Explanipedia

Off-target engagement of sotorasib with PPARγ via FABP4: a novel mechanism driving interstitial lung disease Open

Jiaqi Zhang, Jinjin Li, Mengting Cheng, Haiyang Zhou, Xiaochen Zhang , et al. · 2025

An exhaustive examination of the research progress in identifying potential JAK inhibitors from natural products: a comprehensive overview Open

Wendong Yang, Jiabin Lu, Peihua Luo, Zhifei Xu, Yan‐Tao Hao , et al. · 2025

Direct Lineage Reprogramming of Fibroblasts into Functional Keratinocyte-Like Cells via BMI1 and FGFR2b for Diabetic Wound Repair Open

Huilin Ma, Yashi Cao, Zizheng Gao, Zhifei Xu, Bo Yang , et al. · 2025

This study presents a safe and effective direct reprogramming strategy for skin regeneration, bypassing the pluripotent stage and avoiding cell transplantation. The B2 combination provides a novel molecular tool for wound repair and offers…

The effect of nano‑selenium application on the quality and flavor of kiwifruit Open

Yanan Liu, Sipu Zhang, Jiajia Niu, Zhifei Xu, Yongfeng Yang , et al. · 2025

This study investigates the impact of foliar spraying with different concentrations of nano‑selenium (0, 10, 15, 20, 25 mg/L) on the nutritional value, antioxidant capacity, and volatile compounds of kiwifruit. Using gas chromatography-mas…

Sotorasib-impaired degradation of NEU1 contributes to cardiac injury by inhibiting AKT signaling Open

Mengting Cheng, Wentong Wu, Xiu‐Qing Li, Xinyu Tao, Feng Jiang , et al. · 2025

Sotorasib, the inaugural targeted inhibitor sanctioned for the management of patients afflicted with locally advanced or metastatic non-small cell lung cancer presenting the KRAS G12C mutation, has encountered clinical application constrai…

Disturbing Cholesterol/Sphingolipid Metabolism by Squalene Epoxidase Arises Crizotinib Hepatotoxicity (Adv. Sci. 14/2025) Open

Hao Yan, Xiangliang Huang, Yourong Zhou, Mu Yuan, Shaoyin Zhang , et al. · 2025

Crizotinib Hepatotoxicity In article number 2414923, Peihua Luo, Hao Yan, Xiangliang Huang, and co‐workers report the mechanism of crizotinib hepatotoxicity, wherein crizotinib disturbs normal lipid metabolism through accumulation of squal…

Mechanism and therapeutic potential of liver injury induced by cholesterol-associated proteins Open

Yourong Zhou, Yashi Cao, Yiming Yin, Zhifei Xu, Xiaochun Yang , et al. · 2025

Cholesterol, the most abundant sterol molecule in mammalian organisms, serves not only as a fundamental structural component of cell membranes but also as a critical regulator of cellular signaling and function. Cholesterol-associated prot…

The inducible role of autophagy in cell death: emerging evidence and future perspectives Open

Xiangliang Huang, Hao Yan, Zhifei Xu, Bo Yang, Peihua Luo , et al. · 2025

This review highlights the prodeath effect of autophagy, which is distinct from the generally perceived cytoprotective role, and its mechanisms are mainly associated with the selective degradation of proteins or organelles essential for ce…

Disturbing Cholesterol/Sphingolipid Metabolism by Squalene Epoxidase Arises Crizotinib Hepatotoxicity Open

Hao Yan, Xiangliang Huang, Yourong Zhou, Mu Yuan, Shaoyin Zhang , et al. · 2025

Metabolic disorders have been identified as one of the causes of drug‐induced liver injury; however, the direct regulatory mechanism regarding this disorder has not yet been clarified. In this study, a single regulatory mechanism of small …

The impact of solute carrier proteins on disrupting substance regulation in metabolic disorders: insights and clinical applications Open

Jiangxia Du, Minhui Shen, Jiajia Chen, Hao Yan, Zhifei Xu , et al. · 2025

Carbohydrates, lipids, bile acids, various inorganic salt ions and organic acids are the main nutrients or indispensable components of the human body. Dysregulation in the processes of absorption, transport, metabolism, and excretion of th…

