Fei Ma
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View article: Biologically-informed integration of drug representations for breast cancer treatment using deep learning
Biologically-informed integration of drug representations for breast cancer treatment using deep learning Open
Approximately 50% of breast cancer patients receiving neoadjuvant therapy do not achieve pathological complete response (pCR). Identifying personalized optimal therapeutic strategy is an unmet major challenge. Here, based on 4371 eligible …
View article: Identification of a super enhancer associated gene signature for the prognosis prediction and regulatory mechanism exploration in breast cancer
Identification of a super enhancer associated gene signature for the prognosis prediction and regulatory mechanism exploration in breast cancer Open
This study aims to preliminarily explore the impact of super-enhancer (SE)-associated genes on breast cancer (BC) and their potential regulatory mechanisms. We first identified differentially expressed SE-associated genes between BC patien…
View article: Lysine Acetyltransferase 6 in Health and Disease
Lysine Acetyltransferase 6 in Health and Disease Open
Lysine acetyltransferase 6 (KAT6) consists of KAT6A and its paralog KAT6B, which represent crucial regulators for epigenetic modifications. By acylating histone H3 and nonhistone proteins, KAT6 enzymes play predominant roles in transcripti…
View article: Metronomic Chemotherapy in Breast Cancer: Unleashing the Potential of Combination Regimens
Metronomic Chemotherapy in Breast Cancer: Unleashing the Potential of Combination Regimens Open
This review examines the future of metronomic chemotherapy (MCT) in the treatment of breast cancer and emphasizes its transformative potential. MCT refers to the continuous administration of a low dose of chemotherapeutic agents. It reduce…
View article: Expert Consensus on Tiered Diagnosis and Treatment of Breast Cancer as a Single‐Disease Management Model in China (2025 Edition)
Expert Consensus on Tiered Diagnosis and Treatment of Breast Cancer as a Single‐Disease Management Model in China (2025 Edition) Open
Breast cancer is the most prevalent female malignancy worldwide. In 2022, China recorded approximately 357,000 new breast cancer cases and 75,000 deaths, posing a serious threat to female health. Given the “inverted pyramid” structure of C…
View article: The ENST00000539930 transcript predicts sensitivity to PARP inhibitors and clinical prognosis in cancers
The ENST00000539930 transcript predicts sensitivity to PARP inhibitors and clinical prognosis in cancers Open
Objectives Synthetic lethality-based cancer therapy, particularly using PARP inhibitors, faces resistance challenges. This study aims to explore the role of gene-specific transcripts due to alternative splicing in PARP inhibitor resistance…
View article: Matching-adjusted indirect comparison of ribociclib + nonsteroidal aromatase inhibitor versus abemaciclib + endocrine therapy in hormone receptor-positive/HER2-negative early breast cancer
Matching-adjusted indirect comparison of ribociclib + nonsteroidal aromatase inhibitor versus abemaciclib + endocrine therapy in hormone receptor-positive/HER2-negative early breast cancer Open
Aim: Ribociclib + nonsteroidal aromatase inhibitor (NSAI) and abemaciclib + endocrine therapy (ET) are approved for high-risk hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) early breast cancer based…
View article: Case Report: Hepatic sarcoidosis-like reaction from neoadjuvant pembrolizumab in early-stage triple-negative breast cancer
Case Report: Hepatic sarcoidosis-like reaction from neoadjuvant pembrolizumab in early-stage triple-negative breast cancer Open
Drug-induced sarcoidosis-like reaction (DISR) is a rare adverse event associated with immunotherapy. Currently, there is no standardized treatment protocol for DISR linked to immune checkpoint inhibitors (ICIs). This study presents a case …
View article: Clinicopathological Features and Prognostic Implications of HER2-Low in Early-Stage Male Breast Cancer: A Retrospective Analysis
Clinicopathological Features and Prognostic Implications of HER2-Low in Early-Stage Male Breast Cancer: A Retrospective Analysis Open
Background: The clinicopathological and prognostic features of HER2-low female breast cancer (BC) patients have been widely studied. Current knowledge suggests that low HER2 expression could be identified as a special entity for treatment.…
View article: The characteristics of HER2-positive microinvasive breast cancer and the necessity of systemic adjuvant therapy in these patients: a multicenter real-world study
The characteristics of HER2-positive microinvasive breast cancer and the necessity of systemic adjuvant therapy in these patients: a multicenter real-world study Open
Background: There is currently a lack of sufficient evidence on the prognosis of human epidermal factor receptor 2 (HER2)-positive microinvasive breast cancer (MIBC) and whether chemotherapy (CT) and targeted therapy can bring benefits. Ob…
View article: STS2 deficiency revives CD8<sup>+</sup>T cells from exhaustion and augments checkpoint blockade efficacy in cancer immunotherapy
STS2 deficiency revives CD8<sup>+</sup>T cells from exhaustion and augments checkpoint blockade efficacy in cancer immunotherapy Open
Background T-cell exhaustion is a major barrier to effective antitumor immunity and limits the efficacy of cancer immunotherapies. This study investigates the role of suppressor of T-cell signaling 2 (STS2, also known as UBASH3A) in regula…
View article: Accounting Factors and Spatio-Temporal Differences of the Carbon Footprint Factor in China’s Power System
Accounting Factors and Spatio-Temporal Differences of the Carbon Footprint Factor in China’s Power System Open
The carbon footprint factor of a power system is a crucial basis for calculating carbon emissions from electricity consumption. However, the current carbon footprint factor of China’s power system faces several issues, such as a limited sp…
View article: Comparative efficacy of dietary interventions for glycemic control and pregnancy outcomes in gestational diabetes: a network meta-analysis of randomized controlled trials
Comparative efficacy of dietary interventions for glycemic control and pregnancy outcomes in gestational diabetes: a network meta-analysis of randomized controlled trials Open
Background Gestational diabetes mellitus (GDM) poses significant risks to both maternal and fetal health, and effective dietary interventions are critical for managing the condition. This study aimed to evaluate the efficacy of various die…
View article: Adjuvant Chemotherapy May be Waived for Breast Cancer Nonresponders to Neoadjuvant Chemotherapy: A Population‐Based Large Cohort Study
Adjuvant Chemotherapy May be Waived for Breast Cancer Nonresponders to Neoadjuvant Chemotherapy: A Population‐Based Large Cohort Study Open
Purpose This study aimed to evaluate the efficacy of adjuvant chemotherapy (AC) in breast cancer patients who did not respond to neoadjuvant chemotherapy (NAC) following surgery. Method A retrospective analysis was performed using a large,…
View article: Novel TROP2 antibody–drug conjugates for treatment of HER2-negative metastatic breast cancer patients with brain metastases: a promising option☆
Novel TROP2 antibody–drug conjugates for treatment of HER2-negative metastatic breast cancer patients with brain metastases: a promising option☆ Open
These findings suggest that ESG401 is a promising and well-tolerated treatment option for BMs.
