Xudong Wang
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View article: Submandibular adenoid cystic carcinoma presenting with liver metastasis as the initial symptom: A case report
Submandibular adenoid cystic carcinoma presenting with liver metastasis as the initial symptom: A case report Open
Adenoid cystic carcinoma (ACC) is a rare and aggressive malignancy characterized by a high incidence of distant metastasis. However, cases of ACC with liver and lymph node metastases are rarely reported and lack a standardized treatment co…
View article: Breaking the noninflamed barrier: tumor-secreted erythropoietin as a master regulator of immunosuppressive macrophages
Breaking the noninflamed barrier: tumor-secreted erythropoietin as a master regulator of immunosuppressive macrophages Open
View article: Serum tRF5-23-GlyTCC-2 Functions as a Tumor Suppressor and Novel Biomarker for Colorectal Cancer
Serum tRF5-23-GlyTCC-2 Functions as a Tumor Suppressor and Novel Biomarker for Colorectal Cancer Open
Serum tRF5-23-GlyTCC-2 exhibits high diagnostic accuracy, and its combination with CEA achieves superior sensitivity (84%), highlighting its potential as a powerful non-invasive biomarker to improve CRC detection and prognosis prediction.
View article: SLC39A5 promotes the malignant progression of gastric cancer by activating BATF phosphorylation
SLC39A5 promotes the malignant progression of gastric cancer by activating BATF phosphorylation Open
Despite advances in diagnostic and therapeutic methods for gastric cancer (GC), early detection continues to be a significant challenge, resulting in late-stage diagnoses and poor survival outcomes. Studies have shown that solute carrier f…
View article: The research on intelligent evaluation methods for non-sealing faults in reservoirs based on well test analysis
The research on intelligent evaluation methods for non-sealing faults in reservoirs based on well test analysis Open
In practical reservoirs, there exist a large number of non-sealing faults with flow capacity, which significantly influence oilfield development patterns and wellbore pressure transient behavior. The quantitative evaluation of fault sealin…
View article: Comparison of efficacy and safety of entecavir, tenofovir disoproxil fumarate, and tenofovir alafenamide fumarate treatment in patients with high viral load of hepatitis B virus
Comparison of efficacy and safety of entecavir, tenofovir disoproxil fumarate, and tenofovir alafenamide fumarate treatment in patients with high viral load of hepatitis B virus Open
Nucleos(t)ide analogues (NAs) have demonstrated potent efficacy in suppressing viral replication in chronic hepatitis B (CHB). This 48-week study compared the efficacy and safety of NA treatment for CHB patients with high viral load (hepat…
View article: The efficacy of gasless endoscopic thyroidectomy via trans-subclavian approach in unilateral papillary thyroid carcinoma
The efficacy of gasless endoscopic thyroidectomy via trans-subclavian approach in unilateral papillary thyroid carcinoma Open
Objective To evaluate the efficacy of gasless endoscopic thyroidectomy via the trans-subclavian approach in treating unilateral papillary thyroid carcinoma. Methods A retrospective analysis was conducted on 140 patients who underwent surgi…
View article: Association of stress hyperglycemia ratio with mortality in sepsis-associated acute kidney injury: a retrospective analysis of the MIMIC-IV database
Association of stress hyperglycemia ratio with mortality in sepsis-associated acute kidney injury: a retrospective analysis of the MIMIC-IV database Open
In recent years, the relationship between stress hyperglycemia ratio (SHR) and clinical outcomes in critically ill patients has garnered increasing attention. However, its role in predicting the prognosis of patients with sepsis-associated…
View article: Neurotransmitters: an emerging target for therapeutic resistance to tumor immune checkpoint inhibitors
Neurotransmitters: an emerging target for therapeutic resistance to tumor immune checkpoint inhibitors Open
The critical role of neurotransmitters in the resistance to tumor immune checkpoint inhibitor (ICI) is becoming increasingly significant in therapeutic contexts. ICIs work by enhancing antitumor immunity through the blockade of the PD-1/PD…
