Xuefeng Leng
YOU?
Author Swipe
View article: Long-term outcomes of minimally invasive esophagectomy vs. open esophagectomy in older patients with esophageal squamous cell carcinoma: a propensity score matching analysis
Long-term outcomes of minimally invasive esophagectomy vs. open esophagectomy in older patients with esophageal squamous cell carcinoma: a propensity score matching analysis Open
View article: Global trends of esophageal cancer among individuals over 60 years: an epidemiological analysis from 1990 to 2050 based on the global burden of disease study 1990-2021
Global trends of esophageal cancer among individuals over 60 years: an epidemiological analysis from 1990 to 2050 based on the global burden of disease study 1990-2021 Open
Objective Esophageal cancer (EC) ranks as the sixth leading cause of cancer-related deaths globally, with over 500,000 new cases annually. Understanding trends in individuals over 60 is critical for enhancing treatment and the success of e…
View article: Real-world efficacy of PD-1 inhibitors in treating oesophageal squamous cell carcinoma (ESCAPE): protocol of a multicentre, real-world, observational, cohort study
Real-world efficacy of PD-1 inhibitors in treating oesophageal squamous cell carcinoma (ESCAPE): protocol of a multicentre, real-world, observational, cohort study Open
Introduction Oesophageal cancer (EC) presents a substantial global health challenge, ranking eighth in incidence and sixth in cancer-related mortality. Oesophageal squamous cell carcinoma (ESCC) is the primary subtype and accounts for appr…
View article: Efficacy and safety of dabrafenib-targeted therapy for pediatric langerhans cell histiocytosis: a systematic review and meta-analysis
Efficacy and safety of dabrafenib-targeted therapy for pediatric langerhans cell histiocytosis: a systematic review and meta-analysis Open
Our study supports the integration of dabrafenib into treatment protocols for pediatric LCH, especially children younger than 2 years, and highlighting the need for further prospective studies to validate these results and explore its long…
View article: Enhanced prognosis prediction model in esophageal cancer via lymph node assessment post-neoadjuvant
Enhanced prognosis prediction model in esophageal cancer via lymph node assessment post-neoadjuvant Open
View article: Lymph node ratio predicts adjuvant chemotherapy benefit in esophageal squamous cell carcinoma
Lymph node ratio predicts adjuvant chemotherapy benefit in esophageal squamous cell carcinoma Open
Background The lymph node ratio (LNR) has emerged as an important prognostic factor in various cancers, including esophageal squamous cell carcinoma (ESCC). This study aimed to evaluate the utility of LNR in guiding decisions for adjuvant …
View article: The impact of perineural invasion on prognosis in esophageal cancer patients after surgery: a systematic review and meta-analysis
The impact of perineural invasion on prognosis in esophageal cancer patients after surgery: a systematic review and meta-analysis Open
Objective This study aims to update the prognostic value of perineural invasion(PNI) in various subgroups of esophageal cancer patients. Methods We searched databases including PubMed, Scopus, Wiley, Web of Science, and Embase for full-tex…
View article: Dialogue pathways and narrative analysis in health communication within the social media environment: an empirical study based on user behavior—a case study of China
Dialogue pathways and narrative analysis in health communication within the social media environment: an empirical study based on user behavior—a case study of China Open
Background Social media has transformed health communication into a dynamic and interactive process, shifting from one-way dissemination by experts to user-driven content creation and sharing. However, this openness also facilitates the sp…
View article: Perineural invasion as a prognostic factor and the efficacy of upfront surgery for low-risk cT2/T3N0M0 esophageal squamous cell carcinoma patients
Perineural invasion as a prognostic factor and the efficacy of upfront surgery for low-risk cT2/T3N0M0 esophageal squamous cell carcinoma patients Open
Upfront surgery results in favorable long-term survival outcomes in cT2/T3N0M0-stage ESCC patients without PNI. These findings show the importance of tailoring therapeutic strategies to distinct ESCC subgroups, particularly based on PNI st…
View article: Perioperative therapy for limited-stage small cell esophageal carcinoma: a retrospective cohort study
Perioperative therapy for limited-stage small cell esophageal carcinoma: a retrospective cohort study Open
Background The optimal treatment strategy for limited-stage small cell esophageal carcinoma (LS-SCEC) remains uncertain. This study aimed to retrospectively evaluate the efficacy of perioperative therapy in these patients. Materials and Me…
View article: Comparative analysis and optimization of tumor regression grade assessment systems in neoadjuvant therapy for esophageal squamous cell carcinoma
Comparative analysis and optimization of tumor regression grade assessment systems in neoadjuvant therapy for esophageal squamous cell carcinoma Open
