Explanipedia

Expectation Confirmation Preference Optimization for Multi-Turn Conversational Recommendation Agent Open

Xueyang Feng, Jingsen Zhang, Jiakai Tang, Wei Li, Gengyuan Cai , et al. · 2025

Recent advancements in Large Language Models (LLMs) have significantly propelled the development of Conversational Recommendation Agents (CRAs). However, these agents often generate short-sighted responses that fail to sustain user guidanc…

Improving Retrospective Language Agents via Joint Policy Gradient Optimization Open

Xueyang Feng, Bo Lan, Quanyu Dai, Lei Wang, Jiakai Tang , et al. · 2025

In recent research advancements within the community, large language models (LLMs) have sparked great interest in creating autonomous agents. However, current prompt-based agents often heavily rely on large-scale LLMs. Meanwhile, although …

Enhancing Recommendation Explanations through User-Centric Refinement Open

Jingsen Zhang, Zihang Tian, Xueyang Feng, Xu Chen · 2025

Generating natural language explanations for recommendations has become increasingly important in recommender systems. Traditional approaches typically treat user reviews as ground truth for explanations and focus on improving review predi…

Expectation Confirmation Preference Optimization for Multi-Turn Conversational Recommendation Agent Open

Xueyang Feng, Jingsen Zhang, Jiakai Tang, Wei Li, Gengyuan Cai , et al. · 2025

Improving Retrospective Language Agents via Joint Policy Gradient Optimization Open

Xueyang Feng, Bo Lan, Quanyu Dai, Lei Wang, Jiakai Tang , et al. · 2025

Enhancing Recommendation Explanations through User-Centric Refinement Open

Jingsen Zhang, Zihang Tian, Xueyang Feng, Xu Chen, Chong Chen · 2025

Metabolic programs drive function of therapeutic NK cells in hypoxic tumor environments Open

Philippa R Kennedy, Upasana Sunil Arvindam, Shee Kwan Phung, Brianna Ettestad, Xueyang Feng , et al. · 2024

Limited oxygen (hypoxia) in solid tumors poses a challenge to successful immunotherapy with natural killer (NK) cells. NK cells have impaired cytotoxicity when cultured in hypoxia (1% oxygen) but not physiologic (>5%) or atmospheric oxygen…

A survey on large language model based autonomous agents Open

Lei Wang, Chen Ma, Xueyang Feng, Zeyu Zhang, Hao Yang , et al. · 2024

Autonomous agents have long been a research focus in academic and industry communities. Previous research often focuses on training agents with limited knowledge within isolated environments, which diverges significantly from human learnin…

Large Language Model-based Human-Agent Collaboration for Complex Task Solving Open

Xueyang Feng, Zhiyuan Chen, Yujia Qin, Yankai Lin, Xu Chen , et al. · 2024

In recent developments within the research community, the integration of Large Language Models (LLMs) in creating fully autonomous agents has garnered significant interest. Despite this, LLM-based agents frequently demonstrate notable shor…

A Survey on Large Language Model based Autonomous Agents Open

Lei Wang, Chen Ma, Xueyang Feng, Zeyu Zhang, Hao Yang , et al. · 2023

Autonomous agents have long been a prominent research focus in both academic and industry communities. Previous research in this field often focuses on training agents with limited knowledge within isolated environments, which diverges sig…

Fairness-aware Cross-Domain Recommendation Open

Jiakai Tang, Xu Chen, Xueyang Feng · 2023

Cross-Domain Recommendation (CDR) is an effective way to alleviate the cold-start problem. However, previous work severely ignores fairness and bias when learning the mapping function, which is used to obtain the representations for fresh …

Numerical Simulation of Crack Propagation in Geothermal Well Under Cold Impact Open

Jun Zheng, Xueyang Feng, Bin Dou, Yu Chen, Hong Tian , et al. · 2022

On-chip manufacturing of synthetic proteins for point-of-care therapeutics Open

Travis W. Murphy, Jiayuan Sheng, Lynette B. Naler, Xueyang Feng, Chang Lu · 2019

Systematic Optimization of Protein Secretory Pathways in Saccharomyces cerevisiae to Increase Expression of Hepatitis B Small Antigen Open

Jiayuan Sheng, Hunter Flick, Xueyang Feng · 2017

Hepatitis B is a major disease that chronically infects millions of people in the world, especially in developing countries. Currently, one of the effective vaccines to prevent Hepatitis B is the Hepatitis B Small Antigen (HBsAg), which is…

DeepMetabolism: A Deep Learning System to Predict Phenotype from Genome Sequencing Open

Weihua Guo, You Lin Xu, Xueyang Feng · 2017

Life science is entering a new era of petabyte-level sequencing data. Converting such “big data” to biological insights represents a huge challenge for computational analysis. To this end, we developed DeepMetabolism, a biology-guided deep…

DeepMetabolism: A Deep Learning System to Predict Phenotype from Genome Sequencing Open

