Arthropod-borne viruses (arboviruses) pose significant public health threats, and understanding their evolutionary mechanisms can inform molecular diagnostics and vaccine design. Oropouche virus (OROV), a relatively understudied arbovirus, exhibits unique evolutionary dynamics in nucleotide composition. We analyzed 45 OROV strains across genotypes to assess selective pressures shaping nucleoprotein, glycoprotein, and RNA-dependent RNA polymerase (RdRp) evolution. We utilized information entropy, dinucleotide odds …

Abstract Phase transition of CuAl 2 O 4 to CuAlO 2 during the sintering process of Al 2 O 3 /CuO nanoceramics at high temperatures (973 - 1373 K) were investigated by positron annihilation lifetime spectroscopy (PALS), X-ray diffraction (XRD) and scanning electron microscope (SEM). The XRD results showed that the CuAl 2 O 4 phase was first synthesized at 973 K and then decomposed into CuAlO 2 at 1373 K during the sintering process of Al 2 O 3 /CuO. SEM revealed that a lot of agglomerated small particles were forme…

Influenza epidemics represent a significant threat to global public health, primarily caused by the influenza viruses A and B. Although antiviral drugs targeting the influenza virus, such as zanamivir and oseltamivir, are clinically available, the emergence of virus evolution and drug resistance necessitates the development of host-directed therapies. Protein kinases are essential components of host signaling pathways, including the orchestration of virus–host interactions. By screening a library of kinase inhibit…

Influenza A virus (IAV) poses a threat to patients receiving immunosuppressive medications since they are more susceptible to infection with severe symptoms, and even death. Understanding the direct effects of immunosuppressants on IAV infection is critical for optimizing immunosuppression in these patients who are infected or at risk of influenza virus infection. We profiled the effects of 10 immunosuppressants, explored the antiviral mechanisms of immunosuppressants, and demonstrated the combined effects of immu…

<title>Abstract</title> According to sequencing of the 5’ untranslated region (5’UTR) in viral genome, five strains of bovine viral diarrhea virus (BVDV) isolated from different provinces in China were genetically typed. The phylogenetic tree for BVDV 5’UTR displays that the isolated strain 22AH-1 is clustered into the genotype 1c clade, the strain 22-Gansu-F2 is clustered into the genotype 2a clade, the strains 22Anhui-7, 22-Sichuan-B8 and 22-Gansu-F3 are clustered into the genotype 2d clade. Depending on princip…