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View article: B cell CLL/lymphoma 10 promotes colorectal cancer cell proliferation and regulates cuproptosis sensitivity through the NF-κB signaling pathway
B cell CLL/lymphoma 10 promotes colorectal cancer cell proliferation and regulates cuproptosis sensitivity through the NF-κB signaling pathway Open
BACKGROUND Colorectal cancer (CRC) is a major global health burden. B cell CLL/lymphoma 10 (BCL10), a key component of the caspase recruitment domain protein-BCL10-mucosa-associated lymphoid tissue lymphoma paracaspase complexes, is upregu…
View article: Gut microbiota — bidirectional modulator: role in inflammatory bowel disease and colorectal cancer
Gut microbiota — bidirectional modulator: role in inflammatory bowel disease and colorectal cancer Open
The gut microbiota is a diverse ecosystem that significantly impacts human health and disease. This article focuses on how the gut microbiota interacts with inflammatory bowel diseases and colorectal tumors, especially through immune regul…
View article: Characterization of Immune-Related circRNAs and mRNAs in Human Chronic Atrophic Gastritis
Characterization of Immune-Related circRNAs and mRNAs in Human Chronic Atrophic Gastritis Open
This study is the first systematic analysis of circRNA profiles in CAG and provide important insights for potential immunotherapeutic strategies and early diagnostic biomarkers in CAG treatment.
View article: Activin A plays an essential role in migration and proliferation of hepatic stellate cells via Smad3 and calcium signaling
Activin A plays an essential role in migration and proliferation of hepatic stellate cells via Smad3 and calcium signaling Open
Activin A and hepatic stellate cells (HSCs) are involved in tissue repair and fibrosis in liver injury. This study investigated the impact of activin A on HSC activation and migration. A microfluidic D4-chip was used for examining the cell…
View article: Application and prospect of microfluidic devices for rapid assay of cell activities in the tumor microenvironment
Application and prospect of microfluidic devices for rapid assay of cell activities in the tumor microenvironment Open
The global impact of cancer on human health has raised significant concern. In this context, the tumor microenvironment (TME) plays a pivotal role in the tumorigenesis and malignant progression. In order to enhance the accuracy and efficac…
View article: Activin A, a Novel Chemokine, Induces Mouse NK Cell Migration via AKT and Calcium Signaling
Activin A, a Novel Chemokine, Induces Mouse NK Cell Migration via AKT and Calcium Signaling Open
Natural killer (NK) cells can migrate quickly to the tumor site to exert cytotoxic effects on tumors, and some chemokines, including CXCL8, CXCL10 or and CXCL12, can regulate the migration of NK cells. Activin A, a member of the transformi…
View article: Activin A induces apoptosis of human lung adenocarcinoma A549 cells through endoplasmic reticulum stress pathway
Activin A induces apoptosis of human lung adenocarcinoma A549 cells through endoplasmic reticulum stress pathway Open
Activin A, a member of the transforming growth factor‑β (TGF‑β) superfamily, has been implicated in the tumorigenesis and progression of various cancers. However, it remains unclear whether activin A induces apoptosis in human lung adenoca…
View article: Follistatin is a crucial chemoattractant for mouse decidualized endometrial stromal cell migration by <scp>JNK</scp> signalling
Follistatin is a crucial chemoattractant for mouse decidualized endometrial stromal cell migration by <span>JNK</span> signalling Open
Follistatin (FST) and activin A as gonadal proteins exhibit opposite effects on follicle‐stimulating hormone (FSH) release from pituitary gland, and activin A‐FST system is involved in regulation of decidualization in reproductive biology.…
View article: Follistatin Is a Novel Chemoattractant for Migration and Invasion of Placental Trophoblasts of Mice
Follistatin Is a Novel Chemoattractant for Migration and Invasion of Placental Trophoblasts of Mice Open
Follistatin (FST) as a gonadal protein is central to the establishment and maintenance of pregnancy. Trophoblasts’ migration and invasion into the endometrium are critical events in placental development. This study aimed to elucidate the …
View article: Intrachromosomal Looping and Histone K27 Methylation Coordinately Regulates the lncRNA H19-Fetal Mitogen IGF2 Imprinting Cluster in the Decidual Microenvironment of Early Pregnancy
Intrachromosomal Looping and Histone K27 Methylation Coordinately Regulates the lncRNA H19-Fetal Mitogen IGF2 Imprinting Cluster in the Decidual Microenvironment of Early Pregnancy Open
Recurrent spontaneous abortion (RSA) is a highly heterogeneous complication of pregnancy with the underlying mechanisms remaining uncharacterized. Dysregulated decidualization is a critical contributor to the phenotypic alterations related…
View article: Activin A is a novel chemoattractant for migration of microglial BV2 cells
Activin A is a novel chemoattractant for migration of microglial BV2 cells Open
These findings revealed that activin A regulated the biological behavior of BV2 cells via Smad3 signaling, suggesting that activin A may serve as a potential treatment target for neuroinflammation and glia scar formation in nervous system.
