Xuexia Wang
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View article: Anthracycline-induced cardiomyopathy in childhood cancer survivors is associated with gene signatures of mitochondrial dysfunction—a COG ALTE03N1 report
Anthracycline-induced cardiomyopathy in childhood cancer survivors is associated with gene signatures of mitochondrial dysfunction—a COG ALTE03N1 report Open
View article: Germline Pathogenic/Likely Pathogenic Mutations and Subsequent Neoplasms Among Childhood Cancer Survivors: A Report From the Children's Oncology Group ALTE03N1 Study
Germline Pathogenic/Likely Pathogenic Mutations and Subsequent Neoplasms Among Childhood Cancer Survivors: A Report From the Children's Oncology Group ALTE03N1 Study Open
PURPOSE There is emerging evidence that germline pathogenic/likely pathogenic (P/LP) mutations in cancer predisposition genes (CPGs) increase the risk of subsequent neoplasms (SNs) in childhood cancer survivors. However, clinical applicati…
View article: Exploratory Metabolomic and Lipidomic Profiling in a Manganese-Exposed Parkinsonism-Affected Population in Northern Italy
Exploratory Metabolomic and Lipidomic Profiling in a Manganese-Exposed Parkinsonism-Affected Population in Northern Italy Open
Background/Objectives: Chronic manganese (Mn) exposure is a recognized environmental contributor to Parkinsonian syndromes, including Mn-induced Parkinsonism (MnIP). This study aimed to evaluate whole-blood Mn levels and investigate diseas…
View article: Alternative mRNA splicing in anthracycline-induced cardiomyopathy – a COG-ALTE03N1 report
Alternative mRNA splicing in anthracycline-induced cardiomyopathy – a COG-ALTE03N1 report Open
Background Anthracycline-induced cardiomyopathy is a well-established adverse consequence in childhood cancer survivors. Altered mRNA expression in the peripheral blood has been found at the level of genes and pathways among anthracycline-…
View article: SOX7: Autism associated gene identified by analysis of multi-Omics data
SOX7: Autism associated gene identified by analysis of multi-Omics data Open
Genome-wide association studies and next generation sequencing data analyses based on DNA information have identified thousands of mutations associated with autism spectrum disorder (ASD). However, more than 99% of identified mutations are…
View article: SARS-CoV-2 Antibodies in Response to COVID-19 Vaccination in Underserved Racial/Ethnic Minority People Living with HIV
SARS-CoV-2 Antibodies in Response to COVID-19 Vaccination in Underserved Racial/Ethnic Minority People Living with HIV Open
Background: Understanding immune response is essential for preparing for public health crises. COVID-19 vaccination provides robust immunity against SARS-CoV-2, but immunocompromised populations may have weaker immune responses. We assesse…
View article: A novel phenotype imputation method with copula model
A novel phenotype imputation method with copula model Open
View article: A novel phenotype imputation method with copula model
A novel phenotype imputation method with copula model Open
In a variety of simulations and a real genetic association study for lung function, we show that our method outperforms existing methods and can also increase the power of the association test when compared to other comparable phenotype im…
View article: Predicting the 10-year risk of cardiomyopathy in long-term survivors of childhood cancer: a report from the St. Jude Lifetime Cohort and the Childhood Cancer Survivor Study
Predicting the 10-year risk of cardiomyopathy in long-term survivors of childhood cancer: a report from the St. Jude Lifetime Cohort and the Childhood Cancer Survivor Study Open
Purpose Considering the heightened risk of cancer treatment-related cardiomyopathy and cardiac death in long-term survivors of childhood cancer, we aimed to develop and validate a clinically-applicable risk prediction model for cardiomyopa…
View article: Metabolomic and Lipidomic Analysis of Manganese-Associated Parkinsonism: a Case-Control Study in Brescia, Italy
Metabolomic and Lipidomic Analysis of Manganese-Associated Parkinsonism: a Case-Control Study in Brescia, Italy Open
Background and Objectives Excessive Manganese (Mn) exposure is neurotoxic and can cause Mn-Induced Parkinsonism (MnIP), marked by cognitive and motor dysfunction. Although metabolomic and lipidomic research in Parkinsonism (PD) patients ex…
View article: Alpha-1 antitrypsin deficiency and pregnancy complications and birth outcomes: A population-based cohort study in Denmark
Alpha-1 antitrypsin deficiency and pregnancy complications and birth outcomes: A population-based cohort study in Denmark Open
Background Alpha-1 antitrypsin deficiency (AATD) is related to developing lung and liver disease, but no large-scale studies examine its association with birth outcomes. Objective We investigated the risk of pregnancy complications and adv…
View article: Octt 10th, 2024
Octt 10th, 2024 Open
View article: The neonatal blood spot metabolome in retinoblastoma
The neonatal blood spot metabolome in retinoblastoma Open
View article: Altered Peripheral Blood Gene Expression in Childhood Cancer Survivors With Anthracycline‐Induced Cardiomyopathy – A COG‐ALTE03N1 Report
Altered Peripheral Blood Gene Expression in Childhood Cancer Survivors With Anthracycline‐Induced Cardiomyopathy – A COG‐ALTE03N1 Report Open
Background Anthracycline‐induced cardiomyopathy is a leading cause of premature death in childhood cancer survivors, presenting a need to understand the underlying pathogenesis. We sought to examine differential blood‐based mRNA expression…
View article: Gene-Level Analysis of Anthracycline-Induced Cardiomyopathy in Cancer Survivors
Gene-Level Analysis of Anthracycline-Induced Cardiomyopathy in Cancer Survivors Open
View article: Identification of novel hypermethylated or hypomethylated CpG sites and genes associated with anthracycline-induced cardiomyopathy
Identification of novel hypermethylated or hypomethylated CpG sites and genes associated with anthracycline-induced cardiomyopathy Open
View article: Haptoglobin Gene Expression and Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors
Haptoglobin Gene Expression and Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors Open
View article: A gene based combination test using GWAS summary data
A gene based combination test using GWAS summary data Open
View article: Additional file 2 of A gene based combination test using GWAS summary data
Additional file 2 of A gene based combination test using GWAS summary data Open
Additional file 2. Significant genes identified by OWC, aSPU, GATES, sumSTAAR, and GW in SCZ1 data, SCZ2 data and UKB data.