View article: Association between volatile organic compounds exposure and cardiometabolic function: a population-based study
Association between volatile organic compounds exposure and cardiometabolic function: a population-based study Open
Background The Cardiometabolic Index (CMI) is a new metric used to assess an individual’s cardiovascular and metabolic status. Volatile Organic Compounds (VOCs) are common environmental pollutants associated with cardiovascular diseases an…
View article: Using Integrative Therapies to Improve Patient‐Reported Outcomes in Breast Cancer Survivors: A Living Evidence‐Based Clinical Practice Guideline
Using Integrative Therapies to Improve Patient‐Reported Outcomes in Breast Cancer Survivors: A Living Evidence‐Based Clinical Practice Guideline Open
Aim Breast cancer imposes a serious disease and economic burden on patients. This guideline aims to develop a living evidence‐based clinical practice recommendations to guide the use of integrative therapies for the improvement of patient‐…
View article: Investigating cardiovascular diseases related to endocrine therapy in hormone receptor-positive early breast cancer: insights from a nationwide real-world study
Investigating cardiovascular diseases related to endocrine therapy in hormone receptor-positive early breast cancer: insights from a nationwide real-world study Open
ETs may be associated with alterations in lipid metabolism and a potential increase in CVD risk in early-stage HR + BC patients. These findings highlight the relevance of enhanced lipid monitoring and cardiovascular risk management to supp…
View article: Interpretation of diagnosis and treatment guidelines for breast cancer integrated traditional chinese and western medicine
Interpretation of diagnosis and treatment guidelines for breast cancer integrated traditional chinese and western medicine Open
Breast cancer is the most common malignancy among women worldwide, posing a serious threat to women’s physical and mental health. To address this significant global public health challenge, the Guidelines for the Integrated Diagnosis and T…
View article: Clinicopathological Factors That Predict Different Responses of Breast and Axillary Tumors to Neoadjuvant Chemotherapy and Prognosis Among Patients With Node‐Positive Breast Cancer: Real World Data
Clinicopathological Factors That Predict Different Responses of Breast and Axillary Tumors to Neoadjuvant Chemotherapy and Prognosis Among Patients With Node‐Positive Breast Cancer: Real World Data Open
Background Pathological complete response (pCR) has been proven to be related to prognosis. pCR can be further classified as pCR of the breast (bpCR), pCR of axillary lymph nodes (apCR) or pCR of both tumors. The aim of this study was to e…
View article: Association between exposure to per- and polyfluoroalkyl substances and kidney function: a population study
Association between exposure to per- and polyfluoroalkyl substances and kidney function: a population study Open
Background The relationship between per- and polyfluoroalkyl substances (PFAS) and kidney function markers remains uncertain. Methods We used PFAS detection data from 5,947 adults in NHANES 2005–2012. We employed multivariable linear regre…
View article: Identifying research activity on brain ultrasonography in craniocerebral diseases by bibliometric and visualized analysis of a 20-year journey of global publications
Identifying research activity on brain ultrasonography in craniocerebral diseases by bibliometric and visualized analysis of a 20-year journey of global publications Open
Brain ultrasonography has emerged as a key tool in neurocritical care. This study aimed to investigate the global research trends and future research directions in the application of brain ultrasonography for craniocerebral diseases using …
View article: Exploration of the clonal evolution and construction of the tumor clonal evolution rate as a prognostic indicator in metastatic breast cancer
Exploration of the clonal evolution and construction of the tumor clonal evolution rate as a prognostic indicator in metastatic breast cancer Open
Patients with branched evolution have better treatment efficacy than those with linear evolution. The TER shows potential as a biomarker for treatment efficacy and prognosis, providing new evidence that ctDNA is a valuable molecular indica…
View article: Distinct cellular mechanisms underlie chemotherapies and PD-L1 blockade combinations in triple-negative breast cancer
Distinct cellular mechanisms underlie chemotherapies and PD-L1 blockade combinations in triple-negative breast cancer Open
Combining immune checkpoint blockade (ICB) with chemotherapy shows promise for treating triple-negative breast cancer (TNBC), though the mechanisms remain incompletely understood. Here, we integrate published and new single-cell RNA sequen…