Xu Zhao
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View article: EXO1 overexpression induces homologous recombination deficiency and enhances PARP inhibitor sensitivity in ER-positive breast cancer: modulation by N4BP2L2-Mediated restoration
EXO1 overexpression induces homologous recombination deficiency and enhances PARP inhibitor sensitivity in ER-positive breast cancer: modulation by N4BP2L2-Mediated restoration Open
Exonuclease 1 (EXO1) is a critical enzyme in homologous recombination (HR) and is implicated in cancer progression, with overexpression linked to poor prognosis in multiple tumor types. Yet, the impact of EXO1 overexpression on HR efficien…
View article: 385 A bispecific engager-secreting TIL therapy designed to penetrate stromal barriers and boost tumor killing in solid tumors
385 A bispecific engager-secreting TIL therapy designed to penetrate stromal barriers and boost tumor killing in solid tumors Open
View article: Transcriptomic Analysis of Different Growth Stages of Hymenopellis radicata (Changgenggu)
Transcriptomic Analysis of Different Growth Stages of Hymenopellis radicata (Changgenggu) Open
View article: SLC7A11 as a bridge between ferroptosis and disulfidptosis: a promising target for tumor treatment
SLC7A11 as a bridge between ferroptosis and disulfidptosis: a promising target for tumor treatment Open
View article: Optimal Decision-Making for Annuity Insurance Under the Perspective of Disability Risk
Optimal Decision-Making for Annuity Insurance Under the Perspective of Disability Risk Open
Annuity insurance is a crucial financial tool for mitigating risks associated with aging, yet it has not gained significant traction in China’s insurance market, especially amid the challenges posed by an aging population. This study devel…
View article: Targeted inhibition of MLKL-mediated necroptosis attenuates chronic arsenite exposure-induced lung injury
Targeted inhibition of MLKL-mediated necroptosis attenuates chronic arsenite exposure-induced lung injury Open
Arsenic, a ubiquitous environmental toxicant, poses a global public health concern through drinking water contamination. While chronic arsenic exposure is epidemiologically associated with respiratory diseases, the molecular mechanisms dri…
View article: Parabacteroides as a promising target for disease intervention: current stage and pending issues
Parabacteroides as a promising target for disease intervention: current stage and pending issues Open
View article: MicroRNA-7 as a multifaceted regulator of tumor glycolytic metabolism: Mechanistic insights and therapeutic perspectives
MicroRNA-7 as a multifaceted regulator of tumor glycolytic metabolism: Mechanistic insights and therapeutic perspectives Open
Aberrant glycolysis is a hallmark of tumor and a key oncogenic driver. However, the complex regulatory networks and dynamic signaling interactions governing glycolysis within the tumor microenvironment (TME) remain incompletely understood,…
View article: The Association Between Combined Key Macroelement Exposure and Hypertension Risk Among Permanent Residents in the Qinling-Daba Mountain Region of China
The Association Between Combined Key Macroelement Exposure and Hypertension Risk Among Permanent Residents in the Qinling-Daba Mountain Region of China Open
View article: Modular Design of a self-amplifying mRNA Vaccine for Multivalent Immunization Against Neisseria meningitidis B
Modular Design of a self-amplifying mRNA Vaccine for Multivalent Immunization Against Neisseria meningitidis B Open
View article: Mitigating product defect incidents through blockchain adoption: who should lead the initiative?
Mitigating product defect incidents through blockchain adoption: who should lead the initiative? Open
View article: Robust and High Self-Healing Efficiency Polyamidourea Based on Multiple Hydrogen and Disulfide Bonds with Suitably Packed Hard Segment Domains Strategy
Robust and High Self-Healing Efficiency Polyamidourea Based on Multiple Hydrogen and Disulfide Bonds with Suitably Packed Hard Segment Domains Strategy Open
View article: Dipeptide PA3264 derived from rare and endangered Squama Manis is a novel bioactive peptide for the treatment of triple-negative breast cancer
Dipeptide PA3264 derived from rare and endangered Squama Manis is a novel bioactive peptide for the treatment of triple-negative breast cancer Open
Background Squama Manis is a valuable traditional Chinese medicine with a long history of medicinal use in the treatment of breast-related diseases. However, owing to the excessive exploitation and utilization of the resources, Squama Mani…
View article: A potentially underestimated predictor of coronary artery disease risk: The ApoB/ApoA1 ratio
A potentially underestimated predictor of coronary artery disease risk: The ApoB/ApoA1 ratio Open
View article: Association of serum 25-hydroxyvitamin D levels, vitamin D-binding protein levels, and diabetes mellitus: Two-sample Mendelian randomization
Association of serum 25-hydroxyvitamin D levels, vitamin D-binding protein levels, and diabetes mellitus: Two-sample Mendelian randomization Open
Studies have suggested that Vitamin D deficiency is associated with the occurrence of both type 1 and type 2 diabetes, and that vitamin D-binding proteins (VDBP) are necessary for metabolic stress in pancreatic α-cells. However, the causal…
View article: Evaluating the link between DIO3-FA27 promoter methylation, biochemical indices, and heart failure progression
Evaluating the link between DIO3-FA27 promoter methylation, biochemical indices, and heart failure progression Open
Background Heart failure (HF) is a disease that poses a serious threat to individual health, and DNA methylation is an important mechanism in epigenetics, and its role in the occurrence and development of the disease has attracted more and…
View article: MAPK4 facilitates angiogenesis by inhibiting the ERK pathway in non‐small cell lung cancer
MAPK4 facilitates angiogenesis by inhibiting the ERK pathway in non‐small cell lung cancer Open
