Xueyuan Bai
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View article: Cxcl9high macrophages recruit circulating Cxcr3+ plasmablasts into kidneys to promote pathogenesis of lupus nephritis mice
Cxcl9high macrophages recruit circulating Cxcr3+ plasmablasts into kidneys to promote pathogenesis of lupus nephritis mice Open
View article: Safety and efficacy of umbilical cord mesenchymal stem cell transfusion for the treatment of refractory lupus nephritis
Safety and efficacy of umbilical cord mesenchymal stem cell transfusion for the treatment of refractory lupus nephritis Open
Background: Systemic lupus erythematosus is an autoimmune disease, with lupus nephritis (LN) as its most serious complication, potentially leading to renal failure. Current treatments, primarily glucocorticoids and immunosuppressive agents…
View article: Upper tract urothelial carcinoma in crossed fused renal ectopia: Case report and review of the literature
Upper tract urothelial carcinoma in crossed fused renal ectopia: Case report and review of the literature Open
Upper tract urothelial carcinoma in conjunction with congenital renal malformations is exceedingly rare in clinical practice, presenting significant challenges for surgical intervention. We detail a case involving crossed fused renal ectop…
View article: A case series and literature review of renal anastomosing hemangioma: An often-misdiagnosed benign tumor
A case series and literature review of renal anastomosing hemangioma: An often-misdiagnosed benign tumor Open
Background Renal anastomosing hemangiomas (RAHs) are rare. This study aimed to summarize the clinical, pathological, and imaging characteristics of RAH. Materials and methods We retrospectively analyzed 14 patients who underwent surgery fo…
View article: Correction to: Metanephric mesenchyme-derived Foxd1+ mesangial precursor cells alleviate mesangial proliferative glomerulonephritis
Correction to: Metanephric mesenchyme-derived Foxd1+ mesangial precursor cells alleviate mesangial proliferative glomerulonephritis Open
View article: IL-27 Modulates Mesenchymal Stem Cell Immunoplasticity for Enhanced Lupus Nephritis Therapy via the JAK1–STAT1–IDO Axis and Tryptophan Metabolic Orchestration
IL-27 Modulates Mesenchymal Stem Cell Immunoplasticity for Enhanced Lupus Nephritis Therapy via the JAK1–STAT1–IDO Axis and Tryptophan Metabolic Orchestration Open
Lupus nephritis is recognized as a common and severe complication of systemic lupus erythematosus, without an optimal therapeutic strategy currently available. While mesenchymal stem cells (MSCs) hold therapeutic promise, their efficacy va…
View article: Enhanced glomerular transfection by BMP7 gene nanocarriers inhibits CKD and promotes SOX9-dependent tubule regeneration
Enhanced glomerular transfection by BMP7 gene nanocarriers inhibits CKD and promotes SOX9-dependent tubule regeneration Open
View article: DNA methylation and whole-genome transcription analysis in CD4+ T cells from systemic lupus erythematosus patients with or without renal damage
DNA methylation and whole-genome transcription analysis in CD4+ T cells from systemic lupus erythematosus patients with or without renal damage Open
Background Lupus nephritis (LN) is the most common cause of kidney injury in systemic lupus erythematosus (SLE) patients and is associated with increased mortality. DNA methylation, one of the most important epigenetic modifications, has b…
View article: Targeted glomerular mesangium transfection by antifibrotic gene nanocarriers inhibits kidney fibrosis and promotes regeneration
Targeted glomerular mesangium transfection by antifibrotic gene nanocarriers inhibits kidney fibrosis and promotes regeneration Open
Renal fibrosis and loss of kidney function are key characteristics of chronic kidney disease (CKD). To address the lack of effective treatments, multifunctional layer-by-layer (LbL) assembled polymeric gene-carrier nanoparticles (PCHS-NP) …
View article: Ginseng-derived nanoparticles alleviate inflammatory bowel disease via the TLR4/MAPK and p62/Nrf2/Keap1 pathways
