Explanipedia

Transposable element expression and sub-cellular dynamics during hPSC differentiation to endoderm, mesoderm, and ectoderm lineages Open

Isaac A. Babarinde, Xiuling Fu, Gang Ma, Yuhao Li, Zhendong Liang , et al. · 2025

Characterizing resistant cellular states in nasopharyngeal carcinoma during EBV lytic induction Open

Xinlei Wang, Lei Yu, Xuemeng Zhou, Grace Tin‐Yun Chung, Alyssa Ming-Ting Liu , et al. · 2025

The pervasive occurrence of nasopharyngeal carcinoma (NPC) is intricately linked to Epstein–Barr virus (EBV) infection, making EBV and its associated pathways promising therapeutic targets for NPC and other EBV-related cancers. Lytic induc…

Dissecting the Contribution of Transposable Elements to Interphase Chromosome Structure Open

Liyang Shi, Zhen Xiao, Isaac A. Babarinde, Fu Xiuling, Gang Ma , et al. · 2024

Transposable elements (TEs) occupy nearly half of the human genome and play diverse biological roles. Despite their abundance, the extent to which TEs contribute to three-dimensional (3D) genome structure remains unclear. To investigate th…

A primate-specific endogenous retroviral envelope protein sequesters SFRP2 to regulate human cardiomyocyte development Open

Ran Zhang, Menghua Wu, Dan Xiang, Jieying Zhu, Qi Zhang , et al. · 2024

Endogenous retroviruses (ERVs) occupy a significant part of the human genome, with some encoding proteins that influence the immune system or regulate cell-cell fusion in early extra-embryonic development. However, whether ERV-derived prot…

Transposable Element Expression and Sub-cellular Dynamics During hPSC Differentiation to Endoderm, Mesoderm, and Ectoderm Lineages Open

Isaac A. Babarinde, Xiuling Fu, Gang Ma, Yuhao Li, Mobolaji T. Akinwole , et al. · 2024

Transposable elements (TEs) are genomic elements that are found in multiple copies in mammalian genomes. TEs were previously thought to have little functional relevance but recent studies have reported TE roles in multiple biological proce…

Single‐cell RNA sequencing reveals immune cell dysfunction in the peripheral blood of patients with highly aggressive gastric cancer Open

Rui Ma, Xuemeng Zhou, Xiaohui Zhai, Chuyue Wang, Rong Hu , et al. · 2024

Highly aggressive gastric cancer (HAGC) is a gastric cancer characterized by bone marrow metastasis and disseminated intravascular coagulation (DIC). Information about the disease is limited. Here we employed single‐cell RNA sequencing to …

Single-cell analysis reveals transcriptomic and epigenomic impacts on the maternal–fetal interface following SARS-CoV-2 infection Open

Lin Gao, Vrinda Mathur, Sabrina Ka Man Tam, Xuemeng Zhou, Ming Fung Cheung , et al. · 2023

During pregnancy the maternal–fetal interface plays vital roles in fetal development. Its disruption is frequently found in pregnancy complications. Recent studies show increased incidences of adverse pregnancy outcomes in patients with CO…

A high-performance wordline voltage-generating system for low-power low-voltage flash memory Open

Xuemeng Zhou, Han Yan, Ming Ni · 2023

Wordline (WL) voltage-generating system is a crucial block in flash memory. It generates a voltage higher than the supply voltage for reading, programming and erasing in flash memory. However, operation accuracy is deteriorated by the exce…

Transposable Elements in Pluripotent Stem Cells and Human Disease Open

Gang Ma, Isaac A. Babarinde, Xuemeng Zhou, Andrew P. Hutchins · 2022

Transposable elements (TEs) are mobile genetic elements that can randomly integrate into other genomic sites. They have successfully replicated and now occupy around 40% of the total DNA sequence in humans. TEs in the genome have a complex…

SARS-CoV-2 impacts the transcriptome and epigenome at the maternal-fetal interface in pregnancy Open

Lin Gao, Vrinda Mathur, Sabrina Ka Man Tam, Xuemeng Zhou, Ming Fung Cheung , et al. · 2022

During pregnancy, the maternal-fetal interface plays vital roles in fetal development. Its disruption is frequently found in pregnancy complications. Recent works show increased incidences of adverse pregnancy outcomes in COVID-19 patients…

Channel Estimation and Projection for RIS-assisted MIMO Using Zadoff-Chu Sequences Open

Xuemeng Zhou, Zhiyu Yang, Tianyi Zhang, Yi Jiang · 2022

The reconfigurable intelligent surface (RIS) technology is a promising enabler for millimeter wave (mmWave) wireless communications, as it can potentially provide spectral efficiency comparable to the conventional massive multiple-input mu…

Mouse strain-specific polymorphic provirus functions as cis-regulatory element leading to epigenomic and transcriptomic variations Open

Xuemeng Zhou, Tsz Wing Sam, Ah Young Lee, Danny Leung · 2021

Polymorphic integrations of endogenous retroviruses (ERVs) have been previously detected in mouse and human genomes. While most are inert, a subset can influence the activity of the host genes. However, the molecular mechanism underlying h…

Replication timing maintains the global epigenetic state in human cells Open

Kyle N. Klein, Peiyao A Zhao, Xiaowen Lyu, Takayo Sasaki, Daniel A. Bartlett , et al. · 2021

Replication timing organizes epigenome The temporal order of DNA replication is conserved from yeast to humans, but its biological significance remains unclear. Klein et al. eliminated the protein RIF1, a master regulator of replication ti…

Replication timing maintains the global epigenetic state in human cells Open

Kyle N. Klein, Peiyao A Zhao, Xiaowen Lyu, Daniel A. Bartlett, Amar M. Singh , et al. · 2019

DNA is replicated in a defined temporal order termed the replication timing (RT) program. RT is spatially segregated in the nucleus with early/late replication corresponding to Hi-C A/B chromatin compartments, respectively. Early replicati…

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