Explanipedia

Therapeutic potential of glycyrrhizin in nervous system diseases Open

Junsha An, Mingyu Han, Pingting Chen, Li Wang, Lu Gao , et al. · 2025

Validation of Chinese version of the familiar tools use test for assessing limb apraxia in stroke patients Open

Jinni Wang, Jingxin Wei, Meilian Chen, Lu Gao, Xiaoyan Liao · 2025

Objective To validate the Familiar Tools Use Test (FTT) of the Diagnostic Instrument for Limb Apraxia-Short Version in Chinese stroke patients. Methods Participants were conveniently enrolled from a neurology ward in a tertiary hospital in…

CHRONO regulates the circadian clock via the REV-ERBα – BMAL1 loop Open

Qin Zhou, Lu Gao, Ruohan Wang, Shaoying Lan, Dan Li , et al. · 2025

The period length of the circadian clock is important for organisms to maintain homeostasis. CHRONO has been shown to play an important role in regulating the period of the mammalian clock and has recently been implicated to function in se…

HFIP‐Promoted <i>E</i> ‐selective Asymmetric Crotylboration of Quaternary α‐Silyl Crotylboronate with Aldehydes Open

Ruiqi Tong, Yan Zhang, Shiyang Liu, Jiahui Gao, Liying Huang , et al. · 2025

Polyketide synthesis consistently requires the development of linchpin‐type allylboron reagents, such as α‐silyl crotylboronates. Traditionally, these reagents feature α‐tertiary substitution and are used in aprotic solvents, typically yie…

Effectiveness of Mandibular Advancement Splint in Treating Obstructive Sleep Apnea: A Systematic Review Open

Min Yu, Yanyan Ma, Fang Han, Lu Gao · 2025

Preparation of Highly Stable Oleogel for the Encapsulation and Sustained Release of Quercetin Open

Shengnan Zhang, Lihua Jin, Lu Gao, Han Zhang, Xiaodan Qi , et al. · 2025

Multi-omics analysis of lipids and aroma compounds in beef under grain-fed and grass-fed production methods Open

Pingyang Li, Yulong Yin, Shijie Fan, Longzhu Zhou, Huihui Tian , et al. · 2025

Different production methods for grain-fed and grass-fed cattle affect beef quality and flavor, yet systematic studies on aroma profile differences and the reasons underlying these variations remain limited. This study employed multi-omics…

Guidelines for the diagnosis and treatment of neurally mediated syncope in children and adolescents (revised 2024) Open

Cheng Wang, Ying Liao, Shuo Wang, Hong Tian, Min Huang , et al. · 2024

The effect of single nucleotide polymorphisms on depression in combination with coronary diseases: a systematic review and meta-analysis Open

Jing Zhang, Lu Gao, Guan Lin Yang, De Zhao Kong · 2024

Background Depression and coronary heart disease (CHD) have common risk mechanisms. Common single nucleotide polymorphisms (SNPs) may be associated with the risk of depression combined with coronary heart disease. Methods This study was de…

Engineering Gene-Specific DNAzymes for Accessible and Multiplexed Nucleic Acid Testing Open

Lu Gao, Ke Yi, Yun Tan, Guo Chen, Danxi Zheng , et al. · 2024

The accurate and timely detection of disease biomarkers at the point-of-care is essential to ensuring effective treatment and epidemiological surveillance. Here, we report the selection and engineering of RNA-cleaving DNAzymes that respond…

Aroma Characteristics of Green Huajiao in Sichuan and Chongqing Area Using Sensory Analysis Combined with GC-MS Open

Lu Gao, Bolin Shi, Lei Zhao, Houyin Wang, Yake Xiang , et al. · 2024

Green huajiao has a unique flavor and is widely used in cooking as an edible spice. In this study, the intensity of overall aroma and aroma attributes of seven green huajiao samples from the Sichuan and Chongqing regions were evaluated usi…

Structure of human calcium-sensing receptor in complex with miniGi1 protein in detergent Open

Zuo H, Jaebum Park, Aurel Frangaj, Ye J, Lu Gao , et al. · 2024

Structure of human calcium-sensing receptor in complex with chimeric Gq (miniGisq) protein in detergent Open

Zuo H, Jaebum Park, Aurel Frangaj, Ye J, Lu Gao , et al. · 2024

Structure of human calcium-sensing receptor in complex with chimeric Gq (miniGisq) protein in nanodiscs Open

Zuo H, Jaebum Park, Aurel Frangaj, Ye J, Lu Gao , et al. · 2024

Structure of human calcium-sensing receptor in complex with Gi3 protein in nanodiscs Open

Zuo H, Jaebum Park, Aurel Frangaj, Ye J, Lu Gao , et al. · 2024

Machine learning identifies cell-free DNA 5-hydroxymethylation biomarkers that detect occult colorectal cancer in PLCO Screening Trial subjects Open

Diana C. West-Szymanski, Zhou Zhang, Xiaolong Cui, Krissana Kowitwanich, Lu Gao , et al. · 2024

Background Colorectal cancer (CRC) is a leading cause of cancer-related mortality, and CRC detection through screening improves survival rates. A promising avenue to improve patient screening compliance is the development of minimally-inva…

Efficient Dual Functional Hydrogen Production Synergistic Degradation of Organic Pollutants by Hydroxyl and Cyano Group Modified Crystalline G-C3n4 Under Visible Light Open

