Xuemei Tan
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View article: Early-life antibiotic exposure leads to gut microbial dysbiosis associated with neurodevelopment and neuroregeneration
Early-life antibiotic exposure leads to gut microbial dysbiosis associated with neurodevelopment and neuroregeneration Open
Early-life is a critical period for neurodevelopment and establishment of gut microbiota, which are highly susceptible to antibiotic exposure. Here, we aimed to investigate association between gut microbiota and metabolites with neurodevel…
View article: METTL16 participates in haemoglobin H disease through m6A modification
METTL16 participates in haemoglobin H disease through m6A modification Open
Background Haemoglobin H (HbH) disease is caused by a disorder of α-globin synthesis, and it results in a wide range of clinical symptoms. M 6 A methylation modification may be one of the mechanisms of heterogeneity. Therefore, this articl…
View article: Systematic metabolic engineering of Zymomonas mobilis for β-farnesene production
Systematic metabolic engineering of Zymomonas mobilis for β-farnesene production Open
Zymomonas mobilis is an ethanologenic bacterium that can produce hopanoids using farnesyl pyrophosphate (FPP), which can be used as the precursor by β-farnesene synthase for β-farnesene production. To explore the possibility and bottleneck…
View article: Exploring the key deteriorative microorganisms on ancient ivories unearthed from the Sanxingdui Ruins site during temporary cold storage
Exploring the key deteriorative microorganisms on ancient ivories unearthed from the Sanxingdui Ruins site during temporary cold storage Open
Introduction The ancient ivories unearthed from the Sanxingdui Ruins site are valuable cultural relics, however, the microbial biodeterioration on ivories during temporary cold storage poses a great threat to their later long-term preserva…
View article: Identification and verification of diagnostic biomarkers in recurrent pregnancy loss via machine learning algorithm and WGCNA
Identification and verification of diagnostic biomarkers in recurrent pregnancy loss via machine learning algorithm and WGCNA Open
Background Recurrent pregnancy loss defined as the occurrence of two or more pregnancy losses before 20-24 weeks of gestation, is a prevalent and significant pathological condition that impacts human reproductive health. However, the under…
View article: USP39 stabilizes β-catenin by deubiquitination and suppressing E3 ligase TRIM26 pre-mRNA maturation to promote HCC progression
USP39 stabilizes β-catenin by deubiquitination and suppressing E3 ligase TRIM26 pre-mRNA maturation to promote HCC progression Open
Ubiquitin-specific protease 39(USP39) plays an important role in modulating pre-mRNA splicing and ubiquitin-proteasome dependent proteolysis as a member of conserved deubiquitylation family. Accumulating evidences prove that USP39 particip…
View article: MiR-135a-5p suppresses trophoblast proliferative, migratory, invasive, and angiogenic activity in the context of unexplained spontaneous abortion
MiR-135a-5p suppresses trophoblast proliferative, migratory, invasive, and angiogenic activity in the context of unexplained spontaneous abortion Open
Background Spontaneous abortions (SA) is amongst the most common complications associated with pregnancy in humans, and the underlying causes cannot be identified in roughly half of SA cases. We found miR-135a-5p to be significantly upregu…
View article: Genome assembly of primitive cultivated potato <i>Solanum stenotomum</i> provides insights into potato evolution
Genome assembly of primitive cultivated potato <i>Solanum stenotomum</i> provides insights into potato evolution Open
Genetic diversity is the raw material for germplasm enhancement. Landraces and wild species relatives of potato, which contain a rich gene pool of valuable agronomic traits, can provide insights into the genetic diversity behind the adapta…
View article: Interplay between nuclear factor erythroid 2-related factor 2 and inflammatory mediators in COVID-19-related liver injury
Interplay between nuclear factor erythroid 2-related factor 2 and inflammatory mediators in COVID-19-related liver injury Open
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 is a global pandemic and poses a major threat to human health worldwide. In addition to respiratory symptoms, COVID-19 is usually accompanied by …
View article: Hengshun Aromatic Vinegar Improves Glycolipid Metabolism in Type 2 Diabetes Mellitus via Regulating PGC-1α/PGC-1β Pathway
Hengshun Aromatic Vinegar Improves Glycolipid Metabolism in Type 2 Diabetes Mellitus via Regulating PGC-1α/PGC-1β Pathway Open
Hengshun aromatic vinegar (HSAV), produced by typical solid-state or liquid-state fermentation techniques, is consumed worldwide as a food condiment. HSAV shows multiple bioactivities, but its activity in type 2 diabetes mellitus (T2DM) an…
View article: 3D disorganization and rearrangement of genome provide insights into pathogenesis of NAFLD by integrated Hi-C, Nanopore, and RNA sequencing
3D disorganization and rearrangement of genome provide insights into pathogenesis of NAFLD by integrated Hi-C, Nanopore, and RNA sequencing Open
The three-dimensional (3D) conformation of chromatin is integral to the precise regulation of gene expression. The 3D genome and genomic variations in non-alcoholic fatty liver disease (NAFLD) are largely unknown, despite their key roles i…
View article: Diversity and structure of soil microbiota of the Jinsha earthen relic
Diversity and structure of soil microbiota of the Jinsha earthen relic Open
In order to define the diversity and composition of the microbial communities colonizing of the soil microbiome of the Jinsha earthen relic, we used high-throughput sequencing technology to identify and characterize the microbiota in 22 sa…
View article: Blood Transcriptome Analysis reveals Age-associated changes in Expression Profile of Immune-Related Gene in Golden snub-nosed Monkey (Rhinopithecus roxellana)
