Explanipedia

Cathepsin C-driven enhancement of neutrophil extracellular trap formation contributes to acute lung injury Open

Xinyu Wu, Huijun Liu, Qingwu Qin, Lin Yuan, Ye Yao , et al. · 2025

Summary: Acute lung injury (ALI) is a severe pulmonary inflammatory disease with high morbidity and mortality rates. The pulmonary inflammatory phenotype of ALI is driven by the excessive aggregation and activation of neutrophils, triggeri…

Unraveling the mechanisms of virus-induced asthma exacerbation: epithelial injury, immune dysregulation, and novel interventions Open

Xizi Du, Ming Yang · 2025

Increased expression of cathepsin C in airway epithelia exacerbates airway remodeling in asthma Open

Yuan Lin, Qingwu Qin, Ye Yao, Long Chen, Huijun Liu , et al. · 2024

Airway remodeling is a critical factor determining the pathogenesis and treatment sensitivity of severe asthma (SA) or uncontrolled asthma (UA). The activation of epithelial-mesenchymal trophic units (EMTUs) regulated by airway epithelial …

Airway epithelial‐derived exosomes induce acute asthma exacerbation after respiratory syncytial virus infection Open

Ye Yao, Yu Yang, Ming Ji, Qingwu Qin, Kun Xu , et al. · 2024

Acute asthma exacerbation refers to the progressive deterioration of asthma symptoms that is always triggered by virus infection represented by respiratory syncytial virus (RSV). After RSV infection, exaggerated Th2‐mediated pulmonary infl…

CTSC Overexpression Drives Neutrophil Extracellular Traps And Exacerbates Lung Inflammation in Acute Lung Injury Open

Xinyu Wu, Zhenkun Xia, Huijun Liu, Lin Yuan, Ye Yao , et al. · 2024

Airway epithelial overexpressed CTSK induces airway remodeling through EMTU activation in asthma Open

Ye Yao, Ling Qin, Weijie Wang, Jingjing Liu, Qingwu Qin , et al. · 2023

Accumulating studies in recent years have revealed that airway remodeling is involved in the occurrence, development, and treatment sensitivity of asthma. Airway epithelial cells (AECs) regulate the activation of epithelial-mesenchymal tro…

ITGB4 Deficiency in Airway Epithelium Aggravates RSV Infection and Increases HDM Sensitivity Open

Xizi Du, Yuan Lin, Ye Yao, Yang Yu, Kai Zhou , et al. · 2022

Background The heterogeneity of RSV-infected pathology phenotype in early life is strongly associate with increased susceptibility of asthma in later life. However, the inner mechanism of this heterogeneity is still obscure. ITGB4 is a dow…

Integrins are double-edged swords in pulmonary infectious diseases Open

Ye Yao, Huijun Liu, Lin Yuan, Xizi Du, Yang Yu , et al. · 2022

Integrins are an important family of adhesion molecules that are widely distributed on immune cells in the lungs. Of note, accumulating evidences have shown that integrins are double-edged swords in pulmonary infectious diseases. On one ha…

Aberrant methylation of aging-related genes in asthma Open

Yu Yang, Lin Yuan, Ming Yang, Xizi Du, Ling Qin , et al. · 2022

Background: Asthma is a complex pulmonary inflammatory disease which is common among older adults.Aging-related alterations have also been found in structural cells and immune cells of asthma patients. Of note, DNA methylation have been pr…

A Risk Model Composed of Complete Blood Count, BRAF V600E and MAP2K1 Predicts Inferior Prognosis of Langerhans Cell Histiocytosis in Children Open

Leyuan Wang, Lin Yuan, Xizi Du, Kai Zhou, Yang Yu , et al. · 2022

Background In children, Langerhans cell histiocytosis (LCH), which is the most prevalent histiocytic disorder, exhibits a wide variety of manifestations and outcomes. There is no standard prognosis evaluation system for LCH. We investigate…

ITGB4 deficiency induces mucus hypersecretion by upregulating MUC5AC in RSV-infected airway epithelial cells Open

Xizi Du, Yang Yu, Ming Yang, Yuan Lin, Leyuan Wang , et al. · 2021

Respiratory syncytial virus (RSV) infection is the main cause of bronchiolitis in children. Excessive mucus secretion is one of the primary symbols in RSV related lower respiratory tract infections (RSV-related LRTI), which is closely asso…

miRNA‐34b/c regulates mucus secretion in RSV‐infected airway epithelial cells by targeting FGFR1 Open

Wenkai Li, Xizi Du, Yu Yang, Yuan Lin, Ming Yang , et al. · 2021

Respiratory syncytial virus (RSV) infection in airway epithelial cells is the main cause of bronchiolitis in children. Excessive mucus secretion is one of the primary symbols in RSV related lower respiratory tract infections (RSV‐related L…

Involvement of epithelia-derived exosomes in chronic respiratory diseases Open

Yu Yang, Lin Yuan, Xizi Du, Kai Zhou, Ling Qin , et al. · 2021

Exosomes are tiny membrane lipid bilayer vesicles (φ40-100 nm) formed by the fusion of multivesicular bodies with plasma membrane, which are released extracellular by exocytosis. As natural nanocarriers, exosomes contain a variety of signa…

