Xufan Cai
YOU?
Author Swipe
View article: Histone lactylation drives METTL3 upregulation-mediated RNA m6A modification of CCT2 to hinder CD8+ T cell survival in gastric cancer
Histone lactylation drives METTL3 upregulation-mediated RNA m6A modification of CCT2 to hinder CD8+ T cell survival in gastric cancer Open
Histone lactylation drives upregulation of METTL3 and mediates m6A modification and overexpression of CCT2. CCT2 dampens the activity of CD8+T cells by repressing Ca2+influx, thereby mediating the malignant progressio…
View article: Histone lactylation drives METTL3 upregulation-mediated RNA m6A modification of CCT2 to hinder CD8+ T cell survival in gastric cancer
Histone lactylation drives METTL3 upregulation-mediated RNA m6A modification of CCT2 to hinder CD8+ T cell survival in gastric cancer Open
Histone lactylation drives upregulation of METTL3 and mediates m6A modification and overexpression of CCT2. CCT2 dampens the activity of CD8+T cells by repressing Ca2+influx, thereby mediating the malignant progressio…
View article: Implication of an exosome-based gene signature for estimating clinical outcomes of triple-negative breast cancer and assisting in individualized therapy
Implication of an exosome-based gene signature for estimating clinical outcomes of triple-negative breast cancer and assisting in individualized therapy Open
Exosomes play a crucial role in triple-negative breast cancer (TNBC), influencing various aspects of tumor progression. Given the importance of exosomes in TNBC biology, we proposed a novel exosome-based model that was critically implicate…
View article: The Regulatory Role of Brown Adipocyte - Related Gene CALU in the Progression, Immune Microenvironment and Treatment Response of Pancreatic Cancer
The Regulatory Role of Brown Adipocyte - Related Gene CALU in the Progression, Immune Microenvironment and Treatment Response of Pancreatic Cancer Open
Purpose Pancreatic Ductal Adenocarcinoma (PDAC) remains a lethal malignancy with limited therapeutic options. This study aimed to identify brown adipocyte-related genes (BARGs) influencing PDAC prognosis and explore their roles in the tumo…
View article: Epigenetic-modification associated hnRNPA3 acts as a prognostic biomarker and promotes malignant progression of HCC
Epigenetic-modification associated hnRNPA3 acts as a prognostic biomarker and promotes malignant progression of HCC Open
View article: Combined utility of genomic breakpoints and frame is a reliable predictor of ALK transcript function
Combined utility of genomic breakpoints and frame is a reliable predictor of ALK transcript function Open
Lung cancer is a major cause of cancer-related deaths globally. Targeted therapies, specifically attacking cancer cells based on genetic mutations, offer promising alternatives. ALK (anaplastic lymphoma kinase) fusions result in aberrant p…
View article: Epigenetic-modification associated hnRNPA3 acts as a prognostic biomarker and promotes malignant progression of HCC
Epigenetic-modification associated hnRNPA3 acts as a prognostic biomarker and promotes malignant progression of HCC Open
Objective hnRNPA3 is highly expressed in numerous malignancies, including hepatocellular carcinoma (HCC), but its function and mechanism has not been elucidated. In this study, we performed a comprehensive bioinformatics analysis of hnRNPA…
View article: WYC-209 suppresses gastric cancer by down-regulating FGF18 via inactivating the STAT3 signaling pathway
WYC-209 suppresses gastric cancer by down-regulating FGF18 via inactivating the STAT3 signaling pathway Open
Together, our findings presented the promise of WYC-209 in suppressing GC by down-regulating FGF18 expression through inactivating the STAT3 signaling pathway.
View article: RARB associated with MSI, affects progression and prognosis of gastric cancer
RARB associated with MSI, affects progression and prognosis of gastric cancer Open
View article: Andrographolide induces protective autophagy and targeting DJ-1 triggers reactive oxygen species-induced cell death in pancreatic cancer
Andrographolide induces protective autophagy and targeting DJ-1 triggers reactive oxygen species-induced cell death in pancreatic cancer Open
Background Andrographolide (Andro), an extract of Andrographis paniculate (Burm.f.) Wall. ex Nees (Acanthaceae), possesses diverse biologically active properties. However, the precise mechanisms and effects of Andro on pancreatic cancer (P…
View article: Prognostic Biomarkers for Hepatocellular Carcinoma Based on Serine and Glycine Metabolism-related Genes
Prognostic Biomarkers for Hepatocellular Carcinoma Based on Serine and Glycine Metabolism-related Genes Open
BACKGROUND AND AIMS: Targeted therapy and immunotherapy have emerged as treatment options for hepatocellular carcinoma (HCC) in recent years. The significance of serine and glycine metabolism in various cancers is widely acknowledged. This…
View article: Ginsenoside Rg3 suppresses vasculogenic mimicry by impairing DVL3-maintained stemness via PAAD cell-derived exosomal miR-204 in pancreatic adenocarcinoma
Ginsenoside Rg3 suppresses vasculogenic mimicry by impairing DVL3-maintained stemness via PAAD cell-derived exosomal miR-204 in pancreatic adenocarcinoma Open
Ginsenoside Rg3 increased the PAAD cell-derived exosomal miR-204 levels, which subsequently inhibited its target genes DVL3 expression in the receptor PAAD cells, and the down-regulated DVL3 broke stemness maintenance, ultimately suppressi…
View article: WYC-209 inhibited GC malignant progression by down-regulating WNT4 through RARα
WYC-209 inhibited GC malignant progression by down-regulating WNT4 through RARα Open
Gastric cancer (GC) has been a major health burden all over the world but there are fewer promising chemotherapeutic drugs due to its multidrug resistance. It has been reported that WYC-209 suppresses the growth and metastasis of tumor-rep…
View article: Mechanisms of ginseng in pancreatic cancer metastasis
Mechanisms of ginseng in pancreatic cancer metastasis Open
It has been shown that ginsenosides can inhibit proliferation, migration, and invasion of pancreatic cancer (PC) cells, and promote apoptosis of PC cells. However, the potential mechanisms of ginseng in treating PC metastasis (PCM) have no…
View article: Mechanisms of ginseng in pancreatic cancer metastasis
Mechanisms of ginseng in pancreatic cancer metastasis Open
It has been shown that ginsenosides can inhibit proliferation, migration, and invasion of pancreatic cancer (PC) cells, and promote apoptosis of PC cells. However, the potential mechanisms of ginseng in treating PC metastasis (PCM) have no…
View article: RARB, a gene associated with MSI gastric cancer, affects progression and prognosis of gastric cancer
RARB, a gene associated with MSI gastric cancer, affects progression and prognosis of gastric cancer Open
MSI gastric cancer exhibits greater sensitivity to immunotherapy due to its own characteristics. Here, we firstly identified the RARB gene associated with MSI gastric cancer, which was positively correlated with mismatch repair proteins(MM…
View article: Digestive tract reconstruction after laparoscopic proximal gastrectomy for Gastric cancer: A systematic review
Digestive tract reconstruction after laparoscopic proximal gastrectomy for Gastric cancer: A systematic review Open
The incidence of gastroesophageal junction adenocarcinoma has gradually increased. Proximal gastrectomy or total gastrectomy is recommended for early gastric cancer of the upper third of the stomach. Because total gastrectomy is often acco…