Xia Xu
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View article: TCGA molecular subtypes in endometriosis-associated ovarian cancer: a systematic review and meta-analysis
TCGA molecular subtypes in endometriosis-associated ovarian cancer: a systematic review and meta-analysis Open
The TCGA subtypes of EC may exhibit similarities in prognosis between ENOC and CCOC.
View article: Glymphatic dysfunction in relapsing-remitting multiple sclerosis and its association with brain structural damage and cognitive impairment
Glymphatic dysfunction in relapsing-remitting multiple sclerosis and its association with brain structural damage and cognitive impairment Open
The study implied that glymphatic dysfunction may contribute to brain structural damage, clinical disability, and cognitive impairment in RRMS, indicating that glymphatic dysfunction may play a key role in the pathogenesis of RRMS.
View article: Clinical features and prognostic factors of cardiorenal anemia syndrome in China: a retrospective single-center study
Clinical features and prognostic factors of cardiorenal anemia syndrome in China: a retrospective single-center study Open
View article: Exploration of a miRNA-mRNA network shared between acute pancreatitis and Epstein-Barr virus infection by integrated bioinformatics analysis
Exploration of a miRNA-mRNA network shared between acute pancreatitis and Epstein-Barr virus infection by integrated bioinformatics analysis Open
Acute pancreatitis (AP) stands out as a primary cause of hospitalization within gastrointestinal ailments, attributed to diverse factors, including Epstein-Barr virus (EBV) infection. Nevertheless, the common miRNAs and genes shared betwee…
View article: An Innovation Management Approach for Electric Vertical Take-Off and Landing
An Innovation Management Approach for Electric Vertical Take-Off and Landing Open
With more companies entering the realm of electric vertical take-off and landing (eVTOL) and governments enacting policies to support the development of low-altitude economies, the commercial potential of eVTOL is being recognized by the p…
View article: Genomic alteration discordance in the paired primary-recurrent ovarian cancers: based on the comprehensive genomic profiling (CGP) analysis
Genomic alteration discordance in the paired primary-recurrent ovarian cancers: based on the comprehensive genomic profiling (CGP) analysis Open
View article: Clinical features and prognostic factors of Cardiorenal anemia syndrome in China: a retrospective single-center study
Clinical features and prognostic factors of Cardiorenal anemia syndrome in China: a retrospective single-center study Open
Background There is little research on cardiorenal anemia syndrome (CRAS) in China. This study was to describe the characteristics of patients with CRAS and to explore predictive risk factors of all-cause mortality. Methods A total of 8179…
View article: FIGURE 2 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma
FIGURE 2 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma Open
Double-positive cells in Sftpc-CreER; LSL-KrasG12D-induced lung adenocarcinoma are tumor-propagating cells and forms tumors upon transplantation. A, Experimental outline for growing cells in 3D organoid culture.
View article: FIGURE 1 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma
FIGURE 1 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma Open
Activation of KrasG12D transforms type II cells to dual-positive type I and type II expressing cells. A, Experimental outline to compare type I, type II, and double-positive (type I/II+) population between wild-type and K…
View article: Supplementary Figure S7 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma
Supplementary Figure S7 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma Open
Heat map showing the differentially expressed genes between double positive and Type II cells in KrasG12D induced lungs
View article: Supplementary Table S2 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma
Supplementary Table S2 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma Open
List of the primers used in qPCR analysis
View article: Supplementary Figure S2 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma
Supplementary Figure S2 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma Open
Subcutaneous transplantation of double positive cells (Type I/II+) in Rag1-/- or NOD SCID mice leads to large tumor formation
View article: Supplementary Figure S2 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma
Supplementary Figure S2 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma Open
Subcutaneous transplantation of double positive cells (Type I/II+) in Rag1-/- or NOD SCID mice leads to large tumor formation
View article: FIGURE 2 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma
FIGURE 2 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma Open
Double-positive cells in Sftpc-CreER; LSL-KrasG12D-induced lung adenocarcinoma are tumor-propagating cells and forms tumors upon transplantation. A, Experimental outline for growing cells in 3D organoid culture.
View article: Supplementary Figure S4 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma
Supplementary Figure S4 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma Open
Tumors from both Type II and double positive cells transplants express both Type I and Type II cells
View article: FIGURE 4 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma
FIGURE 4 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma Open
Genetically overexpressing Sox2 and chemically replacing Sox2 inhibit Kras-induced dual-positive cell development and tumor formation in alveolar type II cells. A, Sections of Sftpc-CreER; LSL-KrasG12D and Sftpc…
View article: Supplementary Table S1 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma
Supplementary Table S1 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma Open
Validated alveolar type I and type II epithelial cell markers
View article: Supplementary Figure S8 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma
Supplementary Figure S8 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma Open
Proposed model showing transformation of type II cells into lung adenocarcinoma through Rage+/Sftpc+ double positive stage
View article: Supplementary Figure S5 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma
Supplementary Figure S5 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma Open
Sox2 overexpressing population in Sftpc-CreER; KrasG12D; LSL-Sox2 mice express proximal markers, CC10 and Krt5
View article: Supplementary Figure S6 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma
Supplementary Figure S6 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma Open
RepSox treatment increases Sox2 levels while TGFb remains unchanged in KrasG12D mutant lungs
View article: FIGURE 5 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma
FIGURE 5 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma Open
Notch inhibition or Sox2 upregulation suppresses tumor sphere formation in 3D culture. A, Representative fluorescent microscopy images of cultures (n = 3) showing spheres formed in Matrigel at day 14 from lineage-labeled TdTo…
View article: Supplementary Figure S8 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma
Supplementary Figure S8 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma Open
Proposed model showing transformation of type II cells into lung adenocarcinoma through Rage+/Sftpc+ double positive stage
View article: FIGURE 3 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma
FIGURE 3 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma Open
The KrasG12D-induced upregulation of type I cell markers in double-positive cells requires Notch signaling. A, Representative IF image of lung sections of indicated genotypes stained with GFP (Venus, Notch signaling repor…
View article: Supplementary Figure S1 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma
Supplementary Figure S1 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma Open
Time course for double positive cells in Sftpc-creER; KRasG12D; fGFP mice
View article: Supplementary Table S1 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma
Supplementary Table S1 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma Open
Validated alveolar type I and type II epithelial cell markers
View article: FIGURE 6 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma
FIGURE 6 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma Open
Type I/II+ dual-positive cells share pathways with developing lung progenitors and contain potential therapeutic targets. A, Experimental outline for RNA-seq performed with sorted type I, type II, and double-positive cells. B,
View article: Supplementary Figure S6 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma
Supplementary Figure S6 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma Open
RepSox treatment increases Sox2 levels while TGFb remains unchanged in KrasG12D mutant lungs
View article: Supplementary Figure S5 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma
Supplementary Figure S5 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma Open
Sox2 overexpressing population in Sftpc-CreER; KrasG12D; LSL-Sox2 mice express proximal markers, CC10 and Krt5
View article: Supplementary Figure S7 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma
Supplementary Figure S7 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma Open
Heat map showing the differentially expressed genes between double positive and Type II cells in KrasG12D induced lungs
View article: FIGURE 3 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma
FIGURE 3 from Activation of Kras<sup>G12D</sup> in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma Open
The KrasG12D-induced upregulation of type I cell markers in double-positive cells requires Notch signaling. A, Representative IF image of lung sections of indicated genotypes stained with GFP (Venus, Notch signaling repor…