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View article: Stage-specific requirement for METTL3-dependent m6A epitranscriptomic regulation during myogenesis
Stage-specific requirement for METTL3-dependent m6A epitranscriptomic regulation during myogenesis Open
The regulatory role of N 6 -methyladenosine (m 6 A) modification in skeletal muscle myogenesis and muscle homeostasis remains poorly characterized, particularly regarding the functional significance of methyltransferase-like 3 (METTL3), th…
View article: A LITERATURE REVIEW OF ARTIFICIAL INTELLIGENCE IN DIVERSITY MANAGEMENT: TECHNOLOGICAL ENABLEMENT AND ETHICAL TENSIONS
A LITERATURE REVIEW OF ARTIFICIAL INTELLIGENCE IN DIVERSITY MANAGEMENT: TECHNOLOGICAL ENABLEMENT AND ETHICAL TENSIONS Open
Artificial Intelligence (AI) technology is changing how organizations are managed and run, affecting everything from how platforms are governed and construction projects are managed to automating human resources, reviewing ethics, local th…
View article: A STUDY ON THE DUAL EFFECTS OF ACADEMIC SUPPORT AND CAMPUS ATMOSPHERE ON PSYCHOLOGICAL CAPITAL AND ACADEMIC ENGAGEMENT OF INTERNATIONAL STUDENTS IN THAILAND
A STUDY ON THE DUAL EFFECTS OF ACADEMIC SUPPORT AND CAMPUS ATMOSPHERE ON PSYCHOLOGICAL CAPITAL AND ACADEMIC ENGAGEMENT OF INTERNATIONAL STUDENTS IN THAILAND Open
This study explores how academic support and campus atmosphere affect the academic engagement of international students in Thai universities through psychological capital. By combining the JD-R model, the Conservation of Resources theory (…
View article: Development of a Multiplexed qPCR Kit for the Detection of Bloodstream Infection
Development of a Multiplexed qPCR Kit for the Detection of Bloodstream Infection Open
Background Bloodstream infection (BSI) is associated with high morbidity and mortality worldwide. Currently, BSI diagnosis relies on a time‐consuming blood culture method, which usually takes 2 or more days to identify the causative pathog…
View article: Identification of a Mutation in the PFKP as a Causative Factor in Prenatal Glycolysis Defects and Embryonic Myocardial Hypoplasia
Identification of a Mutation in the PFKP as a Causative Factor in Prenatal Glycolysis Defects and Embryonic Myocardial Hypoplasia Open
Congenital heart disease (CHD) is the most common birth defect worldwide, which lacks effective early preventive methods due to limited knowledge of the genetic defects involved in its development. Through genetic analysis of families with…
View article: Application of the whole petroleum system in the evaluation of the global natural gas hydrate resource
Application of the whole petroleum system in the evaluation of the global natural gas hydrate resource Open
Natural gas hydrate (NGH), as a widely recognized clean energy, has shown a significant resource potential. However, due to the lack of a unified evaluation methodology and the difficult determination of key parameters, the evaluation resu…
View article: A Tale of Two Sides of Wafer: Physical Implementation and Block-Level PPA on Flip FET with Dual-sided Signals
A Tale of Two Sides of Wafer: Physical Implementation and Block-Level PPA on Flip FET with Dual-sided Signals Open
As the conventional scaling of logic devices comes to an end, functional wafer backside and 3D transistor stacking are consensus for next-generation logic technology, offering considerable design space extension for powers, signals or even…
View article: Characteristics of the macroinvertebrate community structure and their habitat suitability conditions in the Chishui River
Characteristics of the macroinvertebrate community structure and their habitat suitability conditions in the Chishui River Open
Introduction As an important tributary of the upper Yangtze River without dams, the study of the macroinvertebrate community structure and habitat suitability conditions in the Chishui River holds significant implications for water ecologi…
View article: From Flip FET to Flip 3D Integration (F3D): Maximizing the Scaling Potential of Wafer Both Sides Beyond Conventional 3D Integration
From Flip FET to Flip 3D Integration (F3D): Maximizing the Scaling Potential of Wafer Both Sides Beyond Conventional 3D Integration Open
In this work, we proposed a new 3D integration technology: the Flip 3D integration (F3D), consisting of the 3D transistor stacking, the 3D dual-sided interconnects, the 3D die-to-die stacking and the dual-sided Monolithic 3D (M3D). Based o…
