Explanipedia

Galectin-1 Promotes Gastric Carcinoma Progression and Cisplatin Resistance Through the NRP-1/c-JUN/Wee1 Pathway Open

Zheng-Yang Pan, Guoxi Xu, Yan Zhang, Meiling Wu, Jiahui Yu , et al. · 2024

These findings revealed a potential mechanism by which Gal-1 promotes GC growth and contributes to chemoresistance, offering new therapeutic targets for the treatment of GC.

MicroRNA-145-5p Inhibits Gastric Cancer Invasiveness through Targeting N-Cadherin and ZEB2 to Suppress Epithelial-Mesenchymal Transition [Retraction] Open

Shibin Jiang, Xujun He, Yingjie Xia, Weijian Hu, Jungang Luo , et al. · 2023

[This retracts the article DOI: 10.2147/OTT.S101853.].

Extended‐spectrum β‐lactamase‐producing Enterobacteriaceae from ready‐to‐eat foods: Genetic diversity and antibiotic susceptibility Open

Yao Liu, Xinghua Chen, Junwei Luifu, Jing Zhao, Xujun He , et al. · 2023

Ready‐to‐eat (RTE) foods are widely marketed in China and are important components of everyday diet. In this study, a total of 2000 RTE food samples were analyzed, 252 (12.60%) of which were positive for Enterobacteriaceae, and 48 were ide…

PBRM1 presents a potential prognostic marker and therapeutic target in duodenal papillary carcinoma Open

Xujun He, Ji Xu, Nan Niu, Guoxi Xu, Honglin Zhu , et al. · 2022

Background Due to its rarity, duodenal papillary carcinoma (DPC) is seldom studied as a unique disease and no specific molecular features or treatment guidelines are provided. Methods Whole‐exome sequencing was performed to gain new insigh…

Retraction Note: Up-regulated miR-199a-5p in gastric cancer functions as an oncogene and targets klotho Open

Xujun He, Ying‐Yu Ma, Sheng Yu, Xiaoting Jiang, Yi-Ding Lu , et al. · 2022

This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/1471-2407-14-218.

4-Hydroxyphenylpyruvate Dioxygenase-Like Protein Promotes Pancreatic Cancer Cell Progression and Is Associated With Glutamine-Mediated Redox Balance Open

Xianglai Ye, Xiujuan Wei, Jing Liao, Peipei Chen, Xueyun Li , et al. · 2021

Tumor cells develop a series of metabolic reprogramming mechanisms to meet the metabolic needs for tumor progression. As metabolic hubs in cells, mitochondria play a significant role in this process, including energy production, biosynthes…

[Expression of tumor-associated vascular insulin receptor in colorectal cancer and its relationship with tumor pathological features]. Open

Zeran Yang, Xin Zhang, Jie Ma, Jin Li, Xujun He · 2020

s: High-expression of TVIR is associated with aggressive pathological features such as invasion, lymph node metastasis and high TNM stage of colorectal cancer, especially for those patients without MS. TVIR could be a useful biological mar…

IL35 predicts prognosis in gastric cancer and is associated with angiogenesis by altering TIMP1, PAI1 and IGFBP1 Open

Xiao Li, Nan Niu, Jing Sun, Yiping Mou, Xujun He , et al. · 2020

Tumor angiogenesis is required for tumor growth and metastasis. Interleukin‐35 (IL35), a member of the IL12 family, is a dimer composed of IL12A and EBV‐induced gene 3（EBI3）. Elevated plasma IL35 levels have been reported to be associated …

Prevalence, antibiotic susceptibility and characterization of <i>Vibrio parahaemolyticus</i> isolates in China Open

Tengfei Xie, Quan Yu, Xiong Tang, Jing Zhao, Xujun He · 2020

Vibrio parahaemolyticus is a marine and estuarine bacterium that poses a major threat to human health worldwide. In this study, from 2017 to 2019, we evaluated 900 food samples collected from China in 2017, with the aim of determining the …

Integrative Analysis of the IQ Motif-Containing GTPase-Activating Protein Family Indicates That the IQGAP3-PIK3C2B Axis Promotes Invasion in Colon Cancer Open

Zhuo Liu, Xiao Li, Jie Ma, Dechuan Li, Haixing Ju , et al. · 2020

The results of our current study and corresponding previous studies provide evidence that IQGAP3 is elevated in CRC and promotes colon cancer growth and metastasis by regulating PIK3C2B activation.