Chaofan Yuan, Na Tian, Lu Gao, Hongwei Huang, Yihe Zhang · 2024

Smart Roads: Roadside Perception, Vehicle-Road Cooperation and Business Model Open

Rui Chen, Lu Gao, Yutian Liu, Yong Liang Guan, Yan Zhang · 2023

Smart roads have become an essential component of intelligent transportation systems (ITS). The roadside perception technology, a critical aspect of smart roads, utilizes various sensors, roadside units (RSUs), and edge computing devices t…

Smart Roads: Roadside Perception, Vehicle-Road Cooperation and Business Model Open

Rui Chen, Lu Gao, Yutian Liu, Yong Liang Guan, Yan Zhang · 2023

Smart roads have become an essential component of intelligent transportation systems (ITS). The roadside perception technology, a critical aspect of smart roads, utilizes various sensors, roadside units (RSUs), and edge computing devices t…

Smart Roads: Roadside Perception, Vehicle-Road Cooperation and Business Model Open

Rui Chen, Lu Gao, Yutian Liu, Yong Liang Guan, Yan Zhang · 2023

Smart roads have become an essential component of intelligent transportation systems (ITS). The roadside perception technology, a critical aspect of smart roads, utilizes various sensors, roadside units (RSUs), and edge computing devices t…

Genetic Causal Association between Rheumatoid Arthritis and Periodontitis: A Bidirectional Two-Sample Mendelian Randomization Analysis Open

Zijian Cheng, Lu Gao, Peng Huang, Dingwen Luo, Chun‐Sheng Bi , et al. · 2023

Background A link between rheumatoid arthritis (RA) and periodontitis (PD) has been established. However, their causal relationship remains unclear and the effect of different serotypes of RA on the PD development has not been investigated…

Enantioconvergent construction of stereogenic silicon via Lewis base-catalyzed dynamic kinetic silyletherification of racemic chlorosilanes Open

Tianbao Hu, Zhao Chen, Yan Zhang, Yuzhong Kuang, Lu Gao , et al. · 2023

Enabling programmable dynamic DNA chemistry using small-molecule DNA binders Open

Junpeng Xu, Guan A. Wang, Lu Gao, Lang Wu, Qian Lei , et al. · 2023

The binding of small molecules to the double helical structure of DNA, through either intercalation or minor groove binding, may significantly alter the stability and functionality of DNA, which is a fundamental basis for many therapeutic …

The Novel Role of Zfp296 in Mammalian Embryonic Genome Activation as an H3K9me3 Modulator Open

Lu Gao, Zihan Zhang, Xiaoman Zheng, Fan Wang, Yi Deng , et al. · 2023

The changes in epigenetic modifications during early embryonic development significantly impact mammalian embryonic genome activation (EGA) and are species-conserved to some degree. Here, we reanalyzed the published RNA-Seq of human, mouse…

Development of CRISPR Cas9, spin-off technologies and their application in model construction and potential therapeutic methods of Parkinson’s disease Open

Jiangbo Qu, Na Liu, Lu Gao, Jia Hu, Miao Sun , et al. · 2023

Parkinson’s disease (PD) is one of the most common degenerative diseases. It is most typically characterized by neuronal death following the accumulation of Lewis inclusions in dopaminergic neurons in the substantia nigra region, with clin…

Comparisons are Odious? The Neural Mechanism of Intergroup and Intragroup Social Comparison among Game Players : An fMRI Study Open

Zijie Fang, Hongwei Wen, Lu Gao · 2023

Social comparison is an important way for individuals to define their social characteristics, and online games with a large number of social information provide a convenient platform for social comparison between players. At the same time,…

Flexible All-Solid-State Fiber Supercapacitor Based on Mxene-Pan Nanofibre@Polypyrrole Yarn Open

Lei Shi, Zeyu Wang, Lu Gao, Yun Wang, Hao Liu , et al. · 2023

Analysis of genome-wide 5-hydroxymethylation of blood samples stored in different anticoagulants: opportunities for the expansion of clinical resources for epigenetic research Open

Lu Gao, Zhou Zhang, Xiaolong Cui, Diana C. West-Szymanski, Chang Ye , et al. · 2023

Background: Elucidating epigenetic mechanisms could provide new biomarkers for disease diagnosis and prognosis. Technological advances allow genome-wide profiling of 5-hydroxymethylcytosines (5hmC) in liquid biopsies. 5hmC-Seal followed by…

Supplementary Material for: Distinguishing intracranial diabetes-related atherosclerotic plaques : A high-resolution MRI-based radiomics study Open

Carlos Díaz Q, Li H, Jia Liu, Zhou C.S., Hao Liu , et al. · 2023

Introduction: Diabetes markedly affects the formation and development of intracranial atherosclerosis. The study was aimed at evaluating whether radiomics features can help distinguish plaques primarily associated with diabetes. Materials …

Midpalatal Suture: Single-Cell RNA-Seq Reveals Intramembrane Ossification and Piezo2 Chondrogenic Mesenchymal Cell Involvement Open

Lu Gao, Tiansong Xu, Liqi Zhang, Yuchen Li, Tianxing Yan , et al. · 2022

The midpalatal suture is mainly responsible for the growth and development of the maxillary and resistance to rapid maxillary expansion (RME). It is essential for clinical researchers to explore the intramembrane ossification and to elucid…

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