Xize Wu
YOU?
Author Swipe
View article: Inflammatory cytokines mediate the common genetic and immunological background between rheumatoid arthritis and osteoporosis
Inflammatory cytokines mediate the common genetic and immunological background between rheumatoid arthritis and osteoporosis Open
IL-17 promotes the progression of RA to OP; FCRL3 regulates the immune infiltration microenvironment of RA and is a potential therapeutic target. Key Points • Genetic correlation, MR, and colocalization analyses confirm a shared genetic ba…
View article: Identification of key genes for heart failure in dilated cardiomyopathy in different populations
Identification of key genes for heart failure in dilated cardiomyopathy in different populations Open
Background Heart failure (HF) represents the end stage of cardiovascular disease and is the leading cause of mortality. The objective of this study was to identify potential biomarkers and elucidate the mechanisms underlying the developmen…
View article: Efficacy and safety of Traditional Chinese Medicine in alleviating symptoms associated with myocardial bridge: a systematic review and meta-analysis
Efficacy and safety of Traditional Chinese Medicine in alleviating symptoms associated with myocardial bridge: a systematic review and meta-analysis Open
Background With the advancement of technology, the detection rate of myocardial bridge (MB) has gradually increased and attracted attention. However, management options for symptomatic MB are limited, and Traditional Chinese Medicine (TCM)…
View article: Abnormal lipid metabolism and atherosclerosis: a new perspective on organelle function regulation and ferroptosis
Abnormal lipid metabolism and atherosclerosis: a new perspective on organelle function regulation and ferroptosis Open
Background Atherosclerosis (AS), characterized by lipid accumulation, contributes significantly to global cardiovascular morbidity. Ferroptosis, an iron-dependent form of cell death triggered by lipid peroxidation, is emerging as a critica…
View article: Ferulic acid inhibits ox-LDL-induced ferroptosis and apoptosis in RAW 264.7 cells via the HIF-1 signaling pathway
Ferulic acid inhibits ox-LDL-induced ferroptosis and apoptosis in RAW 264.7 cells via the HIF-1 signaling pathway Open
Objective Ferulic acid (FA) has shown potential in treating atherosclerosis (AS) by improving lipid metabolism and exerting anti-hypoxic effects. This study aimed to validate the mechanism of FA in AS through in vitro experiments. Methods …
View article: Identification of Potential Diagnostic Biomarkers of Carotid Atherosclerosis in Obese Populations
Identification of Potential Diagnostic Biomarkers of Carotid Atherosclerosis in Obese Populations Open
MMP9, PLA2G7, CD52, CLEC5A, SPP1, and FYB may serve as potential diagnostic biomarkers for CAS in obese populations. PLCB2 and PRKCB are key genes in the calcium signaling pathway in OB and CAS. These findings offer new insights into clini…
View article: Identification of key genes for cuproptosis in carotid atherosclerosis
Identification of key genes for cuproptosis in carotid atherosclerosis Open
Background Atherosclerosis is a leading cause of cardiovascular disease worldwide, while carotid atherosclerosis (CAS) is more likely to cause ischemic cerebrovascular events. Emerging evidence suggests that cuproptosis may be associated w…
View article: Association between inflammatory bowel disease and osteoporosis in European and East Asian populations: exploring causality, mediation by nutritional status, and shared genetic architecture
Association between inflammatory bowel disease and osteoporosis in European and East Asian populations: exploring causality, mediation by nutritional status, and shared genetic architecture Open
Background While previous research has established an association between inflammatory bowel disease (IBD) and osteoporosis (OP), the nature of this association in different populations remains unclear. Objective Our study used linkage dis…
View article: CXCL9, IL2RB, and SPP1, potential diagnostic biomarkers in the co-morbidity pattern of atherosclerosis and non-alcoholic steatohepatitis
CXCL9, IL2RB, and SPP1, potential diagnostic biomarkers in the co-morbidity pattern of atherosclerosis and non-alcoholic steatohepatitis Open
Non-alcoholic steatohepatitis (NASH) is a hepatocyte inflammation based on hepatocellular steatosis, yet there is no effective drug treatment. Atherosclerosis (AS) is caused by lipid deposition in the endothelium, which can lead to various…
View article: Huayu Qutan Recipe promotes lipophagy and cholesterol efflux through the <scp>mTORC1</scp>/<scp>TFEB</scp>/<scp>ABCA1‐SCARB1</scp> signal axis
Huayu Qutan Recipe promotes lipophagy and cholesterol efflux through the <span>mTORC1</span>/<span>TFEB</span>/<span>ABCA1‐SCARB1</span> signal axis Open
This study aims to investigate the mechanism of the anti‐atherosclerosis effect of Huayu Qutan Recipe (HYQT) on the inhibition of foam cell formation. In vivo, the mice were randomly divided into three groups: CTRL group, MOD group and HYQ…
View article: Identification of key genes for atherosclerosis in different arterial beds
Identification of key genes for atherosclerosis in different arterial beds Open
Atherosclerosis (AS) is the pathologic basis of various cardiovascular and cerebrovascular events, with a high degree of heterogeneity among different arterial beds. However, mechanistic differences between arterial beds remain unexplored.…
View article: The association of lipid metabolism with bone metabolism and the role of human traits: a Mendelian randomization study
The association of lipid metabolism with bone metabolism and the role of human traits: a Mendelian randomization study Open
Background The impact of lipid metabolism on bone metabolism remains controversial, and the extent to which human traits mediate the effects of lipid metabolism on bone metabolism remains unclear. Objective This study utilized mendelian ra…