View article: Optimization strategies for ultrasound zoning of cervical lymph nodes in esophageal cancer: a precision medicine approach
Optimization strategies for ultrasound zoning of cervical lymph nodes in esophageal cancer: a precision medicine approach Open
Esophageal cancer is a common malignancy with high incidence and mortality rates. Its pathological types vary by region, with squamous cell carcinoma predominant in Asia and adenocarcinoma in Western countries. Accurate staging before trea…
View article: Evolution of lymph node staging in esophageal squamous cell carcinoma: insights from lymph node metastatic stations
Evolution of lymph node staging in esophageal squamous cell carcinoma: insights from lymph node metastatic stations Open
Esophageal squamous cell carcinoma (ESCC) is a globally prevalent malignancy with distinct regional variations, particularly concentrated in East Asia, including China and Japan. The Union for International Cancer Control/American Joint Co…
View article: Patient-reported outcomes of the prognostic nutritional index for resectable esophageal squamous cell carcinoma
Patient-reported outcomes of the prognostic nutritional index for resectable esophageal squamous cell carcinoma Open
There might be a non-linear association between PNI and the postoperative health-related QOL of ESCC patients. It was emphasized that individualized nutritional intervention should be provided for patients with PNI lower than 45.
View article: Mapping the EORTC QLQ-C30 and QLQ-LC13 to the SF-6D utility index in patients with lung cancer using machine learning and traditional regression methods
Mapping the EORTC QLQ-C30 and QLQ-LC13 to the SF-6D utility index in patients with lung cancer using machine learning and traditional regression methods Open
This study developed an optimized mapping algorithm to predict the utility index from the QLQ-C30 QLQ-LC13 to the SF-6D. This algorithm offers provides an effective alternative for estimating SF-6D estimation when the preference-based heal…
View article: Impact of seasons on elderly patients with esophageal squamous cell carcinoma following esophagectomy: a propensity score matching analysis
Impact of seasons on elderly patients with esophageal squamous cell carcinoma following esophagectomy: a propensity score matching analysis Open
Background Esophageal squamous cell carcinoma (ESCC) is prevalent in East Asia, with elderly patients facing unique postoperative challenges. This study examines the impact of seasonal variations on postoperative complications and survival…
View article: Comparison of recurrence patterns between patients with thoracic esophageal squamous cell carcinoma treated with neoadjuvant chemoradiotherapy and postoperative adjuvant chemoradiotherapy
Comparison of recurrence patterns between patients with thoracic esophageal squamous cell carcinoma treated with neoadjuvant chemoradiotherapy and postoperative adjuvant chemoradiotherapy Open
Purpose To compare the recurrence patterns and survival outcomes between patients with esophageal squamous cell carcinoma (ESCC) treated with neoadjuvant chemoradiotherapy (NCRT) and adjuvant chemoradiotherapy (ACRT). Methods We retrospect…
View article: Neoadjuvant chemotherapy or chemoradiotherapy plus sintilimab versus neoadjuvant chemoradiotherapy for locally advanced oesophageal squamous cell carcinoma: a study protocol of a multicentre, randomised, controlled, phase III trial (SCIENCE study)
Neoadjuvant chemotherapy or chemoradiotherapy plus sintilimab versus neoadjuvant chemoradiotherapy for locally advanced oesophageal squamous cell carcinoma: a study protocol of a multicentre, randomised, controlled, phase III trial (SCIENCE study) Open
Introduction Oesophageal squamous cell carcinoma (ESCC) is a globally challenging digestive tract malignancy with poor prognosis and limited treatment options. Early-stage ESCC is often asymptomatic, leading to a late-stage diagnosis in ma…
View article: Impact of preoperative comorbidities on elderly patients with esophageal squamous cell carcinoma following esophagectomy: a propensity score matching analysis
Impact of preoperative comorbidities on elderly patients with esophageal squamous cell carcinoma following esophagectomy: a propensity score matching analysis Open
View article: Reply: Intrathoracic versus cervical anastomosis in esophagectomy: The analyses for middle and lower thoracic esophageal squamous cell carcinoma
Reply: Intrathoracic versus cervical anastomosis in esophagectomy: The analyses for middle and lower thoracic esophageal squamous cell carcinoma Open
View article: Impact of perineural invasion in thoracic esophageal squamous cell carcinoma—a retrospective study with long-term follow-up outcomes
Impact of perineural invasion in thoracic esophageal squamous cell carcinoma—a retrospective study with long-term follow-up outcomes Open
PNI is a potential independent prognostic factor for ESCC patients. Further study is needed to determine whether postoperative adjuvant therapy is necessary for thoracic ESCC patients who have achieved R0 resection and PNI-positive.
