Explanipedia

Activation of Sirt1 by acetate alleviates silicofibrosis: Contribution of the gut microbiota Open

Weiliang Zhang, Xue‐Jie Qi, Mingming Han, Qiang Jia, Xixi Li , et al. · 2025

Silicosis is a prevalent occupational disease marked by progressive pulmonary fibrosis. Despite its significant health burden, the pathogenesis of silicosis remains unclear, and no specific therapeutic drugs are available. In this study, w…

Ferrocenyl-Substituted Curcumin Derivatives as Potential SHP-2 Inhibitors for Anticolorectal Cancer: Design, Synthesis and <i>In Vitro</i> Evaluation Open

Xingxiang Zhang, Gen Li, Gaoyong Hu, Chen-Lin Wang, Yunyun Fang , et al. · 2024

A panel of ferrocenyl-substituted curcumin derivatives has been designed and synthesized as protein tyrosine phosphatase proto-oncogene SHP-2 inhibitors. Antiproliferative activities of the synthesized compounds were tested against colorec…

A Versatile Fluorescent Aptasensor Based on Programmable Entropy-Driven Dynamic Amplification For Sensitive Detection of Multiple Mycotoxins Open

Jinfeng Liu, Huimin Wei, Sheng Hu, Xue‐Jie Qi, Jingbo Louise Liu , et al. · 2024

Silica dust alters fecal microbiota that contributes silicosis through the lung-gut axis in rats Open

Xue‐Jie Qi, Mingming Han, Qiang Jia, Xin Zhang, Binpeng Qu , et al. · 2023

Background：Silicosis is a lung disease with diffuse nodular pulmonary fibrosis because of long-term inhalation of a large number of free silica dust. Research has been reported that dysbiosis of fecal microbiota was existed in silicosis pa…

Design, characterization of Resveratrol-Thermosensitive Hydrogel System (Res-THS) and evaluation of its anti-depressant effect via intranasal administration Open

Jinfeng Zhou, LiLi Duan, Yuxin Wang, Chen-Lin Wang, Mengli Tian , et al. · 2022

Thermosensitive Hydrogel System (THS) is a suitable candidate for targeted drug delivery, because of its intelligent response and controlled release. In this work, combination of guanidine-chitosan (GCS), β-glycerol phosphate disodium salt…

Comprehensive analysis of differences of N6-methyladenosine of lncRNAs between atrazine-induced and normal Xenopus laevis testis Open

Xue‐Jie Qi, Xiao Geng, Juan Zhang, Binpeng Qu, Xin Zhang , et al. · 2021

Dynamic assessing silica particle-induced pulmonary fibrosis and associated regulation of long non-coding RNA expression in Wistar rats Open

Linlin Sai, Xue‐Jie Qi, Gongchang Yu, Juan Zhang, Yuxin Zheng , et al. · 2021

Background Exposure to respirable crystalline silica (RCS) can induce accelerated silicosis (AS), a form of silicosis that is more progressive and severe form of silicosis. In this project we aimed to assess processes of silicosis in rats …

Thermosensitive hydrogel designed for improving the antidepressant activities of genipin via intranasal delivery Open

Xue‐Jie Qi, Dong Xu, Mengli Tian, Jinfeng Zhou, Qiangsong Wang , et al. · 2021

The release of drugs in the brain is a challenge due to the blood–brain barrier, but intranasal administration of hydrogels enables the continuous release and quick targeting of drugs into the brain. The aim of this study was to prepare a …

Thermo-sensitive hydrogel and their biomedical applications Open

Meng Li Tian, Jin Zhou, Xue‐Jie Qi, Rui Shen · 2021

Thermo-sensitive hydrogel has attracted considerable attention as a kind of intelligent material in the field of biochemistry and biomedicine. They have many kinds of advantages such as easy formulation to deliver hydrophilic and hydrophob…

Comprehensive Analysis of Differences of N6-Methyladenosine of Lncrnas Between Atrazine-Inducedand Normal Xenopus Laevis Testis Open

Xue‐Jie Qi, Geng Xiao, Juan Zhang, Ling Li, Qiang Jia , et al. · 2021

Background: Increasing evidence suggested N⁶-methyladenosine (m⁶A) plays an important role in RNA stability, degradation, splicing and translation. M⁶A is found in different RNA including long non-coding RN…

Effects of chlorpyrifos exposure on liver inflammation and intestinal flora structure in mice Open

Yecui Zhang, Qiang Jia, Chenyang Hu, Mingming Han, Qiming Guo , et al. · 2020

Chlorpyrifos (CPF) is an organophosphate insecticide commonly used to treat fruit and vegetable crops. CPF can cause severe adverse effects on body organs including the liver and central nervous system. This study investigated the CPF-indu…

Anti-depressant effect of curcumin-loaded guanidine-chitosan thermo-sensitive hydrogel by nasal delivery Open

Xue‐Jie Qi, Xiangyun Liu, Leimengyuan Tang, Pan-Feng Li, Feng Qiu , et al. · 2019

Curcumin, a polyphenol compound extracted from the roots of turmeric plants, possesses anti-depressant effect by regulating the levels of neuroendocrine immunological factors. The purpose of this study was to investigate the anti-de…

Preparation and Properties of Fluorescent Labels Coumarin-6/HP-β-CD Complex by Nasal Drug Delivery Open

Mengli Tian, Xiangyun Liu, Lulu Song, Xue‐Jie Qi · 2019

In order to improve the solubility and dissolution of coumarin-6, coumarin-6/HP-β-CD complex was prepared by freeze-drying. Phase solubility, UV-vis spectroscopy and fourier transformation infrared spectrum results showed that as the conce…

Study on Coordination Properties of Metal Ions-Flavonoid Compound Open

Xiangyun Liu, Mengli Tian, Yu Qiao, Xue‐Jie Qi · 2019

The coordination ratio of rutin and Cu2+ was studied. And its coordination mechanism was discussed, which provided a basis for the preparation of rutin-metal complex. Ultraviolet spectrophotometry was used to determine the coordination con…

Optimization of Situ Thermosensitive Hydrogel System for Intranasal Delivery Open

Xiangyun Liu, Leimengyuan Tang, Ai-Cheng Wang, Yaying Cao, Xue‐Jie Qi · 2018

Based on the physiological temperature of nasal cavity, the final hydrogel formulations and preparation method were determined. The screening matrix of thermosensitive hydrogel includes single factor, orthogonal design method and rheologic…

CCDC 774610: Experimental Crystal Structure Determination Open

Ai‐Hong Yang, Li-Hua Zhao, Xue‐Jie Qi, Yiwei Lu · 2015

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 748264: Experimental Crystal Structure Determination Open

Ai‐Hong Yang, Li-Hua Zhao, Xue‐Jie Qi, Yiwei Lu · 2015

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 748309: Experimental Crystal Structure Determination Open

Ai‐Hong Yang, Li-Hua Zhao, Xue‐Jie Qi, Yiwei Lu · 2015

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Preparation of a Thermosensitive Guanidine-Chitosan/Poloxamer in situ Gel for Intranasal Delivery System Open

Yingzong Ren, Xue‐Jie Qi, Yuan‐Lu Cui · 2015

A novel themosensitive in situ gel was prepared by using Poloxamer407 and poloxamer188 combined with membrane penetration enhancer Guanidine-Chitosan.Orthogonal experiment optimization was used to study of formulations conditions that suit…

CCDC 702820: Experimental Crystal Structure Determination Open

Ai‐Hong Yang, Li-Hua Zhao, Xue‐Jie Qi, Yiwei Lu · 2015

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

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