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View article: Sequential treatment of infectious bone defects with 3D-printed body temperature-responsive shape memory scaffold coated with metal-polyphenol layers
Sequential treatment of infectious bone defects with 3D-printed body temperature-responsive shape memory scaffold coated with metal-polyphenol layers Open
Background Infectious bone defects are characterized by persistent bacterial invasion and an immune microenvironment imbalance, which significantly hinders bone regeneration. Recently, numerous bone repair materials have been developed to …
View article: An adeno-associated virus gene therapy strategy for anti-obesity treatment by nanocarrier-based delivery systems
An adeno-associated virus gene therapy strategy for anti-obesity treatment by nanocarrier-based delivery systems Open
Gut microbiota is increasingly recognized for its profound influence on host metabolism. However, the mechanisms underlying the distinct metabolic phenotype observed in germ-free (GF) mice are not fully understood. Here, the serum levels o…
View article: Fast shape memory function and personalized PLTMC/SIM/MBG composite scaffold for bone regeneration
Fast shape memory function and personalized PLTMC/SIM/MBG composite scaffold for bone regeneration Open
Orthopedic clinical practice faces significant challenges in treating critical-sized bone defects due to extensive tissue damage and prolonged healing. To address these limitations, this study integrated shape-memory polymers with 3D print…
View article: Injectable and Sprayable Thermoresponsive Hydrogel with Fouling‐Resistance as an Effective Barrier to Prevent Postoperative Cardiac Adhesions
Injectable and Sprayable Thermoresponsive Hydrogel with Fouling‐Resistance as an Effective Barrier to Prevent Postoperative Cardiac Adhesions Open
Postoperative adhesions are inevitable consequences of surgery, resulting in various complications. The risk increases, particularly in cardiac surgery, where reoperations or staged operations are in high demand. The presence of cardiac ad…
View article: Innovations in hydrogel therapies for diabetic wound healing: bridging the gap between pathophysiology and clinical application
Innovations in hydrogel therapies for diabetic wound healing: bridging the gap between pathophysiology and clinical application Open
Diabetic wounds (DWs), which are complex and challenging to treat due to delayed healing and incomplete regeneration, pose a significant burden on global healthcare systems. Existing clinical interventions, which mainly comprise debridemen…
View article: Research progress of hydrogels in the prevention of pelvic inflammatory disease
Research progress of hydrogels in the prevention of pelvic inflammatory disease Open
Pelvic inflammatory disease (PID) is a critical global health concern with the potential to lead to adverse outcomes, including infertility and chronic pelvic pain. Since PID is often caused by ascending vaginal infections or urinary tract…
View article: 3D bioprinting techniques and hydrogels for osteochondral integration regeneration
3D bioprinting techniques and hydrogels for osteochondral integration regeneration Open
Despite considerable advancements in regenerative medicine, restoring the osteochondral interface and facilitating the integration of osteochondral regeneration remain significant clinical conundrums. This challenge is predominantly attrib…
View article: Current status and challenges of shape memory scaffolds in biomedical applications
Current status and challenges of shape memory scaffolds in biomedical applications Open
The rapid evolution of clinical medicine, materials science, and regenerative medicine has rendered traditional implantable scaffolds inadequate for addressing the complex therapeutic demands of various diseases. Currently, implantable sca…
View article: 3D Printed Multifunctional Biomimetic Bone Scaffold Combined with TP‐Mg Nanoparticles for the Infectious Bone Defects Repair
3D Printed Multifunctional Biomimetic Bone Scaffold Combined with TP‐Mg Nanoparticles for the Infectious Bone Defects Repair Open
Infected bone defects are one of the most challenging problems in the treatment of bone defects due to the high antibiotic failure rate and the lack of ideal bone grafts. In this paper, inspired by clinical bone cement filling treatment, α…
View article: From the microspheres to scaffolds: advances in polymer microsphere scaffolds for bone regeneration applications.
