Explanipedia

Somatic repetitive element insertions Define New Biomarkers in Pan-cancer genome Open

Xia Lin, Kailing Tu, Huan Wang, Xuyan Liu, Yahui Liu , et al. · 2025

Repetitive elements insertions (REIs), including tandem repeat insertions (TRIs) and transposable element insertions (TEIs), constitute >90% of large-scale (>50bp) somatic insertions and are linked to diseases and cancer biomarkers. Howeve…

Landscape of Large-Scale Somatic Genomic Insertions in Non-Small Cell Lung Carcinoma Revealed by Nanopore Sequencing Open

Dan Xie, Xia Lin, Zhoufeng Wang, Tianfu Zeng, Xuenan Pi , et al. · 2023

Previous NSCLC genomic studies were mostly based on the next-generation sequencing of short reads, which is an efficient approach for identifying single nucleotide variants and small indels but ineffective for identifying structural varian…

Integrated fragmentomic profile and 5-Hydroxymethylcytosine of capture-based low-pass sequencing data enables pan-cancer detection via cfDNA Open

Zhidong Zhang, Xuenan Pi, Chang Gao, Jun Zhang, Xia Lin , et al. · 2023

Integrated fragmentomic profile and 5-Hydroxymethylcytosine of capture-based low-pass sequencing data enables pan-cancer detection via cfDNA Open

Zhidong Zhang, Xuenan Pi, Chang Gao, Jun Zhang, Xia Lin , et al. · 2022

Using epigenetic markers and fragmentomics of cell-free DNA for cancer detection has been proven applicable. We further combine the two features and explore the diagnostic potential of the features on pan-cancer detection. We extracted cfD…

Clinical significance of T cell receptor repertoire in primary Sjogren's syndrome Open

Chenyang Lu, Xuenan Pi, Wang‐Dong Xu, Pingying Qing, Honghu Tang , et al. · 2022

Gout inheritance in an extended Chinese family analyzed by whole-exome sequencing Open

Peiqing Yang, Xuenan Pi, Tony N. Marion, Jing Wang, Gang Wang , et al. · 2020

In the case of this family, the GWAS identified gout and UC-related nucleotide sequence variants may increase the risk of developing gout, but penetrance was not complete. The rare sequence variants in low-density lipoprotein receptor-rela…

Susceptibility-guided bismuth quadruple therapies for resistant <i>Helicobacter pylori</i> infections Open

Tiankuo Yang, Renwei Hu, Xiaoqiong Tang, Yalin Shen, Chin Yen Tay , et al. · 2020

Increasing Helicobacter pylori resistance to antibiotics has ledthat molecular testing is appropriate as a sub to adoption of seven different bismuth quadruple therapies (BQT) in China without differentiation of first-line or second-line r…

East-Asian Helicobacter pylori strains synthesize heptan-deficient lipopolysaccharide Open

Hong Li, Michaël Marceau, Tiandi Yang, Tingting Liao, Xiaoqiong Tang , et al. · 2019

The lipopolysaccharide O-antigen structure expressed by the European Helicobacter pylori model strain G27 encompasses a trisaccharide, an intervening glucan-heptan and distal Lewis antigens that promote immune escape. However, several gaps…

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