View article: Impact of occupation on survival of esophageal squamous cell carcinoma patients following esophagectomy: a long-term survival analysis
Impact of occupation on survival of esophageal squamous cell carcinoma patients following esophagectomy: a long-term survival analysis Open
Background Esophageal cancer (EC), particularly esophageal squamous cell carcinoma (ESCC), is a major global health issue with high incidence and mortality rates in Asia. This study examines the impact of occupational background on the lon…
View article: Sex-based analysis of clinical outcomes in elderly patients with esophageal squamous cell carcinoma post-esophagectomy: a propensity score matching analysis
Sex-based analysis of clinical outcomes in elderly patients with esophageal squamous cell carcinoma post-esophagectomy: a propensity score matching analysis Open
Background Esophageal squamous cell carcinoma (ESCC) is a common and aggressive form of esophageal cancer, particularly prevalent in East Asia. This study aimed to investigate the impact of sex on clinical outcomes, including survival and …
View article: Case report: pembrolizumab-induced acute type 1 diabetes mellitus and diabetic ketoacidosis in a perioperative esophageal squamous cell carcinoma patient
Case report: pembrolizumab-induced acute type 1 diabetes mellitus and diabetic ketoacidosis in a perioperative esophageal squamous cell carcinoma patient Open
In summary, this case highlights the rare but potentially life-threatening risk of autoimmune diabetes following pembrolizumab therapy in ESCC patients. The unique clinical contributions of this case include identifying the onset of DM1 du…
View article: Long-term survival outcomes of esophageal squamous cell carcinoma with intraoperative thoracic duct ligation: a large-scale propensity score matching analysis
Long-term survival outcomes of esophageal squamous cell carcinoma with intraoperative thoracic duct ligation: a large-scale propensity score matching analysis Open
Background Esophagectomy is the primary treatment for localized esophageal squamous cell carcinoma (ESCC). Intraoperative thoracic duct ligation (TDL) has been suggested as an adjunct to reduce the risk of postoperative chylothorax in pati…
View article: A preoperative pathological staging prediction model for esophageal cancer based on CT radiomics
A preoperative pathological staging prediction model for esophageal cancer based on CT radiomics Open
This study established a non-invasive preoperative radiomics model that demonstrated good predictive performance in determining the pTNM staging, pT staging, vascular invasion, and perineural invasion for EC patients. These results could i…
View article: Giant thymolipoma in a 16-year-old girl with multimodal diagnostic approach and surgical management: a case report
Giant thymolipoma in a 16-year-old girl with multimodal diagnostic approach and surgical management: a case report Open
This case underscores the effectiveness of a multimodal imaging strategy for the diagnosis and preoperative assessment of pediatric thymolipomas. It emphasizes the feasibility of complete surgical resection, even for large tumors, leading …
View article: Development and validation of a predictive model for overall survival in esophageal squamous cell carcinoma post-esophagectomy: the role of lymph node metastatic stations
Development and validation of a predictive model for overall survival in esophageal squamous cell carcinoma post-esophagectomy: the role of lymph node metastatic stations Open
Background: Esophageal squamous cell carcinoma (ESCC) poses a substantial healthcare challenge, particularly in areas such as East Asia. The pathologic nodal (pN) stage of ESCC remains a controversial factor. Accurately predicting overall …
View article: Comparative analysis of manual vs. mechanical suturing techniques in esophagectomy: A propensity score‑matched study of long‑term outcomes
Comparative analysis of manual vs. mechanical suturing techniques in esophagectomy: A propensity score‑matched study of long‑term outcomes Open
Esophageal cancer, particularly esophageal squamous cell carcinoma (ESCC), is a major health concern worldwide, particularly in China. Surgical resection is still considered the primary curative treatment for this disease. However, the eff…
View article: Supplementary figure legend from Intratumoral Microbiota Composition Regulates Chemoimmunotherapy Response in Esophageal Squamous Cell Carcinoma
Supplementary figure legend from Intratumoral Microbiota Composition Regulates Chemoimmunotherapy Response in Esophageal Squamous Cell Carcinoma Open
Supplementary figure legend