Network pharmacology‑based analysis and <i>in vitro</i> experimental verification of the inhibitory role of luteoloside on gastric cancer cells via the p53/p21 pathway Open

Xiaoyan Lin, Pei-Qing Yang, Xiaojun Li, Zhifei Xu, Hai-Tao Wu , et al. · 2024

The present study aimed to investigate the inhibitory effect of luteoloside on the proliferation, migration and invasion of gastric cancer (GC) cells based on network pharmacology and in vitro experiments. GC-associated targets were…

The Combination of Gefitinib and Acetaminophen Exacerbates Hepatotoxicity via ROS-Mediated Apoptosis Open

Jiangxin Xu, Xiangliang Huang, Yourong Zhou, Zhifei Xu, Xinjun Cai , et al. · 2024

Gefitinib is the well-tolerated first-line treatment of non-small cell lung cancer. As it need for analgesics during oncology treatment, particularly in the context ofthe coronavirus disease, where patients are more susceptible to contract…

Rutin attenuates ensartinib-induced hepatotoxicity by non-transcriptional regulation of TXNIP Open

Wentong Wu, Jinjin Li, Yiming Yin, Yourong Zhou, Xiangliang Huang , et al. · 2024

Research on a machine learning-based adaptive and efficient screening model for psychological symptoms of community correctional prisoners Open

Zhifei Xu, Zhigeng Pan, Yan Wang, Yichao Zhang, Pengfei Leng · 2024

A preliminary study of modified inflatable mediastinoscopic and single-incision plus one-port laparoscopic esophagectomy Open

Hua Tang, Zhihao Song, Rongqiang Wei, Kai Yan, Zihao Chen , et al. · 2024

Inflatable mediastinoscopy combined with single-incision plus one-port laparoscopic esophagectomy is a safe and effective surgical procedure. The use of a 5-mm flexible endoscope, ultra-long five-leaf forceps, and LigaSure Maryland forceps…

Downregulation of Ddit4 Levels with Borneol Attenuates Hepatotoxicity Induced by Gilteritinib Open

Yiming Yin, Yashi Cao, Yourong Zhou, Zhifei Xu, Peihua Luo , et al. · 2024

Blend U-Net: Redesigning Skip Connections to Obtain Multiscale Features forLung CT Images Segmentation Open

Pengfei Leng, Zhifei Xu, Zhaohui Zhu, Zhigeng Pan · 2023

Background:: Lung cancer is a pervasive and persistent issue worldwide, with the highest morbidity and mortality among all cancers for many years. In the medical field, computer tomography (CT) images of the lungs are currently recognized …

Inhibition of PRKAA/AMPK (Ser485/491) phosphorylation by crizotinib induces cardiotoxicity via perturbing autophagosome-lysosome fusion Open

Zhifei Xu, Zezheng Pan, Ying Jin, Zizheng Gao, Feng Jiang , et al. · 2023

Crizotinib, a small-molecule tyrosine kinase inhibitor targeting ALK, MET and ROS1, is the first-line drug for ALK-positive metastatic non-small cell lung cancer and is associated with severe, sometimes fatal, cases of cardiac failure, whi…

Self-Adaption Rapid Screening Model Research on Psychological Symptoms of Prisoners in Community Correction Based on Machine Learning Open

Zhifei Xu, Zhigeng Pan, Yan Wang, Yichao Zhang, Pengfei Leng · 2023

The SCL-90 Symptom Checklist is a widely used screening scale in psychiatry and psychology in clinical practice,has also been adopted by community correction institutions as the main tool for psychological assessment of community correctio…

Chloroquine Intervenes Nephrotoxicity of Nilotinib through Deubiquitinase USP13‐Mediated Stabilization of Bcl‐XL Open

Hao Yan, Xiangliang Huang, Jiangxin Xu, Ying Zhang, Jiajia Chen , et al. · 2023

Nephrotoxicity has become prominent due to the increase in the clinical use of nilotinib, a second‐generation BCR‐ABL1 inhibitor in the first‐line treatment of Philadelphia chromosome‐positive chronic myeloid leukemia. To date, the mechani…

Regorafenib inhibits EphA2 phosphorylation and leads to liver damage via the ERK/MDM2/p53 axis Open

