Xuexin Zhang
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View article: Muscle afferent <scp>ASIC3</scp> upregulation mediates the exacerbated exercise pressor reflex in male rats following hindlimb ischemia–reperfusion
Muscle afferent <span>ASIC3</span> upregulation mediates the exacerbated exercise pressor reflex in male rats following hindlimb ischemia–reperfusion Open
We examined if the hindlimb muscle ischemia–reperfusion (IR) alters ASIC3‐mediated muscle afferent activity in regulating the exercise pressor reflex (EPR). APETx2 (an ASIC3 antagonist) was arterially injected into the hindlimb before stat…
View article: Integration of Artificial Intelligence in English for Specific Purposes Education: Strategies and Effectiveness
Integration of Artificial Intelligence in English for Specific Purposes Education: Strategies and Effectiveness Open
View article: CD226 implicated in Akt-dependent apoptosis of CD4+ T cell contributes to asthmatic pathogenesis
CD226 implicated in Akt-dependent apoptosis of CD4+ T cell contributes to asthmatic pathogenesis Open
Asthma is a chronic airway inflammatory disease in which CD4 + T cell dysregulation occurs. Here, we investigated the molecular role and clinical significance of CD226, a costimulatory molecule of T lymphocytes, in the development of aller…
View article: Deep Learning for Predicting Topographic Changes in River Channels
Deep Learning for Predicting Topographic Changes in River Channels Open
View article: Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells
Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells Open
The essential role of store-operated Ca 2+ entry (SOCE) through Ca 2+ release-activated Ca 2+ (CRAC) channels in T cells is well established. In contrast, the contribution of individual Orai isoforms to SOCE and their downstream signaling …
View article: Correction: Dichotomous role of the human mitochondrial Na+/Ca2+/Li+ exchanger NCLX in colorectal cancer growth and metastasis
Correction: Dichotomous role of the human mitochondrial Na+/Ca2+/Li+ exchanger NCLX in colorectal cancer growth and metastasis Open
View article: Author response: Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells
Author response: Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract The essential role of sto…
View article: Recent Advances in Catalytic Enantioselective Synthesis of <i>α</i>-Chiral Tertiary Azides<sup>★</sup>
Recent Advances in Catalytic Enantioselective Synthesis of <i>α</i>-Chiral Tertiary Azides<sup>★</sup> Open
a 华东师范大学化学与分子工程学院 石油化工分子转化与反应工程全国重点实验室 上海分子治疗与新药创制工程 技术研究中心 上海市绿色化学与化工过程绿色化重点实验室 上海 200062) ( b 中国科学院上海有机化学研究所 金属有机化学国家重点实验室 上海 200032
View article: A Study on the Daily Behavior Management of Students in NCO Higher Vocational Academy
A Study on the Daily Behavior Management of Students in NCO Higher Vocational Academy Open
In recent years, the education of non-commissioned officers is increasingly important. This study takes the daily behavior management of students in private higher vocational colleges as the theme, and selects 122 students and 5 school off…
View article: Curcumin and NCLX inhibitors share anti-tumoral mechanisms in microsatellite-instability-driven colorectal cancer
Curcumin and NCLX inhibitors share anti-tumoral mechanisms in microsatellite-instability-driven colorectal cancer Open
View article: Orai3 and Orai1 are essential for CRAC channel function and metabolic reprogramming in B cells
Orai3 and Orai1 are essential for CRAC channel function and metabolic reprogramming in B cells Open
The essential role of store-operated Ca 2+ entry (SOCE) through Ca 2+ release-activated Ca 2+ (CRAC) channels in T cells is well established. In contrast, the contribution of individual Orai isoforms to SOCE and their downstream signaling …
View article: STIM1 is a core trigger of airway smooth muscle remodeling and hyperresponsiveness in asthma
STIM1 is a core trigger of airway smooth muscle remodeling and hyperresponsiveness in asthma Open
Significance Stromal-interacting molecule 1 (STIM1) proteins are essential for the function of store-operated Ca 2+ entry (SOCE). Using transcriptomics, metabolomics, imaging, and inducible smooth muscle–specific STIM1 knockout mice expres…
View article: PKC-ε regulates vesicle delivery and focal exocytosis for efficient IgG-mediated phagocytosis
PKC-ε regulates vesicle delivery and focal exocytosis for efficient IgG-mediated phagocytosis Open
Protein kinase C (PKC)-ε is required for membrane addition during IgG-mediated phagocytosis, but its role in this process is ill defined. Here, we performed high-resolution imaging, which reveals that PKC-ε exits the Golgi and enters phago…
View article: The Mitochondrial Ca2+ uniporter is a central regulator of interorganellar Ca2+ transfer and NFAT activation
The Mitochondrial Ca2+ uniporter is a central regulator of interorganellar Ca2+ transfer and NFAT activation Open
Mitochondrial Ca2+ uptake tailors the strength of stimulation of plasma membrane phospholipase C-coupled receptors to that of cellular bioenergetics. However, how Ca2+ uptake by the mitochondrial Ca2+ unipo…
View article: Regulation of Interorganellar Ca<sup>2+</sup>Transfer and NFAT Activation by the Mitochondrial Ca<sup>2+</sup>Uniporter
Regulation of Interorganellar Ca<sup>2+</sup>Transfer and NFAT Activation by the Mitochondrial Ca<sup>2+</sup>Uniporter Open
Mitochondrial Ca 2+ uptake is crucial for coupling receptor stimulation to cellular bioenergetics. Further, Ca 2+ uptake by respiring mitochondria prevents Ca 2+ -dependent inactivation (CDI) of store-operated Ca 2+ release-activated Ca 2+…
View article: MicroRNA-221 promotes tumor progression by targeting HHIP in human glioblastoma
MicroRNA-221 promotes tumor progression by targeting HHIP in human glioblastoma Open
Our results indicated that miR-221 is upregulated in GBM and enhances tumor progression by targeting HHIP, which suggests this may be a potential therapeutic target for GBM.
