Xudong Wei
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View article: Identification of CXCL8 as a potential gene associated with lymph node metastasis in papillary thyroid carcinoma through bioinformatics analysis
Identification of CXCL8 as a potential gene associated with lymph node metastasis in papillary thyroid carcinoma through bioinformatics analysis Open
CXC chemokine ligand 8 (CXCL8) has emerged as a critical mediator in tumorigenesis. This study aims to elucidate the role of CXCL8 in the initiation and progression of papillary thyroid carcinoma (PTC). Comprehensive bioinformatic analyses…
View article: Retrospective analysis of sorafenib combined with interferon α-1b, interleukin-2, and thalidomide as maintenance therapy in FLT3-ITD-positive acute myeloid leukemia
Retrospective analysis of sorafenib combined with interferon α-1b, interleukin-2, and thalidomide as maintenance therapy in FLT3-ITD-positive acute myeloid leukemia Open
Objective To evaluate the clinical efficacy of maintenance therapy with sorafenib combined with interferon α-1b, interleukin-2, and thalidomide (the ITI regimen) in patients with FLT3-ITD-positive acute myeloid leukemia (AML). Methods 19 F…
View article: Exploring the mechanism of piperlongumine in promoting ferroptosis in cervical cancer based on network pharmacology and molecular docking analysis
Exploring the mechanism of piperlongumine in promoting ferroptosis in cervical cancer based on network pharmacology and molecular docking analysis Open
View article: Case Report: Venetoclax combined with hypomethylating agents for the treatment of newly diagnosed with mixed-phenotype acute leukemia and a literature review
Case Report: Venetoclax combined with hypomethylating agents for the treatment of newly diagnosed with mixed-phenotype acute leukemia and a literature review Open
Objective To investigate the efficacy and safety of venetoclax (Ven) in combination with hypomethylating agents (HMAs) for the treatment of mixed-phenotype acute leukemia (MPAL). Methods From July 2023 to April 2025, 4 newly diagnosed MPAL…
View article: Efficacy and safety of contezolid in the treatment of Gram-positive bacterial infections in patients with hematological malignancies: a retrospective study
Efficacy and safety of contezolid in the treatment of Gram-positive bacterial infections in patients with hematological malignancies: a retrospective study Open
Contezolid seems promising for these patients, but large-scale prospective studies are needed for confirmation.
View article: Hematological diseases-related mucormycosis: A retrospective single center study
Hematological diseases-related mucormycosis: A retrospective single center study Open
Background and aim Mucormycosis is a life-threatening invasive fungal infection. This study aimed to analyze the clinical characteristics of patients with hematologic malignancies complicated with mucormycosis. Methods This retrospective s…
View article: Retrospective analysis of the efficacy and safety of anlotinib plus sintilimab (anti-PD-1) as maintenance therapy in advanced pediatric solid tumors
Retrospective analysis of the efficacy and safety of anlotinib plus sintilimab (anti-PD-1) as maintenance therapy in advanced pediatric solid tumors Open
Background Advanced solid tumors in children have limited maintenance treatment options. This study assessed the effectiveness and safety of anlotinib in conjunction with sintilimab as maintenance therapy for advanced pediatric solid tumor…
View article: Ferroptosis and head and neck cancer: Mechanisms and therapeutic perspectives (Review)
Ferroptosis and head and neck cancer: Mechanisms and therapeutic perspectives (Review) Open
Head and neck cancer (HNC) is a common malignant disease in otorhinolaryngology; however, its pathogenesis remains to be fully elucidated. Currently, the treatment for HNC mainly comprises surgery assisted by other methods, including radio…
View article: Construction of a prognostic risk model for acute myeloid leukemia based on exosomal genes and analysis of immune microenvironment characteristics
Construction of a prognostic risk model for acute myeloid leukemia based on exosomal genes and analysis of immune microenvironment characteristics Open
Acute myeloid leukemia (AML) exhibits significant heterogeneity in disease progression and therapeutic response, highlighting the urgent need for novel biomarkers to improve risk stratification and therapeutic targeting. In this study, we …
View article: A novel ubiquitin-related genes-based signature demonstrated values in prognostic prediction, immune landscape sculpture and therapeutic options in laryngeal cancer
A novel ubiquitin-related genes-based signature demonstrated values in prognostic prediction, immune landscape sculpture and therapeutic options in laryngeal cancer Open
Background Laryngeal cancer (LC) is characterized by high mortality and remains challenging in prognostic evaluation and treatment benefits. Ubiquitin-related genes (UbRGs) are widely involved in cancer initiation and progression, but thei…
View article: Research and analysis of differential gene expression in CD34 hematopoietic stem cells in myelodysplastic syndromes
Research and analysis of differential gene expression in CD34 hematopoietic stem cells in myelodysplastic syndromes Open
