Xuhua Duan
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View article: Neural Discrete Representation Learning for Sparse-View CBCT Reconstruction: From Algorithm Design to Prospective Multicenter Clinical Evaluation
Neural Discrete Representation Learning for Sparse-View CBCT Reconstruction: From Algorithm Design to Prospective Multicenter Clinical Evaluation Open
Cone beam computed tomography (CBCT)-guided puncture has become an established approach for diagnosing and treating early- to mid-stage thoracic tumours, yet the associated radiation exposure substantially elevates the risk of secondary ma…
View article: High-Resolution C-arm Computed Tomography for Evaluation of Stent Expansion and Apposition after Intracranial Stent Implantation
High-Resolution C-arm Computed Tomography for Evaluation of Stent Expansion and Apposition after Intracranial Stent Implantation Open
Objective : C-arm computed tomography (CT) has always played an important role in neurointerventional surgery, in this study, we aimed to investigate the value of high-resolution C-arm CT in evaluating stent expansion and apposition in car…
View article: Traumatic complications linked to prophylactic drain placement after hepatectomy: A meta-analysis
Traumatic complications linked to prophylactic drain placement after hepatectomy: A meta-analysis Open
Prophylactic drainage had a considerably greater surgical site wound infection rate, and there was no discernible difference between IIACs and non-PD in LR individuals. Nevertheless, because there were not many studies nominated for compar…
View article: Enhanced Cerenkov radiation induced photodynamic therapy based on GSH-responsive biomimetic nanoplatform to trigger immunogenic cell death for tumor immunotherapy
Enhanced Cerenkov radiation induced photodynamic therapy based on GSH-responsive biomimetic nanoplatform to trigger immunogenic cell death for tumor immunotherapy Open
View article: MRI-based multimodal AI model enables prediction of recurrence risk and adjuvant therapy in breast cancer
MRI-based multimodal AI model enables prediction of recurrence risk and adjuvant therapy in breast cancer Open
Timely intervention and improved prognosis for breast cancer patients rely on early metastasis risk detection and accurate treatment predictions. This study introduces an advanced multimodal MRI and AI-driven 3D deep learning model, termed…
View article: Latent profile and determinants of self-management behaviors among older adult patients with chronic diseases: a cross-sectional study
Latent profile and determinants of self-management behaviors among older adult patients with chronic diseases: a cross-sectional study Open
Objective To explore latent profiles of self-management behaviors in older adult patients with chronic diseases and identify the factors that influence different profiles, guiding targeted interventions. Methods This study used convenience…
View article: Effect of different ventilation modes on postoperative cognitive dysfunction in elderly patients undergoing laparoscopic abdominal wall herniorrhaphy
Effect of different ventilation modes on postoperative cognitive dysfunction in elderly patients undergoing laparoscopic abdominal wall herniorrhaphy Open
In elderly patients undergoing abdominal wall hernia repair, PRVC ventilation reduced the incidence of early POCD, particularly compared to PC ventilation. This neuroprotective effect appears to be linked to improved respiratory mechanics …
View article: Disseminated Combined Talaromyces marneffei and Enterococcus faecium Bloodstream Infection Presenting as Gastrointestinal Perforation in a Patient with CARD9 Gene Mutation
Disseminated Combined Talaromyces marneffei and Enterococcus faecium Bloodstream Infection Presenting as Gastrointestinal Perforation in a Patient with CARD9 Gene Mutation Open
This study presents a case of Talaromyces marneffei combined with Enterococcus faecium bloodstream infection with gastrointestinal symptoms as the sole initial clinical manifestation.The patient is a resident of Shanghai and …
View article: Immune checkpoint inhibitors and anti-vascular endothelial growth factor antibody/tyrosine kinase inhibitors with or without transarterial chemoembolization as first-line treatment for advanced hepatocellular carcinoma (CHANCE2201): a target trial emulation study
Immune checkpoint inhibitors and anti-vascular endothelial growth factor antibody/tyrosine kinase inhibitors with or without transarterial chemoembolization as first-line treatment for advanced hepatocellular carcinoma (CHANCE2201): a target trial emulation study Open
BACKGROUND: The role of transarterial chemoembolization (TACE) in the treatment of advanced hepatocellular carcinoma (HCC) is unconfirmed. This study aimed to assess the efficacy and safety of immune checkpoint inhibitors (ICIs) plus anti-…
View article: Pioglitazone, a peroxisome proliferator‑activated receptor γ agonist, induces cell death and inhibits the proliferation of hypoxic HepG2 cells by promoting excessive production of reactive oxygen species
Pioglitazone, a peroxisome proliferator‑activated receptor γ agonist, induces cell death and inhibits the proliferation of hypoxic HepG2 cells by promoting excessive production of reactive oxygen species Open
Hypoxia is a hallmark of solid tumors. Hypoxic cancer cells adjust their metabolic characteristics to regulate the production of cellular reactive oxygen species (ROS) and facilitate ROS-mediated metastasis. Peroxisome proliferator-activat…
