Xuewen Zhang
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View article: Fumarylacetoacetate Hydrolase Regulates Seed Dormancy and Germination Through the Gibberellin Pathway in Arabidopsis
Fumarylacetoacetate Hydrolase Regulates Seed Dormancy and Germination Through the Gibberellin Pathway in Arabidopsis Open
Tyrosine (Tyr) degradation is a crucial pathway in animals. However, its role in plants remains to be examined. Fumarylacetoacetate hydrolase (FAH) is the final enzyme involved in Tyr degradation. Studies of a mutant of the SHORT-DAY SENSI…
View article: Preoperative pectoralis muscle index predicts distant metastasis-free survival in non-small cell lung cancer patients: a retrospective study
Preoperative pectoralis muscle index predicts distant metastasis-free survival in non-small cell lung cancer patients: a retrospective study Open
Low PMI is significantly associated with worse distant metastasis-free survival (DMFS) and recurrence-free survival (RFS) in non-small cell lung cancer (NSCLC) patients, supporting its utility in refining preoperative risk stratification. …
View article: Combined inhibition by PRMT5 and MAT2A demonstrates a strong synthetic lethality in MTAP homozygous-deficient glioma models
Combined inhibition by PRMT5 and MAT2A demonstrates a strong synthetic lethality in MTAP homozygous-deficient glioma models Open
The intra- and intertumoral heterogeneity of gliomas present major challenges to effective chemotherapy. This study explored the combined effects of PRMT5 and MAT2A inhibitors on glioma progression. The expression of drug targets was deter…
View article: Incidence of Metastasis in the Central Nervous System in Advanced Breast Cancer Treated With CDK 4/6 Inhibitors: A Multicenter, Retrospective Study
Incidence of Metastasis in the Central Nervous System in Advanced Breast Cancer Treated With CDK 4/6 Inhibitors: A Multicenter, Retrospective Study Open
Central nervous system (CNS) metastasis remains a major cause of mortality in advanced breast cancer (ABC). While cyclin‐dependent kinase 4/6 inhibitors (CDKIs) combined with endocrine therapy (ET) delay resistance in hormone receptor (HR)…
View article: Characterization of adverse reactions to four common targeted drugs for hepatocellular carcinoma in WHO-VigiAccess
Characterization of adverse reactions to four common targeted drugs for hepatocellular carcinoma in WHO-VigiAccess Open
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality, with limited therapeutic options available for advanced stages of the disease. Treatment strategies for HCC are multimodal and largely depend on the d…
View article: A Framework for Developing Biodiversity Conservation Networks Based on Morphological Spatial Pattern Analysis and the Maximum Entropy Model: A Case Study of the Jianghan Plain, China
A Framework for Developing Biodiversity Conservation Networks Based on Morphological Spatial Pattern Analysis and the Maximum Entropy Model: A Case Study of the Jianghan Plain, China Open
Constructing ecological networks in urban areas improves ecosystem stability and biodiversity protection. However, most studies focus on optimizing ecological environments through objective assessments, often neglecting species diversity. …
View article: Phytoremediation of soil co‐contaminated with uranium and chromium by sunflower (<i>Helianthus annuus</i> L.) enhanced with slow‐release composite chelating agent (<scp>EDTA</scp>/ammonium citrate)
Phytoremediation of soil co‐contaminated with uranium and chromium by sunflower (<i>Helianthus annuus</i> L.) enhanced with slow‐release composite chelating agent (<span>EDTA</span>/ammonium citrate) Open
BACKGROUND Soil in uranium mining areas is contaminated by uranium and associated heavy metals, posing a significant threat to human health and ecological security. Chelating agent assisted phytoremediation is a cost‐effective and ecologic…
View article: Modulation of esophageal squamous cell carcinoma progression: the impact of CCR7 on JAK2/STAT3 signaling pathway
Modulation of esophageal squamous cell carcinoma progression: the impact of CCR7 on JAK2/STAT3 signaling pathway Open
This study proves the modulation of CCR7 on ESCA in vitro, which was achieved via JAK2/STAT3 signaling pathway. Our discovery will provide new therapeutic basis and insights for ESCA.
View article: Preoperative pectoralis muscle index predicts recurrence and metastasis in early-stage non- small cell lung cancer patients
Preoperative pectoralis muscle index predicts recurrence and metastasis in early-stage non- small cell lung cancer patients Open
Background Sarcopenia is a well-established prognostic factor in patients with malignancies, with the muscle index serving as a key parameter in evaluating sarcopenia. However, the relationship between the pectoralis muscle index (PMI) det…
View article: Discovery of Novel HDAC3 Inhibitors with PD-L1 Downregulating/Degrading and Antitumor Immune Effects
Discovery of Novel HDAC3 Inhibitors with PD-L1 Downregulating/Degrading and Antitumor Immune Effects Open
Targeting the programmed cell death-1/ligand 1 (PD-1/PD-L1) pathway is one of the most promising cancer treatment strategies. Studies have shown that HDAC inhibitors can enhance the antitumor immune response by modulating the expression of…
View article: Comparative efficacy of immune checkpoint inhibitors combined with chemotherapy in patients with advanced driver-gene negative non-small cell lung cancer: A systematic review and network meta-analysis
Comparative efficacy of immune checkpoint inhibitors combined with chemotherapy in patients with advanced driver-gene negative non-small cell lung cancer: A systematic review and network meta-analysis Open
Tislelizumab, camrelizumab or pembrolizumab combined with chemotherapy may be the optimal first-line treatment strategies for NSCLC.
