Xuejun Ge
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View article: FTO deficiency facilitates epithelia dysfunction in oral lichen planus
FTO deficiency facilitates epithelia dysfunction in oral lichen planus Open
View article: Prefabricated 3D-printed full-arch implant for functional and esthetic rehabilitation: A prosthesis-integrated drill guide solution
Prefabricated 3D-printed full-arch implant for functional and esthetic rehabilitation: A prosthesis-integrated drill guide solution Open
Purpose: This study presents a detailed digital workflow for a prefabricated, 3D-printed full-arch fixed implant system, integrating an interim prosthesis with a full or pilot hole drill implant guide. The aim is to offer a precise and eff…
View article: MMP12 disrupts epithelial barrier integrity in oral lichen planus by degrading fibronectin
MMP12 disrupts epithelial barrier integrity in oral lichen planus by degrading fibronectin Open
Oral lichen planus (OLP) is a chronic inflammatory disorder featured with T lymphocytes infiltration and epithelial basement membrane breakdown. Although matrix metalloproteinase-12 (MMP12) is reported to be involved in the pathogenesis of…
View article: Youthful small extracellular vesicles restore the function and reparative capacity of inflammatory-impaired periodontal ligament stem cells via delivering protein biglycan for bone regeneration
Youthful small extracellular vesicles restore the function and reparative capacity of inflammatory-impaired periodontal ligament stem cells via delivering protein biglycan for bone regeneration Open
Regenerating inflamed bone defects represents a severe clinical challenge due to the undesirable inflammatory microenvironment. The inflammatory stimulus poses a weighty threat to the regenerative capacity of endogenously derived mesenchym…
View article: Recombinant Humanized Collagen Type XVII Promotes Oral Ulcer Healing via Anti-Inflammation and Accelerate Tissue Healing
Recombinant Humanized Collagen Type XVII Promotes Oral Ulcer Healing via Anti-Inflammation and Accelerate Tissue Healing Open
In summary, the collagen sprays containing rhCol 17 have excellent anti-inflammatory effects and could accelerate tissue healing and are expected to provide a new effective treatment for patients with recurrent oral ulcers.
View article: METTL14-upregulated miR-6858 triggers cell apoptosis in keratinocytes of oral lichen planus through decreasing GSDMC
METTL14-upregulated miR-6858 triggers cell apoptosis in keratinocytes of oral lichen planus through decreasing GSDMC Open
View article: Combination of niclosamide and quinacrine inactivates Akt/HK2/Cyclin D1 axis mediated by glucose deprivation towards the inhibition of melanoma cell proliferation
Combination of niclosamide and quinacrine inactivates Akt/HK2/Cyclin D1 axis mediated by glucose deprivation towards the inhibition of melanoma cell proliferation Open
Malignant melanoma is one of the most aggressive and lethal skin cancer. At present, the treatment methods for melanoma have shortcomings. Glucose is the primary energy source of cancer cells. However, it is unclear whether glucose depriva…
View article: Carbon quantum dots as immune modulatory therapy in a Sjögren's syndrome mouse model
Carbon quantum dots as immune modulatory therapy in a Sjögren's syndrome mouse model Open
Objectives The objective of the study was to evaluate the therapeutic effects of carbon quantum dots (CQDs) in immunomodulation on non‐obese diabetic (NOD) mice, as the model for Sjögren's syndrome (SS). Methods Carbon quantum dots were ge…
View article: The Loss of YTHDC1 in Gut Macrophages Exacerbates Inflammatory Bowel Disease
The Loss of YTHDC1 in Gut Macrophages Exacerbates Inflammatory Bowel Disease Open
The nuclear N 6 ‐methyladenosine (m 6 A) reader YT521‐B homology‐domain‐containing protein 1 (YTHDC1) is required to maintain embryonic stem cell identity. However, little is known about its biological functions in intestinal‐resident macr…
View article: N6-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice
N6-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice Open
Bacteria-triggered sepsis is characterized by systemic, uncontrolled inflammation in affected individuals. Controlling the excessive production of pro-inflammatory cytokines and subsequent organ dysfunction in sepsis remains challenging. H…
View article: 1,25(<scp>OH</scp>)<scp><sub>2</sub>D<sub>3</sub></scp> blocks <scp>IFNβ</scp> production through regulating <scp>STING</scp> in epithelial layer of oral lichen planus
1,25(<span>OH</span>)<span><sub>2</sub>D<sub>3</sub></span> blocks <span>IFNβ</span> production through regulating <span>STING</span> in epithelial layer of oral lichen planus Open
Stimulator of interferon genes (STING) is reported to exert vital functions in inflammatory responses and autoimmune diseases. Nevertheless, the status and roles of STING in oral lichen planus (OLP) remain elusive. Here, we state that STIN…
View article: Evaluation of staff satisfaction after the implementation of a daily goals sheet in the routine work of an oral outpatient department and its influence on work efficiency
Evaluation of staff satisfaction after the implementation of a daily goals sheet in the routine work of an oral outpatient department and its influence on work efficiency Open
Background In March 2021, the supervision group of our hospital inspected the daily work of the outpatient department in the branch and found many problems in the process, such as an excessive number of daily check-up forms, nurses’ confus…
View article: Evaluation of Staff Satisfaction After Implementation of a Routine Work Checklist in An Oral Outpatient Department and Its Effect On Work Efficiency
Evaluation of Staff Satisfaction After Implementation of a Routine Work Checklist in An Oral Outpatient Department and Its Effect On Work Efficiency Open