From the microspheres to scaffolds: advances in polymer microsphere scaffolds for bone regeneration applications. Open
The treatment and repair of bone tissue damage and loss due to infection, tumours, and trauma are major challenges in clinical practice. Artificial bone scaffolds offer a safer, simpler, and more feasible alternative to bone transplantatio…
View article: Efficacy and safety of glucagon-like peptide-1 receptor agonists in the elderly <i>versus</i> non-elderly patients with type 2 diabetes mellitus: insights from a systematic review
Efficacy and safety of glucagon-like peptide-1 receptor agonists in the elderly <i>versus</i> non-elderly patients with type 2 diabetes mellitus: insights from a systematic review Open
This systematic review aimed to compare the influence of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on the efficacy and safety of elderly patients with type 2 diabetes and younger individuals. A comprehensive search of PubMed, Em…
View article: Cyclical endometrial repair and regeneration: Molecular mechanisms, diseases, and therapeutic interventions
Cyclical endometrial repair and regeneration: Molecular mechanisms, diseases, and therapeutic interventions Open
The endometrium is a unique human tissue with an extraordinary ability to undergo a hormone‐regulated cycle encompassing shedding, bleeding, scarless repair, and regeneration throughout the female reproductive cycle. The cyclical repair an…
View article: Autonomous exploration for radioactive sources localization based on radiation field reconstruction
Autonomous exploration for radioactive sources localization based on radiation field reconstruction Open
In recent years, unmanned ground vehicles (UGVs) have been used to search for lost or stolen radioactive sources to avoid radiation exposure for operators. To achieve autonomous localization of radioactive sources, the UGVs must have the a…
View article: An Injectable Thermosensitive Hydrogel Containing Resveratrol and Dexamethasone‐Loaded Carbonated Hydroxyapatite Microspheres for the Regeneration of Osteoporotic Bone Defects
An Injectable Thermosensitive Hydrogel Containing Resveratrol and Dexamethasone‐Loaded Carbonated Hydroxyapatite Microspheres for the Regeneration of Osteoporotic Bone Defects Open
Bone defects in osteoporosis usually present excessive reactive oxygen species (ROS), abnormal inflammation levels, irregular shapes and impaired bone regeneration ability; therefore, osteoporotic bone defects are difficult to repair. In t…
View article: Evaluation of polyetheretherketone composites modified by calcium silicate and carbon nanotubes for bone regeneration: mechanical properties, biomineralization and induction of osteoblasts
Evaluation of polyetheretherketone composites modified by calcium silicate and carbon nanotubes for bone regeneration: mechanical properties, biomineralization and induction of osteoblasts Open
Desired orthopedic implant materials must have a good biological activity and possess appropriate mechanical property that correspond to those of human bone. Although polyetheretherketone (PEEK) has displayed a promising application prospe…
View article: Research progress of 3D printed poly (ether ether ketone) in the reconstruction of craniomaxillofacial bone defects
Research progress of 3D printed poly (ether ether ketone) in the reconstruction of craniomaxillofacial bone defects Open
The clinical challenge of bone defects in the craniomaxillofacial region, which can lead to significant physiological dysfunction and psychological distress, persists due to the complex and unique anatomy of craniomaxillofacial bones. Thes…
View article: ACA: Automatic search strategy for radioactive source
ACA: Automatic search strategy for radioactive source Open
Nowadays, mobile robots have been used to search for uncontrolled radioactive source in indoor environments to avoid radiation exposure for technicians. However, in the indoor environments, especially in the presence of obstacles, how to m…
View article: Targeting staphylococcal bone infections
Targeting staphylococcal bone infections Open
A novel quinolone antibiotic was developed by Shiladitya Sengupta and colleagues using molecular-docking simulation, and one lead compound, VCD-077, was selected based on this strategy.1 Antimicrobial resistance is increasing, driven by wi…
View article: <scp>3D</scp> printed <scp>PCLA</scp> scaffold with nano‐hydroxyapatite coating doped green tea <scp>EGCG</scp> promotes bone growth and inhibits multidrug‐resistant bacteria colonization
<span>3D</span> printed <span>PCLA</span> scaffold with nano‐hydroxyapatite coating doped green tea <span>EGCG</span> promotes bone growth and inhibits multidrug‐resistant bacteria colonization Open
Objectives 3D‐printing scaffold with specifically customized and biomimetic structures gained significant recent attention in tissue engineering for the regeneration of damaged bone tissues. However, constructed scaffolds that simultaneous…
View article: Recent progress in 3D printing degradable polylactic acid‐based bone repair scaffold for the application of cancellous bone defect
Recent progress in 3D printing degradable polylactic acid‐based bone repair scaffold for the application of cancellous bone defect Open
Large size bone defects have become a growing clinical challenge. Cancellous bone, which has the highest volume ratio, the fastest replacement rate, and interconnected porous structure, plays a major role in bone repairing. Considering the…
View article: 3D-Printed Poly (P-Dioxanone) Stent for Endovascular Application: In Vitro Evaluations
3D-Printed Poly (P-Dioxanone) Stent for Endovascular Application: In Vitro Evaluations Open
Rapid formation of innovative, inexpensive, personalized, and quickly reproducible artery bioresorbable stents (BRSs) is significantly important for treating dangerous and sometimes deadly cerebrovascular disorders. It is greatly challengi…