View article: Integration of meta-analysis and network pharmacology analysis to investigate the pharmacological mechanisms of traditional Chinese medicine in the treatment of hepatocellular carcinoma
Integration of meta-analysis and network pharmacology analysis to investigate the pharmacological mechanisms of traditional Chinese medicine in the treatment of hepatocellular carcinoma Open
Background: This study will explore the therapeutic value of traditional Chinese medicine (TCM) in Hepatocellular Carcinoma (HCC) through meta-analysis, combined with network pharmacology analysis. Methods: The results of randomized contro…
View article: Tumor-derived apoptotic extracellular vesicle-mediated intercellular communication promotes metastasis and stemness of lung adenocarcinoma
Tumor-derived apoptotic extracellular vesicle-mediated intercellular communication promotes metastasis and stemness of lung adenocarcinoma Open
Apoptosis has long been recognized as a significant mechanism for inhibiting tumor formation, and a plethora of stimuli can induce apoptosis during the progression and treatment of tumors. Moreover, tumor-derived apoptotic extracellular ve…
View article: The generation of glioma organoids and the comparison of two culture methods
The generation of glioma organoids and the comparison of two culture methods Open
Background The intra‐ and inter‐tumoral heterogeneity of gliomas and the complex tumor microenvironment make accurate treatment of gliomas challenging. At present, research on gliomas mainly relies on cell lines, stem cell tumor spheres, a…
View article: Probiotic Lactobacillus plantarum GUANKE effectively alleviates allergic rhinitis symptoms by modulating functions of various cytokines and chemokines
Probiotic Lactobacillus plantarum GUANKE effectively alleviates allergic rhinitis symptoms by modulating functions of various cytokines and chemokines Open
Background Currently, the prevalence of allergic rhinitis (AR) remains high and there is a great need to develop better and safer ways to alleviate AR symptoms. The Lactobacillus plantarum GUANKE probiotic was reported as an immunomodulato…
View article: <scp>SERPINB5</scp> is a prognostic biomarker and promotes proliferation, metastasis and epithelial‐mesenchymal transition (<scp>EMT)</scp> in lung adenocarcinoma
<span>SERPINB5</span> is a prognostic biomarker and promotes proliferation, metastasis and epithelial‐mesenchymal transition (<span>EMT)</span> in lung adenocarcinoma Open
Background Serine protease inhibitors clade B serpins (SERPINBs) are the largest subclass of protease inhibitors, once thought of as a tumor suppressor gene family. However, some SERPINBs exhibit functions unrelated to the inhibition of ca…
View article: Intrinsic Immunogenic Tumor Cell Death Subtypes Delineate Prognosis and Responsiveness to Immunotherapy in Lung Adenocarcinoma
Intrinsic Immunogenic Tumor Cell Death Subtypes Delineate Prognosis and Responsiveness to Immunotherapy in Lung Adenocarcinoma Open
Recent studies have highlighted the combination of activation of host immunogenic cell death (ICD) and tumor-directed cytotoxic strategies. However, overall multiomic analysis of the intrinsic ICD property in lung adenocarcinoma (LUAD) has…
View article: Ten-year trends of the clinicopathological characteristics, surgical treatments and survival outcomes of operable lung cancer patients in monocenter: a retrospective cohort study
Ten-year trends of the clinicopathological characteristics, surgical treatments and survival outcomes of operable lung cancer patients in monocenter: a retrospective cohort study Open
Background Lung cancer is one of the cancers with the highest morbidity and mortality. During the last decade, the trends of clinical characteristics, surgical treatments and survival of lung cancer patients in China have remained unclear.…
View article: Precision diagnosis of hepatocellular carcinoma
Precision diagnosis of hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) is the most common type of primary hepatocellular carcinoma (PHC). Early diagnosis of HCC remains the key to improve the prognosis. In recent years, with the promotion of the concept of precision medicine and…
View article: rhTPO Ameliorates Radiation-Induced Long-Term Hematopoietic Stem Cell Injury in Mice
rhTPO Ameliorates Radiation-Induced Long-Term Hematopoietic Stem Cell Injury in Mice Open
Exposure to medium and high doses of ionizing radiation (IR) can induce long-term bone marrow (BM) suppression. We previously showed that recombinant human thrombopoietin (rhTPO) significantly promotes recovery from hematopoietic-acute rad…
View article: COMMD proteins function and their regulating roles in tumors
COMMD proteins function and their regulating roles in tumors Open
