Xueming Meng
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View article: Chaperonin TRiC bridges radial spokes for folding proteins locally translated in mammalian sperm flagella
Chaperonin TRiC bridges radial spokes for folding proteins locally translated in mammalian sperm flagella Open
As animals evolved from external to internal fertilization, sperm flagella, which once transiently propelled sperm in water to reach nearby eggs, developed to beat for days or even longer within the female reproductive tract. How flagella …
View article: An immobilized antibody-based affinity grid strategy for on-grid purification of target proteins enables high-resolution cryo-EM
An immobilized antibody-based affinity grid strategy for on-grid purification of target proteins enables high-resolution cryo-EM Open
In cryo-electron microscopy (cryo-EM), sample preparation poses a critical bottleneck, particularly for rare or fragile macromolecular assemblies and those suffering from denaturation and particle orientation distribution issues related to…
View article: Development of immobilized antibody-based affinity grid strategy and application in on-grid purification of target proteins for high-resolution cryo-EM
Development of immobilized antibody-based affinity grid strategy and application in on-grid purification of target proteins for high-resolution cryo-EM Open
In cryo-electron microscopy (cryo-EM), sample preparation, especially for rare or fragile macromolecular assemblies and those suffering from air-water interface denaturation and particle orientation distribution problems, is a major bottle…
View article: Multi-scale structures of the mammalian radial spoke and divergence of axonemal complexes in ependymal cilia
Multi-scale structures of the mammalian radial spoke and divergence of axonemal complexes in ependymal cilia Open
Radial spokes (RS) transmit mechanochemical signals between the central pair (CP) and axonemal dynein arms to coordinate ciliary motility. Atomic-resolution structures of metazoan RS and structures of axonemal complexes in ependymal cilia,…