Gao Wang
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View article: Machine Learning-Based Prediction of Cell-type Resolved Brain eQTLs Enhances Discovery of Variants Explaining Alzheimer’s Disease Heritability
Machine Learning-Based Prediction of Cell-type Resolved Brain eQTLs Enhances Discovery of Variants Explaining Alzheimer’s Disease Heritability Open
The majority of causal genome-wide association studies (GWAS) variants for Alzheimer’s disease (AD) are believed to reside in noncoding regions of the genome, where they likely affect gene regulation, particularly in microglia. Although ex…
View article: SuSiE 2.0: improved methods and implementations for genetic fine-mapping and phenotype prediction
SuSiE 2.0: improved methods and implementations for genetic fine-mapping and phenotype prediction Open
Sum of Single Effects regression (SuSiE) has become widely adopted for genetic fine-mapping, yet its original implementation faces architectural limitations that hinder extensibility and performance. We present SuSiE 2.0, featuring a modul…
View article: Neuroimaging-derived brain endophenotypes link molecular mechanisms to Alzheimer’s disease and aging
Neuroimaging-derived brain endophenotypes link molecular mechanisms to Alzheimer’s disease and aging Open
Alzheimer’s disease (AD) genome-wide association studies (GWAS), typically based on clinical phenotypes, have identified numerous risk loci, yet linking these variants to brain changes and molecular processes remains challenging. We develo…
View article: Integrating axis quantitative trait loci looks beyond cell types and offers insights into brain-related traits
Integrating axis quantitative trait loci looks beyond cell types and offers insights into brain-related traits Open
Genome-wide association studies have identified many loci for brain disorders, but most non-coding variants fail to colocalize with bulk expression quantitative trait loci. Single-cell expression quantitative trait loci studies capture cel…
View article: Improving fecal transplantation precision for enhanced maturation of intestinal function in germ-free mice through microencapsulation and probiotic intervention
Improving fecal transplantation precision for enhanced maturation of intestinal function in germ-free mice through microencapsulation and probiotic intervention Open
View article: Accounting for uncertainty in residual variances improves calibration for fine-mapping with small sample sizes
Accounting for uncertainty in residual variances improves calibration for fine-mapping with small sample sizes Open
The Sum of Single Effects (SuSiE) model is a widely adopted method for genetic fine-mapping. We show that, in small-sample studies, the original SuSiE fitting procedure produces substantially higher rates of false positive findings. We sho…
View article: CoxMDS: Multiple Data Splitting for High-dimensional Mediation Analysis with Survival Outcomes in Epigenome-wide Studies
CoxMDS: Multiple Data Splitting for High-dimensional Mediation Analysis with Survival Outcomes in Epigenome-wide Studies Open
Causal mediation analysis investigates whether the effect of an exposure on an outcome operates through intermediate variables known as mediators. Although progress has been made in high-dimensional mediation analysis, current methods do n…
View article: The role and mechanism of transcription factor KLF4 in regulating mitochondrial damage and apoptosis by activating chondrocyte autophagy in osteoarthritis
The role and mechanism of transcription factor KLF4 in regulating mitochondrial damage and apoptosis by activating chondrocyte autophagy in osteoarthritis Open
View article: Mapping disease critical spatially variable gene programs by integrating spatial transcriptomics with human genetics
Mapping disease critical spatially variable gene programs by integrating spatial transcriptomics with human genetics Open
Spatial gene expression patterns underlie tissue organization, development, and disease, yet current methods for detecting spatially variable genes (SVGs) lack the flexibility to capture multi-scale structure, ensure robustness across plat…
View article: fSuSiE enables fine-mapping of QTLs from genome-scale molecular profiles
fSuSiE enables fine-mapping of QTLs from genome-scale molecular profiles Open
Molecular quantitative trait locus (QTL) studies seek to identify the causal variants affecting molecular traits like DNA methylation and histone modifications. However, existing fine-mapping tools are not well suited to molecular traits, …
View article: Sleep chart of biological aging clocks across organs and omics
Sleep chart of biological aging clocks across organs and omics Open
Optimal sleep plays a vital role in promoting healthy aging and enhancing longevity. This study proposes a Sleep Chart to assess the relationship between sleep duration and 23 biological aging clocks across 17 organ systems or tissues and …
View article: Integrated genomic analysis and CRISPRi implicates<i>EGFR</i>in Alzheimer’s disease risk
Integrated genomic analysis and CRISPRi implicates<i>EGFR</i>in Alzheimer’s disease risk Open
Genome-wide association studies (GWAS) have identified numerous loci linked to late-onset Alzheimer’s disease (LOAD), but the pan-brain regional effects of these loci remain largely uncharacterized. To address this, we systematically analy…
View article: The role and mechanism of transcription factor KLF4 in regulating mitochondrial damage and apoptosis by activating chondrocyte autophagy in osteoarthritis
The role and mechanism of transcription factor KLF4 in regulating mitochondrial damage and apoptosis by activating chondrocyte autophagy in osteoarthritis Open
Objective To explore the role and mechanism of transcription factor KLF4 in regulating mitochondrial damage and apoptosis by activating chondrocyte autophagy. Methods Human primary chondrocytes were treated with IL-1β to establish an in vi…
View article: Accounting for uncertainty in residual variances improves calibration for fine-mapping with small sample sizes
Accounting for uncertainty in residual variances improves calibration for fine-mapping with small sample sizes Open
The Sum of Single Effects (SuSiE) model is a widely adopted method for genetic fine-mapping. We show that, in small-sample studies, the original SuSiE fitting procedure produces substantially higher rates of false positive findings. We sho…
View article: Rare-variant aggregate association analysis using imputed data is a powerful approach
