Xuehui Yang
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View article: Exploration of Conserved Human Adipose Subpopulations Using Targeted Single‐Nuclei RNA Sequencing Data Sets
Exploration of Conserved Human Adipose Subpopulations Using Targeted Single‐Nuclei RNA Sequencing Data Sets Open
Background Smooth‐muscle cells and pericytes are mural cells. Pericytes can differentiate into myofibroblasts, chondrocytes, vascular smooth‐muscle cells, and adipocytes, marking them as a distinct progenitor population. Our goal was to mo…
View article: Cellular Characteristics and Protein Signatures of Human Adipose Tissues from Donors With or Without Advanced Coronary Artery Disease
Cellular Characteristics and Protein Signatures of Human Adipose Tissues from Donors With or Without Advanced Coronary Artery Disease Open
Background/Objectives: Perivascular adipose tissue (PVAT) exerts a paracrine effect on blood vessels and our objective was to understand PVAT molecular signatures related to cardiovascular disease. Methods: We studied two groups: those und…
View article: An Analysis of the Evolution and Influencing Factors of Customs Function
An Analysis of the Evolution and Influencing Factors of Customs Function Open
The evolution and influence factors analysis of the contemporary customs function is an important research topic. The purpose of this paper is to probe into the evolution of China s customs function under the current complex international …
View article: Endothelial IL17RD promotes Western diet-induced aortic myeloid cell infiltration
Endothelial IL17RD promotes Western diet-induced aortic myeloid cell infiltration Open
View article: Notch Signaling Regulates Mouse Perivascular Adipose Tissue Function via Mitochondrial Pathways
Notch Signaling Regulates Mouse Perivascular Adipose Tissue Function via Mitochondrial Pathways Open
Perivascular adipose tissue (PVAT) regulates vascular function by secreting vasoactive substances. In mice, Notch signaling is activated in the PVAT during diet-induced obesity, and leads to the loss of the thermogenic phenotype and adipoc…
View article: Sprouty1 has a protective role in atherogenesis and modifies the migratory and inflammatory phenotype of vascular smooth muscle cells
Sprouty1 has a protective role in atherogenesis and modifies the migratory and inflammatory phenotype of vascular smooth muscle cells Open
View article: Integrated genetic analysis of leaf blast resistance in upland rice: QTL mapping, bulked segregant analysis and transcriptome sequencing
Integrated genetic analysis of leaf blast resistance in upland rice: QTL mapping, bulked segregant analysis and transcriptome sequencing Open
Elite upland rice cultivars have the advantages of less water requirement along with high yield but are usually susceptible to various diseases. Rice blast caused by Magnaporthe oryzae is the most devastating disease in rice. Identificatio…
View article: Artemisinin derivative SM934, influences the activation, proliferation, differentiation and antibody-secreting capacity of β-cells in systemic lupus erythematosus mice via inhibition of TLR7/9 signaling pathway
Artemisinin derivative SM934, influences the activation, proliferation, differentiation and antibody-secreting capacity of β-cells in systemic lupus erythematosus mice via inhibition of TLR7/9 signaling pathway Open
Purpose: To study the influence of artemisinin derivative, SM934 on activation, proliferation, differentiation and antibody-secreting capacity of B cells of systemic lupus erythematosus (SLE) mice, and the underlying mechanism.
