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View article: The Significance and Diagnostic Potential of CEA and FIB in Colorectal Cancer
The Significance and Diagnostic Potential of CEA and FIB in Colorectal Cancer Open
Background Colorectal cancer (CRC) is the third most common cancer worldwide; most cases are diagnosed at an advanced stage. This study explored the value of carcinoembryonic antigen (CEA) and fibrinogen (FIB) in the differential diagnosis…
View article: Improving speech depression detection using transfer learning with wav2vec 2.0 in low-resource environments
Improving speech depression detection using transfer learning with wav2vec 2.0 in low-resource environments Open
Depression, a pervasive global mental disorder, profoundly impacts daily lives. Despite numerous deep learning studies focused on depression detection through speech analysis, the shortage of annotated bulk samples hampers the development …
View article: Role cognition of assigned nurses supporting Hubei Province in the fight against COVID-19 in China: a hermeneutic phenomenological study
Role cognition of assigned nurses supporting Hubei Province in the fight against COVID-19 in China: a hermeneutic phenomenological study Open
Aims During the COVID-19 epidemic, nurses played a crucial role in clinical treatment. As a special group, front-line nurses, especially those assigned to support Hubei Province in the fight against COVID-19 between February and April 2020…
View article: TRAF6 regulates autophagy and apoptosis of melanoma cells through c‐Jun/ATG16L2 signaling pathway
TRAF6 regulates autophagy and apoptosis of melanoma cells through c‐Jun/ATG16L2 signaling pathway Open
Autophagy and apoptosis are essential processes that participate in cell death and maintain cellular homeostasis. Dysregulation of these biological processes results in the development of diseases, including cancers. Therefore, targeting t…
View article: Seroprevalence of Epizootic Hemorrhagic Disease Virus in Guangdong Cattle Farms during 2013–2017, China
Seroprevalence of Epizootic Hemorrhagic Disease Virus in Guangdong Cattle Farms during 2013–2017, China Open
Epizootic hemorrhagic disease (EHD) is an infectious viral disease caused by epizootic hemorrhagic disease virus (EHDV) and EHDV frequently circulates in wild and domestic ruminants. Sporadic outbreaks of EHD have caused thousands of death…
View article: The impact of eating behaviors during COVID-19 in health-care workers: A conditional process analysis of eating, affective disorders, and PTSD
The impact of eating behaviors during COVID-19 in health-care workers: A conditional process analysis of eating, affective disorders, and PTSD Open
View article: CD147 mediates epidermal malignant transformation through the RSK2/AP-1 pathway
CD147 mediates epidermal malignant transformation through the RSK2/AP-1 pathway Open
Background Malignant transformation of the epidermis is an essential process in the pathogenesis of cutaneous squamous-cell carcinoma (cSCC). Although evidence has demonstrated that CD147 plays key roles in various tumors, the role of CD14…
View article: Identification and characterization of FGFR2+ hematopoietic stem cell-derived fibrocytes as precursors of cancer-associated fibroblasts induced by esophageal squamous cell carcinoma
Identification and characterization of FGFR2+ hematopoietic stem cell-derived fibrocytes as precursors of cancer-associated fibroblasts induced by esophageal squamous cell carcinoma Open
Background Cancer-associated fibroblast (CAF) is an ideal target for cancer treatment. Recent studies have focused on eliminating CAFs and their effects by targeting their markers or blocking individual CAF-secreted factors. However, these…
View article: Genomic alterations of dermatofibrosarcoma protuberans revealed by whole‐genome sequencing
Genomic alterations of dermatofibrosarcoma protuberans revealed by whole‐genome sequencing Open
This is the first large-scale whole-genome sequencing for DFSP, and our findings describe the comprehensive genomic landscape, highlighting the molecular complexity and genomic aberrations of DFSP. Our findings also provide novel potential…
View article: Hematopoietic stem cell-derived fibrocytes as targets and tools for cancer therapy: mechanisms and therapeutic implications