Blood Transcriptome Analysis reveals Age-associated changes in Expression Profile of Immune-Related Gene in Golden snub-nosed Monkey (Rhinopithecus roxellana) Open
Background: Golden snub-nosed monkeys ( Rhinopithecus roxellana ) are endangered species of monkeys found in China. In this study, we provided the blood transcriptome sequences of golden snub-nosed monkeys obtained using RNA-Seq technology…
View article: Blood Transcriptome Analysis reveals Age-associated changes in Expression Profile of Immune-Related Gene in Golden snub-nosed Monkey(Rhinopithecus roxellana)
Blood Transcriptome Analysis reveals Age-associated changes in Expression Profile of Immune-Related Gene in Golden snub-nosed Monkey(Rhinopithecus roxellana) Open
Background Golden snub-nosed monkeys ( Rhinopithecus roxellana ) are an endangered species in China.In the present study, the blood transcriptomes of nine monkeys were characterized by using RNA-Seq technology.Results 57.31 Gb high-quality…
View article: Complete Genome Sequence and Characterization of a Polyethylene Biodegradation Strain, Streptomyces Albogriseolus LBX-2
Complete Genome Sequence and Characterization of a Polyethylene Biodegradation Strain, Streptomyces Albogriseolus LBX-2 Open
A bacterial strain, Streptomyces albogriseolus LBX-2, was isolated from a soil sample in Chengdu, China. S. albogriseolus LBX-2 is an aerobic and Gram-positive microorganism that is capable of using the polyethylene as the sole carbon sour…
View article: The complete mitogenome of Smith’s shrew (<i>Chodsigoa smithii</i>)
The complete mitogenome of Smith’s shrew (<i>Chodsigoa smithii</i>) Open
The Smith's shrew (Chodsigoa smithii) belongs to subfamily Soricinae, which is an endemic shrew to China. In this study, we obtained the complete mitochondrial genome of the C. smithii. This mitogenome is a circular molecule with 17,108 bp…
View article: A comprehensive assessment of Next‐Generation Sequencing variants validation using a secondary technology
A comprehensive assessment of Next‐Generation Sequencing variants validation using a secondary technology Open
Background Recently, increasing innovations improved the accuracy of next generation sequencing (NGS) data. However, the validation of all NGS variants increased the cost and turn‐around time of clinical diagnosis, and therefore limited th…
View article: Clinical diagnosis and genetic counseling of atypical ataxia‑telangiectasia in a Chinese family
Clinical diagnosis and genetic counseling of atypical ataxia‑telangiectasia in a Chinese family Open
Ataxia‑telangiectasia (A‑T) is an autosomal recessive chromosome breakage disorder caused by mutations in the ATM serine/threonine kinase (ATM) gene. Typically, it presents in early childhood with progressive cerebellar dysfunction, accomp…
View article: Co-Expression Network-based Analysis associated with potato initial resistance
Co-Expression Network-based Analysis associated with potato initial resistance Open
RNA sequencing (RNA-seq) providing genome-wide expression datasets has been successfully used to study gene expression patterns and regulation mechanism among multiple samples. Gene co-expression networks (GCNs) studies within or across sp…
View article: Genome comparison of different Zymomonas mobilis strains provides insights on conservation of the evolution
Genome comparison of different Zymomonas mobilis strains provides insights on conservation of the evolution Open
Zymomonas mobilis has the special Entner-Doudoroff (ED) pathway and it has excellent industrial characteristics, including low cell mass formation, high-specific productivity,ethanol yield, notable ethanol tolerance and wide pH range, a re…
View article: RecET recombination system driving chromosomal target gene replacement in Zymomonas mobilis
RecET recombination system driving chromosomal target gene replacement in Zymomonas mobilis Open
Background: Zymomonas mobilis is a Gram-negative microaerophilic bacterium with excellent ethanol-producing capabilities. The RecET recombination system provides an efficient tool for direct targeting of genes in the bacterial chromosome b…
View article: Additional file 6: of Transcriptome profiling analysis reveals metabolic changes across various growth phases in Bacillus pumilus BA06
Additional file 6: of Transcriptome profiling analysis reveals metabolic changes across various growth phases in Bacillus pumilus BA06 Open
List of the differentially expressed genes assigned to protein secretion systems by KEGG analysis. (XLSX 17Â kb)
View article: Additional file 7: of Transcriptome profiling analysis reveals metabolic changes across various growth phases in Bacillus pumilus BA06
Additional file 7: of Transcriptome profiling analysis reveals metabolic changes across various growth phases in Bacillus pumilus BA06 Open
List of the differentially expressed genes encoding regulatory proteins and the sigma factors. (XLSX 19Â kb)
View article: Additional file 9: of Transcriptome profiling analysis reveals metabolic changes across various growth phases in Bacillus pumilus BA06
Additional file 9: of Transcriptome profiling analysis reveals metabolic changes across various growth phases in Bacillus pumilus BA06 Open
List of the differentially expressed genes assigned as the â Stress Responseâ subsystem by RAST analysis. (XLSX 37Â kb)
View article: Additional file 4: of Transcriptome profiling analysis reveals metabolic changes across various growth phases in Bacillus pumilus BA06
Additional file 4: of Transcriptome profiling analysis reveals metabolic changes across various growth phases in Bacillus pumilus BA06 Open
List of the differentially expressed genes involved in flagellar assembly and the chemotaxis signaling pathway enriched by KEGG analysis. (XLSX 34Â kb)
View article: Additional file 5: of Transcriptome profiling analysis reveals metabolic changes across various growth phases in Bacillus pumilus BA06
Additional file 5: of Transcriptome profiling analysis reveals metabolic changes across various growth phases in Bacillus pumilus BA06 Open
List of the differentially expressed genes involved in dormancy and sporulation by RAST analysis. (XLSX 45Â kb)