Xuewen Wei
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View article: Houttuynia cordata Thunb-derived extracellular vesicle-like particles alleviate ischemic brain injury by miR159a targeting ACSL4 to suppress ferroptosis
Houttuynia cordata Thunb-derived extracellular vesicle-like particles alleviate ischemic brain injury by miR159a targeting ACSL4 to suppress ferroptosis Open
Introduction Neuroprotective agents for acute ischemic stroke often fall short in efficacy due to the blood–brain barrier challenges, lack of target specificity, and limited effectiveness. Recently, plant-derived extracellular vesicle-like…
View article: Research on dual-robot cooperative path planning for multi-material additive manufacturing
Research on dual-robot cooperative path planning for multi-material additive manufacturing Open
To improve the efficiency of multi-material additive manufacturing and enhance the safety of multi-robot cooperative printing with uncertain execution delay, a dual-robot cooperative path planning method is proposed for the layer-by-layer …
View article: Exosome-like nanovesicles derived from Momordica charantia ameliorate delayed t-PA thrombolysis-induced hemorrhagic transformation by inhibiting the ONOO−/HMGB1/MMP-9 pathway
Exosome-like nanovesicles derived from Momordica charantia ameliorate delayed t-PA thrombolysis-induced hemorrhagic transformation by inhibiting the ONOO−/HMGB1/MMP-9 pathway Open
Hemorrhagic transformation (HT) and restrictive therapeutic time window are significant limitations of delayed t-PA (tissue-type plasminogen activator) thrombolytic therapy in ischemic stroke patients. Plant Momordica charantia-derived exo…
View article: Disintegration of the Cav-1/β-catenin complex protects neuronal death by promoting β-catenin nuclear translocation after ischemia-reperfusion injury
Disintegration of the Cav-1/β-catenin complex protects neuronal death by promoting β-catenin nuclear translocation after ischemia-reperfusion injury Open
The roles of Caveolin-1 (Cav-1) and Wnt/β-catenin signaling pathways in cerebral ischemia-reperfusion (I/R) injury are well established. Translocation of β-catenin into the nucleus is critical in regulating the apoptosis, repair, and nerve…
View article: Analysis of <i>Momordica charantia</i> Polysaccharide Components and Their Effects on KA-Induced Oxidative Stress and Neuronal Loss in the Hippocampus of Epileptic Rats
Analysis of <i>Momordica charantia</i> Polysaccharide Components and Their Effects on KA-Induced Oxidative Stress and Neuronal Loss in the Hippocampus of Epileptic Rats Open
Polysaccharides of Momordica charantia have been reported to be the primary bioactive components that confer its antioxidant activity. To some degree, antioxidants may provide beneficial effects on neuronal damage induced by seizures. Howe…
View article: Neuroprotective Effects of Inhibiting Fyn S-Nitrosylation on Cerebral Ischemia/Reperfusion-Induced Damage to CA1 Hippocampal Neurons
Neuroprotective Effects of Inhibiting Fyn S-Nitrosylation on Cerebral Ischemia/Reperfusion-Induced Damage to CA1 Hippocampal Neurons Open
Nitric oxide (NO) can regulate signaling pathways via S-nitrosylation. Fyn can be post-translationally modified in many biological processes. In the present study, using a rat four-vessel-occlusion ischemic model, we aimed to assess whethe…