Upregulation of miRNA‑301a‑3p promotes tumor progression in gastric cancer by suppressing NKRF and activating NF‑κB signaling Open

Xiaodong Xu, Yingjie Xia, Jie Ma, Weijun Li, Nan Niu , et al. · 2020

MicroRNA‑301a (miRNA/miR‑301a) and nuclear factor (NF)‑κB signaling play important roles in tumor invasion, migration and progression. However, the role of miRNA‑301a‑3p in human gastric cancer (GC), and specifically in the activation of N…

COX6B2 drives metabolic reprogramming toward oxidative phosphorylation to promote metastasis in pancreatic ductal cancer cells Open

Ke Nie, Jin Li, Xujun He, Yuqing Wang, Qiongya Zhao , et al. · 2020

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer type with poor prognosis due to its high metastatic potential, however, the role of metabolic reprogramming in the metastasis of PDAC cell is not known. Here, we report that C…

Bifidobacterium infantis Relieves Allergic Asthma in Mice by Regulating Th1/Th2 Open

Wenlan Wang, Xiaoming Luo, Qin Zhang, Xujun He, Zhifang Zhang , et al. · 2020

BACKGROUND Bifidobacteria are among the probiotics used in treating intestinal diseases and are rarely used for allergic asthma treatment. The present study investigated the mechanism of B. infantis in treating allergic asthma in mice. MAT…

Advantages of Restoring miR-205-3p Expression for Better Prognosis of Gastric Cancer via Prevention of Epithelial-mesenchymal Transition Open

Zhen Zhang, Xujun He, Ji Xu, Genhua Zhang, Yue Yang , et al. · 2020

miR-205-3p promotes GC progression and affects the prognosis of patients by targeting both ZEB1 and ZEB2 to directly influence EMT.

Antimicrobial resistance and genetic diversity of <i>Salmonella enterica</i> from eggs Open

Tengfei Xie, Gang Wu, Xujun He, Zengzhe Lai, Huatong Zhang , et al. · 2019

Salmonella enterica is a common foodborne pathogen responsible for major global health problems such as paratyphoid fever and gastroenteritis. Here, we report the prevalence, antibiotic resistance phenotypes, serotypes, and molecular subty…

Breast cancer prognosis is better in patients who develop subsequent metachronous thyroid cancer Open

Kefeng Lei, Xujun He, Leibo Yu, Chao Ni, Hailong Chen , et al. · 2019

Breast cancer (BC) and thyroid cancer (TC) are common malignancies among females. However, the connection between TC and BC is not well understood. To explore the relationship between these two cancers and to determine the effect of second…

Tumor-associated macrophages induce invasion and poor prognosis in human gastric cancer in a cyclooxygenase-2/MMP9-dependent manner. Open

Ji Xu, Yajuan Yu, Xujun He, Nan Niu, Xiao Li , et al. · 2019

Cyclooxygenase-2 (COX2) and tumor-associated macrophages (TAMs) are associated with invasion, angiogenesis, and poor prognosis in many human cancers. However, the role of TAMs in human gastric cancer (GC) remains elusive. In the present st…

GENE-42. THE GENOMIC LANDSCAPE OF TRIPLE-NEGATIVE GLIOBLASTOMA Open

Bill H. Diplas, Matthew S. Waitkus, Xujun He, Jackie Brosnan-Cashman, Heng Liu , et al. · 2018

Glioblastoma (GBM) is the most common and deadly primary malignant brain tumor in adults. Mutations in the TERT promoter (TERTp) and isocitrate dehydrogenase 1 or 2 (IDH1/2) can classify ~80% of GBMs into molecular subgroups with distinct …

GENE-01. THE GENOMIC LANDSCAPE OF TRIPLE-NEGATIVE GLIOBLASTOMA Open

Bill H. Diplas, Matthew S. Waitkus, Xujun He, Jackie Brosnan-Cashman, Heng Liu , et al. · 2018

Glioblastoma (GBM) is the most common and deadly primary malignant brain tumor in adults. Mutations in the TERT promoter (TERTp) and isocitrate dehydrogenase 1 or 2 (IDH1/2) can classify ~80% of GBMs into molecular subgroups with distinct …

P3.01-84 The Association of CDKN2A Gene Mutation with Clinicopathological Features and Prognosis in Advanced Lung Cancer Patients Open

