Xueding Wang
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View article: Photoacoustic imaging combined with robotics: a review of current works
Photoacoustic imaging combined with robotics: a review of current works Open
Photoacoustic imaging (PAI) is a hybrid imaging modality that combines optical excitation with ultrasound (US) detection to achieve high-resolution, high-contrast imaging of biological tissues. As a non-ionizing and scalable imaging techni…
View article: Translational photoacoustic and ultrasound imaging catheter for characterizing gastrointestinal inflammation and fibrosis: a study with a pig model <i>in vivo</i>
Translational photoacoustic and ultrasound imaging catheter for characterizing gastrointestinal inflammation and fibrosis: a study with a pig model <i>in vivo</i> Open
Our previous studies demonstrated that a prototype photoacoustic (PA) and ultrasound (US) imaging catheter can differentiate intestinal inflammation and fibrosis. However, its compatibility with clinical endoscopic procedures has not been …
View article: <b>Volumetric ultrasound and photoacoustic imaging of inflammatory arthritis in human finger joints via robotic arm powered arc scans</b>
<b>Volumetric ultrasound and photoacoustic imaging of inflammatory arthritis in human finger joints via robotic arm powered arc scans</b> Open
Ultrasound (US) imaging is a standard clinical tool for assessment of soft tissue inflammation, particularly for imaging the peripheral joints of the hands and feet, which are usually the first to be affected by rheumatoid arthritis. Robot…
View article: Towards quantitative ionizing radiation acoustic imaging (iRAI) for radiation dose measurement: Validation from simulations to experiments
Towards quantitative ionizing radiation acoustic imaging (iRAI) for radiation dose measurement: Validation from simulations to experiments Open
Background In clinical radiation therapy (RT), accurately quantifying the delivered radiation dose to the targeted tumors and surrounding tissues is essential for evaluating treatment outcomes. Ionizing radiation acoustic imaging (iRAI), a…
View article: Noninvasive Mapping of Extracellular Potassium in Breast Tumors via Multi-Wavelength Photoacoustic Imaging
Noninvasive Mapping of Extracellular Potassium in Breast Tumors via Multi-Wavelength Photoacoustic Imaging Open
Elevated extracellular potassium (K+) in the tumor microenvironment (TME) of breast and other cancers is increasingly recognized as a critical factor influencing tumor progression and immune suppression. Current methods for noninvasive map…
View article: Noninvasive Mapping of Extracellular Potassium in Breast Tumors via Multi-Wavelength Photoacoustic Imaging
Noninvasive Mapping of Extracellular Potassium in Breast Tumors via Multi-Wavelength Photoacoustic Imaging Open
Elevated extracellular potassium (K⁺) in the tumor microenvironment (TME) is increasingly recognized as a critical factor influencing tumor progression and immune suppression. Current methods for noninvasively mapping of potassium distribu…
View article: Ionizing radiation acoustic and ultrasound dual-modality imaging for visualization of dose on anatomical structures during radiotherapy
Ionizing radiation acoustic and ultrasound dual-modality imaging for visualization of dose on anatomical structures during radiotherapy Open
The aim of this study is to visualize the radiation dose on anatomical structures during radiation therapy (RT) by mapping radiation dose deposition and tracking anatomical structures simultaneously. A dual-modality volumetric imaging syst…
View article: SwinDAF3D: Pyramid Swin Transformers with Deep Attentive Features for Automated Finger Joint Segmentation in 3D Ultrasound Images for Rheumatoid Arthritis Assessment
SwinDAF3D: Pyramid Swin Transformers with Deep Attentive Features for Automated Finger Joint Segmentation in 3D Ultrasound Images for Rheumatoid Arthritis Assessment Open
Rheumatoid arthritis (RA) is a chronic autoimmune disease that can cause severe joint damage and functional impairment. Ultrasound imaging has shown promise in providing real-time assessment of synovium inflammation associated with the ear…
View article: Gas Vesicle-Expressing Human Pluripotent Stem Cells Enable Multimodal Ultrasound and Optical Coherence Tomographic Imaging
Gas Vesicle-Expressing Human Pluripotent Stem Cells Enable Multimodal Ultrasound and Optical Coherence Tomographic Imaging Open
Summary Genetically encoded imaging reporters are critical tools for tracking cell fate and function in regenerative medicine. Gas vesicles (GVs), air-filled protein nanostructures derived from bacteria, offer unique advantages for noninva…