View article: Cyclo (Pro-Tyr) upregulates GmPOD53L to enhance soybean resistance to cyst nematode (Heterodera glycines Ichinohe)
Cyclo (Pro-Tyr) upregulates GmPOD53L to enhance soybean resistance to cyst nematode (Heterodera glycines Ichinohe) Open
The soybean cyst nematode ( Heterodera glycines Ichinohe, SCN) poses a significant threat to soybean yield, often leading to total crop failure in heavily infested areas. Identifying key resistance genes is essential for enhancing soybean …
View article: Influence of Macrocyclization Strategies on DNA-Encoded Cyclic Peptide Libraries
Influence of Macrocyclization Strategies on DNA-Encoded Cyclic Peptide Libraries Open
Discovery of cyclic peptide hits using DNA-encoded libraries (DELs) has recently been extensively researched, with significant efforts directed toward developing DEL-compatible macrocyclization methods. To investigate how different cyclic …
View article: Influence of Macrocyclization Strategies on DNA-Encoded Cyclic Peptide Libraries
Influence of Macrocyclization Strategies on DNA-Encoded Cyclic Peptide Libraries Open
Discovery of cyclic peptide hits using DNA-encoded libraries (DELs) has recently been extensively researched, with significant efforts directed toward developing DEL-compatible macrocyclization methods. To investigate how different cyclic …
View article: Engineered extracellular vesicles with sequential cell recruitment and osteogenic functions to effectively promote senescent bone repair
Engineered extracellular vesicles with sequential cell recruitment and osteogenic functions to effectively promote senescent bone repair Open
View article: Efficacy and toxicity of PD-1 inhibitor combined with induction chemotherapy for locally advanced laryngeal and hypopharyngeal cancers
Efficacy and toxicity of PD-1 inhibitor combined with induction chemotherapy for locally advanced laryngeal and hypopharyngeal cancers Open
The combination of PD-1 inhibitors with induction chemotherapy improve remission rates and survival in patients with locally advanced laryngeal and hypopharyngeal cancers. However, increased toxicity and voice rehabilitation challenges hig…
View article: Integrated ctDNA Methylation P2CC Model as Pancreatic Ductal Adenocarcinoma Biomarkers: Identification and Mechanistic Insights
Integrated ctDNA Methylation P2CC Model as Pancreatic Ductal Adenocarcinoma Biomarkers: Identification and Mechanistic Insights Open
View article: Integrated transcriptomic analysis reveals evolutionary and developmental characteristics of tendon ossification in teleost
Integrated transcriptomic analysis reveals evolutionary and developmental characteristics of tendon ossification in teleost Open
The results elucidate cell differentiation process during tendon ossification in teleosts and identify the key factor clec3bb involved in this process. These findings provide a foundation for understanding tendon ossification in teleosts a…
View article: Dual rectification of metabolism abnormality in pancreatic cancer by a programmed nanomedicine
Dual rectification of metabolism abnormality in pancreatic cancer by a programmed nanomedicine Open
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and lethal malignancy characterized by dysregulated energy and stromal metabolism. It is strongly supported by activated pancreatic stellate cells (PSC) which drive excessive d…
View article: Engineered extracellular vesicles with sequential cell recruitment and osteogenic functions to effectively promote senescent bone repair
Engineered extracellular vesicles with sequential cell recruitment and osteogenic functions to effectively promote senescent bone repair Open
Senescent mandibular bone repair pose a formidable challenge without an entirely satisfactory strategy. Endogenous cell recruitment and osteogenic differentiation are two sequential stages for bone regeneration, and the disorder in these t…
View article: ABALON regulates mitophagy and 5-FU sensitivity in colorectal cancer via PINK1-Parkin pathway
ABALON regulates mitophagy and 5-FU sensitivity in colorectal cancer via PINK1-Parkin pathway Open
Collectively, our study proposed that ABALON potentiates CRC progression via PINK1/Parkin mediated mitophagy, and ABALON is a promising therapeutic target in reversing 5-FU resistance.
