Yubao Lu
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View article: Mechanisms and therapeutic potential of hydrogen sulfide in traumatic central nervous system injuries
Mechanisms and therapeutic potential of hydrogen sulfide in traumatic central nervous system injuries Open
Traumatic central nervous system injuries encompass brain and spinal cord injuries. Recent studies have identified hydrogen sulfide (H₂S) as a potent endogenous gasotransmitter with multifaceted roles in neuroprotection and central nervous…
View article: How Interest Translates into the Choice of Profession - A Discussion Based on Self-efficacy Theory
How Interest Translates into the Choice of Profession - A Discussion Based on Self-efficacy Theory Open
In contemporary China, a significant number of university graduates pursue careers that diverge from their original fields of study, reflecting a broader trend of academic and occupational mismatch. This review examines the principal facto…
View article: Dual-Targeting Nanoparticles Enhance Microglial P2Y12R Expression to Promote Neuronal Mitophagy for Repairing Spinal Cord Injury
Dual-Targeting Nanoparticles Enhance Microglial P2Y12R Expression to Promote Neuronal Mitophagy for Repairing Spinal Cord Injury Open
Spinal cord injury (SCI) leads to severe mitochondrial dysfunction and ROS cascade, with microglia playing a dual role in both exacerbating damage and providing neuroprotection. Recent evidence has highlighted the importance of P2Y12R in m…
View article: Global incidence and characteristics of spinal cord injury since 2000–2021: a systematic review and meta-analysis
Global incidence and characteristics of spinal cord injury since 2000–2021: a systematic review and meta-analysis Open
Background This study employs systematic review and meta-analysis to explore the incidence and characteristics of spinal cord injury (SCI) between 2000 and 2021, aiming to provide the most recent and comprehensive data support for the prev…
View article: Research progress and prospects of benefit-risk assessment methods for umbilical cord mesenchymal stem cell transplantation in the clinical treatment of spinal cord injury
Research progress and prospects of benefit-risk assessment methods for umbilical cord mesenchymal stem cell transplantation in the clinical treatment of spinal cord injury Open
Over the past decade, we have witnessed the development of cell transplantation as a new strategy for repairing spinal cord injury (SCI). However, due to the complexity of the central nervous system (CNS), achieving successful clinical tra…
View article: Multi-pass deep-drawing process and mould design for thin-walled hollow cylindrical parts
Multi-pass deep-drawing process and mould design for thin-walled hollow cylindrical parts Open
Thin-walled hollow cylindrical parts are widely employed in various industries, including automobiles, ships, and aviation, due to their increased demand and the escalating quality requirements for their formation. The production of these …
View article: Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury
Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury Open
JOURNAL/nrgr/04.03/01300535-202510000-00026/figure1/v/2024-11-26T163120Z/r/image-tiff Microglia, the resident monocyte of the central nervous system, play a crucial role in the response to spinal cord injury. However, the precise mechanism…
View article: SCAN: Spatiotemporal Cloud Atlas for Neural cells
SCAN: Spatiotemporal Cloud Atlas for Neural cells Open
The nervous system is one of the most complicated and enigmatic systems within the animal kingdom. Recently, the emergence and development of spatial transcriptomics (ST) and single-cell RNA sequencing (scRNA-seq) technologies have provide…
View article: The optimal transplantation strategy of umbilical cord mesenchymal stem cells in spinal cord injury: a systematic review and network meta-analysis based on animal studies
The optimal transplantation strategy of umbilical cord mesenchymal stem cells in spinal cord injury: a systematic review and network meta-analysis based on animal studies Open
View article: Novel Immunotherapies for Osteosarcoma
Novel Immunotherapies for Osteosarcoma Open
Osteosarcoma (OS) is the most common primary malignant bone sarcoma mainly affecting adolescents and young adults, which often progresses to pulmonary metastasis and leads to the death of OS patients. OS is characterized as a highly hetero…
View article: Research Progress of Exosome-Loaded miRNA in Osteosarcoma
Research Progress of Exosome-Loaded miRNA in Osteosarcoma Open
Currently, although the improvement of surgical techniques and the development of chemotherapy drugs have brought a certain degree of development to the treatment of osteosarcoma, the treatment of osteosarcoma has many shortcomings, and it…
View article: Graphene and graphene-based materials in axonal repair of spinal cord injury
Graphene and graphene-based materials in axonal repair of spinal cord injury Open
Graphene and graphene-based materials have the ability to induce stem cells to differentiate into neurons, which is necessary to overcome the current problems faced in the clinical treatment of spinal cord injury. This review summarizes th…
View article: Myeloperoxidase: a new target for the treatment of stroke?
Myeloperoxidase: a new target for the treatment of stroke? Open
Myeloperoxidase is an important inflammatory factor in the myeloid system, primarily expressed in neutrophils and microglia. Myeloperoxidase and its active products participate in the occurrence and development of hemorrhagic and ischemic …
View article: Research Progress of Micro-RNAs in Apoptosis of Osteosarcoma
Research Progress of Micro-RNAs in Apoptosis of Osteosarcoma Open
Osteosarcoma is a primary malignant bone tumor with no effective treatment. Apoptosis, one of the programmed cell death, is any pathological form of cell death mediated by intracellular processes. Under the pathological state, the unregula…
View article: New perspective into mesenchymal stem cells: Molecular mechanisms regulating osteosarcoma
New perspective into mesenchymal stem cells: Molecular mechanisms regulating osteosarcoma Open
Mesenchymal stem cells (MSCs) are multipotent stem cells with significant potential for regenerative medicine. The tumorigenesis of osteosarcoma is an intricate system and MSCs act as an indispensable part of this, interacting with the tum…
View article: Retraction Note: Exosomes from glioma cells induce a tumor-like phenotype in mesenchymal stem cells by activating glycolysis
Retraction Note: Exosomes from glioma cells induce a tumor-like phenotype in mesenchymal stem cells by activating glycolysis Open
View article: Research Progress of MicroRNA in Chemotherapy Resistance of Osteosarcoma
Research Progress of MicroRNA in Chemotherapy Resistance of Osteosarcoma Open
Osteosarcoma (OS) is a malignant tumor prevalent in adolescents; however, a clinically effective treatment for this malignancy is lacking. The lack of effective treatment methods and factors, such as recurrence and drug resistance, further…
View article: Progress in clinical trials of cell transplantation for the treatment of spinal cord injury: how many questions remain unanswered?