The COMMD proteins are a highly conserved protein family with ten members that play a crucial role in a variety of biological activities, including copper metabolism, endosomal sorting, ion transport, and other processes. Recent research h…
View article: Construction of a prognostic model for advanced non-small cell lung cancer using combined analysis of public databases
Construction of a prognostic model for advanced non-small cell lung cancer using combined analysis of public databases Open
Non-small cell lung cancer (NSCLC) has become a global health problem owing to its high incidence and poor treatment efficacy. This study aimed to establish a prognostic model for advanced NSCLC using The Cancer Genome Atlas (TCGA) and Gen…
View article: RT-based combination therapy for brain metastasis from NSCLC with non-EGFR mutation/ALK gene rearrangement: A network meta-analysis
RT-based combination therapy for brain metastasis from NSCLC with non-EGFR mutation/ALK gene rearrangement: A network meta-analysis Open
Introduction Radiotherapy (RT) is currently the main treatment for brain metastases (BMs) from non-small cell lung cancer (NSCLC). Due to the short survival time and obvious adverse reactions of RT, we urgently need more appropriate treatm…
View article: Nutritional Value and Physicochemical Characteristics of Alternative Protein for Meat and Dairy—A Review
Nutritional Value and Physicochemical Characteristics of Alternative Protein for Meat and Dairy—A Review Open
In order to alleviate the pressure on environmental resources faced by meat and dairy production and to satisfy the increasing demands of consumers for food safety and health, alternative proteins have drawn considerable attention in the f…
View article: Telomere-to-telomere genome assembly of bitter melon (<i>Momordica charantia</i> L. var. <i>abbreviata</i> Ser.) reveals fruit development, composition and ripening genetic characteristics
Telomere-to-telomere genome assembly of bitter melon (<i>Momordica charantia</i> L. var. <i>abbreviata</i> Ser.) reveals fruit development, composition and ripening genetic characteristics Open
Momordica charantia L. var. abbreviata Ser. (Mca), known as bitter gourd or bitter melon, is a Momordica variety with medicinal value and belongs to the Cucurbitaceae family. In view of the lack of genomic information on bitter gourd and o…
View article: Functional and Expressional Analyses Reveal the Distinct Role of Complement Factor I in Regulating Complement System Activation during GCRV Infection in Ctenopharyngodon idella
Functional and Expressional Analyses Reveal the Distinct Role of Complement Factor I in Regulating Complement System Activation during GCRV Infection in Ctenopharyngodon idella Open
Complement factor I (CFI), a complement inhibitor, is well known for regulating the complement system activation by degrading complement component 3b (C3b) in animal serum, thus becoming involved in innate defense. Nevertheless, the functi…
View article: Isolation and Identification of an α-Galactosidase-Producing Lactosphaera pasteurii Strain and Its Enzymatic Expression Analysis
Isolation and Identification of an α-Galactosidase-Producing Lactosphaera pasteurii Strain and Its Enzymatic Expression Analysis Open
α-Galactosidase (EC 3.2.1.22) refers to a group of enzymes that hydrolyze oligosaccharides containing α-galactoside-banded glycosides, such as stachyose, raffinose, and verbascose. These enzymes also possess great potential for application…
View article: Ferroptosis-related lncRNAs signature to predict the survival and immune evasion for lung squamous cell carcinoma
Ferroptosis-related lncRNAs signature to predict the survival and immune evasion for lung squamous cell carcinoma Open
Introduction: the investigation on the interactions between ferroptosis and lncRNAs for lung squamous cell carcinoma (LUSC) has been scare, and its impact on tumor immune microenvironment remained unknown. We aim to not only identify a fer…
View article: CRISPR/Cas9-mediated genetic correction reverses spinocerebellar ataxia 3 disease-associated phenotypes in differentiated cerebellar neurons
CRISPR/Cas9-mediated genetic correction reverses spinocerebellar ataxia 3 disease-associated phenotypes in differentiated cerebellar neurons Open
The neurodegenerative disease spinocerebellar ataxia type 3 (SCA3; also called Machado-Joseph disease, MJD) is a trinucleotide repeat disorder caused by expansion of the CAG repeats in the ATXN3 gene. Here, we applied a CRISPR/Cas9-mediate…
View article: Comparative analysis of buds transcriptome and identification of two florigen gene AkFTs in Amorphophallus konjac
Comparative analysis of buds transcriptome and identification of two florigen gene AkFTs in Amorphophallus konjac Open
Leaves and flowers of Amorphophallus konjac do not develop simultaneously thus unique features can be elucidated through study of flowering transformation in A. konjac. In this study, transcriptome libraries of A. konjac leaf buds (LB) and…