Objective This study aims to investigate and analyze the differentially expressed genes (DEGs) in CD34 + hematopoietic stem cells (HSCs) from patients with myelodysplastic syndromes (MDS) through bioinformatics analysis, with the ultimate …
View article: Metagenomic next-generation sequencing assists in the diagnosis of visceral leishmaniasis in non-endemic areas of China
Metagenomic next-generation sequencing assists in the diagnosis of visceral leishmaniasis in non-endemic areas of China Open
Introduction Leishmaniasis, a protozoan disease caused by infection by Leishmania , is a critical issue in Asia, South America, East Africa, and North Africa. With 12 million cases globally, leishmaniasis is one of the most serious neglect…
View article: Inaticabtagene autoleucel in adult relapsed or refractory B-cell acute lymphoblastic leukemia
Inaticabtagene autoleucel in adult relapsed or refractory B-cell acute lymphoblastic leukemia Open
Before November 2023, CD19 chimeric antigen receptor (CAR) T-cell therapies had not been approved in China for patients with relapsed or refractory B-cell acute lymphoblastic leukemia (R/R B-ALL), leaving a significant unmet need. In respo…
View article: Efficacy and safety of the combination of decitabine and CHAG priming regimen in the relapsed or refractory acute myeloid leukemia
Efficacy and safety of the combination of decitabine and CHAG priming regimen in the relapsed or refractory acute myeloid leukemia Open
View article: Impact of prior cancer history on the prognosis of extranodal NK/T-cell lymphoma
Impact of prior cancer history on the prognosis of extranodal NK/T-cell lymphoma Open
Our goal was to assess the impact of prior cancer history on the prognosis of extranodal NK/T-cell lymphoma (ENKTCL). We searched the SEER database to retrospectively enroll patients with ENKTCL. The effects of cancer history on overall su…
View article: [A case of trichoblastoma of the auricular cavity and review of the literature].
[A case of trichoblastoma of the auricular cavity and review of the literature]. Open
Trichoblastoma（TB） is a rare germ cell skin adnexal tumor of the hair, and it is a rare follicular tumor of the skin that differentiates from the hair germ epithelium and is often regarded as a benign skin tumorHowever, it is poorl…
View article: Inaticabtagene Autoleucel ((CNCT19), a CD19-Directed Chimeric Antigen Receptor T-Cell Therapy in Adult Relapsed or Refractory B-Cell Acute Lymphoblastic Leukaemia: A Multicenter, Open-Label, Single-Arm, Phase 2 Study
Inaticabtagene Autoleucel ((CNCT19), a CD19-Directed Chimeric Antigen Receptor T-Cell Therapy in Adult Relapsed or Refractory B-Cell Acute Lymphoblastic Leukaemia: A Multicenter, Open-Label, Single-Arm, Phase 2 Study Open
View article: Case report: Venetoclax plus Azacitidine in treatment of acute undifferentiated leukemia
Case report: Venetoclax plus Azacitidine in treatment of acute undifferentiated leukemia Open
The "VA" scheme has been extensively used in AML treatment, but its application in AUL treatment has not yet been reported. This study is the first to report an AUL patient treated with the "VA" scheme and achieved CR. Our result prelimina…
View article: Oridonin Synergistically Enhances the Pro-Apoptotic Effect of Venetoclax on Acute Myeloid Leukemia Cells by Inhibiting AKT Signaling
Oridonin Synergistically Enhances the Pro-Apoptotic Effect of Venetoclax on Acute Myeloid Leukemia Cells by Inhibiting AKT Signaling Open
Background: Acute myeloid leukemia (AML) is a recurrence-prone hematologic malignancy. The advent of molecularly targeted therapies provides new opportunities to enhance the effectiveness of AML treatments. Venetoclax, a selective inhibito…
View article: P539: A PHASE 1 STUDY OF HMPL-306, A DUAL INHIBITOR OF MUTANT ISOCITRATE DEHYDROGENASE (IDH) 1 AND 2, IN PTS WITH RELAPSED/REFRACTORY MYELOID HEMATOLOGICAL MALIGNANCIES HARBORING IDH1 AND/OR 2 MUTATIONS
P539: A PHASE 1 STUDY OF HMPL-306, A DUAL INHIBITOR OF MUTANT ISOCITRATE DEHYDROGENASE (IDH) 1 AND 2, IN PTS WITH RELAPSED/REFRACTORY MYELOID HEMATOLOGICAL MALIGNANCIES HARBORING IDH1 AND/OR 2 MUTATIONS Open
Topic: 16. Myeloproliferative neoplasms - Clinical Background: HMPL-306 is a potent selective inhibitor of mutant IDH1/2. Aims: The phase 1 study aimed to evaluate safety, tolerability, recommended phase 2 study (RP2D), pharmacokinetics/ph…
View article: Clinical Characteristics and Prognosis of Bloodstream Infection with Carbapenem-Resistant Pseudomonas aeruginosa in Patients with Hematologic Malignancies
Clinical Characteristics and Prognosis of Bloodstream Infection with Carbapenem-Resistant Pseudomonas aeruginosa in Patients with Hematologic Malignancies Open
Patients with hematologic neoplasms had high mortality from CRPA bloodstream infections, and admission to the intensive care unit, higher Pitt bacteremia score (PBS) scores, granulocyte deficiency, and granulocyte deficiency at discharge w…
View article: Low incidence of hepatitis B virus reactivation in patients with hematological malignancies receiving novel anticancer drugs: A report from a high epidemic area and literature review
Low incidence of hepatitis B virus reactivation in patients with hematological malignancies receiving novel anticancer drugs: A report from a high epidemic area and literature review Open
Most episodes of HBV-R are preventable, and most cases with HBV-R are manageable. We recommend that novel anticancer drugs should not be intentionally avoided when treating cancer patients with HBV infection.
