Xueting Wang
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View article: Synergistic acetate-butyrate co-utilization enhances caproate production by Clostridium kluyveri CICC 24509 under high substrate loads
Synergistic acetate-butyrate co-utilization enhances caproate production by Clostridium kluyveri CICC 24509 under high substrate loads Open
Microbial chain elongation presents a compelling circular economy strategy for converting low-value waste streams into valuable chemicals like caproate. However, realizing its full potential is hampered by challenges, including limited mic…
View article: Circular RNAs and immunotherapy in retinoblastoma: emerging biomarkers and precision therapeutic strategies
Circular RNAs and immunotherapy in retinoblastoma: emerging biomarkers and precision therapeutic strategies Open
Retinoblastoma (RB) immunotherapy represents a paradigm shift in managing this aggressive pediatric eye cancer, overcoming limitations of conventional therapies. Recent breakthroughs reveal how circular RNAs (circRNAs) critically modulate …
View article: Rectal Nanoparticulate-Hydrogel Delivery of Corticosteroid Altering Enterohepatic Metabolism and Clearance for Improved Drug Disposition
Rectal Nanoparticulate-Hydrogel Delivery of Corticosteroid Altering Enterohepatic Metabolism and Clearance for Improved Drug Disposition Open
Precise dosing is a critical aspect of determining effective therapeutics, but high enterohepatic metabolism poses a significant barrier to many administered small-molecule therapeutics. Orally given budesonide is a potent corticosteroid f…
View article: EnzymeTuning: a Deep-learning-based Toolbox for Optimizing Enzyme-constrained Metabolic Modeling with Enhanced Proteome Abundance Prediction
EnzymeTuning: a Deep-learning-based Toolbox for Optimizing Enzyme-constrained Metabolic Modeling with Enhanced Proteome Abundance Prediction Open
The accuracy of enzyme kinetic parameters, particularly the turnover number ( k cat), is critical for the predictive power of enzyme-constrained genome-scale metabolic models (ecGEMs). However, current kinetic datasets remain sparse and of…
View article: Emergence and molecular evolution of carbapenem-resistant hypervirulent ST23 <i>Klebsiella pneumoniae</i> : The superbug phenomenon in China
Emergence and molecular evolution of carbapenem-resistant hypervirulent ST23 <i>Klebsiella pneumoniae</i> : The superbug phenomenon in China Open
This study aimed to investigate the molecular epidemiology of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) ST23 in China. We conducted comprehensive searches across five databases (PubMed, Web of Science, MEDLI…
View article: A Comparison of in-vitro Pharmacokinetics and Pharmacodynamics of Branded and Its Locally Produced Cefuroxime Sodium Against Staphylococcus and Escherichia Escherichia coli
A Comparison of in-vitro Pharmacokinetics and Pharmacodynamics of Branded and Its Locally Produced Cefuroxime Sodium Against Staphylococcus and Escherichia Escherichia coli Open
The in-vitro antibacterial effect of locally produced cefuroxime sodium against Staphylococci and E. coli is comparable to that of branded cefuroxime sodium.
View article: Comparative physiological and cytological analysis, and omics approach provide clues to the coloring mechanism of the pumpkin yellow stems
Comparative physiological and cytological analysis, and omics approach provide clues to the coloring mechanism of the pumpkin yellow stems Open
These findings provide clues into the molecular mechanisms of stem yellowing, and will facilitate the exploration of candidate targets as markers or genetic improvement through molecular breeding.
View article: Lung Adenocarcinoma With Initially Co‐Occurring <scp>EGFR</scp> and <scp>BRAF</scp> Double Mutation: A Case Report and Literature Review
Lung Adenocarcinoma With Initially Co‐Occurring <span>EGFR</span> and <span>BRAF</span> Double Mutation: A Case Report and Literature Review Open
Vrafmurine sarcoma viral oncogene homolog B (BRAF) mutations, including both V600E and non‐V600E variants, are infrequent in non‐small cell lung cancer (NSCLC), representing approximately 2% of lung adenocarcinomas. Activated BRAF mutation…
View article: Mechanism of Iron Ions Redox Cycle on the Anaerobic Degradation of 3, 5, 6-Trichloro-2-Pyridinol by Pseudomonas Aeruginosa D-2
Mechanism of Iron Ions Redox Cycle on the Anaerobic Degradation of 3, 5, 6-Trichloro-2-Pyridinol by Pseudomonas Aeruginosa D-2 Open
View article: A multi-sectoral approach to antimicrobial resistance containment: Insights from One Health
A multi-sectoral approach to antimicrobial resistance containment: Insights from One Health Open
Antimicrobial resistance (AMR) has become a serious threat to global public health. By 2050, AMR is estimated to cause 1.91 million deaths annually, with related mortality reaching 8.22 million. The challenges posed by AMR extend beyond th…
View article: Study on the Characteristics of Flash Drought and the Response Regularity of Photosynthesis to Flash Drought in Different Vegetation Ecosystems in the Middle and Lower Reaches of the Yangtze River Basin.
