinical translation is impeded by poor performance of lysosomal escape and tumor targeting. This challenge is especially prominent in gliobl…
View article: Hypoxia-tropic delivery of nanozymes targeting transferrin receptor 1 for nasopharyngeal carcinoma radiotherapy sensitization
Hypoxia-tropic delivery of nanozymes targeting transferrin receptor 1 for nasopharyngeal carcinoma radiotherapy sensitization Open
Nasopharyngeal carcinoma (NPC), a malignancy highly prevalent in East and Southeast Asia, is primarily treated with radiotherapy (RT). However, hypoxia-induced radioresistance presents a significant challenge. Nanozymes, nanomaterials with…
View article: Oral iron sulfide prevents acute alcohol intoxication by initiating the endogenous multienzymatic antioxidant defense system
Oral iron sulfide prevents acute alcohol intoxication by initiating the endogenous multienzymatic antioxidant defense system Open
Acute alcohol intoxication could cause multiorgan damage, including nervous, digestive, and cardiovascular systems, and in particular, irreversible damage to the brain and liver. Emerging studies have revealed that the endogenous multienzy…
View article: Ferritin‐Based Supramolecular Assembly Drug Delivery System for Aminated Fullerene Derivatives to Enhance Tumor‐Targeted Therapy
Ferritin‐Based Supramolecular Assembly Drug Delivery System for Aminated Fullerene Derivatives to Enhance Tumor‐Targeted Therapy Open
Owing to their attractive antitumor effects, aminated fullerene derivatives are emerging as promising therapeutic drugs for cancer. However, their in vivo applications are severely limited due to cation toxicity. To address this problem, h…
View article: A bioinspired sulfur–Fe–heme nanozyme with selective peroxidase-like activity for enhanced tumor chemotherapy
A bioinspired sulfur–Fe–heme nanozyme with selective peroxidase-like activity for enhanced tumor chemotherapy Open
Iron-based nanozymes, recognized for their biocompatibility and peroxidase-like activities, hold promise as catalysts in tumor therapy. However, their concurrent catalase-like activity undermines therapeutic efficacy by converting hydrogen…
View article: The Role of T Cells in the Pathogenesis of Narcolepsy Type 1: A Narrative Review
The Role of T Cells in the Pathogenesis of Narcolepsy Type 1: A Narrative Review Open
Narcolepsy type 1 (NT1) is an uncommon, persistent sleep disorder distinguished by significant daytime sleepiness, episodes of cataplexy, and irregularities in rapid eye movement sleep. The etiology of NT1 is linked to the destruction of h…
View article: A ruthenium single atom nanozyme-based antibiotic for the treatment of otitis media caused by Staphylococcus aureus
A ruthenium single atom nanozyme-based antibiotic for the treatment of otitis media caused by Staphylococcus aureus Open
Staphylococcus aureus ( S. aureus ) infection is a primary cause of otitis media (OM), the most common disease for which children are prescribed antibiotics. However, the abuse of antibiotics has led to a global increase in antimicrobial r…
View article: A Self‐Catalytic NO/O<sub>2</sub> Gas‐Releasing Nanozyme for Radiotherapy Sensitization through Vascular Normalization and Hypoxia Relief
A Self‐Catalytic NO/O<sub>2</sub> Gas‐Releasing Nanozyme for Radiotherapy Sensitization through Vascular Normalization and Hypoxia Relief Open
Radiotherapy (RT), essential for treating various cancers, faces challenges from tumor hypoxia, which induces radioresistance. A tumor‐targeted “prosthetic‐Arginine” coassembled nanozyme system, engineered to catalytically generate nitric …
View article: Cu‐Doping Layered Double Hydroxides Nanozyme Integrated with Nitric Oxide Donor for Enhanced Antioxidant Therapy in Retinopathy
Cu‐Doping Layered Double Hydroxides Nanozyme Integrated with Nitric Oxide Donor for Enhanced Antioxidant Therapy in Retinopathy Open
The prevalence of retinal neovascular diseases necessitates novel treatments beyond current therapies like laser surgery or anti‐VEGF treatments, which often carry significant side effects. A novel therapeutic approach is introduced using …