View article: Integrated ctDNA Methylation Profiling of P2RX1, CBFA2T3, and CERS4 as Pancreatic Ductal Adenocarcinoma Biomarkers: Identification and Mechanistic Insights
Integrated ctDNA Methylation Profiling of P2RX1, CBFA2T3, and CERS4 as Pancreatic Ductal Adenocarcinoma Biomarkers: Identification and Mechanistic Insights Open
Background: Pancreatic ductal adenocarcinoma (PDAC) stands as one of the most formidable cancers globally, yet its diagnosis continues to be a pressing challenge, largely owing to the inherent limitations of current diagnostic methodologie…
View article: Molecular Characterization of Peroxidase (PRX) Gene Family in Cucumber
Molecular Characterization of Peroxidase (PRX) Gene Family in Cucumber Open
Background: The Peroxidase (PRX) gene family is essential for plant growth and significantly contributes to defense against stresses. However, information about PRX genes in cucumber (Cucumis sativus L.) remains limited. Methods: In this p…
View article: Safety and efficiency of deep brain stimulation in the elderly patients with Parkinson's disease
Safety and efficiency of deep brain stimulation in the elderly patients with Parkinson's disease Open
Aims Deep brain stimulation (DBS) is not routinely performed in elderly patients (≥75 years old) to date because of concerns about complications and decreased benefit. This study aimed to evaluate the safety and efficacy of DBS in elderly …
View article: Analysis of the integrated role of the Yangtze River Delta based on the industrial economic resilience of cities during COVID-19
Analysis of the integrated role of the Yangtze River Delta based on the industrial economic resilience of cities during COVID-19 Open
The enhancement of regional comprehensive development ability is significantly impacted by the study on the implementation effect of regional integration strategies. The integration strategy's impact on urban development during COVID-19 in…
View article: Oroxin A from Oroxylum indicum improves disordered lipid metabolism by inhibiting SREBPs in oleic acid-induced HepG2 cells and high-fat diet-fed non-insulin-resistant rats
Oroxin A from Oroxylum indicum improves disordered lipid metabolism by inhibiting SREBPs in oleic acid-induced HepG2 cells and high-fat diet-fed non-insulin-resistant rats Open
Our results suggested that oroxin A may modulate the nuclear transcriptional activity of SREBPs by binding to LDLR proteins and increasing AMPK phosphorylation. Oroxin A may thus reduce lipid synthesis and could be used for the treatment a…
View article: The prognostic and immune significance of SLAMF9 in pan-cancer and validation of its role in colorectal cancer
The prognostic and immune significance of SLAMF9 in pan-cancer and validation of its role in colorectal cancer Open
SLAMF9 is a member of the family of conserved lymphocyte activation molecules (SLAMF), Unlike other SLAMs, which have been extensively studied, investigations on SLAMF9 have primarily concentrated on an individual or limited number of type…
View article: Linc-00475 and p53 co-expression in gastric cancer: a predictor of clinical prognosis and potential effect on glycolysis
Linc-00475 and p53 co-expression in gastric cancer: a predictor of clinical prognosis and potential effect on glycolysis Open
The purpose of this study was to investigate the effects of clinical expression of glucose metabolism-related genes Linc-00475 and p53 on glycolysis and survival. A key differential gene Linc-00475 was screened using a metabolic database, …
View article: CircBIRC6 facilitates the malignant progression via miR-488/GRIN2D-mediated CAV1-autophagy signal axis in gastric cancer
CircBIRC6 facilitates the malignant progression via miR-488/GRIN2D-mediated CAV1-autophagy signal axis in gastric cancer Open
Circular RNAs (circRNAs) represent a novel class of non-coding RNAs that play significant roles in tumorigenesis and tumor progression. High-throughput sequencing of gastric cancer (GC) tissues has identified circRNA BIRC6 (circBIRC6) as a…
View article: COL4A2 enhances thyroid cancer cell proliferation through the AKT pathway
COL4A2 enhances thyroid cancer cell proliferation through the AKT pathway Open
COL4A2 can promote the growth as well as development of THCA through the AKT pathway and COL4A2 could be used as a target for THCA.
View article: Identifying circRNA–miRNA–mRNA Regulatory Networks in Chemotherapy-Induced Peripheral Neuropathy
Identifying circRNA–miRNA–mRNA Regulatory Networks in Chemotherapy-Induced Peripheral Neuropathy Open
Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent and severe side effect of first-line chemotherapeutic agents. The association between circular RNAs (circRNAs) and CIPN remains unclear. In this study, CIPN models were constr…
View article: Correction: LncRNA MALAT1 promotes growth and metastasis of head and neck squamous cell carcinoma by repressing VHL through a non-canonical function of EZH2
Correction: LncRNA MALAT1 promotes growth and metastasis of head and neck squamous cell carcinoma by repressing VHL through a non-canonical function of EZH2 Open