Xóchitl G. Pérez-Leonor
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View article: Umbilical Cord Blood Cell Transcriptional and Methylation Signatures at Birth Are Associated with BPD Development
Umbilical Cord Blood Cell Transcriptional and Methylation Signatures at Birth Are Associated with BPD Development Open
Bronchopulmonary dysplasia (BPD) is the most common respiratory disease in preterm infants born at less than 28 weeks gestation. Most existing clinical prediction models for BPD show limited accuracy in predicting BPD development when vali…
View article: Profibrotic monocyte-derived alveolar macrophages as a biomarker and therapeutic target in systemic sclerosis-associated interstitial lung disease
Profibrotic monocyte-derived alveolar macrophages as a biomarker and therapeutic target in systemic sclerosis-associated interstitial lung disease Open
Interstitial lung disease (ILD) is present in over 60% of patients with systemic sclerosis (SSc) and is the leading cause of SSc-related deaths. Profibrotic monocyte-derived alveolar macrophages (MoAM) play a causal role in the pathogenesi…
View article: Novel enzyme-based reduced representation method for DNA methylation profiling with low inputs
Novel enzyme-based reduced representation method for DNA methylation profiling with low inputs Open
Commonly used bisulfite-based procedures for DNA methylation sequencing can degrade DNA, worsening signal-to-noise ratios in samples with low DNA input. Enzymatic methylation sequencing (EM-seq) has been proposed as a less biased alternati…
View article: Novel enzyme-based reduced representation method for DNA methylation profiling with low inputs
Novel enzyme-based reduced representation method for DNA methylation profiling with low inputs Open
DNA methylation at cytosine-phospho-guanine (CpG) residues is a vital biological process that regulates cell identity and function. Although widely used, bisulfite-based cytosine conversion procedures for DNA methylation sequencing require…
View article: Prolonged exposure to lung-derived cytokines is associated with activation of microglia in patients with COVID-19
Prolonged exposure to lung-derived cytokines is associated with activation of microglia in patients with COVID-19 Open
BACKGROUNDSurvivors of pneumonia, including SARS-CoV-2 pneumonia, are at increased risk for cognitive dysfunction and dementia. In rodent models, cognitive dysfunction following pneumonia has been linked to the systemic release of lung-der…
View article: A distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia
A distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia Open
Pathogen clearance and resolution of inflammation in patients with pneumonia require an effective local T cell response. Nevertheless, local T cell activation may drive lung injury, particularly during prolonged episodes of respiratory fai…
View article: Prolonged exposure to lung-derived cytokines is associated with inflammatory activation of microglia in patients with COVID-19
Prolonged exposure to lung-derived cytokines is associated with inflammatory activation of microglia in patients with COVID-19 Open
Neurological impairment is the most common finding in patients with post-acute sequelae of COVID-19. Furthermore, survivors of pneumonia from any cause have an elevated risk of dementia 1–4 . Dysfunction in microglia, the primary immune ce…