Hematopoietic stem cell-derived fibrocytes as targets and tools for cancer therapy: mechanisms and therapeutic implications Open
Background: Cancer-associated fibroblast (CAF) is an ideal target for cancer treatment. Recent studies have focused on eliminating CAFs and their effects by targeting their markers or blocking individual CAF-secreted factors. However, thes…
View article: Hematopoietic stem cell-derived fibrocytes as targets and tools for cancer therapy: mechanisms and therapeutic implications
Hematopoietic stem cell-derived fibrocytes as targets and tools for cancer therapy: mechanisms and therapeutic implications Open
Background: Cancer-associated fibroblast (CAF) is an ideal target for cancer treatment. Recent studies have focused on eliminating CAFs and their effects by targeting their markers or blocking individual CAF-secreted factors. However, thes…
View article: The plasma exosomal miR-1180-3p serves as a novel potential diagnostic marker for cutaneous melanoma
The plasma exosomal miR-1180-3p serves as a novel potential diagnostic marker for cutaneous melanoma Open
View article: Rapid migration from traditional or hybrid to fully virtual education in the age of the coronavirus pandemic: challenges, experiences and views of college and university students
Rapid migration from traditional or hybrid to fully virtual education in the age of the coronavirus pandemic: challenges, experiences and views of college and university students Open
The abrupt outbreak of the coronavirus pandemic throughout the world in March 2020 resulted in the sudden closure of all schools, colleges and universities, institutions, and an unprecedented pivot to remote learning. Students and teachers…
View article: Built Environment Factors Influencing Prevalence of Hypertension at Community Level in China: The Case of Wuhan
Built Environment Factors Influencing Prevalence of Hypertension at Community Level in China: The Case of Wuhan Open
This paper studies the correlation between built environment factors and the prevalence of hypertension in Wuhan, a typical city in central China. Data were obtained from a regional epidemiological database, which is the 2015 Epidemiologic…
View article: Pyroptosis: mechanisms and diseases
Pyroptosis: mechanisms and diseases Open
View article: Inhibition of xCT suppresses the efficacy of anti-PD-1/L1 melanoma treatment through exosomal PD-L1-induced macrophage M2 polarization
Inhibition of xCT suppresses the efficacy of anti-PD-1/L1 melanoma treatment through exosomal PD-L1-induced macrophage M2 polarization Open
View article: Unemployment and Health-Related Quality of Life in Melanoma Patients During the COVID-19 Pandemic
Unemployment and Health-Related Quality of Life in Melanoma Patients During the COVID-19 Pandemic Open
The outbreak of coronavirus disease-2019 (COVID-19) ineluctably caused social distancing and unemployment, which may bring additional health risks for patients with cancer. To investigate the association of the pandemic-related impacts wit…
View article: Correction to: The phosphorylation of CD147 by Fyn plays a critical role for melanoma cells growth and metastasis
Correction to: The phosphorylation of CD147 by Fyn plays a critical role for melanoma cells growth and metastasis Open
View article: Novel Functions of CD147 in the Mitochondria Exacerbates Melanoma Metastasis
Novel Functions of CD147 in the Mitochondria Exacerbates Melanoma Metastasis Open
Melanoma is an aggressive form of skin cancer characterized by rapid invasion and metastasis. CD147 is known to be functioning in cell invasion. In this study, we showed that CD147 was translocated from the cell membrane to the mitochondri…
View article: Association of Socioeconomic Changes due to the COVID-19 Pandemic With Health Outcomes in Patients With Skin Diseases: Cross-Sectional Survey Study
Association of Socioeconomic Changes due to the COVID-19 Pandemic With Health Outcomes in Patients With Skin Diseases: Cross-Sectional Survey Study Open
Background The outbreak of COVID-19 has profoundly influenced people’s lifestyles; these impacts have varied across subgroups of people. The pandemic-related impacts on the health outcomes of people with dermatological conditions are unkno…