View article: Cell Membrane Hybrid Lipid Nanovesicles Enhance Innate Immunity for Synergistic Immunotherapy by Promoting Immunogenic Cell Death and cGAS Activation
Cell Membrane Hybrid Lipid Nanovesicles Enhance Innate Immunity for Synergistic Immunotherapy by Promoting Immunogenic Cell Death and cGAS Activation Open
Immunotherapy shows great therapeutic potential for long-term protection against tumor relapse and metastasis. Innate immune sensors, such as cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING), dissolve DNA and induc…
View article: Transarterial chemoembolization combined donafenib with/without PD-1 for unresectable HCC in a multicenter retrospective study
Transarterial chemoembolization combined donafenib with/without PD-1 for unresectable HCC in a multicenter retrospective study Open
Background & aims This multicenter retrospective study evaluated the efficacy and safety of transarterial chemoembolization (TACE) combined with donafenib and a programmed death-1 (PD-1) inhibitor (TACE+DP) and TACE combined with donaf…
View article: Covered SEMS failed to cure airway fistula closed by an amplatzer device
Covered SEMS failed to cure airway fistula closed by an amplatzer device Open
Background Airway fistula is a rare but threatening complication associated with high rates of morbidity and mortality. We report the experience of Amplatzer device application in airway fistulae that failed to be cured with a covered self…
View article: Transcatheter arterial chemoembolization plus apatinib with or without camrelizumab for unresectable hepatocellular carcinoma: a multicenter retrospective cohort study
Transcatheter arterial chemoembolization plus apatinib with or without camrelizumab for unresectable hepatocellular carcinoma: a multicenter retrospective cohort study Open
View article: The impact of drug-eluting bead (vs. conventional) transarterial chemoembolization on hepatic fibrosis in treating intermediate or advanced hepatocellular carcinoma
The impact of drug-eluting bead (vs. conventional) transarterial chemoembolization on hepatic fibrosis in treating intermediate or advanced hepatocellular carcinoma Open
DEB-TACE displays attenuated hepatic fibrosis progression and noninferior tolerance compared to cTACE in treating intermediate- or advanced-stage HCC patients.
View article: Cell Membrane Hybrid Lipid Nanovesicles Enhance Innate Immunity for Synergistic Chemo-Immunotherapy by Promoting Immunogenic Cell Death and Cgas/Sting Activation
Cell Membrane Hybrid Lipid Nanovesicles Enhance Innate Immunity for Synergistic Chemo-Immunotherapy by Promoting Immunogenic Cell Death and Cgas/Sting Activation Open
View article: Nrf2-siRNA Enhanced the Anti-Tumor Effects of As2O3 in 5-Fluorouracil-Resistant Hepatocellular Carcinoma by Inhibiting HIF-1α/HSP70 Signaling
Nrf2-siRNA Enhanced the Anti-Tumor Effects of As2O3 in 5-Fluorouracil-Resistant Hepatocellular Carcinoma by Inhibiting HIF-1α/HSP70 Signaling Open
Nrf2 knockdown could improve the effect of As2O3 on reversing drug resistance in 5-FU-resistant HCC cells.
View article: 143P Efficacy and safety of bronchial arterial chemoembolization (BACE) in combination with tislelizumab for non-small cell lung cancer (NSCLC): A single-arm phase II trial
143P Efficacy and safety of bronchial arterial chemoembolization (BACE) in combination with tislelizumab for non-small cell lung cancer (NSCLC): A single-arm phase II trial Open
Immunotherapy and BACE are important therapy for NSCLC. This trial is designed to determine the efficacy and safety of immunotherapy with tislelizumab in addition to BACE in stage III-IV NSCLC patients (pts) who failed, refused or ineligib…
View article: Comparison of Treatment Response, Survival Profiles, as Well as Safety Profiles Between CalliSpheres® Microsphere Transarterial Chemoembolization and Conventional Transarterial Chemoembolization in Huge Hepatocellular Carcinoma
Comparison of Treatment Response, Survival Profiles, as Well as Safety Profiles Between CalliSpheres® Microsphere Transarterial Chemoembolization and Conventional Transarterial Chemoembolization in Huge Hepatocellular Carcinoma Open
Purpose CalliSpheres ® microspheres (CSM) are the first drug-eluting beads (DEB) developed in China. This study aimed to compare treatment response, survival, and safety profiles between DEB transarterial chemoembolization (DEB-TACE) with …
View article: Liposome quercetin enhances the ablation effects of microwave ablation in treating the rabbit VX2 liver tumor model
Liposome quercetin enhances the ablation effects of microwave ablation in treating the rabbit VX2 liver tumor model Open
Preoperative infusion of LQ can significantly enhance the MWA effects of liver VX2 tumor, inhibit the excessive proliferation of residual tumor and angiogenesis, and decrease metastasis and prolong the survival period of experimental anima…
View article: PSMC2/ITGA6 axis plays critical role in the development and progression of hepatocellular carcinoma
PSMC2/ITGA6 axis plays critical role in the development and progression of hepatocellular carcinoma Open
View article: Occurrence, Related Factors and Prognostic Value of Vascular Lake in Hepatocellular Carcinoma Patients Treated with Drug-Eluting Bead Transarterial Chemoembolization
Occurrence, Related Factors and Prognostic Value of Vascular Lake in Hepatocellular Carcinoma Patients Treated with Drug-Eluting Bead Transarterial Chemoembolization Open
VL occurs in 17.1% of HCC patients treated with DEB-TACE, and it is correlated with larger tumor size, pseudocapsule, smaller bead size, more favorable treatment response and better survival.
