Xueyou Zhang
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View article: Study on the Effect of Unit Capacity Ratio on Air-Water Source Coupling Heat Pump System
Study on the Effect of Unit Capacity Ratio on Air-Water Source Coupling Heat Pump System Open
View article: MiR-516a-3p is a Novel Mediator of Hepatocellular Carcinoma Oncogenic Activity and Cellular Metabolism
MiR-516a-3p is a Novel Mediator of Hepatocellular Carcinoma Oncogenic Activity and Cellular Metabolism Open
Hepatocellular carcinoma (HCC) remains one of the most lethal malignancies. We previously demonstrated that the chromosome 19 microRNA cluster (C19MC) was associated with tumor burden and prognosis in patients with HCC. In the current stud…
View article: Alterations of the Gut Microbiome and Metabolome in Patients With Proliferative Diabetic Retinopathy
Alterations of the Gut Microbiome and Metabolome in Patients With Proliferative Diabetic Retinopathy Open
Diabetic retinopathy (DR) has been reported to associate with gut microbiota alterations in murine models and thus “gut-retina-axis” has been proposed. However, the role of gut microbiome and the associated metabolism in DR patients still …
View article: Sarcomatoid hepatocellular carcinoma: From clinical features to cancer genome
Sarcomatoid hepatocellular carcinoma: From clinical features to cancer genome Open
Background Sarcomatoid hepatocellular carcinoma (HCC) is a rare and highly lethal histological subtype of HCC, with completely unknown genetic etiology and therapeutic targets. Methods We included 16 patients with sarcomatoid HCC receiving…
View article: Primary nonfunction following liver transplantation: Learning of graft metabolites and building a predictive model
Primary nonfunction following liver transplantation: Learning of graft metabolites and building a predictive model Open
Dear Editor, Primary nonfunction (PNF) is defined as the need for emergent re-transplant when a graft never presented any evidence of initial function following liver transplantation (LT) after excluding other causes such as acute cellular…
View article: Comparative genomic analysis of head and body/tail of pancreatic ductal adenocarcinoma at early and late stages
Comparative genomic analysis of head and body/tail of pancreatic ductal adenocarcinoma at early and late stages Open
Pancreatic ductal adenocarcinoma (PDAC), one of the most lethal human cancers, can be divided into head and body/tail cancers anatomically. We previously reported a prognostic relevance of tumour location in resectable PDAC. This study aim…
View article: Decoding the single-cell landscape and intercellular crosstalk in the transplanted liver: a 4-dimension mouse model
Decoding the single-cell landscape and intercellular crosstalk in the transplanted liver: a 4-dimension mouse model Open
Graft remodeling after transplantation maintains graft functionality and determines graft survival. However, a comprehensive understanding of cellular diversity and interplay during graft remodeling remains to be fully characterized. In th…
View article: Alterations of the Gut Microbiome and Metabolome in Patients with Proliferative Diabetic Retinopathy
Alterations of the Gut Microbiome and Metabolome in Patients with Proliferative Diabetic Retinopathy Open
Background: Diabetic retinopathy (DR) has been reported to associate with gut microbiota alterations in murine models and thus “gut-retina-axis” has been proposed. However, the role of gut microbiome and the associated metabolism in DR pat…
View article: A model integrating donor gene polymorphisms predicts fibrosis after liver transplantation
A model integrating donor gene polymorphisms predicts fibrosis after liver transplantation Open
Post-transplant liver fibrosis (PTLF) is a common and severe complication in liver recipients. In this study, we assessed the impact of donor liver genetics on the development of PTLF. A total of 232 patients undergoing liver transplantati…
View article: The Similar Effects of miR-512-3p and miR-519a-2-5p on the Promotion of Hepatocellular Carcinoma: Different Tunes Sung With Equal Skill
The Similar Effects of miR-512-3p and miR-519a-2-5p on the Promotion of Hepatocellular Carcinoma: Different Tunes Sung With Equal Skill Open
Although the therapeutic methods of hepatocellular carcinoma (HCC) have made great advances, the current situation is that HCC is the common malignancy. Our previous bioinformatic study presented that two members of C19MC (mir-512-1 and mi…
View article: TCF7L2 rs290487 C allele aberrantly enhances hepatic gluconeogenesis through allele-specific changes in transcription and chromatin binding
TCF7L2 rs290487 C allele aberrantly enhances hepatic gluconeogenesis through allele-specific changes in transcription and chromatin binding Open
In this study, we investigated the mechanisms underlying the altered hepatic glucose metabolism and enhanced diabetes risk in individuals with the TCF7L2 rs290487 C allele. Analysis of 195 cirrhotic patients revealed a higher insuli…
View article: Comparative genomic analysis of head and body/tail of pancreatic ductal adenocarcinoma at early and late stages
Comparative genomic analysis of head and body/tail of pancreatic ductal adenocarcinoma at early and late stages Open
Background Pancreatic ductal adenocarcinoma (PDAC), one of the most lethal human cancers, can be divided into head and body/tail cancers according to the anatomy. We previously reported a prognostic relevance of tumor location in resectabl…
View article: Predicting dyslipidemia after liver transplantation: A significant role of recipient metabolic inflammation profile
Predicting dyslipidemia after liver transplantation: A significant role of recipient metabolic inflammation profile Open
Recipients' pre-transplant serum interleukin-12 (p70) level is associated with the risk of PTDL and has potential clinical value for predicting PTDL.
View article: The mir-767-105 cluster: a crucial factor related to the poor prognosis of hepatocellular carcinoma
The mir-767-105 cluster: a crucial factor related to the poor prognosis of hepatocellular carcinoma Open
MiRNAs have been widely reported as the therapeutic target for hepatocellular carcinoma (HCC). However, mirna clusters, as the more impressive tumor regulatory factors, have received little attention. By deeply digging the Cancer Genome At…
View article: <i>TCF7L2</i> rs290487 Variant Modulates Hepatic Glucose Metabolism <i>via</i> an Allele-Specific Transcriptional and Chromatin Regulation
<i>TCF7L2</i> rs290487 Variant Modulates Hepatic Glucose Metabolism <i>via</i> an Allele-Specific Transcriptional and Chromatin Regulation Open
View article: The tacrolimus-induced glucose homeostasis imbalance in terms of the liver: From bench to bedside
The tacrolimus-induced glucose homeostasis imbalance in terms of the liver: From bench to bedside Open
Tacrolimus (TAC), the mainstay of maintenance immunosuppressive agents, plays a crucial role in new-onset diabetes after transplant (NODAT). Previous studies investigating the diabetogenic effects of TAC have focused on the β cells of isle…
View article: The time-dependent shift in the hepatic graft and recipient macrophage pool following liver transplantation
The time-dependent shift in the hepatic graft and recipient macrophage pool following liver transplantation Open