Xufeng Cao
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View article: OsEL2 Regulates Rice Cold Tolerance by MAPK Signaling Pathway and Ethylene Signaling Pathway
OsEL2 Regulates Rice Cold Tolerance by MAPK Signaling Pathway and Ethylene Signaling Pathway Open
Low temperature stress represents a significant abiotic stress factor affecting rice yields. While the structure and some of the functions of cell cycle protein-dependent protein kinase inhibitor (CKI) family proteins have been the subject…
View article: Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate
Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate Open
View article: Genetic Determinants of Acinetobacter baumannii Serum-Associated Adaptive Efflux-Mediated Antibiotic Resistance
Genetic Determinants of Acinetobacter baumannii Serum-Associated Adaptive Efflux-Mediated Antibiotic Resistance Open
Acinetobacter baumannii is a nosocomial pathogen of serious healthcare concern that is becoming increasingly difficult to treat due to antibiotic treatment failure. Recent studies have revealed that clinically defined antibiotic-susceptibl…
View article: Efficacy of a brain-penetrant antiviral in lethal Venezuelan and eastern equine encephalitis mouse models
Efficacy of a brain-penetrant antiviral in lethal Venezuelan and eastern equine encephalitis mouse models Open
Venezuelan and eastern equine encephalitis viruses (VEEV and EEEV, respectively) are mosquito-borne, neuroinvasive human pathogens for which no FDA-approved therapeutic exists. Besides the biothreat posed by these viruses when aerosolized,…
View article: Structure-activity relationship studies for inhibitors for vancomycin-resistant <i>Enterococcus</i> and human carbonic anhydrases
Structure-activity relationship studies for inhibitors for vancomycin-resistant <i>Enterococcus</i> and human carbonic anhydrases Open
Vancomycin-resistant enterococci (VRE), consisting of pathogenic Enterococcus faecalis and E. faecium, is a leading cause of hospital-acquired infections (HAIs). We recently repurposed the FDA-approved human carbonic anhydrase (CA) …
View article: Piperazinobenzodiazepinones: New Encephalitic Alphavirus Inhibitors via Ring Expansion of 2-Dichloromethylquinazolinones
Piperazinobenzodiazepinones: New Encephalitic Alphavirus Inhibitors via Ring Expansion of 2-Dichloromethylquinazolinones Open
Venezuelan and eastern equine encephalitis viruses are disease-causing, neuropathic pathogens with no approved treatment options in humans. While expanding the pharmacophoric model of antialphaviral amidines prepared via a quinazolinone re…
View article: Optimization of 2-Acylaminocycloalkylthiophene Derivatives for Activity against Staphylococcus aureus RnpA
Optimization of 2-Acylaminocycloalkylthiophene Derivatives for Activity against Staphylococcus aureus RnpA Open
Staphylococcus aureus is well-recognized to cause debilitating bacterial infections that are difficult to treat due to the emergence of antibiotic resistance. As such, there is a need to develop new antimicrobials for the therapeutic inter…
View article: Structure–Activity Relationship Studies of Acetazolamide-Based Carbonic Anhydrase Inhibitors with Activity against <i>Neisseria gonorrhoeae</i>
Structure–Activity Relationship Studies of Acetazolamide-Based Carbonic Anhydrase Inhibitors with Activity against <i>Neisseria gonorrhoeae</i> Open
Neisseria gonorrhoeae is an urgent threat to public health in the United States and around the world. Many of the current classes of antibiotics to treat N. gonorrhoeae infection are quickly becoming obsolete due to increased…
View article: Optimization of Acetazolamide-Based Scaffold as Potent Inhibitors of Vancomycin-Resistant <i>Enterococcus</i>
Optimization of Acetazolamide-Based Scaffold as Potent Inhibitors of Vancomycin-Resistant <i>Enterococcus</i> Open
Vancomycin-resistant enterococci (VRE) are the second leading cause of hospital-acquired infections (HAIs) attributed to a drug-resistant bacterium in the United States, and resistance to the frontline treatments is well documented. To com…
View article: Optimization of 4‐Substituted Benzenesulfonamide Scaffold To Reverse <i>Acinetobacter baumannii</i> Serum‐Adaptive Efflux Associated Antibiotic Tolerance
Optimization of 4‐Substituted Benzenesulfonamide Scaffold To Reverse <i>Acinetobacter baumannii</i> Serum‐Adaptive Efflux Associated Antibiotic Tolerance Open
Acinetobacter baumannii is a nosocomial pathogen of urgent concern for public health due to rising rates of multidrug and pandrug resistance. In the context of environmental cues such as growth in human serum, A. baumannii is known to disp…
View article: Efficacy of a ML336 derivative against Venezuelan and eastern equine encephalitis viruses
Efficacy of a ML336 derivative against Venezuelan and eastern equine encephalitis viruses Open
Currently, there are no licensed human vaccines or antivirals for treatment of or prevention from infection with encephalitic alphaviruses. Because epidemics are sporadic and unpredictable, and endemic disease is common but rarely diagnose…
View article: Telescoped synthesis of C3-functionalized (<i>E</i>)-arylamidines using Ugi–Mumm and regiospecific quinazolinone rearrangements
Telescoped synthesis of C3-functionalized (<i>E</i>)-arylamidines using Ugi–Mumm and regiospecific quinazolinone rearrangements Open
An efficient, telescoped, multicomponent assembly and regiospecific rearrangement of highly diversified quinazolinones affords C3 modified,N-aryl- andN-alkylamide arylamidines requiring only a single purification.
View article: CCDC 1880156: Experimental Crystal Structure Determination
CCDC 1880156: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Isolation of a novel leucine-rich repeat receptor-like kinase (<i>OsLRR2</i>) gene from rice and analysis of its relation to abiotic stress responses
Isolation of a novel leucine-rich repeat receptor-like kinase (<i>OsLRR2</i>) gene from rice and analysis of its relation to abiotic stress responses Open
Leucine-rich repeat receptor-like kinase protein (LRR-RLK) is involved in a wide range of biological pathways. So far, the function of LRR-RLK in the growth, developmental processes and various external stimuli has still not been clearly e…
View article: Identification and characterization of a novel abiotic stress responsive sulphotransferase gene (<i>OsSOT9</i>) from rice
Identification and characterization of a novel abiotic stress responsive sulphotransferase gene (<i>OsSOT9</i>) from rice Open
Abiotic stresses may seriously affect plant growth and development. In order to explore new stress tolerance genes in rice (Oryza sativa L.), expression profiles were obtained for leaf and panicle tissues. They were taken at seedling, boot…