Methods: F…
View article: Molecular mechanisms of esophageal epithelial regeneration following repair of surgical defects with acellular silk fibroin grafts
Molecular mechanisms of esophageal epithelial regeneration following repair of surgical defects with acellular silk fibroin grafts Open
View article: Interleukin-17 receptor D (Sef) is a multi-functional regulator of cell signaling
Interleukin-17 receptor D (Sef) is a multi-functional regulator of cell signaling Open
Interleukin-17 receptor D (IL17RD or IL-17RD) also known as Sef (similar expression to fibroblast growth factor), is a single pass transmembrane protein that is reported to regulate several signaling pathways . IL17RD was initially describ…
View article: Sprouty1 regulates gonadal white adipose tissue growth through a PDGFRα/β-Akt pathway
Sprouty1 regulates gonadal white adipose tissue growth through a PDGFRα/β-Akt pathway Open
Expansion of visceral white adipose tissue (vWAT) occurs in response to nutrient excess, and is a risk factor for metabolic disease. SPRY1, a feedback inhibitor of receptor tyrosine kinase (RTK) signaling, is expressed in PDGFRa+ adipocyte…
View article: First Report of Stem Rot of Huangjing (<i>Polygonatum sibiricum</i>) Caused by <i>Athelia rolfsii</i>
First Report of Stem Rot of Huangjing (<i>Polygonatum sibiricum</i>) Caused by <i>Athelia rolfsii</i> Open
Huangjing (Polygonatum sibiricum) is a medicinal plant widely distributed in China, Japan, and Korea. The dried rhizome of Huangjing has been reported to have many pharmacological applications and biological activities, such as antioxidant…
View article: Evaluation of Bilayer Silk Fibroin Grafts for Tubular Esophagoplasty in a Porcine Defect Model
Evaluation of Bilayer Silk Fibroin Grafts for Tubular Esophagoplasty in a Porcine Defect Model Open
Surgical reconstruction of tubular esophageal defects with autologous gastrointestinal segments is the gold standard treatment to replace damaged or diseased esophageal tissues. Unfortunately, this approach is associated with adverse compl…
View article: First report of Fusarium proliferatum causing root rot of Gerbera in China
First report of Fusarium proliferatum causing root rot of Gerbera in China Open
In January 2018, gerbera plants showed root rot symptoms were found in a greenhouse at Guizhou Horticultural Institute in Guiyang city, Guizhou Province in southwest China. Morphological and molecular identifications confirmed the isolatio…
View article: Macrophage colony‐stimulating factor pretreatment of bone marrow progenitor cells regulates osteoclast differentiation based upon the stage of myeloid development
Macrophage colony‐stimulating factor pretreatment of bone marrow progenitor cells regulates osteoclast differentiation based upon the stage of myeloid development Open
Osteoclasts (OCs) are large, multinucleated bone resorbing cells originating from the bone marrow myeloid lineage, and share a common progenitor with macrophages and dendritic cells. Bone marrow cells (BMCs) are a common source for in vitr…
View article: Augmentation Cystoplasty of Diseased Porcine Bladders with Bi-Layer Silk Fibroin Grafts
Augmentation Cystoplasty of Diseased Porcine Bladders with Bi-Layer Silk Fibroin Grafts Open
The search for an ideal "off-the-shelf" biomaterial for augmentation cystoplasty remains elusive and current scaffold configurations are hampered by mechanical and biocompatibility restrictions. In addition, preclinical evaluations of pote…
View article: Mode of Surgical Injury Influences the Source of Urothelial Progenitors during Bladder Defect Repair
Mode of Surgical Injury Influences the Source of Urothelial Progenitors during Bladder Defect Repair Open
View article: A truncated p53 in human lung cancer cells as a critical determinant of proliferation and invasiveness
A truncated p53 in human lung cancer cells as a critical determinant of proliferation and invasiveness Open
As a transcription factor, p53 must accumulate in the nucleus to be effective. Signals related to nuclear localization are distributed mainly in the C-terminal of p53. So these nuclear location domains were reserved and the other part of t…
View article: Erratum to: Suppression of Spry4 enhances cancer stem cell properties of human MDA-MB-231 breast carcinoma cells
Erratum to: Suppression of Spry4 enhances cancer stem cell properties of human MDA-MB-231 breast carcinoma cells Open
View article: Correction: Corrigendum: Suppression of Spry1 inhibits triple-negative breast cancer malignancy by decreasing EGF/EGFR mediated mesenchymal phenotype