Innate lymphoid cells are double‐edged swords under the mucosal barrier Open

Zhen Duan, Mandie Liu, Yuan Lin, Xizi Du, Mengping Wu , et al. · 2021

As the direct contacting site for pathogens and allergens, the mucosal barrier plays a vital role in the lungs and intestines. Innate lymphoid cells (ILCs) are particularly resident in the mucosal barrier and participate in several pathoph…

Aberrant Methylation of Aging-Related Genes in Asthma Open

Yu Yang, Lin Yuan, Ming Yang, Xizi Du, Ling Qin , et al. · 2021

Background: Asthma is a complex pulmonary inflammatory disease which is common among older adults. Aging-related alterations have also been found in structural cells and immune cells of asthma patients. Nonetheless, the underlying mechanis…

Correction to: The DNA methylation of FOXO3 and TP53 as a blood biomarker of late-onset asthma Open

Lin Yuan, Leyuan Wang, Xizi Du, Ling Qin, Ming Yang , et al. · 2021

An amendment to this paper has been published and can be accessed via the original article.

The DNA methylation of FOXO3 and TP53 as a blood biomarker of late-onset asthma Open

Lin Yuan, Leyuan Wang, Xizi Du, Ling Qin, Ming Yang , et al. · 2020

Variable expressed methylation sites of aging-related genes in asthma Open

Yu Yang, Lin Yuan, Ming Yang, Xizi Du, Ling Qin , et al. · 2020

Background: Asthma is a complex pulmonary inflammatory disease which is common in the elderly. Aging-related alterations have also been found in the structural cells and immune cells of asthma patients although the pathological mechanism o…

Respiratory syncytial virus infection‐induced mucus secretion by down‐regulation of miR‐34b/c‐5p expression in airway epithelial cells Open

Xizi Du, Yang Yu, Gelei Xiao, Ming Yang, Yuan Lin , et al. · 2020

Severe RSV infection is the main cause of hospitalization to children under the age of five. The regulation of miRNAs on the severity of RSV infection is unclear. The aim of the study was to identify the critical differential expression mi…

Variable Expressed Methylation Sites of Aging-related Genes in Asthma Open

Yu Yang, Lin Yuan, Ming Yang, Xizi Du, Ling Qin , et al. · 2020

Background: Asthma is a complex pulmonary inflammatory disease which is common in the elderly. Aging-related alterations have also been found in the structural cells and immune cells of asthma patients although the pathological mechanism o…

Airway epithelial integrin β4 suppresses allergic inflammation by decreasing CCL17 production Open

Yuan Lin, Xun Zhang, Ming Yang, Xizi Du, Leyuan Wang , et al. · 2020

Airway epithelial cells (AECs) play a key role in asthma susceptibility and severity. Integrin β4 (ITGB4) is a structural adhesion molecule that is down-regulated in the airway epithelium of asthma patients. Although a few studies hint tow…

Airway epithelial ITGB4 deficiency in early life mediates pulmonary spontaneous inflammation and enhanced allergic immune response Open

Sha Tang, Xizi Du, Yuan Lin, Gelei Xiao, Mengping Wu , et al. · 2020

Lung immune responses to respiratory pathogens and allergens are initiated in early life which will further influence the later onset of asthma. The airway epithelia form the first mechanical physical barrier to allergic stimuli and enviro…

Respiratory Syncytial Virus Infection Induced Mucus Secretion by Down Regulation of miR-34b/c-5p Expression in Airway Epithelial Cells Open

Xizi Du, Yuan Lin, Gelei Xiao, Ming Yang, Ling Qin , et al. · 2020

Variable DNA methylation of aging-related genes is associated with male COPD Open

Xizi Du, Lin Yuan, Mengping Wu, Meichao Men, Ruoxi He , et al. · 2019

Background Chronic obstructive pulmonary disease (COPD) is a chronic lung inflammatory disease which has a close relationship with aging. Genome-wide analysis reveals that DNA methylation markers vary obviously with age. DNA methylation va…

Airway epithelial integrin β4 suppresses allergic inflammation by decreasing CCL17 production Open

Yuan Lin, Xun Zhang, Ming Yang, Yizhou Zou, Yang Xiang , et al. · 2019

Airway epithelial cells (AECs) play a key role in asthma susceptibility and severity. Integrin β4 (ITGB4) is a structural adhesion molecule that is downregulated in the airway epithelium of asthma patients. Specific ITGB4 deficiency in AEC…

ITGB4 deficiency in bronchial epithelial cells directs airway inflammation and bipolar disorder-related behavior Open

Li Han, Leyuan Wang, Sha Tang, Yuan Lin, Shuangyan Wu , et al. · 2018

These findings confirmed that airway inflammatory induced by ITGB4 deficiency is the important incentive for the BD-like behavior during asthma pathogenesis. The ITGB4-deficient mice provide a validated animal model for us to study the pos…

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