View article: An essential role of the E3 ubiquitin ligase RNF126 in ensuring meiosis I completion during spermatogenesis
An essential role of the E3 ubiquitin ligase RNF126 in ensuring meiosis I completion during spermatogenesis Open
View article: Outcomes and the effect of PGT-M in women with hormone-related hereditary tumor syndrome
Outcomes and the effect of PGT-M in women with hormone-related hereditary tumor syndrome Open
Purpose To review the outcome of PGT-M in hormone-related hereditary tumor syndrome and evaluate the effect of ovarian induction on tumor growth in those patients. Methods Medical records of PGT-M were retrospectively analyzed in patients …
View article: RACGAP1 promotes the progression and poor prognosis of lung adenocarcinoma through its effects on the cell cycle and tumor stemness
RACGAP1 promotes the progression and poor prognosis of lung adenocarcinoma through its effects on the cell cycle and tumor stemness Open
View article: SPOCK1, as a potential prognostic and therapeutic biomarker for lung adenocarcinoma, is associated with epithelial-mesenchymal transition and immune evasion
SPOCK1, as a potential prognostic and therapeutic biomarker for lung adenocarcinoma, is associated with epithelial-mesenchymal transition and immune evasion Open
Background The occurrence of epithelial-mesenchymal transition (EMT) and immune evasion is considered to contribute to poor prognosis in lung adenocarcinoma (LUAD). Therefore, this study aims to explore the key oncogenes that promote EMT a…
View article: Proenkephalin-A secreted by renal proximal tubules functions as a brake in kidney regeneration
Proenkephalin-A secreted by renal proximal tubules functions as a brake in kidney regeneration Open
Organ regeneration necessitates precise coordination of accelerators and brakes to restore organ function. However, the mechanisms underlying this intricate molecular crosstalk remain elusive. In this study, the level of proenkephalin-A (P…
View article: Clinical practice and outcomes of preimplantation genetic testing for CMT1A using a novel direct detection method
Clinical practice and outcomes of preimplantation genetic testing for CMT1A using a novel direct detection method Open
View article: CD4 levels and NSCLC metastasis: the benefits of maintaining moderate levels
CD4 levels and NSCLC metastasis: the benefits of maintaining moderate levels Open
View article: Molecular Engineering of Corrole Radicals by Polycyclic Aromatic Fusion: Towards Open‐Shell Near‐Infrared Materials for Efficient Photothermal Therapy
Molecular Engineering of Corrole Radicals by Polycyclic Aromatic Fusion: Towards Open‐Shell Near‐Infrared Materials for Efficient Photothermal Therapy Open
Open‐shell radicals are promising near‐infrared (NIR) photothermal agents (PTAs) owing to their easily accessible narrow band gaps, but their stabilization and functionalization remain challenging. Herein, highly stable π‐extended nickel c…
View article: Molecular Engineering of Corrole Radicals by Polycyclic Aromatic Fusion: Towards Open‐Shell Near‐Infrared Materials for Efficient Photothermal Therapy
Molecular Engineering of Corrole Radicals by Polycyclic Aromatic Fusion: Towards Open‐Shell Near‐Infrared Materials for Efficient Photothermal Therapy Open
Open‐shell radicals are promising near‐infrared (NIR) photothermal agents (PTAs) owing to their easily accessible narrow band gaps, but their stabilization and functionalization remain challenging. Herein, highly stable π‐extended nickel c…
View article: SPOCK1, as a potential prognostic and therapeutic biomarker for lung adenocarcinoma, is associated with epithelial-mesenchymal transition and immune evasion
SPOCK1, as a potential prognostic and therapeutic biomarker for lung adenocarcinoma, is associated with epithelial-mesenchymal transition and immune evasion Open
Background The occurrence of epithelial-mesenchymal transition (EMT) and immune evasion is considered to contribute to poor prognosis in lung adenocarcinoma (LUAD). Therefore, this study aims to explore the key oncogenes that promote EMT a…
View article: P-066 Testis expressed 44 is essential for spermatogenesis and male fertility
P-066 Testis expressed 44 is essential for spermatogenesis and male fertility Open