Correction: Corrigendum: Suppression of Spry1 inhibits triple-negative breast cancer malignancy by decreasing EGF/EGFR mediated mesenchymal phenotype Open
Scientific Reports 6: Article number: 23216; published online: 15 March 2016; updated: 02 May 2017 The Acknowledgements section in this Article is incomplete. “We thank Dr. Robert Friesel for critical reading of the manuscript. We thank MM…
View article: Bilayer silk fibroin grafts support functional oesophageal repair in a rodent model of caustic injury
Bilayer silk fibroin grafts support functional oesophageal repair in a rodent model of caustic injury Open
Surgical repair of caustic oesophageal injuries with autologous gastrointestinal segments is often associated with dysmotility, dysphagia and donor site morbidity, and therefore alternative graft options are needed. Bilayer silk fibroin (B…
View article: Cyclooxygenase-2 is associated with malignant phenotypes in human lung cancer
Cyclooxygenase-2 is associated with malignant phenotypes in human lung cancer Open
The objective of the present study was to investigate whether cyclooxygenase-2 (COX-2) is associated with malignancy, and to investigate its molecular mechanisms in human lung cancer tumor malignancy. The present study used RNA interferenc…
View article: Suppression of Spry1 inhibits triple-negative breast cancer malignancy by decreasing EGF/EGFR mediated mesenchymal phenotype
Suppression of Spry1 inhibits triple-negative breast cancer malignancy by decreasing EGF/EGFR mediated mesenchymal phenotype Open
View article: Suppression of Spry4 enhances cancer stem cell properties of human MDA-MB-231 breast carcinoma cells
Suppression of Spry4 enhances cancer stem cell properties of human MDA-MB-231 breast carcinoma cells Open
[This corrects the article DOI: 10.1186/s12935-016-0292-7.].
View article: Sef Regulates Epithelial‐Mesenchymal Transition in Breast Cancer Cells
Sef Regulates Epithelial‐Mesenchymal Transition in Breast Cancer Cells Open
Sef ( s imilar e xpression to f gf), also know as IL17RD, is a transmembrane protein shown to inhibit fibroblast growth factor signaling in developmental and cancer contexts; however, its role as a tumor suppressor remains to be fully eluc…
View article: Identification of an Endogenously Generated Cryptic Collagen Epitope (XL313) That May Selectively Regulate Angiogenesis by an Integrin Yes-associated Protein (YAP) Mechano-transduction Pathway
Identification of an Endogenously Generated Cryptic Collagen Epitope (XL313) That May Selectively Regulate Angiogenesis by an Integrin Yes-associated Protein (YAP) Mechano-transduction Pathway Open
Extracellular matrix (ECM) remodeling regulates angiogenesis. However, the precise mechanisms by which structural changes in ECM proteins contribute to angiogenesis are not fully understood. Integrins are molecules with the ability to dete…
View article: Concurrent BMP7 and FGF9 signalling governs AP-1 function to promote self-renewal of nephron progenitor cells
Concurrent BMP7 and FGF9 signalling governs AP-1 function to promote self-renewal of nephron progenitor cells Open
View article: Spry1 increases, Spry4 decreases <i>Myocd</i> expression associated with their corresponding regulation of PI3K/Akt signaling.
Spry1 increases, Spry4 decreases <i>Myocd</i> expression associated with their corresponding regulation of PI3K/Akt signaling. Open
A) Representative immunoblot to verify overexpression of Spry1 increases, while overexpression of Spry4 decreases pAkt and pFoxO3a. B) Quantification from at least three independent immunoblotting experiments shows Spry1 increases, while S…
View article: Working model whereby Spry1 and Spry4 have opposing functions in VSMC phenotypic modulation.
Working model whereby Spry1 and Spry4 have opposing functions in VSMC phenotypic modulation. Open
Spry1 and Spry4 differentially regulate VSMC phenotypes in part by modulating different RTK signaling outputs, where Spry4 inhibits both MAPK/ERK and PI3K/Akt activation and therefore the VSMC proliferation and differentiation, while Spry1…
View article: A better experimental method to detect the sensitivity of cancer cells to anticancer drugs after adenovirus-mediated introduction of two kinds of p53 in vivo
A better experimental method to detect the sensitivity of cancer cells to anticancer drugs after adenovirus-mediated introduction of two kinds of p53 in vivo Open
p53 plays an important role in drug responses by regulating cell cycle progression and inducing programmed cell death. The C-terminal of p53 self-regulates the protein negatively; however, whether it affects the sensitivity of cancer cells…