Hao Yan, Wentong Wu, Yuhuai Hu, Jinjin Li, Jiangxin Xu , et al. · 2023

The hepatotoxicity of regorafenib is one of the most noteworthy concerns for patients, however the mechanism is poorly understood. Hence, there is a lack of effective intervention strategies. Here, by comparing the target with sorafenib, w…

Development and safety of PI3K inhibitors in cancer Open

Miaomiao Yu, Jiajia Chen, Zhifei Xu, Bo Yang, Qiaojun He , et al. · 2023

The phosphatidylinositol 3-kinase (PI3K) signalling pathway regulates cell survival, proliferation, migration, metabolism and other vital cellular life processes. In addition, activation of the PI3K signalling pathway is important for canc…

PTX3 from vascular endothelial cells contributes to trastuzumab-induced cardiac complications Open

Zhifei Xu, Zizheng Gao, Huangxi Fu, Yan Zeng, Ying Jin , et al. · 2023

Aims Trastuzumab, the first humanized monoclonal antibody that targets human epidermal growth factor receptor 2 (ERBB2/HER2), is currently used as a first-line treatment for HER2 (+) tumours. However, trastuzumab increases the risk of card…

Application of wireless thoracoscopy in thoracic surgery Open

Ning Xin, Xiaoyu Wu, Junjie Hu, Rongqiang Wei, Zihao Chen , et al. · 2023

To explore the safety and feasibility of wireless thoracoscope in thoracic surgery. A retrospective analysis was made of all the clinical data of 90 patients with thoracoscope lung resection, from April to August 2021, Shanghai changzheng …

Construction and application of intelligent mental health management system for prisoners Open

Zhifei Xu, Jiagang Dong, Yichao Zhang · 2023

As a special group, prisoners' mental health problems endanger the safety of supervision and social security.The traditional psychological assessment scale for prisoners has a large number of topics and a complicated assessment process, wh…

Inhibition of PRKAA/AMPK (Ser485/491) phosphorylation by crizotinib induces cardiotoxicity via perturbing autophagosome-lysosome fusion Open

Zhifei Xu, Zezheng Pan, Ying Jin, Zizheng Gao, Feng Jiang , et al. · 2023

Crizotinib, a small-molecule tyrosine kinase inhibitor targeting ALK, MET and ROS1, is the first-line drug for ALK-positive metastatic non-small cell lung cancer and is associated with severe, sometimes fatal, cases of cardiac failure, whi…

Inhibition of PRKAA/AMPK (Ser485/491) phosphorylation by crizotinib induces cardiotoxicity via perturbing autophagosome-lysosome fusion Open

Zhifei Xu, Zezheng Pan, Ying Jin, Zizheng Gao, Feng Jiang , et al. · 2023

Crizotinib, a small-molecule tyrosine kinase inhibitor targeting ALK, MET and ROS1, is the first-line drug for ALK-positive metastatic non-small cell lung cancer and is associated with severe, sometimes fatal, cases of cardiac failure, whi…

Regorafenib inhibits EphA2 phosphorylation damages the liver via ERK/MDM2/p53 axis Open

Hao Yan, Wentong Wu, Yuhuai Hu, Jinjin Li, Xueqin Chen , et al. · 2022

Hepatotoxicity of regorafenib is one of the most noteworthy concerns for patients, however the mechanism has poorly understood. Hence, lack of effective intervention strategy. In this study, we found that regorafenib-induced liver injury m…

Clinical comparative study of glasses-free 3D and 2D thoracoscopic surgery in minimally invasive esophagectomy Open

Rongqiang Wei, Xinyu Ding, Zihao Chen, Ning Xin, Chengdong Liu , et al. · 2022

Objective To investigate the safety and efficacy of glasses-free three-dimensional (3D) thoracoscopic surgery in minimally invasive esophagectomy (MIE). Methods The clinical data of 98 patients, including 81 men and 17 women aged 45–77 yea…

Comparison of low-dose morphine intrathecal analgesia and sufentanil PCIA in elderly patients with hip fracture undergoing single spinal anesthesia — a randomized clinical trial Open

Zhifei Xu, Zairong Tang, Juan Yao, Dongliang Liang, Feng Jin , et al. · 2022

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