View article: Dichotomous role of the human mitochondrial Na+/Ca2+/Li+ exchanger NCLX in colorectal cancer growth and metastasis
Dichotomous role of the human mitochondrial Na+/Ca2+/Li+ exchanger NCLX in colorectal cancer growth and metastasis Open
Despite the established role of mitochondria in cancer, the mechanisms by which mitochondrial Ca 2+ (mtCa 2+ ) regulates tumorigenesis remain incompletely understood. The crucial role of mtCa 2+ in tumorigenesis is highlighted by altered e…
View article: Author response: Dichotomous role of the human mitochondrial Na+/Ca2+/Li+ exchanger NCLX in colorectal cancer growth and metastasis
Author response: Dichotomous role of the human mitochondrial Na+/Ca2+/Li+ exchanger NCLX in colorectal cancer growth and metastasis Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Despite the establ…
View article: Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels
Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels Open
View article: Redox and mTOR-dependent regulation of plasma lamellar calcium influx controls the senescence-associated secretory phenotype
Redox and mTOR-dependent regulation of plasma lamellar calcium influx controls the senescence-associated secretory phenotype Open
Cellular senescence has evolved as a protective mechanism to arrest growth of cells with oncogenic potential but is accompanied by the often pathologically deleterious senescence-associated secretory phenotype (SASP). Here we demonstrate a…
View article: L-type Ca <sup>2+</sup> channel blockers promote vascular remodeling through activation of STIM proteins
L-type Ca <sup>2+</sup> channel blockers promote vascular remodeling through activation of STIM proteins Open
Voltage-gated L-type Ca 2+ channel (Ca v 1.2) blockers (LCCBs) are major drugs for treating hypertension, the preeminent risk factor for heart failure. Vascular smooth muscle cell (VSMC) remodeling is a pathological hallmark of chronic hyp…
View article: The native ORAI channel trio underlies the diversity of Ca2+ signaling events
The native ORAI channel trio underlies the diversity of Ca2+ signaling events Open
The essential role of ORAI1 channels in receptor-evoked Ca 2+ signaling is well understood, yet little is known about the physiological activation of the ORAI channel trio natively expressed in all cells. The roles of ORAI2 and ORAI3 have …
View article: Colorectal adenocarcinomas downregulate the mitochondrial Na<sup>+</sup>/Ca<sup>2+</sup>exchanger NCLX to drive metastatic spread
Colorectal adenocarcinomas downregulate the mitochondrial Na<sup>+</sup>/Ca<sup>2+</sup>exchanger NCLX to drive metastatic spread Open
Summary Despite the established role of mitochondria in tumorigenesis, the molecular mechanisms by which mitochondrial Ca 2+ (mtCa 2+ ) signaling regulates tumor growth and metastasis remain unknown. The crucial role of mtCa 2+ in tumorige…
View article: A New Selective Pharmacological Enhancer of the Orai1 Ca<sup>2+</sup> Channel Reveals Roles for Orai1 in Smooth and Skeletal Muscle Functions
A New Selective Pharmacological Enhancer of the Orai1 Ca<sup>2+</sup> Channel Reveals Roles for Orai1 in Smooth and Skeletal Muscle Functions Open
Store operated calcium (Ca2+) entry is an important homeostatic mechanism in cells, whereby the release of Ca2+ from intracellular endoplasmic reticulum stores triggers the activation of a Ca2+ influx pathw…
View article: Lipidic synthetic alkaloids as SK3 channel modulators. Synthesis and biological evaluation of 2-substituted tetrahydropyridine derivatives with potential anti-metastatic activity
Lipidic synthetic alkaloids as SK3 channel modulators. Synthesis and biological evaluation of 2-substituted tetrahydropyridine derivatives with potential anti-metastatic activity Open
View article: ECDI‐fixed donor splenocytes prolong skin allograft survival by promoting M2 macrophage polarization and inducing regulatory T cells
ECDI‐fixed donor splenocytes prolong skin allograft survival by promoting M2 macrophage polarization and inducing regulatory T cells Open
Rejection is a common complication of allogeneic tissue transplantation. Fixation of splenocytes (SP) with 1‐ethyl‐3‐(3'‐dimethylaminopropyl)‐carbodiimide (ECDI) induces immune tolerance in recipients post‐transplantation; however, the mec…
View article: Genomics course design and combined teaching strategy to enhance learning initiatives in classroom
Genomics course design and combined teaching strategy to enhance learning initiatives in classroom Open
Genomics is a core course for bioscience‐majored undergraduates in many universities. However, the teaching of genomics faces many challenges such as the need for rapid updating of related knowledge, content overlap between genomics and mo…
View article: A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction
A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction Open
View article: Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity
Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity Open
Store-operated Ca2+ entry (SOCE) is a ubiquitous pathway for Ca2+ influx across the plasma membrane (PM). SOCE is mediated by the endoplasmic reticulum (ER)-associated Ca2+-sensing proteins stromal interact…
View article: Oncogenic KRAS suppresses store-operated Ca2+ entry and ICRAC through ERK pathway-dependent remodelling of STIM expression in colorectal cancer cell lines
Oncogenic KRAS suppresses store-operated Ca2+ entry and ICRAC through ERK pathway-dependent remodelling of STIM expression in colorectal cancer cell lines Open