Ginseng-derived nanoparticles alleviate inflammatory bowel disease via the TLR4/MAPK and p62/Nrf2/Keap1 pathways Open
Inflammatory bowel disease (IBD) is closely linked to the homeostasis of the intestinal environment, and exosomes can be used to treat IBD due to their high biocompatibility and ability to be effectively absorbed by the intestinal tract. H…
View article: ATGL Regulates Renal Fibrosis by Reprogramming Lipid Metabolism in Renal Tubular Epithelial Cells
ATGL Regulates Renal Fibrosis by Reprogramming Lipid Metabolism in Renal Tubular Epithelial Cells Open
View article: Turmeric Volatile Oil Ameliorates Ovalbumin-Induced Allergic Rhinitis in Mice through the suppression of the MAPK and NF-κB Signaling Pathways
Turmeric Volatile Oil Ameliorates Ovalbumin-Induced Allergic Rhinitis in Mice through the suppression of the MAPK and NF-κB Signaling Pathways Open
View article: Pyruvate kinase <scp>M2</scp> regulates kidney fibrosis through pericyte glycolysis during the progression from acute kidney injury to chronic kidney disease
Pyruvate kinase <span>M2</span> regulates kidney fibrosis through pericyte glycolysis during the progression from acute kidney injury to chronic kidney disease Open
We aimed to investigate the role of renal pericyte pyruvate kinase M2 (PKM2) in the progression of acute kidney injury (AKI) to chronic kidney disease (CKD). The role of PKM2 in renal pericyte‐myofibroblast transdifferentiation was investi…
View article: The PI3K-Akt-mTOR pathway mediates renal pericyte-myofibroblast transition by enhancing glycolysis through HKII
The PI3K-Akt-mTOR pathway mediates renal pericyte-myofibroblast transition by enhancing glycolysis through HKII Open
View article: Strategies for the induction of anti-inflammatory mesenchymal stem cells and their application in the treatment of immune-related nephropathy
Strategies for the induction of anti-inflammatory mesenchymal stem cells and their application in the treatment of immune-related nephropathy Open
Mesenchymal stem cells (MSCs) have potent immunomodulatory functions. Animal studies and clinical trials have demonstrated that MSCs can inhibit immune/inflammatory response in tissues and have good therapeutic effects on a variety of immu…
View article: Complement factor B inhibitor LNP023 improves lupus nephritis in MRL/lpr mice
Complement factor B inhibitor LNP023 improves lupus nephritis in MRL/lpr mice Open
View article: 14-3-3ζ inhibits maladaptive repair in renal tubules by regulating YAP and reduces renal interstitial fibrosis
14-3-3ζ inhibits maladaptive repair in renal tubules by regulating YAP and reduces renal interstitial fibrosis Open
View article: Generation of induced pluripotent stem cells from peripheral blood mononuclear cells obtained from an adult with autosomal recessive polycystic kidney disease
Generation of induced pluripotent stem cells from peripheral blood mononuclear cells obtained from an adult with autosomal recessive polycystic kidney disease Open
View article: Role of NOD-Like Receptors in a Miniature Pig Model of Diabetic Renal Injuries
Role of NOD-Like Receptors in a Miniature Pig Model of Diabetic Renal Injuries Open
Activation of NOD-like receptor (NLR) signaling pathway can promote downstream cytokine and proinflammatory cytokines release, and inflammation induced by excess nutrients leads to renal metabolic injury. How the NLRs influence metabolic p…
View article: Establishment of the induced pluripotent stem cell line PLAFMCi006-A from peripheral blood mononuclear cells of polycystic kidney disease patients with PKD2 gene mutation
Establishment of the induced pluripotent stem cell line PLAFMCi006-A from peripheral blood mononuclear cells of polycystic kidney disease patients with PKD2 gene mutation Open
View article: Transient upregulation of EGR1 signaling enhances kidney repair by activating SOX9<sup>+</sup> renal tubular cells
Transient upregulation of EGR1 signaling enhances kidney repair by activating SOX9<sup>+</sup> renal tubular cells Open
Background: Acute kidney injury (AKI) is associated with damage to the nephrons and tubular epithelial cells (TECs), which can lead to chronic kidney disease and end-stage renal disease. Identifying new biomarkers before kidney dysf…