Background Angiogenesis plays an important role in the occurrence and development of non‐small cell lung cancer (NSCLC). The atypical mitogen‐activated protein kinase 4 (MAPK4) has been shown to be involved in the pathogenesis of various d…
View article: The motor-clutch model in mechanobiology and mechanomedicine
The motor-clutch model in mechanobiology and mechanomedicine Open
Cellular behaviors such as migration, spreading, and differentiation arise from the interplay of cell-matrix interactions. The comprehension of this interplay has been advanced by the motor-clutch model, a theoretical framework that captur…
View article: The role of amino acid metabolism in autoimmune hepatitis
The role of amino acid metabolism in autoimmune hepatitis Open
Autoimmune hepatitis (AIH) is an inflammatory chronic liver disease with persistent and recurrent immune-mediated liver injury. The exact cause of AIH is still not fully understood, but it is believed to be primarily due to an abnormal act…
View article: MicroRNA‐7 deficiency ameliorates <scp>d</scp>‐galactose‐induced aging in mice by regulating senescence of Kupffer cells
MicroRNA‐7 deficiency ameliorates <span>d</span>‐galactose‐induced aging in mice by regulating senescence of Kupffer cells Open
Aging is intricately linked to immune system dysfunction. Recent studies have highlighted the biological function of microRNA‐7 (miR‐7) as a novel regulator of immune cell function and related diseases. However, the potential role of miR‐7…
View article: Advances in metabolic reprogramming of NK cells in the tumor microenvironment on the impact of NK therapy
Advances in metabolic reprogramming of NK cells in the tumor microenvironment on the impact of NK therapy Open
Natural killer (NK) cells are unique from other immune cells in that they can rapidly kill multiple neighboring cells without the need for antigenic pre-sensitization once the cells display surface markers associated with oncogenic transfo…
View article: Targeting lipid metabolism of macrophages: A new strategy for tumor therapy
Targeting lipid metabolism of macrophages: A new strategy for tumor therapy Open
View article: Promoter A1312C mutation leads to microRNA-7 downregulation in human non-small cell lung cancer
Promoter A1312C mutation leads to microRNA-7 downregulation in human non-small cell lung cancer Open
MicroRNA-7 (miRNA-7, miR-7) is a unique class of tumor suppressors, plays an important role in various physiological and pathological processes including human non-small cell lung cancer (NSCLC). In previous works, we revealed that miR-7 c…
View article: Erythrocyte‐Leveraged Oncolytic Virotherapy (ELeOVt): Oncolytic Virus Assembly on Erythrocyte Surface to Combat Pulmonary Metastasis and Alleviate Side Effects (Adv. Sci. 5/2024)
Erythrocyte‐Leveraged Oncolytic Virotherapy (ELeOVt): Oncolytic Virus Assembly on Erythrocyte Surface to Combat Pulmonary Metastasis and Alleviate Side Effects (Adv. Sci. 5/2024) Open
Erythrocyte‐Leveraged Oncolytic Virotherapy In article number 2303907, Funan Liu, Zhiqing Pang, Zhenning Wang, and their colleagues, present a straightforward and effective strategy known as erythrocyte‐leveraged oncolytic virotherapy (ELe…
View article: DOP90 Amphiregulin promotes colitis-associated intestinal fibrosis through activation of PI3K/AKT signaling in Intestinal fibroblasts
DOP90 Amphiregulin promotes colitis-associated intestinal fibrosis through activation of PI3K/AKT signaling in Intestinal fibroblasts Open
Background Intestinal fibrosis is one of the most threatening complications of Crohn’s disease (CD). Amphiregulin (AREG) expression is increased in patients with CD with fibrosis. Methods The role of AREG in activating intestinal fibroblas…
View article: Research progress on the role of tumor‑associated macrophages in tumor development and their use as molecular targets (Review)
Research progress on the role of tumor‑associated macrophages in tumor development and their use as molecular targets (Review) Open
The tumor microenvironment (TME) is a complex system composed mainly of tumor cells, mesenchymal cells and immune cells. Macrophages, also known as tumor‑associated macrophages (TAMs), among innate immune cells, are some of the most abunda…
View article: Reference gene selection for quantitative real-time PCR analysis of Hymenopellis radicata under abiotic stress
Reference gene selection for quantitative real-time PCR analysis of Hymenopellis radicata under abiotic stress Open
Hymenopellis radicata (H. radicata) is an edible fungus rich in protein and mineral elements, with high edible and medical value. And reference genes suitable for normalization of qRT-PCR data from this species have not been investigated. …
View article: Intestinal microbiota: A bridge between intermittent fasting and tumors
Intestinal microbiota: A bridge between intermittent fasting and tumors Open
Intestinal microbiota and their metabolites are essential for maintaining intestinal health, regulating inflammatory responses, and enhancing the body's immune function. An increasing number of studies have shown that the intestinal microb…
View article: Akkermansia muciniphila: A potential target and pending issues for oncotherapy
Akkermansia muciniphila: A potential target and pending issues for oncotherapy Open
In the wake of the development of metagenomic, metabolomic, and metatranscriptomic approaches, the intricate interactions between the host and various microbes are now being progressively understood. Numerous studies have demonstrated evid…
View article: Enhancement effects of extracellular fluid viscosity and matrix stiffness on cancer cell mechanosensing
Enhancement effects of extracellular fluid viscosity and matrix stiffness on cancer cell mechanosensing Open
Cancer cells are in vivo situated in a complex and heterogeneous tumor microenvironment (TME) that includes various biochemical and biophysical cues, such as the elasticity of extracellular matrix (ECMwo) and the viscosity of extracellular…