View article: Association of Socioeconomic Changes due to the COVID-19 Pandemic With Health Outcomes in Patients With Skin Diseases: Cross-Sectional Survey Study (Preprint)
Association of Socioeconomic Changes due to the COVID-19 Pandemic With Health Outcomes in Patients With Skin Diseases: Cross-Sectional Survey Study (Preprint) Open
BACKGROUND The outbreak of COVID-19 has profoundly influenced people’s lifestyles; these impacts have varied across subgroups of people. The pandemic-related impacts on the health outcomes of people with dermatological conditions are unkn…
View article: Unemployment and health-related quality of life in melanoma patients during the COVID-19 pandemic: A web-based cross-sectional study
Unemployment and health-related quality of life in melanoma patients during the COVID-19 pandemic: A web-based cross-sectional study Open
Background The outbreak of coronavirus disease-2019 (COVID-19) ineluctably caused social distancing and unemployment, which may bring additional health risks for patients with cancer. To investigate the association of the pandemic-related …
View article: A novel chalcone derivative suppresses melanoma cell growth through targeting Fyn/Stat3 pathway
A novel chalcone derivative suppresses melanoma cell growth through targeting Fyn/Stat3 pathway Open
Background Fyn has been documented to have oncogenic features in multiple tumors, which might be a potential therapeutic target, however, few studies on the function role of Fyn and its specific inhibitors in melanoma. Methods We investiga…
View article: A Novel Chalcone derivative suppresses Melanoma cell growth through targeting Fyn/Stat3 pathway
A Novel Chalcone derivative suppresses Melanoma cell growth through targeting Fyn/Stat3 pathway Open
Background: Fyn has been documented to have oncogenic features in multiple tumors, which might be a potential therapeutic target, however, few studies on the function role of Fyn and its specific inhibitors in melanoma. Methods: We investi…
View article: First Fatal Infection and Phylodynamic Analysis of Severe Fever with Thrombocytopenia Syndrome Virus in Jilin Province, Northeastern China
First Fatal Infection and Phylodynamic Analysis of Severe Fever with Thrombocytopenia Syndrome Virus in Jilin Province, Northeastern China Open
View article: An ERA-Based Study of Built Environment Factors Affecting Lung Cancer Incidence Rate among Chinese Women
An ERA-Based Study of Built Environment Factors Affecting Lung Cancer Incidence Rate among Chinese Women Open
Objective: Application of ERA methods to investigate the atmospheric pollution and built environment factors influencing lung cancer incidence rate in Chinese women. Methods: Lung cancer incidence rate among Chinese women at 339 cancer reg…
View article: A Novel Chalcone derivative suppresses Melanoma cell growth through targeting Fyn/Stat3 pathway
A Novel Chalcone derivative suppresses Melanoma cell growth through targeting Fyn/Stat3 pathway Open
Background : Fyn has been documented to have oncogenic features in multiple tumors, which might be a potential therapeutic target, however, few studies on the function role of Fyn and its specific inhibitors in melanoma. Methods : We inves…
View article: Additional file 1 of A novel chalcone derivative suppresses melanoma cell growth through targeting Fyn/Stat3 pathway
Additional file 1 of A novel chalcone derivative suppresses melanoma cell growth through targeting Fyn/Stat3 pathway Open
Additional file 1: Table S1. The primers used in the RT-PCR reaction.
View article: Proteogenomic Analysis Unveils the HLA Class I Presented Immunopeptidome in Melanoma and EGFR Mutant Lung Adenocarcinoma
Proteogenomic Analysis Unveils the HLA Class I Presented Immunopeptidome in Melanoma and EGFR Mutant Lung Adenocarcinoma Open
View article: Contributions to species of Xylariales in China—2. Rosellinia pervariabilis and R. tetrastigmae spp. nov., and a new record of R. caudata
Contributions to species of Xylariales in China—2. Rosellinia pervariabilis and R. tetrastigmae spp. nov., and a new record of R. caudata Open
Three species of Rosellinia collected from China are reported based on morphological and molecular characteristics. Rosellinia pervariabilis is proposed as a new species, differentiated by its narrow ascospores (19.5–24.5 × 4–5 μm) without…