View article: Loss of imprinting control of the lncRNA H19-fetal mitogen IGF2 gene cluster in the decidual microenvironment of patients with idiopathic spontaneous miscarriages
Loss of imprinting control of the lncRNA H19-fetal mitogen IGF2 gene cluster in the decidual microenvironment of patients with idiopathic spontaneous miscarriages Open
Miscarriage, the spontaneous loss of a pregnancy before the fetus achieves viability, is a common complication of pregnancy. Decidualization plays a critical role in the implantation of the embryo. To search for molecular factors underlyin…
View article: Establishment of prediction models for COVID-19 patients in different age groups based on Random Forest algorithm
Establishment of prediction models for COVID-19 patients in different age groups based on Random Forest algorithm Open
Summary Background Coronavirus disease 2019 (COVID-19) has rapidly become a global pandemic. Age is an independent factor in death from the disease, and predictive models to stratify patients according to their mortality risk are needed. A…
View article: Activin A as a Novel Chemokine Induces Migration of L929 Fibroblasts by ERK Signaling in Microfluidic Devices
Activin A as a Novel Chemokine Induces Migration of L929 Fibroblasts by ERK Signaling in Microfluidic Devices Open
Activin A, a member of the transforming growth factor-beta (TGF-β) superfamily, contributes to tissue healing and fibrosis. As the innate tissue cells, fibroblasts also play an important role in wound healing and fibrosis. Herein, this stu…
View article: Activin A impairs ActRIIA+ neutrophil recruitment into infected skin of mice
Activin A impairs ActRIIA+ neutrophil recruitment into infected skin of mice Open
Activin A levels are elevated during multiple severe infections and associated with an increased risk of death. However, the role of activin A in bacterial infection is still unclear. Here, we found that activin A levels were increased dur…
View article: Involvement of CHOP in activin A‑induced myeloma NS‑1 cell apoptosis
Involvement of CHOP in activin A‑induced myeloma NS‑1 cell apoptosis Open
Activin A, a multifunctional cytokine, is a member of transforming growth factor‑β (TGF‑β) superfamily. It is associated with a variety of pathophysiological processes, including inflammation, fibrosis, and tumorigenesis. Chronic or prolon…
View article: Profiling the long noncoding RNA interaction network in the regulatory elements of target genes by chromatin in situ reverse transcription sequencing
Profiling the long noncoding RNA interaction network in the regulatory elements of target genes by chromatin in situ reverse transcription sequencing Open
Long noncoding RNAs (lncRNAs) can regulate the activity of target genes by participating in the organization of chromatin architecture. We have devised a “chromatin-RNA in situ reverse transcription sequencing” (CRIST-seq) approach to prof…
View article: Emodin protects against lipopolysaccharide-induced inflammatory injury in HaCaT cells through upregulation of miR-21
Emodin protects against lipopolysaccharide-induced inflammatory injury in HaCaT cells through upregulation of miR-21 Open
Background/aim: Pressure ulcers are a disastrous health issue in which inflammation is involved. Emodin possesses biological properties in inflammation. Our study investigated functions of emodin in lipopolysaccharide (LPS)-treated HaCaT c…
View article: Perspectives of small molecule inhibitors of activin receptor‑like kinase in anti‑tumor treatment and stem cell differentiation (Review)
Perspectives of small molecule inhibitors of activin receptor‑like kinase in anti‑tumor treatment and stem cell differentiation (Review) Open
Activin receptor‑like kinases (ALKs), members of the type I activin receptor family, belong to the serine/threonine kinase receptors of the transforming growth factor‑β (TGF‑β) superfamily. ALKs mediate the roles of activin/TGF‑β in a wide…
View article: Activin A regulates activities of peripheral blood natural killer cells of mouse in an autocrine and paracrine manner
Activin A regulates activities of peripheral blood natural killer cells of mouse in an autocrine and paracrine manner Open
Activin A, a multifunctional cytokine of transforming growth factor-β (TGF-β) superfamily, can be produced by the diverse immune cells. NK cells in peripheral blood are one of the major immune cells applied to cancer therapy in recent year…
View article: Identification of risk factors for sepsis-associated mortality by gene expression profiling analysis
Identification of risk factors for sepsis-associated mortality by gene expression profiling analysis Open
Sepsis is a common cause of mortality due to systemic infection. Although numerous studies have investigated this life-threatening condition, there remains a lack of suitable markers to evaluate the severity of sepsis. The present study fo…
View article: Activin A regulates activation of mouse neutrophils by Smad3 signalling
Activin A regulates activation of mouse neutrophils by Smad3 signalling Open
Activin A, a member of the transforming growth factor beta superfamily, acts as a pro-inflammatory factor in acute phase response, and influences the pathological progress of neutrophil-mediated disease. However, whether activin A can exer…
View article: Involvement of TGF-β1/Smad3 Signaling in Carbon Tetrachloride-Induced Acute Liver Injury in Mice
Involvement of TGF-β1/Smad3 Signaling in Carbon Tetrachloride-Induced Acute Liver Injury in Mice Open
Transforming growth factor-beta1 (TGF-β1) is a major factor in pathogenesis of chronic hepatic injury. Carbon tetrachloride (CCl4) is a liver toxicant, and CCl4-induced liver injury in mouse is a classical animal model of chemical liver in…