Xuling Jiang
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View article: Supramolecular Self‐Assembled Multivalent Anti‐VEGF Protein Nanospheres for Prolonged Ocular Retention
Supramolecular Self‐Assembled Multivalent Anti‐VEGF Protein Nanospheres for Prolonged Ocular Retention Open
To meet the therapeutic demands for long‐acting anti‐vascular endothelial growth factor (VEGF) agents in retinal vascular diseases—specifically prolonged half‐life, high bioactivity, and high concentration with low viscosity—a supramolecul…
View article: Oral Doxorubicin Lipid Nanoparticles Enhance Triple‐Negative Breast Cancer Therapy via Immune Activation and Reduced Cardiotoxicity
Oral Doxorubicin Lipid Nanoparticles Enhance Triple‐Negative Breast Cancer Therapy via Immune Activation and Reduced Cardiotoxicity Open
Doxorubicin (Dox) is a cornerstone chemotherapeutic agent for treating triple‐negative breast cancer, but its clinical utility is limited by cardiotoxicity. While oral administration can circumvent the toxicity risks of intravenous deliver…
View article: A Multi-Enzyme Cascade for Efficient Production of Pyrrolidone from <scp>l-</scp> Glutamate
A Multi-Enzyme Cascade for Efficient Production of Pyrrolidone from <span>l-</span> Glutamate Open
This study developed a three-enzyme cascade pathway for the production of pyrrolidone from l- Glu. The catalytic efficiency of carnitine CoA ligase from Escherichia coli ( Ec CaiC) was improved by mechanism-based protein engineering, and t…