View article: Application of mPEG-CS-cRGD/ <i>Bmi-1RNAi</i> -PTX nanoparticles in suppression of laryngeal cancer by targeting cancer stem cells
Application of mPEG-CS-cRGD/ <i>Bmi-1RNAi</i> -PTX nanoparticles in suppression of laryngeal cancer by targeting cancer stem cells Open
Although surgery-based comprehensive therapy is becoming the main approach to treat laryngeal cancer, recurrence, metastasis, radiotherapy resistance and chemotherapy tolerance are still the main causes of death in patients. Targeted inhib…
View article: RGD Peptide Inhibits Tumor Growth by Affecting Angiogenesis Related Signaling Pathway of Laryngeal Cancer Stem Cells
RGD Peptide Inhibits Tumor Growth by Affecting Angiogenesis Related Signaling Pathway of Laryngeal Cancer Stem Cells Open
This study is to investigate the role and mechanism of RGD peptide in laryngeal cancer stem cells (CSCs). Laryngeal cancer CD133+Hep-2 CSCs were sorted by flow cytometry. RGD peptide was co-cultured with sorted laryngeal CSCs. Cell prolife…
View article: Refractory/relapse thrombocytopenia in a patient with Evans' syndrome successfully treated with zanubrutinib
Refractory/relapse thrombocytopenia in a patient with Evans' syndrome successfully treated with zanubrutinib Open
Evans' syndrome (ES) was first described by Evans in 1951 and is a rare autoimmune disorder that is defined as the concomitant or sequential occurrence of Coombs positive immune thrombocytopenia (ITP) and autoimmune haemolytic anaemia (AIH…
View article: The impact of government environmental attention on public health: Implications for corporate sustainable development
The impact of government environmental attention on public health: Implications for corporate sustainable development Open
As major contributors to air pollution, enterprises have a growing impact on the environment, which puts public health at risk and requires urgent government intervention. This study constructs a government environmental attention variable…
View article: Refractory/relapse thrombocytopenia in a patient with Evans’ syndrome successfully treated with zanubrutinib
Refractory/relapse thrombocytopenia in a patient with Evans’ syndrome successfully treated with zanubrutinib Open
BackgroundEvans’ syndrome (ES) is a rare autoimmune disorder and has high mortality rate. Due to the rarity of the disease, the treatments of ES are always emprical, including steroids, IVIG, rituximab, TPO-RAs, immunosuppressants, splenec…
View article: Refractory/relapse thrombocytopenia in a patient with Evans’ syndrome successfully treated with zanubrutinib
Refractory/relapse thrombocytopenia in a patient with Evans’ syndrome successfully treated with zanubrutinib Open
Methods We report a case of a 15-year-old Chinese girl with Evans’ syndrome who presented with refractory/relapse thrombocytopenia successfully treated with zanubrutinib. There is no published cases of treating refractory/relapse thrombocy…
View article: The different predictive effects of the intensity and proportion of CD20 expression on the prognosis of B‐lineage acute lymphocyte leukemia
The different predictive effects of the intensity and proportion of CD20 expression on the prognosis of B‐lineage acute lymphocyte leukemia Open
The prognostic effects of the CD20 positivity have been studied extensively in B‐lineage acute lymphocyte leukemia (B‐ALL) patients, but the results remain controversial. The aim of this study is to investigate the different predictive eff…
View article: Study on the chemotherapeutic effect and mechanism of cucurbitacin E on laryngeal cancer stem cells
Study on the chemotherapeutic effect and mechanism of cucurbitacin E on laryngeal cancer stem cells Open
Objectives Study on the chemotherapeutic effect and mechanism of cucurbitacin E (CuE) on laryngeal cancer stem cells. Methods We used flow cytometry to sort out CD133 + laryngeal cancer stem cells; trypan blue rejection assay to detect the…