Xuebin Liao
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View article: Enhancing anti-tumour immunity through modulating dendritic cell activation by combination therapy with a novel TLR2 agonist and PD-L1 Blockade
Enhancing anti-tumour immunity through modulating dendritic cell activation by combination therapy with a novel TLR2 agonist and PD-L1 Blockade Open
Background Dendritic cells (DCs) play a predominant role in antitumor immunity. As professional antigen-presenting cells (APCs), DCs can be functionally matured by TLR2 ligand binding to enhance innate immune response and subsequent T cell…
View article: Profiling tumour-infiltrating immune cells in a large paediatric medulloblastoma cohort: a retrospective analysis
Profiling tumour-infiltrating immune cells in a large paediatric medulloblastoma cohort: a retrospective analysis Open
Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes (PWD & RPP-MRI: JYY2018-7); National Natural Science Foundation of China (32300773); China Postdoctoral Science Foundation (2022M721864).
View article: KDM5A enhances MHC-I antigen presentation and potentiates antitumor immunity unleashed by immune checkpoint blockade
KDM5A enhances MHC-I antigen presentation and potentiates antitumor immunity unleashed by immune checkpoint blockade Open
While some studies have implicated the histone 3 lysine 4 demethylase KDM5A in tumorigenesis and promotion of metastasis, KDM5A has also been shown to boost immunotherapy responses in melanoma. The distinct functional role of KDM5A in the …
View article: Nickel-catalyzed domino annulation coupling to construct oxindole analogues: A mechanistic and synthetic investigation
Nickel-catalyzed domino annulation coupling to construct oxindole analogues: A mechanistic and synthetic investigation Open
View article: Enhance Memory CD8<sup>+</sup>T Cell Formation via Downregulation of Hematopoietic Progenitor Kinase 1 and Sustained Mitochondrial Fitness
Enhance Memory CD8<sup>+</sup>T Cell Formation via Downregulation of Hematopoietic Progenitor Kinase 1 and Sustained Mitochondrial Fitness Open
Memory CD8 + T cells are pivotal for long-term anti-tumor immunity due to their longevity and rapid response upon encountering tumor cells. Hematopoietic progenitor kinase 1 (HPK1), a member of the Ste20 family of kinases, restricts proxim…
View article: Nickel-Catalyzed Enantioselective Reductive Vinyl-Alkynylation of Unactivated Alkenes with Bromoalkynes
Nickel-Catalyzed Enantioselective Reductive Vinyl-Alkynylation of Unactivated Alkenes with Bromoalkynes Open
View article: Phase I dose escalation study of IO-108, an anti-LILRB2 antibody, in patients with advanced solid tumors
Phase I dose escalation study of IO-108, an anti-LILRB2 antibody, in patients with advanced solid tumors Open
Purpose In this first-in-human dose escalation study, the safety and efficacy of IO-108, a fully human monoclonal antibody targeting leukocyte immunoglobulin-like receptor B2 (LILRB2), was investigated in patients with advanced solid tumor…
View article: Mi-2β promotes immune evasion in melanoma by activating EZH2 methylation
Mi-2β promotes immune evasion in melanoma by activating EZH2 methylation Open
Recent development of new immune checkpoint inhibitors has been particularly successfully in cancer treatment, but still the majority patients fail to benefit. Converting resistant tumors to immunotherapy sensitive will provide a significa…
View article: Protocol for Sonogashira coupling of alkynes and aryl halides via nickel catalysis
Protocol for Sonogashira coupling of alkynes and aryl halides via nickel catalysis Open
View article: Nickel-catalyzed Difluoromethylation of Alkene using Difluoroacetic Anhydride
Nickel-catalyzed Difluoromethylation of Alkene using Difluoroacetic Anhydride Open
Herein, we describe a nickel-catalyzed reductive difluoromethylation reaction of alkene using inexpensive and easy-to-handle DFAA/pyridine N-oxide reagent system. A variety of C(sp3)-CF2H containing compounds were prepared through a hydrod…
View article: 1400 YF550-C1 promotes T cell activation, cytokines release and induces robust tumor growth inhibition in syngeneic and PDX tumor models
1400 YF550-C1 promotes T cell activation, cytokines release and induces robust tumor growth inhibition in syngeneic and PDX tumor models Open