Progress in clinical trials of cell transplantation for the treatment of spinal cord injury: how many questions remain unanswered? Open
Spinal cord injury can lead to severe motor, sensory and autonomic nervous dysfunctions. However, there is currently no effective treatment for spinal cord injury. Neural stem cells and progenitor cells, bone marrow mesenchymal stem cells,…
View article: Mesenchymal stem cell-derived exosomes: Toward cell-free therapeutic strategies in regenerative medicine
Mesenchymal stem cell-derived exosomes: Toward cell-free therapeutic strategies in regenerative medicine Open
Mesenchymal stem cells (MSCs) are multipotent stem cells with marked potential for regenerative medicine because of their strong immunosuppressive and regenerative abilities. The therapeutic effects of MSCs are based in part on their secre…
View article: Research progress in use of traditional Chinese medicine for treatment of spinal cord injury
Research progress in use of traditional Chinese medicine for treatment of spinal cord injury Open
View article: Diagnosis and treatment of novel coronavirus pneumonia based on the theory of traditional Chinese medicine
Diagnosis and treatment of novel coronavirus pneumonia based on the theory of traditional Chinese medicine Open
Since the outbreak of novel coronavirus pneumonia (coronavirus disease 2019, COVID-19), it has rapidly spread to 187 countries, causing serious harm to the health of people and a huge social burden. However, currently, drugs specifically a…
View article: Targeting the Epithelial-to-Mesenchymal Transition in Cancer Stem Cells for a Better Clinical Outcome of Glioma
Targeting the Epithelial-to-Mesenchymal Transition in Cancer Stem Cells for a Better Clinical Outcome of Glioma Open
Glioma is one of the most common malignant tumors of the central nervous system with a poor prognosis at present due to lack of effective treatment options. Its initiation, migration, and multipotency are affected by cancer stem cell’s tra…
View article: Cognition and status quo of antibiotic use amongprimary doctors in Sichuan Province, China
Cognition and status quo of antibiotic use amongprimary doctors in Sichuan Province, China Open
Introduction The aim of this study was to understand the knowledge and current situation of antibiotic use among primary doctors in Sichuan Province, 10 years after the new healthcare reform, to analyze the implementation and impact of the…
View article: Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways
Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways Open
Background: Spinal cord injury (SCI) is a severe central nervous system injury for which few efficacious drugs are available. Rosmarinic acid (RA), a water-soluble polyphenolic phytochemical, has antioxidant, anti-inflammatory, and anti-ap…
View article: Bone marrow mesenchymal stem cells suppress growth and promote the apoptosis of glioma U251 cells through downregulation of the PI3K/AKT signaling pathway
Bone marrow mesenchymal stem cells suppress growth and promote the apoptosis of glioma U251 cells through downregulation of the PI3K/AKT signaling pathway Open
View article: RETRACTED ARTICLE: Exosomes from glioma cells induce a tumor-like phenotype in mesenchymal stem cells by activating glycolysis
RETRACTED ARTICLE: Exosomes from glioma cells induce a tumor-like phenotype in mesenchymal stem cells by activating glycolysis Open
View article: Combining Amplitude Spectrum Area with Previous Shock Information Using Neural Networks Improves Prediction Performance of Defibrillation Outcome for Subsequent Shocks in Out-Of-Hospital Cardiac Arrest Patients
Combining Amplitude Spectrum Area with Previous Shock Information Using Neural Networks Improves Prediction Performance of Defibrillation Outcome for Subsequent Shocks in Out-Of-Hospital Cardiac Arrest Patients Open
In this retrospective study, combining AMSA with previous shock information using neural networks greatly improves prediction performance of defibrillation outcome for subsequent shocks.
View article: The Role of Targeted Temperature Management in Adult Patients Resuscitated from Nonshockable Cardiac Arrests: An Updated Systematic Review and Meta-Analysis
The Role of Targeted Temperature Management in Adult Patients Resuscitated from Nonshockable Cardiac Arrests: An Updated Systematic Review and Meta-Analysis Open
Routine targeted temperature management is recommended for comatose adult patients with return of spontaneous circulation after cardiac arrest. However, the role of targeted temperature management in patients resuscitated from nonshockable…
View article: Predict Defibrillation Outcome Using Stepping Increment of Poincare Plot for Out-of-Hospital Ventricular Fibrillation Cardiac Arrest
Predict Defibrillation Outcome Using Stepping Increment of Poincare Plot for Out-of-Hospital Ventricular Fibrillation Cardiac Arrest Open
Early cardiopulmonary resuscitation together with early defibrillation is a key point in the chain of survival for cardiac arrest. Optimizing the timing of defibrillation by predicting the possibility of successful electric shock can guide…