Rare-variant aggregate association analysis using imputed data is a powerful approach Open
Imputation can cost-effectively generate genotypes for millions of variants. The power of performing rare variant aggregate association tests using imputed genotypes was evaluated. White Europeans from the UK Biobank with exome sequence an…
View article: Integrative multi-omics QTL colocalization maps regulatory architecture in aging human brain
Integrative multi-omics QTL colocalization maps regulatory architecture in aging human brain Open
Multi-trait QTL (xQTL) colocalization has shown great promises in identifying causal variants with shared genetic etiology across multiple molecular modalities, contexts, and complex diseases. However, the lack of scalable and efficient me…
View article: Genetic and functional analysis of unproductive splicing using LeafCutter2
Genetic and functional analysis of unproductive splicing using LeafCutter2 Open
Alternative splicing commonly generates unproductive mRNA transcripts that harbor premature termination codons 1 , leading to their degradation by nonsense-mediated decay (NMD). These events reduce overall protein expression levels of affe…
View article: Draw2Cut: Direct On-Material Annotations for CNC Milling
Draw2Cut: Direct On-Material Annotations for CNC Milling Open
Creating custom artifacts with computer numerical control (CNC) milling machines typically requires mastery of complex computer-aided design (CAD) software. To eliminate this user barrier, we introduced Draw2Cut, a novel system that allows…
View article: Probiotic potential and safety properties of Limosilactobacillus fermentum A51 with high exopolysaccharide production
Probiotic potential and safety properties of Limosilactobacillus fermentum A51 with high exopolysaccharide production Open
Introduction Exopolysaccharides (EPS) produced by Lactic acid bacteria have many health benefits and unique physicochemical properties. They are widely used in the food industry to improve viscosity, mouthfeel, and textural properties of f…
View article: GWAS highlights the neuronal contribution to multiple sclerosis susceptibility
GWAS highlights the neuronal contribution to multiple sclerosis susceptibility Open
Multiple Sclerosis (MS) is a chronic inflammatory and neurodegenerative disease affecting the brain and spinal cord. Genetic studies have identified many risk loci, that were thought to primarily impact immune cells and microglia. Here, we…
View article: GWAS highlights the neuronal contribution to multiple sclerosis susceptibility
GWAS highlights the neuronal contribution to multiple sclerosis susceptibility Open
Multiple Sclerosis (MS) is a chronic inflammatory and neurodegenerative disease affecting the brain and spinal cord. Genetic studies have identified many risk loci, that were thought to primarily impact immune cells and microglia. Here, we…
View article: Multi‐omics QTL provide insights into cell specific effects on molecular functions and intermediate traits in Alzheimer’s disease and its iPSC‐derived model systems
Multi‐omics QTL provide insights into cell specific effects on molecular functions and intermediate traits in Alzheimer’s disease and its iPSC‐derived model systems Open
Background We examined AD‐associated loci to demonstrate how the new FunGen‐xQTL resource reveals new insights into the sequence of events leading from health to the amyloid and tau proteinopathies that define AD, as well as subsequent cog…
View article: Publisher Correction: Robo-Matter towards reconfigurable multifunctional smart materials
Publisher Correction: Robo-Matter towards reconfigurable multifunctional smart materials Open
View article: WITHDRAWN: MIRAGE: a Bayesian rare variant association analysis method incorporating functional information of variants
WITHDRAWN: MIRAGE: a Bayesian rare variant association analysis method incorporating functional information of variants Open
Withdraw Statement The authors have withdrawn this manuscript due to a duplicate submission and request that it not be cited as a reference for ongoing projects. For further inquiries, please contact the corresponding author. Details regar…
View article: Alterations in gut microbiota and inflammatory cytokines after administration of antibiotics in mice
Alterations in gut microbiota and inflammatory cytokines after administration of antibiotics in mice Open
Antibiotics are widely used to treat bacterial infection and reduce the mortality rate, while antibiotic overuse can cause gut microbiota dysbiosis. The impact of antibiotics on gut microbiota is not fully understood. In our study, four co…
View article: Oxymatrine protects articular chondrocytes from IL-1β-induced damage through autophagy activation via AKT/mTOR signaling pathway inhibition
Oxymatrine protects articular chondrocytes from IL-1β-induced damage through autophagy activation via AKT/mTOR signaling pathway inhibition Open
View article: Fire Resistance of Steel Beams with Integrated Fire-Resistant and Decorative Constructions
Fire Resistance of Steel Beams with Integrated Fire-Resistant and Decorative Constructions Open
View article: Novel Missing Data Imputation Approaches Enhance Quantitative Trait Loci Discovery in Multi-Omics Analysis
Novel Missing Data Imputation Approaches Enhance Quantitative Trait Loci Discovery in Multi-Omics Analysis Open
Handling missing values in multi-omics datasets is essential for a broad range of analyses. While several benchmarks for multi-omics data imputation methods have recommended certain approaches for practical applications, these recommendati…
View article: xQTLbiolinks: a comprehensive and scalable tool for integrative analysis of molecular QTLs
xQTLbiolinks: a comprehensive and scalable tool for integrative analysis of molecular QTLs Open
Genome-wide association studies (GWAS) have identified thousands of disease-associated non-coding variants, posing urgent needs for functional interpretation. Molecular Quantitative Trait Loci (xQTLs) such as eQTLs serve as an essential in…
View article: CRISPR‐Cas9 screening identified lethal genes enriched in necroptosis pathway and of prognosis significance in osteosarcoma
CRISPR‐Cas9 screening identified lethal genes enriched in necroptosis pathway and of prognosis significance in osteosarcoma Open
Background The present study aimed to identify indispensable genes associated with tumor cell viability according to the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated protein 9 (Cas9) datasets, which …