Li Xu, Xiaohan Qu, Xujun He, Hang Zhou, Yihan Li · 2018

The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma Open

Bill H. Diplas, Xujun He, Jacqueline A. Brosnan‐Cashman, Heng Liu, Lee H. Chen , et al. · 2018

Overexpression of MMP21 and MMP28 is associated with gastric cancer progression and poor prognosis Open

Jizhen Zhang, Qi Pan, Wenhui Yan, Yiru Wang, Xujun He , et al. · 2018

Matrix metalloproteinase (MMP)-21 and MMP-28, or epilysin, are overexpressed during the invasion and metastasis of solid tumors. The present study investigated MMP-21 and MMP-28 expression levels in human gastric cancer using tissue microa…

Low FAT4 expression is associated with a poor prognosis in gastric cancer patients Open

Xiaoting Jiang, Zhengchuang Liu, Yingjie Xia, Jungang Luo, Ji Xu , et al. · 2017

In this study, we investigated the role of Fat atypical cadherin 4 (FAT4) in gastric cancer (GC) progression. Immunohistochemical analysis showed lower FAT4 expression in tumor tissues from GC patients than in normal gastric epithelium. Lo…

Lentivirus-mediated silencing of HOTAIR lncRNA restores gefitinib sensitivity by activating Bax/Caspase-3 and suppressing TGF-α/EGFR signaling in lung adenocarcinoma Open

Yuanshun Liu, Hua Jiang, Hongbin Zhou, Xiwang Ying, Zhehua Wang , et al. · 2017

Secondary resistance is a major limitation in the efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor treatment of lung cancer. Previous studies have shown that expression of the long non-coding RNA HOX transcript…

Overexpression of forkhead box M1 and urokinase‑type plasminogen activator in gastric cancer is associated with cancer progression and poor prognosis Open

Jie Ma, Guangwei Qi, Ji Xu, Haibing Ni, Wulin Xu , et al. · 2017

Forkhead box M1 (FOXM1) and urokinase-type plasminogen activator (uPA) are overexpressed and associated with the pathogenesis of multiple types of human malignancy. The aims of the present study were to investigate FOXM1 and uPA expression…

FoxM1 is associated with metastasis in colorectal cancer through induction of the epithelial‑mesenchymal transition Open

Bao‐Ying Fei, Xujun He, Jie Ma, Mei Zhang, Rui Chai · 2017

The aim of the present study was to investigate the role of forkhead box M1 (FoxM1) in epithelial-mesenchymal transition (EMT) and metastasis in colorectal cancer (CRC). Immunohistochemical assays were performed to detect FoxM1 and epithel…

Marsdeniae tenacissima extract-induced growth inhibition and apoptosis in hepatoma carcinoma cells is mediated through the p53/nuclear factor-κB signaling pathway Open

Zhen Wang, You‐Min Ying, Kaiqiang Li, Yu Zhang, Bingyu Chen , et al. · 2017

An extract from a traditional Chinese herb, Marsdeniae tenacissima (trade name, Xiao-Ai-Ping) has been approved for use on the Chinese market as a cancer chemotherapeutic agent for decades. Previous studies have demonstrated the cyt…

PHD3 affects gastric cancer progression by negatively regulating HIF1A Open

Yingjie Xia, Xiaoting Jiang, Shibin Jiang, Xujun He, Jungang Luo , et al. · 2017

Prolyl hydroxylase 3 (PHD3) is widely accepted as a tumor suppressor; however, the expression of PHD3 in various cancer types remains controversial. The present study aimed to investigate the association between PHD3 expression and the cli…

Overexpression of Musashi-1 protein is associated with progression and poor prognosis of gastric cancer Open

Zhangxuan Shou, Xue Jin, Xujun He, Zhong‐Sheng Zhao, Yuan Chen , et al. · 2017

Musashi-1, an evolutionally conserved RNA-binding protein, has been implicated in the promotion of pathological stem cell proliferation, including tumorigenesis. The objective of the present study was to evaluate the expression of Musashi-…

The diagnostic value of polymerase chain reaction for Mycobacterium tuberculosis to distinguish intestinal tuberculosis from crohn's disease: A meta-analysis Open

Ting Jin, Baoying Fei, Yu Zhang, Xujun He · 2017

The current evidence suggests that PCR for MTB is a promising and highly specific diagnostic method to distinguish ITB from CD. However, physicians should also keep in mind that negative results cannot exclude ITB for its low sensitivity. …

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