Background Casitas B-lineage lymphoma b (CBL-B) is an E3 ubiquitin ligase, which is highly expressed in peripheral T cells.1 CBL-B knockout T cells upregulate TCR-mediated T cell activation regardless of CD28,2 and ha…
View article: 1073 A phase 1, first-in-human, open-label study evaluating the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of PRJ1–3024in subjects with advanced solid tumors
1073 A phase 1, first-in-human, open-label study evaluating the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of PRJ1–3024in subjects with advanced solid tumors Open
Background PRJ1–3024 is a small molecule hematopoietic progenitor kinase 1 (HPK1) inhibitor designed to enhance T-cell function and anti-tumor responses. HPK1 is an immunosuppressive regulatory kinase with a restricted expression profile i…
View article: Single‐cell transcriptomics identify TNFRSF1B as a novel T‐cell exhaustion marker for ovarian cancer
Single‐cell transcriptomics identify TNFRSF1B as a novel T‐cell exhaustion marker for ovarian cancer Open
Background: Ovarian cancer (OC) patients routinely show poor immunotherapeutic response due to the complex tumour microenvironment (TME). It is urgent to explore new immunotherapeutic markers. Methods: Through the single‐cell RNA sequencin…
View article: Coupling of alkynes and aryl halides with nickel-catalyzed Sonogashira reactions
Coupling of alkynes and aryl halides with nickel-catalyzed Sonogashira reactions Open
Methods for incorporating alkynes into molecular skeletons have been the subject of continued research. Compared to the cross-couplings used to form C–C(sp3) and C–C(sp2) bonds, couplings that form C–C(sp) bonds, particularly those catalyz…
View article: Anti-tumor efficacy of anti-GD2 CAR NK-92 cells in diffuse intrinsic pontine gliomas
Anti-tumor efficacy of anti-GD2 CAR NK-92 cells in diffuse intrinsic pontine gliomas Open
Background Diffuse intrinsic pontine gliomas (DIPGs) are rare and fatal pediatric brainstem gliomas with no cure. Chimeric antigen receptor (CAR)-engineered natural killer (NK) cells have been proven effective in treating glioblastoma (GBM…
View article: The induction of potent anti-tumor efficacy in diffuse intrinsic pontine glioma by YF-PRJ8-1011 of a novel cyclin-dependent kinase 4/6 inhibitor
The induction of potent anti-tumor efficacy in diffuse intrinsic pontine glioma by YF-PRJ8-1011 of a novel cyclin-dependent kinase 4/6 inhibitor Open
Objective Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brainstem tumor. Despite numerous efforts to improve survival benefits, its prognosis remains poor. This study aimed to design and synthesize a novel CDK4/6 inhibitor …
View article: Novel TLR7/8 agonists promote activation of HIV-1 latent reservoirs and human T and NK cells
Novel TLR7/8 agonists promote activation of HIV-1 latent reservoirs and human T and NK cells Open
Antiretroviral therapy can successfully suppress HIV-1 replication to undetectable levels but fails to eliminate latent and persistent HIV-1 reservoirs. Recent studies have focused on the immunomodulatory agents such as Toll-like receptor …
View article: [Retracted] An Eight‐mRNA Prognostic Model to Predict Survival in Hepatic Cellular Cancer
[Retracted] An Eight‐mRNA Prognostic Model to Predict Survival in Hepatic Cellular Cancer Open
Background . Transcriptional dysregulation plays a critical role in the onset and development of malignant tumors. Employing gene dysregulation to forecast the change of tumors is valuable for cancer diagnosis. However, the prognostic pred…
View article: Modular Construction of C(<i>sp<sup>2</sup></i>)-C(<i>sp</i>) Bonds Through Nickel-Catalyzed Sonogashira Reactions: Scope, Selectivity and Mechanism
Modular Construction of C(<i>sp<sup>2</sup></i>)-C(<i>sp</i>) Bonds Through Nickel-Catalyzed Sonogashira Reactions: Scope, Selectivity and Mechanism Open
View article: 747 A phase 1 trial of IO-202, an antagonist antibody targeting myeloid checkpoint LILRB4 (ILT3), as monotherapy and in combination with pembrolizumab in adult patients with advanced relapsed or refractory solid tumors
747 A phase 1 trial of IO-202, an antagonist antibody targeting myeloid checkpoint LILRB4 (ILT3), as monotherapy and in combination with pembrolizumab in adult patients with advanced relapsed or refractory solid tumors Open
