Xueyang Zou
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View article: Circadian rhythms of gut microbiota and plaque vulnerability: mechanisms and chrono-microbiota modulation interventions
Circadian rhythms of gut microbiota and plaque vulnerability: mechanisms and chrono-microbiota modulation interventions Open
The stability of atherosclerotic plaques constitutes the fundamental pathological basis for acute cardiovascular events, and their circadian rhythm characteristics highlight the essential role of dynamic interactions between the host and m…
View article: High disease activity correlate with decreased serum calcium in systemic lupus erythematosus
High disease activity correlate with decreased serum calcium in systemic lupus erythematosus Open
View article: Peripheral helper T cells in human diseases
Peripheral helper T cells in human diseases Open
Peripheral helper T cells (Tph) are a specialized subset of CD4+ T cells with the ability to help B cells and induce antibody production. Although usually located in ectopic lymphoid-like structures (ELS), inside the peripheral …
View article: Transcriptional and metabolic programs promote the expansion of follicular helper T cells in lupus-prone mice
Transcriptional and metabolic programs promote the expansion of follicular helper T cells in lupus-prone mice Open
View article: Aire and Fezf2, two regulators in medullary thymic epithelial cells, control autoimmune diseases by regulating TSAs: Partner or complementer?
Aire and Fezf2, two regulators in medullary thymic epithelial cells, control autoimmune diseases by regulating TSAs: Partner or complementer? Open
The expression of tissue-specific antigens (TSAs) in medullary thymic epithelial cells (mTECs) is believed to be responsible for the elimination of autoreactive T cells, a critical process in the maintenance of central immune tolerance. Th…
View article: The Correlation between Aire and ICOSL Expression in Peripheral Blood CD14+ Cells and Tfh Cells and Disease Activity in RA Patients
The Correlation between Aire and ICOSL Expression in Peripheral Blood CD14+ Cells and Tfh Cells and Disease Activity in RA Patients Open
Background: Recent trans-ethnic genome-wide association study (GWAS) showed that autoimmune regulator (Aire) played a pivotal role in Rheumatoid Arthritis (RA). Our preliminary research showed that Aire can affect T follicular helper (Tfh)…
View article: The Role of AIRE Deficiency in Infertility and Its Potential Pathogenesis
The Role of AIRE Deficiency in Infertility and Its Potential Pathogenesis Open
The increasing number of patients with infertility is recognized as an emerging problem worldwide. However, little is known about the cause of infertility. At present, it is believed that infertility may be related to genetic or abnormal i…
View article: T cells expressing the lupus susceptibility allele Pbx1d enhance autoimmunity and atherosclerosis in dyslipidemic mice
T cells expressing the lupus susceptibility allele Pbx1d enhance autoimmunity and atherosclerosis in dyslipidemic mice Open
Patients with systemic lupus erythematosus (SLE) present a high incidence of atherosclerosis, which contributes significantly to morbidity and mortality in this autoimmune disease. An impaired balance between regulatory (Treg) and follicul…
View article: The Generation and Regulation of Tissue‐Resident Tregs and Their Role in Autoimmune Diseases
The Generation and Regulation of Tissue‐Resident Tregs and Their Role in Autoimmune Diseases Open
Regulatory T cells (Tregs), as an important subset of T cells, play an important role in maintaining body homeostasis by regulating immune responses and preventing autoimmune diseases. In‐depth research finds that Tregs have strong instabi…
View article: The Role of Dendritic Cells in the Differentiation of T Follicular Helper Cells
The Role of Dendritic Cells in the Differentiation of T Follicular Helper Cells Open
T follicular helper cells (T FH ) are a subset of recently discovered CD4 + T cells. Their major function is to participate in the formation of germinal centres (GCs) and promote B cell proliferation and differentiation to play important r…