Background: To evaluate the feasibility, effectiveness and sustainability of using a checklist in the routine work of a stomatological outpatient department and investigate the satisfaction of the nursing staff with the checklist. Methods:…
View article: Recent Advances in Three-Dimensional Stem Cell Culture Systems and Applications
Recent Advances in Three-Dimensional Stem Cell Culture Systems and Applications Open
Cell culture is one of the most core and fundamental techniques employed in the fields of biology and medicine. At present, although the two-dimensional cell culture method is commonly used in vitro, it is quite different from the cell gro…
View article: Evaluation of Staff Satisfaction After Implementation of a Routine Work Checklist in an Oral Outpatient Department and its Effect on Work Efficiency
Evaluation of Staff Satisfaction After Implementation of a Routine Work Checklist in an Oral Outpatient Department and its Effect on Work Efficiency Open
Background: To evaluate the feasibility, effectiveness and sustainability of using a checklist in the routine work of a stomatological outpatient department and investigate the satisfaction of the nursing staff with the checklist. Methods:…
View article: ZFP36 promotes VDR mRNA degradation to facilitate cell death in oral and colonic epithelial cells
ZFP36 promotes VDR mRNA degradation to facilitate cell death in oral and colonic epithelial cells Open
Background Vitamin D receptor (VDR) plays a vital protective role in oral and colonic epithelial cells. Albeit we know that VDR expression is reduced in the mucosal epithelial layers of autoimmune diseases, the mechanism by which VDR is de…
View article: MicroRNA‐122 promotes apoptosis of keratinocytes in oral lichen planus through suppressing VDR expression
MicroRNA‐122 promotes apoptosis of keratinocytes in oral lichen planus through suppressing VDR expression Open
MicroRNA‐122 (miR‐122) is known to be up‐regulated by inflammation to exert a variety of biological functions in hepatocellular carcinoma (HCC)‐derived human cell lines. Vitamin D receptor (VDR) is reported to regulate excessive oral kerat…
View article: Dysbiosis of saliva microbiome in patients with oral lichen planus
Dysbiosis of saliva microbiome in patients with oral lichen planus Open
Background Oral microbiota is not only important for maintaining oral health but also plays a role in various oral diseases. However, studies regarding microbiome changes in oral lichen planus (OLP) are very limited. To the best of our kno…
View article: Renin Promotes STAT4 Phosphorylation to Induce IL-17 Production in Keratinocytes of Oral Lichen Planus
Renin Promotes STAT4 Phosphorylation to Induce IL-17 Production in Keratinocytes of Oral Lichen Planus Open
Interleukin-17 (IL-17) is highly expressed in the epithelial layer of oral lichen planus (OLP), but the underlying mechanism for IL-17 overexpression remains unknown. Here, we identify renin that is induced by NF-κB pathway contributes to …
View article: Dysbiosis of saliva microbiome in patients with oral lichen planus
Dysbiosis of saliva microbiome in patients with oral lichen planus Open
Background : Oral microbiota is not only important for maintaining oral health but also plays a role in oral diseases. However, studies regarding microbiome changes in oral lichen planus(OLP)are very limited. Therefore, the purpose of this…
View article: Vitamin D/VDR signaling induces miR-27a/b expression in oral lichen planus
Vitamin D/VDR signaling induces miR-27a/b expression in oral lichen planus Open
MicroRNA-27a/b are small non-coding RNAs which are reported to regulate inflammatory response and cell proliferation. Although some studies have demonstrated that miR-27b is down-regulated in the oral specimens of patients suffering with o…
View article: MicroRNA-26a/b have protective roles in oral lichen planus
MicroRNA-26a/b have protective roles in oral lichen planus Open
Oral lichen planus (OLP) is a kind of oral epithelial disorder featured with keratinocyte apoptosis and inflammatory reaction. The pathogenesis of OLP remains an enigma. Herein, we showed that the levels of miR-26a/b were robustly down-reg…
View article: Additional file 2 of Dysbiosis of saliva microbiome in patients with oral lichen planus
Additional file 2 of Dysbiosis of saliva microbiome in patients with oral lichen planus Open
Additional file 2: Figure S7. The Mean Decrease Gini Index in OLP and C groups. The abscissa on the left figure was the mean decrease Gini index, and the ordinate represented the bacteria classification. The right box plot was the relative…
View article: Additional file 1 of Dysbiosis of saliva microbiome in patients with oral lichen planus
Additional file 1 of Dysbiosis of saliva microbiome in patients with oral lichen planus Open
Additional file 1: Figure S4. The Box-plot of higher relative abundance in genus level. The ordinate represents the classification attribute, phylum, and genera level. The abscissa represents the reading abundance. The boxed line near the …
View article: Dysbiosis of saliva microbiome in patients with oral lichen planus
Dysbiosis of saliva microbiome in patients with oral lichen planus Open
Background : Oral microbiota is not only important for maintaining oral health but also plays a role in oral diseases. However, studies regarding microbiome changes in oral lichen planus(OLP)are very limited. Therefore, the purpose of this…
View article: Vitamin D/VDR signaling inhibits LPS-induced IFNγ and IL-1β in Oral epithelia by regulating hypoxia-inducible factor-1α signaling pathway
Vitamin D/VDR signaling inhibits LPS-induced IFNγ and IL-1β in Oral epithelia by regulating hypoxia-inducible factor-1α signaling pathway Open
View article: LPS-induced Vitamin D Receptor Decrease in Oral Keratinocytes Is Associated With Oral Lichen Planus
LPS-induced Vitamin D Receptor Decrease in Oral Keratinocytes Is Associated With Oral Lichen Planus Open