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View article: In vivo AAV9-SB-CRISPR screen identifies fatty acid elongase ELOVL5 as a pro-resolving mediator in lung inflammation
In vivo AAV9-SB-CRISPR screen identifies fatty acid elongase ELOVL5 as a pro-resolving mediator in lung inflammation Open
View article: Efficient glycosylase-mediated base editing with minimal off-target effects in mammalian embryos
Efficient glycosylase-mediated base editing with minimal off-target effects in mammalian embryos Open
Developing glycosylase-based base editors (gBEs) to broaden the editing scope is highly desirable for biomedical research and agricultural applications. However, the off-target effects and applicability of gBEs need further investigation. …
View article: Retraction Note: Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells
Retraction Note: Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells Open
View article: Effectiveness of Anti-CD20 B cells depleting therapy versus conventional treatment in severe Anti-N-methyl-d-aspartate receptor encephalitis: A real-world multi-center prospective cohort study
Effectiveness of Anti-CD20 B cells depleting therapy versus conventional treatment in severe Anti-N-methyl-d-aspartate receptor encephalitis: A real-world multi-center prospective cohort study Open
Approximately 25 %-40 % of anti-N-methyl-d-aspartate receptor encephalitis (NMDARE) patients develop refractory disease with prolonged neurological deficits. We aim to evaluate the efficacy of B cell depletion therapy (BCDT) via CD20 ant…
View article: David Baltimore (1938–2025): a visionary in science, education, and leadership
David Baltimore (1938–2025): a visionary in science, education, and leadership Open
View article: Bridging basic insights to therapeutic revolutions
Bridging basic insights to therapeutic revolutions Open
View article: Lymph node sterol metabolite drives chemokine-independent lymphocyte trafficking for immune activation
Lymph node sterol metabolite drives chemokine-independent lymphocyte trafficking for immune activation Open
View article: Design, Deposition, Performance Evaluation, and Modulation Analysis of Nanocoatings for Cutting Tools: A Review
Design, Deposition, Performance Evaluation, and Modulation Analysis of Nanocoatings for Cutting Tools: A Review Open
With the rapid development of advanced machining technologies such as high-speed cutting, dry cutting, and ultra-precision cutting, as well as the widespread application of various difficult-to-machine materials, the surface degradation pr…
View article: Neuroinflammation drives apathy in cancer cachexia
Neuroinflammation drives apathy in cancer cachexia Open
View article: The RNA-binding protein RRP1 brakes macrophage one-carbon metabolism to suppress autoinflammation
The RNA-binding protein RRP1 brakes macrophage one-carbon metabolism to suppress autoinflammation Open
View article: Phosphorylated Toll-like receptor 3 nuclear translocation in cancer cell promotes metastasis and chemoresistance
Phosphorylated Toll-like receptor 3 nuclear translocation in cancer cell promotes metastasis and chemoresistance Open
Aberrant expression and subcellular location of innate sensors in cancer cells, such as Toll-like receptors (TLRs), correlates with pro-tumoral inflammation and cancer progression, but the mechanism is still largely unknown. Deciphering th…
View article: In vivo AAV9-SB-CRISPR screen identifies fatty acid elongase ELOVL5 as a pro-resolving mediator in lung inflammation
In vivo AAV9-SB-CRISPR screen identifies fatty acid elongase ELOVL5 as a pro-resolving mediator in lung inflammation Open
Timely resolution of inflammation is essential to prevent tissue damage and maintain homeostasis. Immunometabolism is critical for innate immunity and inflammation. However, how metabolic enzymes and metabolites contribute to inflammatory …
View article: Pan-cancer analysis of GJB5 as a novel prognostic and immunological biomarker
Pan-cancer analysis of GJB5 as a novel prognostic and immunological biomarker Open
View article: Neoleukin-2/15-armored CAR-NK cells sustain superior therapeutic efficacy in solid tumors via c-Myc/NRF1 activation
Neoleukin-2/15-armored CAR-NK cells sustain superior therapeutic efficacy in solid tumors via c-Myc/NRF1 activation Open
View article: p62/SQSTM1 in cancer: phenomena, mechanisms, and regulation in DNA damage repair
p62/SQSTM1 in cancer: phenomena, mechanisms, and regulation in DNA damage repair Open
View article: SARS-CoV-2 enhances complement-mediated endothelial injury via the suppression of membrane complement regulatory proteins
SARS-CoV-2 enhances complement-mediated endothelial injury via the suppression of membrane complement regulatory proteins Open
Complement hyperactivation and thrombotic microangiopathy are closely associated with severe COVID-19. Endothelial dysfunction is a key mechanism underlying thrombotic microangiopathy. To address the relationship between endothelial injury…