View article: Arsenic trioxide-loaded CalliSpheres: <i>In vitro</i> study of drug release and antitumor activity, and <i>in vivo</i> study of pharmacokinetics, treatment efficacy and safety in liver cancer
Arsenic trioxide-loaded CalliSpheres: <i>In vitro</i> study of drug release and antitumor activity, and <i>in vivo</i> study of pharmacokinetics, treatment efficacy and safety in liver cancer Open
The aim of the present study was to investigate the arsenic trioxide (ATO) loading/releasing efficiency of CalliSphere beads (CBs), as well as the in vitro anticancer activity, in vivo pharmacokinetics, treatment efficacy and…
View article: Combined use of microwave ablation and cell immunotherapy induces nonspecific immunity of hepatocellular carcinoma model mice
Combined use of microwave ablation and cell immunotherapy induces nonspecific immunity of hepatocellular carcinoma model mice Open
Microwave ablation (MWA) has been widely used in the treatment of solid tumors. Studies have been less conducted on the efficacy of MWA used with cell immunotherapy in treating hepatocellular carcinoma (HCC). The current study aimed at exp…
View article: Arsenic trioxide-eluting electrospun nanofiber-covered self-expandable metallic stent reduces granulation tissue hyperplasia in rabbit trachea
Arsenic trioxide-eluting electrospun nanofiber-covered self-expandable metallic stent reduces granulation tissue hyperplasia in rabbit trachea Open
Stent-related granulation tissue hyperplasia is a major complication that limits the application of stents in airways. In this study, an arsenic trioxide-eluting electrospun nanofiber-covered self-expandable metallic stent (ATO-NFCS) was d…
View article: A novel application of drug-eluting transarterial chemoembolization in treating non-liver cancers
A novel application of drug-eluting transarterial chemoembolization in treating non-liver cancers Open
This case series aimed to preliminarily evaluate the efficacy and safety of drug-eluting beads transarterial chemoembolization (DEB-TACE) in patients with lung, renal, gastric, and other non-liver cancers.Twenty-four patients who underwent…
View article: Liver Damage After Radiofrequency Ablation Combined with Transcatheter Therapy in Treating Rabbit VX2 Liver Tumors
Liver Damage After Radiofrequency Ablation Combined with Transcatheter Therapy in Treating Rabbit VX2 Liver Tumors Open
Background: To evaluate the effect of transcatheter therapies combining with radiofrequency ablation (RFA) treatment on hepatocellular necrosis, apoptosis and proliferation by using the rabbit VX2 tumor model. Methods: Ninety six models we…
View article: Comparison of treatment response, survival profiles as well as safety profiles between CalliSpheres® microspheres transarterial chemoembolization and conventional transarterial chemoembolization in huge hepatocellular carcinoma
Comparison of treatment response, survival profiles as well as safety profiles between CalliSpheres® microspheres transarterial chemoembolization and conventional transarterial chemoembolization in huge hepatocellular carcinoma Open
Background: This study aimed to compare treatment response, survival and safety profiles between drug-eluting beads transarterial chemoembolization (DEB-TACE) with CalliSpheres® microspheres (CSM) and conventional TACE (cTACE) i…
View article: Antitumor properties of arsenic trioxide-loaded CalliSpheres<sup>®</sup> microspheres by transarterial chemoembolization in VX2 liver tumor rabbits: suppression of tumor growth, angiogenesis, and metastasis and elongation of survival.
Antitumor properties of arsenic trioxide-loaded CalliSpheres<sup>®</sup> microspheres by transarterial chemoembolization in VX2 liver tumor rabbits: suppression of tumor growth, angiogenesis, and metastasis and elongation of survival. Open
This study aimed to investigate the antitumor effect of arsenic trioxide (ATO)-loaded CalliSpheres® microspheres (CSM) by transarterial chemoembolization (TACE) in rabbits with VX2 liver tumors. A total of 120 VX2 liver tumor ra…
View article: <p>Hepatic Arterial Chemoembolization With Arsenic Trioxide Eluting CalliSpheres Microspheres Versus Lipiodol Emulsion: Pharmacokinetics And Intratumoral Concentration In A Rabbit Liver Tumor Model</p>
Hepatic Arterial Chemoembolization With Arsenic Trioxide Eluting CalliSpheres Microspheres Versus Lipiodol Emulsion: Pharmacokinetics And Intratumoral Concentration In A Rabbit Liver Tumor Model Open
Administration of ATO via DEB-TACE decreases systemic concentration while increasing intratumoral concentration of ATO without increasing liver or kidney toxicity compared with cTACE.