View article: SwinDAF3D: Pyramid Swin Transformers with Deep Attentive Features for Automated Finger Joint Segmentation in 3D Ultrasound Images for Rheumatoid Arthritis Assessment
SwinDAF3D: Pyramid Swin Transformers with Deep Attentive Features for Automated Finger Joint Segmentation in 3D Ultrasound Images for Rheumatoid Arthritis Assessment Open
Rheumatoid arthritis (RA) is a chronic autoimmune disease that can cause severe joint damage and functional impairment. Ultrasound imaging has shown promise in providing real-time assessment of synovium inflammation associated with the ear…
View article: Photo-Mediated Ultrasound Therapy (PUT) for the Treatment of Deep Cutaneous Vasculature
Photo-Mediated Ultrasound Therapy (PUT) for the Treatment of Deep Cutaneous Vasculature Open
Traditionally, pulsed dye laser (PDL) therapy has been used to treat cutaneous blood vessels in patients with port-wine stain (PWS) birthmarks. PDL therapy, however, has limited treatment depth, and frequently results in suboptimal therape…
View article: Detecting metastatic potential of cancer through longitudinal vasculature imaging of biomaterial scaffold using non-invasive <i>in vivo</i> photoacoustic microscopy and optical coherence tomography
Detecting metastatic potential of cancer through longitudinal vasculature imaging of biomaterial scaffold using non-invasive <i>in vivo</i> photoacoustic microscopy and optical coherence tomography Open
Metastasis represents a stage in which the therapeutic objective changes from curing disease to prolonging survival, as detection typically occurs at advanced stages. Technologies for the early identification of disease would enable treatm…
View article: Multimodal photoacoustic microscopy and optical coherence tomography ocular biomarker imaging in Alzheimer's disease in mice
Multimodal photoacoustic microscopy and optical coherence tomography ocular biomarker imaging in Alzheimer's disease in mice Open
Alzheimer's disease (AD) is a neurodegenerative disease characterized by amyloid beta (Aβ)-containing extracellular plaques and tau-containing intracellular neurofibrillary tangles. Reliable and more accessible biomarkers along with associ…
View article: Selective nanosecond laser removal of retinal pigment epithelium for cell therapy
Selective nanosecond laser removal of retinal pigment epithelium for cell therapy Open
Retinal pigment epithelial (RPE) cells play a crucial role in the health of the retina, and their dysfunction is associated with various ocular diseases. The transplantation of RPE cells has been proposed as a potential treatment for numer…
View article: Ultrasound-assisted laser therapy for selective removal of melanoma cells
Ultrasound-assisted laser therapy for selective removal of melanoma cells Open
The current study explores the potential of ultrasound-assisted laser therapy (USaLT) to selectively destroy melanoma cells. The technology was tested on an ex vivo melanoma model, which was established by growing melanoma cells in chicken…
View article: Label-free photoacoustic computed tomography of visually evoked responses in the primary visual cortex and four subcortical retinorecipient nuclei of anesthetized mice
Label-free photoacoustic computed tomography of visually evoked responses in the primary visual cortex and four subcortical retinorecipient nuclei of anesthetized mice Open
PACT demonstrated sufficient sensitivity to detecting post-retinal functional deficits.
View article: Introducing the Special Issue Honoring Lihong V. Wang, Pioneer in Biomedical Optics
Introducing the Special Issue Honoring Lihong V. Wang, Pioneer in Biomedical Optics Open
The editorial concludes the JBO Special Issue Honoring Lihong V. Wang, outlining Prof. Wang's salient contributions to advancing the field of biomedical optics.
View article: Photoacoustic lifetime oxygen imaging of radiotherapy-induced tumor reoxygenation In Vivo
Photoacoustic lifetime oxygen imaging of radiotherapy-induced tumor reoxygenation In Vivo Open
Our PALT imaging presented here is simple, fast, and non-invasive. Facilized by the PALT approach, imaging of tumor reoxygenation may be utilized as a simple, early indicator for evaluating cancer response to radiotherapy. Further characte…
View article: Real-Time Cavitation Monitoring During Optical Coherence Tomography Guided Photo-Mediated Ultrasound Therapy of the Retina
Real-Time Cavitation Monitoring During Optical Coherence Tomography Guided Photo-Mediated Ultrasound Therapy of the Retina Open
Real-time OCT monitoring can thus improve the safety and efficiency of PUT in removing the retinal and choroidal microvasculature.
