Explanipedia

Indisulam exerts anticancer effects via modulation of transcription, translation and alternative splicing on human cervical cancer cells. Open

Zhihui Dou, Xuetian Zhang, Wei Su, Taotao Zhang, Fei Ye , et al. · 2023

Indisulam is a synthetic sulfonamides drug with anticancer activity in various tumors. However, the effect and molecular mechanism of indisulam have still not been studied in human cervical cancer. We treated human cervical cancer cell lin…

RNA-binding protein 39: a promising therapeutic target for cancer Open

Caipeng Xu, Xiaohua Chen, Xuetian Zhang, Dapeng Zhao, Zhihui Dou , et al. · 2021

RNA-binding motif protein 39 (RBM39), as a key factor in tumor-targeted mRNA and protein expression, not only plays a vital role in tumorigenesis, but also has broad development prospects in clinical treatment and drug research. Moreover, …

Aberrant Bcl-x splicing in cancer: from molecular mechanism to therapeutic modulation Open

Zhihui Dou, Dapeng Zhao, Xiaohua Chen, Caipeng Xu, Xiaodong Jin , et al. · 2021

Crosstalk of the Caspase Family and Mammalian Target of Rapamycin Signaling Open

Junfang Yan, Yi Xie, Jing Si, Lu Gan, Hongyan Li , et al. · 2021

Cell can integrate the caspase family and mammalian target of rapamycin (mTOR) signaling in response to cellular stress triggered by environment. It is necessary here to elucidate the direct response and interaction mechanism between the t…

A SNP involved in alternative splicing of ABCB1 is associated with clopidogrel resistance in coronary heart disease in Chinese population Open

Shasha Zhang, Jing Wang, Anan Zhang, Xiaowei Zhang, Tao You , et al. · 2020

Although many scientists are studying the association between genetic polymorphism of ABCB1 and CR in patients, the molecular mechanism has not been further studied in patients with CHD. This study investigated the relationship betw…

Multilevel regulation and molecular mechanism of poly (rC)‐binding protein 1 in cancer Open

Xuetian Zhang, Cuixia Di, Yuhong Chen, Jing Wang, Ruowei Su , et al. · 2020

Poly (rC)‐binding protein 1 (PCBP1), an RNA‐ or DNA‐binding protein with a relative molecular weight of 38 kDa, which is characterized by downregulation in many cancer types. Numerous cases have indicated that PCBP1 could be considered as …

Overexpression of splicing factor poly(rC)-binding protein 1 elicits cycle arrest, apoptosis induction, and p73 splicing in human cervical carcinoma cells Open

Hong Zhang, Yuhong Chen, Cuixia Di, Caipeng Xu, Xiaohua Chen , et al. · 2020

Background Splicing factor poly(rC)-binding protein 1 (PCBP1) is a novel tumor suppressor that is downregulated in many cancers thereby regulates tumor formation and metastasis. However, to date, little information has been available on th…

Transforming growth factor β signaling pathway: A promising therapeutic target for cancer Open

Yuhong Chen, Cuixia Di, Xuetian Zhang, Jing Wang, Fang Wang , et al. · 2019

Transforming growth factor β (TGF‐β) is part of the transforming growth factor β superfamily which is involved in many physiological processes and closely related to the carcinogenesis. Here, we discuss the TGF‐β structure, function, and i…

Inhibition of SF3b1 by pladienolide B evokes cycle arrest, apoptosis induction and p73 splicing in human cervical carcinoma cells Open

Qianjing Zhang, Cuixia Di, Junfang Yan, Fang Wang, Tao Qu , et al. · 2019

Pladienolide B is a potent cancer cell growth inhibitor that targets the SF3b1 subunit of the spliceosome. There is considerable interest in the compound as a tool to study SF3b1 function in cancer. However, so far little information is av…

Function, clinical application, and strategies of Pre-mRNA splicing in cancer Open

Cuixia Di, Syafrizayanti Syafrizayanti, Qianjing Zhang, Yuhong Chen, Yupei Wang , et al. · 2018

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