Heng Xu
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View article: Feeding Preferences of Giant Pandas May Reflect the Detection of Specific Volatiles and Bitter-Tasting Metabolites in Bamboo Leaves as Markers of Nutritional Status
Feeding Preferences of Giant Pandas May Reflect the Detection of Specific Volatiles and Bitter-Tasting Metabolites in Bamboo Leaves as Markers of Nutritional Status Open
Giant pandas feed preferentially on bamboo but choose different species and organs depending on factors such as the altitude and season, suggesting preferential selection according to their nutritional requirements. However, the mechanism …
View article: Repurposing Mercaptopurine Through Collateral Lethality to Treat Cancers with Somatic <i>RB1–NUDT15</i> Loss
Repurposing Mercaptopurine Through Collateral Lethality to Treat Cancers with Somatic <i>RB1–NUDT15</i> Loss Open
Somatic retinoblastoma 1 ( RB1 ) loss is prevalent across different cancer types and is enriched in treatment‐refractory tumors, such as castration‐resistant prostate cancer (CRPC) and small‐cell lung cancer, but cannot be considered as a …
View article: RoTO: Robust Topology Obfuscation Against Tomography Inference Attacks
RoTO: Robust Topology Obfuscation Against Tomography Inference Attacks Open
Tomography inference attacks aim to reconstruct network topology by analyzing end-to-end probe delays. Existing defenses mitigate these attacks by manipulating probe delays to mislead inference, but rely on two strong assumptions: (i) prob…
View article: The Chinese Pulsar Timing Array Data Release I
The Chinese Pulsar Timing Array Data Release I Open
The Chinese Pulsar Timing Array (CPTA) has collected observations from 57 millisecond pulsars using the Five-hundred-meter Aperture Spherical Radio Telescope (FAST) for close to three years, for the purpose of searching for gravitational w…
View article: Moderation of treatment outcomes by polygenic risk for alcohol‐related traits in placebo‐controlled trials of topiramate
Moderation of treatment outcomes by polygenic risk for alcohol‐related traits in placebo‐controlled trials of topiramate Open
Background In two 12‐week, randomized, placebo‐controlled trials (RCTs) in individuals with alcohol use disorder (AUD), topiramate significantly reduced heavy drinking days (HDDs), and alcohol‐related problems. In a secondary analysis of t…
View article: Identification of Novel Selective Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists
Identification of Novel Selective Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists Open
Aims: We aimed to synthesize small-molecule compounds by modifying the chemical structure of GSK101 and screening for novel TRPV4 agonists with high specificity and selective sensory response. Background: GSK1016790A (GSK101) effectively a…
View article: Compound heterozygous PROC mutations cause lipedema in humans
Compound heterozygous PROC mutations cause lipedema in humans Open
Lipedema is a hereditary disorder characterized by excessive accumulation of subcutaneous adipose tissue in the limbs. The genetic causes and mechanisms underlying abnormal adipocyte expansion in lipedema, however, remain unknown. Here, we…
View article: Multi-round smHCR-FISH for archaea v1
Multi-round smHCR-FISH for archaea v1 Open
Understanding archaeal gene regulation is technically challenging due to the difficulty of measuring gene expression in individual archaeal cells. Here, we develop a multi-round smHCR-FISH method to quantify the transcription of multiple g…
View article: Multi-round smHCR-FISH for archaea v1
Multi-round smHCR-FISH for archaea v1 Open
Understanding archaeal gene regulation is technically challenging due to the difficulty of measuring gene expression in individual archaeal cells. Here, we develop a multi-round smHCR-FISH method to quantify the transcription of multiple g…
View article: CGSE-DETR: An Efficient and Accurate Method for Detecting Defects in Circular Knitting Machine Triangular Line Grooves
CGSE-DETR: An Efficient and Accurate Method for Detecting Defects in Circular Knitting Machine Triangular Line Grooves Open
The circular knitting machine plays a vital role in the textile industry, with the surface quality of its triangular line grooves directly affecting fabric performance. Existing detection methods struggle with accuracy due to the grooves’ …
View article: Targeted regulation of 5-aminolevulinic acid enhances flavonoids, anthocyanins and proanthocyanidins accumulation in Vitis davidii callus