Study question Dose Testis expressed 44 (TEX44) gene associated with spermatogenesis and TEX44 mutations required for male infertility ? Summary answer TEX44 is expressed in testis and participated in spermatogenesis. And mutations of TEX4…
View article: Transcatheter closure of post-myocardial infarction ventricular septal defect: A systematic review and single-arm meta-analysis
Transcatheter closure of post-myocardial infarction ventricular septal defect: A systematic review and single-arm meta-analysis Open
View article: Supplementary Figures from E3 Ubiquitin Ligase RNF126 Promotes Cancer Cell Proliferation by Targeting the Tumor Suppressor p21 for Ubiquitin-Mediated Degradation
Supplementary Figures from E3 Ubiquitin Ligase RNF126 Promotes Cancer Cell Proliferation by Targeting the Tumor Suppressor p21 for Ubiquitin-Mediated Degradation Open
Figure S1. RNF126 knockdown decreases cell viability in breast cancer cell lines Figure S2. The expression, subcellular localization, stability, and ubiquitination of RNF126 Figure S3. RNF126 knockdown increases p21 protein levels but does…
View article: Supplementary Figures from E3 Ubiquitin Ligase RNF126 Promotes Cancer Cell Proliferation by Targeting the Tumor Suppressor p21 for Ubiquitin-Mediated Degradation
Supplementary Figures from E3 Ubiquitin Ligase RNF126 Promotes Cancer Cell Proliferation by Targeting the Tumor Suppressor p21 for Ubiquitin-Mediated Degradation Open
Figure S1. RNF126 knockdown decreases cell viability in breast cancer cell lines Figure S2. The expression, subcellular localization, stability, and ubiquitination of RNF126 Figure S3. RNF126 knockdown increases p21 protein levels but does…
View article: Data from E3 Ubiquitin Ligase RNF126 Promotes Cancer Cell Proliferation by Targeting the Tumor Suppressor p21 for Ubiquitin-Mediated Degradation
Data from E3 Ubiquitin Ligase RNF126 Promotes Cancer Cell Proliferation by Targeting the Tumor Suppressor p21 for Ubiquitin-Mediated Degradation Open
To identify novel oncogenic E3 ubiquitin ligases as anticancer targets, we screened an E3 ubiquitin ligase siRNA library containing siRNA pools against 555 individual E3s using the sulphorhodamine B assay in the MDA-MB-231 breast cancer ce…
View article: [Correlation analysis of vitamin D level and anti-Müllerian hormone in infertile female and the role in predicting pregnancy outcome].
[Correlation analysis of vitamin D level and anti-Müllerian hormone in infertile female and the role in predicting pregnancy outcome]. Open
Based on the current diagnostic criteria, most infertile females had vitamin D insufficiency or deficiency, but there was not significant correlation between serum 25(OH)D and ovarian reserve. While vitamin D could not be used as an indepe…
View article: RNF126‐Mediated MRE11 Ubiquitination Activates the DNA Damage Response and Confers Resistance of Triple‐Negative Breast Cancer to Radiotherapy
RNF126‐Mediated MRE11 Ubiquitination Activates the DNA Damage Response and Confers Resistance of Triple‐Negative Breast Cancer to Radiotherapy Open
Triple‐negative breast cancer (TNBC) has higher molecular heterogeneity and metastatic potential and the poorest prognosis. Because of limited therapeutics against TNBC, irradiation (IR) therapy is still a common treatment option for patie…
View article: Identification of risk genes in Chinese nonobstructive azoospermia patients based on whole-exome sequencing
Identification of risk genes in Chinese nonobstructive azoospermia patients based on whole-exome sequencing Open
Nonobstructive azoospermia (NOA) is a severe condition in infertile men, and increasing numbers of causative genes have been identified during the last few decades. Although certain causative genes can explain the presence of NOA in some p…
View article: Genetic screening of Chinese patients with hydatidiform mole by whole-exome sequencing and comprehensive analysis
Genetic screening of Chinese patients with hydatidiform mole by whole-exome sequencing and comprehensive analysis Open
View article: Application of next-generation sequencing to preimplantation genetic testing for recurrent hydatidiform mole patients
Application of next-generation sequencing to preimplantation genetic testing for recurrent hydatidiform mole patients Open
View article: Dwarf mice as models for reproductive ageing research
Dwarf mice as models for reproductive ageing research Open