View article: High Q‐Factor Polymer Microring Resonators Realized by Versatile Damascene Soft Nanoimprinting Lithography
High Q‐Factor Polymer Microring Resonators Realized by Versatile Damascene Soft Nanoimprinting Lithography Open
High‐quality‐factor microring resonators are highly desirable in many applications. Fabricating a microring resonator typically requires delicate instruments to ensure a smooth side wall of waveguides and 100‐nm critical feature size in th…
View article: Photoacoustic imaging of squirrel monkey cortical responses induced by peripheral mechanical stimulation
Photoacoustic imaging of squirrel monkey cortical responses induced by peripheral mechanical stimulation Open
Non‐human primates (NHPs) are crucial models for studies of neuronal activity. Emerging photoacoustic imaging modalities offer excellent tools for studying NHP brains with high sensitivity and high spatial resolution. In this research, a p…
View article: Longitudinal Monitoring of Angiogenesis in a Murine Window Chamber Model <i>In Vivo</i>
Longitudinal Monitoring of Angiogenesis in a Murine Window Chamber Model <i>In Vivo</i> Open
Angiogenesis induced by growth factor administration, which can augment the blood supply in regenerative applications, has drawn wide attention in medical research. Longitudinal monitoring of vascular structure and development in vivo is i…
View article: Photoacoustic imaging of visually evoked cortical and subcortical hemodynamic activity in mouse brain: feasibility study with piezoelectric and capacitive micromachined ultrasonic transducer (CMUT) arrays
Photoacoustic imaging of visually evoked cortical and subcortical hemodynamic activity in mouse brain: feasibility study with piezoelectric and capacitive micromachined ultrasonic transducer (CMUT) arrays Open
This study investigates the feasibility of capturing visually evoked hemodynamic responses in the mouse brain using photoacoustic tomography (PAT) and ultrasound (US) dual-modality imaging. A commercial piezoelectric transducer array and a…
View article: 3D imaging of aqueous veins and surrounding sclera using a dual-wavelength photoacoustic microscopy
3D imaging of aqueous veins and surrounding sclera using a dual-wavelength photoacoustic microscopy Open
Understanding aqueous outflow resistance at the level of aqueous veins has been a challenge to the management of glaucoma. This study investigated resolving the anatomies of aqueous veins and the textures of surrounding sclera using photoa…
View article: Photoacoustic Chemical Imaging Sodium Nano-Sensor Utilizing a Solvatochromic Dye Transducer for In Vivo Application
Photoacoustic Chemical Imaging Sodium Nano-Sensor Utilizing a Solvatochromic Dye Transducer for In Vivo Application Open
Sodium has many vital and diverse roles in the human body, including maintaining the cellular pH, generating action potential, and regulating osmotic pressure. In cancer, sodium dysregulation has been correlated with tumor growth, metastas…
View article: Development of a semi‐anthropomorphic photoacoustic calcaneus phantom based on nano computed tomography and stereolithography 3D printing
Development of a semi‐anthropomorphic photoacoustic calcaneus phantom based on nano computed tomography and stereolithography 3D printing Open
Osteoporosis is a major public health threat with significant physical, psychosocial, and financial consequences. The calcaneus bone has been used as a measurement site for risk prediction of osteoporosis by noninvasive quantitative ultras…
View article: Cutaneous Hypervascularization Treatment Using Photo-Mediated Ultrasound Therapy
Cutaneous Hypervascularization Treatment Using Photo-Mediated Ultrasound Therapy Open
Photo-mediated ultrasound therapy (PUT) is a cavitation-based, highly selective antivascular technique. In this study, the effectiveness and safety of PUT on cutaneous vascular malformation was examined through in vivo experiments in a cli…
View article: An Automatic 3-D Ultrasound and Photoacoustic Combined Imaging System for Human Inflammatory Arthritis
An Automatic 3-D Ultrasound and Photoacoustic Combined Imaging System for Human Inflammatory Arthritis Open
Aiming at a point-of-care device for rheumatology clinics, we developed an automatic 3-D imaging system combining the emerging photoacoustic (PA) imaging with conventional Doppler ultrasound (US) for detecting human inflammatory arthritis.…
View article: Renally Clearable Ultraminiature Chain‐Like Gold Nanoparticle Clusters for Multimodal Molecular Imaging of Choroidal Neovascularization
Renally Clearable Ultraminiature Chain‐Like Gold Nanoparticle Clusters for Multimodal Molecular Imaging of Choroidal Neovascularization Open
Currently, available gold nanoparticles (GNPs) typically accumulate in the liver and spleen, leading to concerns for their long‐term biosafety. To address this long‐standing problem, ultraminiature chain‐like gold nanoparticle clusters (GN…