Targeted regulation of 5-aminolevulinic acid enhances flavonoids, anthocyanins and proanthocyanidins accumulation in Vitis davidii callus Open
This study revealed a novel mode of ALA-mediated promotion of plant anthocyanin biosynthesis and accumulation at the cellular level, and a strategy for enhancing anthocyanin content in spine grape callus. The findings advance commercial-sc…
View article: Metallogenic regularity and prospecting direction of cobalt deposits in Yunnan Province
Metallogenic regularity and prospecting direction of cobalt deposits in Yunnan Province Open
Cobalt is a scarce strategic metal and is widely used in emerging industries. Due to the unique chemical properties of cobalt, there are mostly cobalt co-associated deposits, with little independent cobalt deposits. At present, cobalt depo…
View article: Preparation of tobacco pyrolysis liquids in subcritical/supercritical ethanol and their application in the aroma enhancement of heated cigarettes
Preparation of tobacco pyrolysis liquids in subcritical/supercritical ethanol and their application in the aroma enhancement of heated cigarettes Open
For the aroma enhancement research of heated cigarettes, it is worth exploring whether tobacco can be pyrolyzed into pyrolysis liquids containing a large number of volatile aroma components. In this study, tobacco pyrolysis liquids were pr…
View article: Graphical Abstract: Angew. Chem. Int. Ed. 2/2024
Graphical Abstract: Angew. Chem. Int. Ed. 2/2024 Open
In their Communication (e202313590), Yi Zhang, Yujian Zhang,Da-Wei Fu et al. report the unusual thermal quenching of photoluminescence in an organic-inorganic [MnBr 4 ] 2À -based halide mediated by crystalline-crystalline phase transition.
View article: <i>Phytophthora sojae</i> Effector PsCRN108 Targets CAMTA2 to Suppress <i>HSP40</i> Expression and ROS Burst
<i>Phytophthora sojae</i> Effector PsCRN108 Targets CAMTA2 to Suppress <i>HSP40</i> Expression and ROS Burst Open
Oomycete pathogens secrete numerous crinkling and necrosis proteins (CRNs) to manipulate plant immunity and promote infection. However, the functional mechanism of CRN effectors is still poorly understood. Previous research has shown that …
View article: Identifying genetic loci and phenomic associations of substance use traits: A multi‐trait analysis of GWAS (MTAG) study
Identifying genetic loci and phenomic associations of substance use traits: A multi‐trait analysis of GWAS (MTAG) study Open
Background and Aims Genome‐wide association studies (GWAS) of opioid use disorder (OUD) and cannabis use disorder (CUD) have lagged behind those of alcohol use disorder (AUD) and smoking, where many more loci have been identified. We sough…
View article: Association of gut microbiome and metabolites with onset and treatment response of patients with pemphigus vulgaris
Association of gut microbiome and metabolites with onset and treatment response of patients with pemphigus vulgaris Open
Background Gut dysbiosis and gut microbiome-derived metabolites have been implicated in both disease onset and treatment response, but this has been rarely demonstrated in pemphigus vulgaris (PV). Here, we aim to systematically characteriz…
View article: Deciphering the Clinical Significance and Kinase Functions of GSK3α in Colon Cancer by Proteomics and Phosphoproteomics
Deciphering the Clinical Significance and Kinase Functions of GSK3α in Colon Cancer by Proteomics and Phosphoproteomics Open
GSK3α and GSK3β are two GSK3 isoforms with 84% overall identity and 98% identity in their catalytic domains. GSK3β plays important roles in the pathogenesis of cancer, while GSK3α has long been considered a functionally redundant protein o…
View article: Correlation between serum lipid profiles and cognitive impairment in old age: a cross-sectional study
Correlation between serum lipid profiles and cognitive impairment in old age: a cross-sectional study Open
Background The correlation between cognitive function and lipid profiles, including total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides, is inconsistent. Aims This …
View article: Bifidobacterium pseudocatenulatum-Mediated Bile Acid Metabolism to Prevent Rheumatoid Arthritis via the Gut–Joint Axis
Bifidobacterium pseudocatenulatum-Mediated Bile Acid Metabolism to Prevent Rheumatoid Arthritis via the Gut–Joint Axis Open
Early intervention in rheumatoid arthritis (RA) is critical for optimal treatment, but initiation of pharmacotherapy to prevent damage remains unsatisfactory currently. Manipulation of the gut microbiome and microbial metabolites can be ef…