Background Most patients with advanced solid tumors relapse after T-cell checkpoint blockade despite of immunotherapy becoming the mainstream with the approvals of T-cell checkpoint inhibitors. Myeloid checkpoint inhibition is a new approa…
View article: Nickel-catalyzed enantioselective domino Heck/Sonogashira coupling for construction of C(sp)-C(sp) bond-substituted quaternary carbon centers
Nickel-catalyzed enantioselective domino Heck/Sonogashira coupling for construction of C(sp)-C(sp) bond-substituted quaternary carbon centers Open
View article: 304 Antagonistic antibodies targeting LAIR1 enhance T lymphocyte activation and promote inflammatory phenotypes in myeloid cells
304 Antagonistic antibodies targeting LAIR1 enhance T lymphocyte activation and promote inflammatory phenotypes in myeloid cells Open
Background The Leukocyte Associated Immunoglobulin-like Receptor 1 (LAIR1) is an immune inhibitory transmembrane glycoprotein expressed on lymphocytes and myeloid cells. The known ligands for LAIR1 are proteins containing collagen-like dom…
View article: Structure-Based Design of Highly Potent Toll-like Receptor 7/8 Dual Agonists for Cancer Immunotherapy
Structure-Based Design of Highly Potent Toll-like Receptor 7/8 Dual Agonists for Cancer Immunotherapy Open
Activation of the toll-like receptors 7 and 8 has emerged as a promising strategy for cancer immunotherapy. Herein, we report the design and synthesis of a series of pyrido[3,2-d]pyrimidine-based toll-like receptor 7/8 dual agonists…
View article: Tumor immunological phenotype signature-based high-throughput screening for the discovery of combination immunotherapy compounds
Tumor immunological phenotype signature-based high-throughput screening for the discovery of combination immunotherapy compounds Open
A high-throughput screening approach enables the discovery of tumor immune microenvironment modulator and immunotherapy booster.
View article: Mi-2β-targeted inhibition induces immunotherapy response in melanoma
Mi-2β-targeted inhibition induces immunotherapy response in melanoma Open
Recent development of some new immune checkpoint inhibitors has been particularly successfully in melanoma, but the majority of melanoma patients exhibit resistance. Understanding and targeting the potential underlying mechanism/targets, e…
View article: 686 Preclinical characterization of a novel therapeutic antibody targeting LILRB2
686 Preclinical characterization of a novel therapeutic antibody targeting LILRB2 Open
Background Myeloid-derived suppressor cells and tumor-associated macrophages inhibit anti-cancer immune responses systemically and in the tumor microenvironment, respectively, thereby limiting the efficacy of immune checkpoint blockers.
View article: Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies
Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies Open
View article: In situ generation of N-unsubstituted imines from alkyl azides and their applications for imine transfer via copper catalysis
In situ generation of N-unsubstituted imines from alkyl azides and their applications for imine transfer via copper catalysis Open
Multisubstituted pyridines or indoles were synthesized using N-unsubstituted imines in situ–generated from alkyl azides.
View article: The Novel Toll-Like Receptor 2 Agonist SUP3 Enhances Antigen Presentation and T Cell Activation by Dendritic Cells
The Novel Toll-Like Receptor 2 Agonist SUP3 Enhances Antigen Presentation and T Cell Activation by Dendritic Cells Open
Dendritic cells (DCs) are highly specialized antigen-presenting cells that play crucial roles in innate and adaptive immunity. Previous studies suggested that Toll-like receptor (TLR) agonists could be used as potential adjuvants, as activ…
View article: Enantioselective Total Syntheses of (−)-Taiwaniaquinone H and (−)-Taiwaniaquinol B by Iridium-Catalyzed Borylation and Palladium-Catalyzed Asymmetric α-Arylation
Enantioselective Total Syntheses of (−)-Taiwaniaquinone H and (−)-Taiwaniaquinol B by Iridium-Catalyzed Borylation and Palladium-Catalyzed Asymmetric α-Arylation Open
We report a concise, enantioselective total synthesis of (−)-taiwaniaquinone H and the first enantioselective total synthesis of (−)-taiwaniaquinol B by a route that includes asymmetric palladium-catalyzed α-arylation of a ketone with an a…