View article: Nonenzymatic lysine d-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses
Nonenzymatic lysine d-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses Open
Immunometabolism is critical in the regulation of immunity and inflammation; however, the mechanism of preventing aberrant activation-induced immunopathology remains largely unclear. Here, we report that glyoxalase II (GLO2) in the glycoly…
View article: Dialect-SQL: An Adaptive Framework for Bridging the Dialect Gap in Text-to-SQL
Dialect-SQL: An Adaptive Framework for Bridging the Dialect Gap in Text-to-SQL Open
View article: Lung DC‐T immunity hub in immune surveillance: new concepts and future directions
Lung DC‐T immunity hub in immune surveillance: new concepts and future directions Open
View article: Promotion of TLR7-MyD88-dependent inflammation and autoimmunity in mice through stem-loop changes in Lnc-Atg16l1
Promotion of TLR7-MyD88-dependent inflammation and autoimmunity in mice through stem-loop changes in Lnc-Atg16l1 Open
View article: Identification of FBLL1 as a neuron-specific RNA 2′-O-methyltransferase mediating neuronal differentiation
Identification of FBLL1 as a neuron-specific RNA 2′-O-methyltransferase mediating neuronal differentiation Open
2′-O-methylation is one of the most prevalent RNA modifications found in different RNA types. However, the identities of enzymes participating in the transfer of methyl groups are not well defined. To date, fibrillarin (FBL) is the only kn…
View article: Single-cell spatiotemporal analysis of the lungs reveals Slamf9+ macrophages involved in viral clearance and inflammation resolution
Single-cell spatiotemporal analysis of the lungs reveals Slamf9+ macrophages involved in viral clearance and inflammation resolution Open
View article: Single-cell spatiotemporal analysis reveals alveolar dendritic cell–T cell immunity hubs defending against pulmonary infection
Single-cell spatiotemporal analysis reveals alveolar dendritic cell–T cell immunity hubs defending against pulmonary infection Open
How immune cells are spatiotemporally coordinated in the lung to effectively monitor, respond to, and resolve infection and inflammation in primed form needs to be fully illustrated. Here we apply immunocartography, a high-resolution techn…
View article: NPM1 inhibits tumoral antigen presentation to promote immune evasion and tumor progression
NPM1 inhibits tumoral antigen presentation to promote immune evasion and tumor progression Open
View article: The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the antiviral innate immune response
The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the antiviral innate immune response Open
Ubiquitination is essential for the proteasomal turnover of IRF3, the central factor mediating the antiviral innate immune response. However, the spatiotemporal regulation of IRF3 ubiquitination for the precise activation and timely resolu…
View article: E3 Ubiquitin Ligase RNF13 Suppresses TLR Lysosomal Degradation by Promoting LAMP‐1 Proteasomal Degradation
E3 Ubiquitin Ligase RNF13 Suppresses TLR Lysosomal Degradation by Promoting LAMP‐1 Proteasomal Degradation Open
As a highly organized system, endo‐lysosomes play a crucial role in maintaining immune homeostasis. However, the mechanisms involved in regulating endo‐lysosome progression and subsequent inflammatory responses are not fully understood. By…
View article: Hydrogen therapy promotes macrophage polarization to the M2 subtype in radiation lung injury by inhibiting the NF-κB signalling pathway
Hydrogen therapy promotes macrophage polarization to the M2 subtype in radiation lung injury by inhibiting the NF-κB signalling pathway Open
View article: Dietary long‐chain fatty acid metabolism boosts antitumor immune response
Dietary long‐chain fatty acid metabolism boosts antitumor immune response Open
Overcoming resistance to immune checkpoint blockade (ICB) therapy will pave the way for effective ICB cancer immunotherapy since a large proportion of cancer patients are not responsive to ICB immunotherapy [1]. The molecular mechanisms of…
View article: Eosinophils promote CD8+ T cell memory generation to potentiate anti-bacterial immunity
Eosinophils promote CD8+ T cell memory generation to potentiate anti-bacterial immunity Open
Memory CD8 + T cell generation is crucial for pathogen elimination and effective vaccination against infection. The cellular and molecular circuitry that underlies the generation of memory CD8 + T cells remains elusive. Eosinophils can mod…
View article: Methyltransferase Setd2 prevents T cell–mediated autoimmune diseases via phospholipid remodeling
Methyltransferase Setd2 prevents T cell–mediated autoimmune diseases via phospholipid remodeling Open
Coordinated metabolic reprogramming and epigenetic remodeling are critical for modulating T cell function and differentiation. However, how the epigenetic modification controls Th17/Treg cell balance via metabolic reprogramming remains obs…