Study on the Characteristics of Flash Drought and the Response Regularity of Photosynthesis to Flash Drought in Different Vegetation Ecosystems in the Middle and Lower Reaches of the Yangtze River Basin. Open
In recent decades, flash drought events have frequently occurred in the humid regions of southern China. Due to the sudden onset and rapid intensification of these droughts, they often cause severe damage to vegetation photosynthesis. Our …
View article: Understanding carbapenem-resistant hypervirulent Klebsiella pneumoniae: Key virulence factors and evolutionary convergence
Understanding carbapenem-resistant hypervirulent Klebsiella pneumoniae: Key virulence factors and evolutionary convergence Open
The emergence of hypervirulence (hv) and carbapenem resistance (CR) as distinct evolutionary directions for Klebsiella pneumoniae presents a significant threat in clinical settings. However, in recent years, there has been a growing identi…
View article: Discovery of indole-2-one derivatives as BRD4 (BD1) selective inhibitors
Discovery of indole-2-one derivatives as BRD4 (BD1) selective inhibitors Open
View article: rBMA: A robust Bayesian Model Averaging Method for phase II basket trials based on informative mixture priors
rBMA: A robust Bayesian Model Averaging Method for phase II basket trials based on informative mixture priors Open
View article: Comparison of in vitro synergy between polymyxin B or colistin in combination with 16 antimicrobial agents against multidrug-resistant Acinetobacter baumannii isolates
Comparison of in vitro synergy between polymyxin B or colistin in combination with 16 antimicrobial agents against multidrug-resistant Acinetobacter baumannii isolates Open
Nearly no antagonism was observed when combining polymyxins with other drugs by both chequerboard and time-kill assays, suggesting that polymyxins may be effective in combination therapy. The combinations of POLB/COL with RFB, RIF, and RFP…
View article: Multi-omics analysis defines 5-fluorouracil drug resistance in 3D HeLa carcinoma cell model
Multi-omics analysis defines 5-fluorouracil drug resistance in 3D HeLa carcinoma cell model Open
In this study, we formulate a rapid, scalable and reproducible in vitro model of 3D MTS for drug screening purposes, and the cytotoxicity results showed an enhanced 5-FU resistance of HeLa carcinoma cells in 3D MTSs than 2D monolayer cultu…
View article: Morphological, Physiological, Element Absorption and Transcriptomic Analysis Reveals the Mechanism of 2-(3,4-Dichlorophenoxy) Trimethylamine Alleviating Copper Stress in Cucumber Seedlings
Morphological, Physiological, Element Absorption and Transcriptomic Analysis Reveals the Mechanism of 2-(3,4-Dichlorophenoxy) Trimethylamine Alleviating Copper Stress in Cucumber Seedlings Open
View article: Degradation of 1-Hexadecene by Newly Isolated Bacillus Sp. Hex-Hit36
Degradation of 1-Hexadecene by Newly Isolated Bacillus Sp. Hex-Hit36 Open
View article: Large Language Model for Horizontal Transfer of Resistance Gene: From Resistance Gene Prevalence Detection to Plasmid Conjugation Rate Evaluation
Large Language Model for Horizontal Transfer of Resistance Gene: From Resistance Gene Prevalence Detection to Plasmid Conjugation Rate Evaluation Open
View article: Exposure Modes Determined the Effects of Nanomaterials on Antibiotic Resistance Genes: The Different Roles of Oxidative Stress and Quorum Sensing
Exposure Modes Determined the Effects of Nanomaterials on Antibiotic Resistance Genes: The Different Roles of Oxidative Stress and Quorum Sensing Open
View article: Metabolic Mechanism of P-Cresol Biodegradation by Bacillus Subtilis Zw: Coexistence of Diverse Metabolic Pathways
Metabolic Mechanism of P-Cresol Biodegradation by Bacillus Subtilis Zw: Coexistence of Diverse Metabolic Pathways Open
View article: Comparison of the inoculum effect of in vitro antibacterial activity of Imipenem/relebactam and Ceftazidime/avibactam against ESBL-, KPC- and AmpC-producing Escherichia coli and Klebsiella pneumoniae
Comparison of the inoculum effect of in vitro antibacterial activity of Imipenem/relebactam and Ceftazidime/avibactam against ESBL-, KPC- and AmpC-producing Escherichia coli and Klebsiella pneumoniae Open