View article: Effect of oral esketamine on preoperative sedation and venipuncture analgesia in pediatric patients: a prospective randomized double-blind controlled clinical trial
Effect of oral esketamine on preoperative sedation and venipuncture analgesia in pediatric patients: a prospective randomized double-blind controlled clinical trial Open
Background Anxiety and uncooperation are common among pediatric patients during the preoperative preparation, which requires adequate and appropriate analgesia and sedation. Methods We performed a prospective, randomized, double-blind, con…
View article: The Clinical Efficacy of Microsuture Technique Combined With Voice Therapy in Patients with Reinke's Edema
The Clinical Efficacy of Microsuture Technique Combined With Voice Therapy in Patients with Reinke's Edema Open
The microsuture technique is preferable for eliminating vocal folds surgical wounds and promoting mucosal recovery, and combined with voice therapy is more helpful to comprehensive improve the quality of phonation.
View article: Genome-Wide Association Study Identifies <i>ROBO2</i> as a Novel Susceptibility Gene for Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors
Genome-Wide Association Study Identifies <i>ROBO2</i> as a Novel Susceptibility Gene for Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors Open
PURPOSE Interindividual variability in the dose-dependent association between anthracyclines and cardiomyopathy suggests a modifying role of genetic susceptibility. Few previous studies have examined gene-anthracycline interactions. We add…
View article: Including diverse and admixed populations in genetic epidemiology research
Including diverse and admixed populations in genetic epidemiology research Open
The inclusion of ancestrally diverse participants in genetic studies can lead to new discoveries and is important to ensure equitable health care benefit from research advances. Here, members of the Ethical, Legal, Social, Implications (EL…
View article: Correction: Detection of Neisseria gonorrhoeae and Chlamydia trachomatis infections in pregnant women by multiplex recombinase polymerase amplification
Correction: Detection of Neisseria gonorrhoeae and Chlamydia trachomatis infections in pregnant women by multiplex recombinase polymerase amplification Open
[This corrects the article DOI: 10.1371/journal.pone.0251119.].
View article: A Gene Based Optimally Weighted Combination Test Using GWAS Summary Data
A Gene Based Optimally Weighted Combination Test Using GWAS Summary Data Open
Background: Gene-based association tests provide a useful alternative and complement to the usual single marker association tests, especially in genome-wide association studies (GWAS). The way of weighting for variants in a gene plays an i…
View article: A Novel Locus on 6p21.2 for Cancer Treatment–Induced Cardiac Dysfunction Among Childhood Cancer Survivors
A Novel Locus on 6p21.2 for Cancer Treatment–Induced Cardiac Dysfunction Among Childhood Cancer Survivors Open
Background Adult survivors of childhood cancer are at increased risk of cardiac late effects. Methods Using whole-genome sequencing data from 1870 survivors of European ancestry in the St. Jude Lifetime Cohort (SJLIFE) study, genetic varia…
View article: Genome-wide variants and polygenic risk scores for cognitive impairment following blood or marrow transplantation
Genome-wide variants and polygenic risk scores for cognitive impairment following blood or marrow transplantation Open
View article: Gene-based association tests using GWAS summary statistics and incorporating eQTL
Gene-based association tests using GWAS summary statistics and incorporating eQTL Open
View article: Prognostic Factors in Acute Myeloid Leukemia with t(8;21)/AML1-ETO: Strategies to Define High-Risk Patients
Prognostic Factors in Acute Myeloid Leukemia with t(8;21)/AML1-ETO: Strategies to Define High-Risk Patients Open
View article: Detection of Chrysin as Agent for potential treatment of Alzheimer's Disease using Electrochemical sensor Based on CuO@Ta2O5 nanocomposite Modified Glassy Carbon Electrode
Detection of Chrysin as Agent for potential treatment of Alzheimer's Disease using Electrochemical sensor Based on CuO@Ta2O5 nanocomposite Modified Glassy Carbon Electrode Open