View article: Establishment of PLAFMCi005-A induced pluripotent stem cells derived from PBMC from a patient with renal cysts and diabetes syndrome
Establishment of PLAFMCi005-A induced pluripotent stem cells derived from PBMC from a patient with renal cysts and diabetes syndrome Open
Renal cysts and diabetes syndrome (RCAD) is caused by gene mutations in hepatocyte nuclear factor 1-β (HNF1B), but the underlying molecular mechanism is still unclear. This study established PLAFMCi005-A human induced pluripotent stem cell…
View article: Establishment of PLAFMCi004-A induced pluripotent stem cells derived from PBMCs from a healthy individual
Establishment of PLAFMCi004-A induced pluripotent stem cells derived from PBMCs from a healthy individual Open
Peripheral blood mononuclear cells (PBMCs) were isolated from a healthy male individual. PBMCs were reprogrammed into human induced pluripotent stem cells (iPSCs) using plasmids carrying the following reprogramming factors: NANOG, LIN28, O…
View article: KLF14 Inhibits Renal Mesangial Cell Proliferation by Promoting Btg2 Gene Expression
KLF14 Inhibits Renal Mesangial Cell Proliferation by Promoting Btg2 Gene Expression Open
Krüppel-like factor 14 is one of zinc finger protein family that are closely associated with regulation of transcription, and its function in the kidneys remains unclear. So KLF14-deficient mouse models were established using TALEN. The le…
View article: Generation of induced pluripotent stem cell PLAFMCi002-A derived from peripheral blood mononuclear cells of polycystic kidney disease patient with PKD1 mutation
Generation of induced pluripotent stem cell PLAFMCi002-A derived from peripheral blood mononuclear cells of polycystic kidney disease patient with PKD1 mutation Open
Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disease, which characterized by formation and expansion of cysts within the kidney, leading to kidney failure. Thus, Peripheral blood mononuclear cells (PBMCs) were isolated…
View article: Multifunctional Natural Polymer Nanoparticles as Antifibrotic Gene Carriers for CKD Therapy
Multifunctional Natural Polymer Nanoparticles as Antifibrotic Gene Carriers for CKD Therapy Open
Significance Statement Progressive fibrosis, the underlying pathophysiologic process of CKD, is driven by myofibroblasts and activated profibrotic cells. Treatments targeting these cells for the reversal and amelioration of CKD are lacking…
View article: ROBO2-mediated RALDH2 signaling is required for common nephric duct fusion with primitive bladder
ROBO2-mediated RALDH2 signaling is required for common nephric duct fusion with primitive bladder Open
Congenital anomalies of the urinary tract are a significant cause of morbidity in infancy, and many congenital anomalies are linked to ureter development; however, the mechanism by which congenital anomalies control ureter development rema…
View article: Chlorzoxazone, a small molecule drug, augments immunosuppressive capacity of mesenchymal stem cells via modulation of FOXO3 phosphorylation
Chlorzoxazone, a small molecule drug, augments immunosuppressive capacity of mesenchymal stem cells via modulation of FOXO3 phosphorylation Open
View article: <i>Ganab</i> Haploinsufficiency Does Not Cause Polycystic Kidney Disease or Polycystic Liver Disease in Mice
<i>Ganab</i> Haploinsufficiency Does Not Cause Polycystic Kidney Disease or Polycystic Liver Disease in Mice Open
Background . Heterozygous GANAB mutations that can cause autosomal dominant polycystic kidney disease (ADPKD) and polycystic liver disease (PLD) have been described previously, but their roles in ADPKD and PLD are largely unknown. With the…
View article: Disruption of Robo2-Baiap2 integrated signaling drives cystic disease
Disruption of Robo2-Baiap2 integrated signaling drives cystic disease Open
Hereditary renal cystic diseases are characterized by defects in primary cilia of renal tubular epithelial cells and abnormality of tubular epithelium, which ultimately result in the development of renal cysts. However, the mechanism leadi…