View article: Relation between fat and protein from various types of food and the confirmed and death rates of COVID-19
Relation between fat and protein from various types of food and the confirmed and death rates of COVID-19 Open
In the past three years, all countries and populations have been challenged by COVID-19 in the economy, education, lifestyle, etc., and it has raised concerns about food security. Some researchers demonstrated the effective role of diet in…
View article: Epitranscriptome analysis of NAD-capped RNA by spike-in-based normalization and prediction of chronological age
Epitranscriptome analysis of NAD-capped RNA by spike-in-based normalization and prediction of chronological age Open
Nicotinamide adenine dinucleotide (NAD) can be used as an initiating nucleotide in RNA transcription to produce NAD-capped RNA (NAD-RNA). RNA modification by NAD that links metabolite with expressed transcript is a poorly studied epitransc…
View article: Comparison of the inoculum effect of in vitro antibacterial activity of IMR and CZA against ESBL-, KPC- and AmpC-producing Escherichia coli and Klebsiella pneumoniae
Comparison of the inoculum effect of in vitro antibacterial activity of IMR and CZA against ESBL-, KPC- and AmpC-producing Escherichia coli and Klebsiella pneumoniae Open
Objective To evaluate effect of inoculum size of extended-spectrum β-Lactamase (ESBL)-producing-, AmpC-producing-, and KPC-producing Escherichia coli and Klebsiella pneumoniae on the in vitro antibacterial effects of imipenem/relebactam (I…
View article: Cyclovirobuxine D alleviates aldosterone-induced myocardial hypertrophy by protecting mitochondrial function depending on the mutual regulation of Nrf2-SIRT3
Cyclovirobuxine D alleviates aldosterone-induced myocardial hypertrophy by protecting mitochondrial function depending on the mutual regulation of Nrf2-SIRT3 Open
Thus, CVB-D ameliorates ALD-induced myocardial hypertrophy by recovering mitochondrial function by activating the mutual regulation of Nrf2 and SIRT3. Thus, CVB-D could be a beneficial drug for myocardial hypertrophy.
View article: Study on the Optimization and Renewal Design of Campus Cultural and Creative Products Based on the Emotion Mapping Approach
Study on the Optimization and Renewal Design of Campus Cultural and Creative Products Based on the Emotion Mapping Approach Open
This paper takes the current situation of the campus cultural and creative products of the City University of Macau as the starting point, focuses on analyzing the characteristics and deficiencies of the existing campus cultural and creati…
View article: An industrial perspective on in vivo kinetics of central metabolite pools and dynamic flux responses in Penicillium chrysogenum during periodic dissolved oxygen feast-famine cycles in a scale-down system
An industrial perspective on in vivo kinetics of central metabolite pools and dynamic flux responses in Penicillium chrysogenum during periodic dissolved oxygen feast-famine cycles in a scale-down system Open
Limitations in mixing and mass transfer coupled with high hydrostatic pressures lead to significant spatial variations in dissolved oxygen (DO) concentrations in large-scale bioreactors. While traveling through different zones in the biore…
View article: Pyroptosis, apoptosis, and autophagy are involved in infection induced by two clinical Klebsiella pneumoniae isolates with different virulence
Pyroptosis, apoptosis, and autophagy are involved in infection induced by two clinical Klebsiella pneumoniae isolates with different virulence Open
Klebsiella pneumoniae can cause widespread infections and is an important factor of hospital- and community-acquired pneumonia. The emergence of hypervirulent K. pneumoniae poses a serious clinical therapeutic challenge and is associated w…
View article: Epitranscriptome analysis of NAD-capped RNA by spike-in-based normalization
Epitranscriptome analysis of NAD-capped RNA by spike-in-based normalization Open
The hub metabolite, nicotinamide adenine dinucleotide (NAD), can be used as an initiating nucleotide in RNA transcription to result in NAD-capped RNA (NAD-RNA). NAD-RNA that intimately connects metabolite with gene expression can be develo…