Weihua Guo, You Lin Xu, Xueyang Feng · 2017

Life science is entering a new era of petabyte-level sequencing data. Converting such big data to biological insights represents a huge challenge for computational analysis. To this end, we developed DeepMetabolism, a biology-guided deep l…

Data-Driven Prediction of CRISPR-Based Transcription Regulation for Programmable Control of Metabolic Flux Open

Jiayuan Sheng, Guo Weihua, Christine Ash, Brendan T. Freitas, Mitchell Paoletti , et al. · 2017

Multiplex and multi-directional control of metabolic pathways is crucial for metabolic engineering to improve product yield of fuels, chemicals, and pharmaceuticals. To achieve this goal, artificial transcriptional regulators such as CRISP…

Data-Driven Prediction of CRISPR-Based Transcription Regulation for Programmable Control of Metabolic Flux Open

Jiayuan Sheng, Weihua Guo, Christine Ash, Brendan T. Freitas, Mitchell Paoletti , et al. · 2017

Multiplex and multi-directional control of metabolic pathways is crucial for metabolic engineering to improve product yield of fuels, chemicals, and pharmaceuticals. To achieve this goal, artificial transcriptional regulators such as CRISP…

Cell-free protein synthesis of norovirus virus-like particles Open

Jiayuan Sheng, Shaohua Lei, Lijuan Yuan, Xueyang Feng · 2017

Cell-free protein expression of norovirus virus-like-particles.

Mini-review: In vitro Metabolic Engineering for Biomanufacturing of High-value Products Open

Weihua Guo, Jiayuan Sheng, Xueyang Feng · 2017

Investigate the Metabolic Reprogramming of Saccharomyces cerevisiae for Enhanced Resistance to Mixed Fermentation Inhibitors via 13C Metabolic Flux Analysis Open

Weihua Guo, Yingying Chen, Na Wei, Xueyang Feng · 2016

The fermentation inhibitors from the pretreatment of lignocellulosic materials, e.g., acetic acid and furfural, are notorious due to their negative effects on the cell growth and chemical production. However, the metabolic reprogramming of…

Pathway Compartmentalization in Peroxisome of Saccharomyces cerevisiae to Produce Versatile Medium Chain Fatty Alcohols Open

Jiayuan Sheng, Joseph R. Stevens, Xueyang Feng · 2016

OM-FBA: Integrate Transcriptomics Data with Flux Balance Analysis to Decipher the Cell Metabolism Open

Weihua Guo, Xueyang Feng · 2016

Constraint-based metabolic modeling such as flux balance analysis (FBA) has been widely used to simulate cell metabolism. Thanks to its simplicity and flexibility, numerous algorithms have been developed based on FBA and successfully predi…

Metabolic Engineering for Production of Small Molecule Drugs: Challenges and Solutions Open

Herbert M. Huttanus, Jiayuan Sheng, Xueyang Feng · 2016

Production of small molecule drugs in a recombinant host is becoming an increasingly popular alternative to chemical synthesis or production in natural hosts such as plants due to the ease of growing microorganisms with higher titers and l…

13C Pathway Analysis for the Role of Formate in Electricity Generation by Shewanella Oneidensis MR-1 Using Lactate in Microbial Fuel Cells Open

Shuai Luo, Weihua Guo, Kenneth H. Nealson, Xueyang Feng, Zhen He · 2016

Metabolic engineering of Saccharomyces cerevisiae to produce 1-hexadecanol from xylose Open

Weihua Guo, Jiayuan Sheng, Huimin Zhao, Xueyang Feng · 2016

Transcriptional profiling reveals molecular basis and novel genetic targets for improved resistance to multiple fermentation inhibitors in Saccharomyces cerevisiae Open

Yingying Chen, Jiayuan Sheng, Tao Jiang, Joseph R. Stevens, Xueyang Feng , et al. · 2016

MOESM4 of Transcriptional profiling reveals molecular basis and novel genetic targets for improved resistance to multiple fermentation inhibitors in Saccharomyces cerevisiae Open

Yingying Chen, Jiayuan Sheng, Tao Jiang, Joseph R. Stevens, Xueyang Feng , et al. · 2016

Additional file 4: Table S3. Transcriptional analysis and GO analysis of consensus genes.

MOESM2 of Transcriptional profiling reveals molecular basis and novel genetic targets for improved resistance to multiple fermentation inhibitors in Saccharomyces cerevisiae Open

Yingying Chen, Jiayuan Sheng, Tao Jiang, Joseph R. Stevens, Xueyang Feng , et al. · 2016

Additional file 2: Table S1. Transcriptional analysis and GO analysis of the wild-type strain to different stress conditions.

Molecular basis of 5-hydroxytryptophan synthesis in Saccharomyces cerevisiae Open

Jiantao Zhang, Chaochen Wu, Jiayuan Sheng, Xueyang Feng · 2016

We report for the first time that 5-hydroxytryptophan can be synthesized in Saccharomyces cerevisiae by heterologously expressing prokaryotic phenylalanine 4-hydroxylase or eukaryotic tryptophan 3/5-hydroxylase, together with enhanced synt…

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